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Research Objectives – Types, Examples and Writing Guide

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Research Objectives

Research objectives refer to the specific goals or aims of a research study. They provide a clear and concise description of what the researcher hopes to achieve by conducting the research . The objectives are typically based on the research questions and hypotheses formulated at the beginning of the study and are used to guide the research process.

Types of Research Objectives

Here are the different types of research objectives in research:

• Exploratory Objectives: These objectives are used to explore a topic, issue, or phenomenon that has not been studied in-depth before. The aim of exploratory research is to gain a better understanding of the subject matter and generate new ideas and hypotheses .
• Descriptive Objectives: These objectives aim to describe the characteristics, features, or attributes of a particular population, group, or phenomenon. Descriptive research answers the “what” questions and provides a snapshot of the subject matter.
• Explanatory Objectives : These objectives aim to explain the relationships between variables or factors. Explanatory research seeks to identify the cause-and-effect relationships between different phenomena.
• Predictive Objectives: These objectives aim to predict future events or outcomes based on existing data or trends. Predictive research uses statistical models to forecast future trends or outcomes.
• Evaluative Objectives : These objectives aim to evaluate the effectiveness or impact of a program, intervention, or policy. Evaluative research seeks to assess the outcomes or results of a particular intervention or program.
• Prescriptive Objectives: These objectives aim to provide recommendations or solutions to a particular problem or issue. Prescriptive research identifies the best course of action based on the results of the study.
• Diagnostic Objectives : These objectives aim to identify the causes or factors contributing to a particular problem or issue. Diagnostic research seeks to uncover the underlying reasons for a particular phenomenon.
• Comparative Objectives: These objectives aim to compare two or more groups, populations, or phenomena to identify similarities and differences. Comparative research is used to determine which group or approach is more effective or has better outcomes.
• Historical Objectives: These objectives aim to examine past events, trends, or phenomena to gain a better understanding of their significance and impact. Historical research uses archival data, documents, and records to study past events.
• Ethnographic Objectives : These objectives aim to understand the culture, beliefs, and practices of a particular group or community. Ethnographic research involves immersive fieldwork and observation to gain an insider’s perspective of the group being studied.
• Action-oriented Objectives: These objectives aim to bring about social or organizational change. Action-oriented research seeks to identify practical solutions to social problems and to promote positive change in society.
• Conceptual Objectives: These objectives aim to develop new theories, models, or frameworks to explain a particular phenomenon or set of phenomena. Conceptual research seeks to provide a deeper understanding of the subject matter by developing new theoretical perspectives.
• Methodological Objectives: These objectives aim to develop and improve research methods and techniques. Methodological research seeks to advance the field of research by improving the validity, reliability, and accuracy of research methods and tools.
• Theoretical Objectives : These objectives aim to test and refine existing theories or to develop new theoretical perspectives. Theoretical research seeks to advance the field of knowledge by testing and refining existing theories or by developing new theoretical frameworks.
• Measurement Objectives : These objectives aim to develop and validate measurement instruments, such as surveys, questionnaires, and tests. Measurement research seeks to improve the quality and reliability of data collection and analysis by developing and testing new measurement tools.
• Design Objectives : These objectives aim to develop and refine research designs, such as experimental, quasi-experimental, and observational designs. Design research seeks to improve the quality and validity of research by developing and testing new research designs.
• Sampling Objectives: These objectives aim to develop and refine sampling techniques, such as probability and non-probability sampling methods. Sampling research seeks to improve the representativeness and generalizability of research findings by developing and testing new sampling techniques.

How to Write Research Objectives

Writing clear and concise research objectives is an important part of any research project, as it helps to guide the study and ensure that it is focused and relevant. Here are some steps to follow when writing research objectives:

• Identify the research problem : Before you can write research objectives, you need to identify the research problem you are trying to address. This should be a clear and specific problem that can be addressed through research.
• Define the research questions : Based on the research problem, define the research questions you want to answer. These questions should be specific and should guide the research process.
• Identify the variables : Identify the key variables that you will be studying in your research. These are the factors that you will be measuring, manipulating, or analyzing to answer your research questions.
• Write specific objectives: Write specific, measurable objectives that will help you answer your research questions. These objectives should be clear and concise and should indicate what you hope to achieve through your research.
• Use the SMART criteria: To ensure that your research objectives are well-defined and achievable, use the SMART criteria. This means that your objectives should be Specific, Measurable, Achievable, Relevant, and Time-bound.
• Revise and refine: Once you have written your research objectives, revise and refine them to ensure that they are clear, concise, and achievable. Make sure that they align with your research questions and variables, and that they will help you answer your research problem.

Example of Research Objectives

Examples of research objectives Could be:

Research Objectives for the topic of “The Impact of Artificial Intelligence on Employment”:

• To investigate the effects of the adoption of AI on employment trends across various industries and occupations.
• To explore the potential for AI to create new job opportunities and transform existing roles in the workforce.
• To examine the social and economic implications of the widespread use of AI for employment, including issues such as income inequality and access to education and training.
• To identify the skills and competencies that will be required for individuals to thrive in an AI-driven workplace, and to explore the role of education and training in developing these skills.
• To evaluate the ethical and legal considerations surrounding the use of AI for employment, including issues such as bias, privacy, and the responsibility of employers and policymakers to protect workers’ rights.

When to Write Research Objectives

• At the beginning of a research project : Research objectives should be identified and written down before starting a research project. This helps to ensure that the project is focused and that data collection and analysis efforts are aligned with the intended purpose of the research.
• When refining research questions: Writing research objectives can help to clarify and refine research questions. Objectives provide a more concrete and specific framework for addressing research questions, which can improve the overall quality and direction of a research project.
• After conducting a literature review : Conducting a literature review can help to identify gaps in knowledge and areas that require further research. Writing research objectives can help to define and focus the research effort in these areas.
• When developing a research proposal: Research objectives are an important component of a research proposal. They help to articulate the purpose and scope of the research, and provide a clear and concise summary of the expected outcomes and contributions of the research.
• When seeking funding for research: Funding agencies often require a detailed description of research objectives as part of a funding proposal. Writing clear and specific research objectives can help to demonstrate the significance and potential impact of a research project, and increase the chances of securing funding.
• When designing a research study : Research objectives guide the design and implementation of a research study. They help to identify the appropriate research methods, sampling strategies, data collection and analysis techniques, and other relevant aspects of the study design.
• When communicating research findings: Research objectives provide a clear and concise summary of the main research questions and outcomes. They are often included in research reports and publications, and can help to ensure that the research findings are communicated effectively and accurately to a wide range of audiences.
• When evaluating research outcomes : Research objectives provide a basis for evaluating the success of a research project. They help to measure the degree to which research questions have been answered and the extent to which research outcomes have been achieved.
• When conducting research in a team : Writing research objectives can facilitate communication and collaboration within a research team. Objectives provide a shared understanding of the research purpose and goals, and can help to ensure that team members are working towards a common objective.

Purpose of Research Objectives

Some of the main purposes of research objectives include:

• To clarify the research question or problem : Research objectives help to define the specific aspects of the research question or problem that the study aims to address. This makes it easier to design a study that is focused and relevant.
• To guide the research design: Research objectives help to determine the research design, including the research methods, data collection techniques, and sampling strategy. This ensures that the study is structured and efficient.
• To measure progress : Research objectives provide a way to measure progress throughout the research process. They help the researcher to evaluate whether they are on track and meeting their goals.
• To communicate the research goals : Research objectives provide a clear and concise description of the research goals. This helps to communicate the purpose of the study to other researchers, stakeholders, and the general public.

Advantages of Research Objectives

Here are some advantages of having well-defined research objectives:

• Focus : Research objectives help to focus the research effort on specific areas of inquiry. By identifying clear research questions, the researcher can narrow down the scope of the study and avoid getting sidetracked by irrelevant information.
• Clarity : Clearly stated research objectives provide a roadmap for the research study. They provide a clear direction for the research, making it easier for the researcher to stay on track and achieve their goals.
• Measurability : Well-defined research objectives provide measurable outcomes that can be used to evaluate the success of the research project. This helps to ensure that the research is effective and that the research goals are achieved.
• Feasibility : Research objectives help to ensure that the research project is feasible. By clearly defining the research goals, the researcher can identify the resources required to achieve those goals and determine whether those resources are available.
• Relevance : Research objectives help to ensure that the research study is relevant and meaningful. By identifying specific research questions, the researcher can ensure that the study addresses important issues and contributes to the existing body of knowledge.

About the author

Muhammad Hassan

Researcher, Academic Writer, Web developer

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Research Aims, Objectives & Questions

The “Golden Thread” Explained Simply (+ Examples)

By: David Phair (PhD) and Alexandra Shaeffer (PhD) | June 2022

The research aims , objectives and research questions (collectively called the “golden thread”) are arguably the most important thing you need to get right when you’re crafting a research proposal , dissertation or thesis . We receive questions almost every day about this “holy trinity” of research and there’s certainly a lot of confusion out there, so we’ve crafted this post to help you navigate your way through the fog.

Overview: The Golden Thread

• What is the golden thread
• What are research aims ( examples )
• What are research objectives ( examples )
• What are research questions ( examples )
• The importance of alignment in the golden thread

What is the “golden thread”?  

The golden thread simply refers to the collective research aims , research objectives , and research questions for any given project (i.e., a dissertation, thesis, or research paper ). These three elements are bundled together because it’s extremely important that they align with each other, and that the entire research project aligns with them.

Importantly, the golden thread needs to weave its way through the entirety of any research project , from start to end. In other words, it needs to be very clearly defined right at the beginning of the project (the topic ideation and proposal stage) and it needs to inform almost every decision throughout the rest of the project. For example, your research design and methodology will be heavily influenced by the golden thread (we’ll explain this in more detail later), as well as your literature review.

The research aims, objectives and research questions (the golden thread) define the focus and scope ( the delimitations ) of your research project. In other words, they help ringfence your dissertation or thesis to a relatively narrow domain, so that you can “go deep” and really dig into a specific problem or opportunity. They also help keep you on track , as they act as a litmus test for relevance. In other words, if you’re ever unsure whether to include something in your document, simply ask yourself the question, “does this contribute toward my research aims, objectives or questions?”. If it doesn’t, chances are you can drop it.

Alright, enough of the fluffy, conceptual stuff. Let’s get down to business and look at what exactly the research aims, objectives and questions are and outline a few examples to bring these concepts to life.

Research Aims: What are they?

Simply put, the research aim(s) is a statement that reflects the broad overarching goal (s) of the research project. Research aims are fairly high-level (low resolution) as they outline the general direction of the research and what it’s trying to achieve .

Research Aims: Examples  

True to the name, research aims usually start with the wording “this research aims to…”, “this research seeks to…”, and so on. For example:

“This research aims to explore employee experiences of digital transformation in retail HR.”   “This study sets out to assess the interaction between student support and self-care on well-being in engineering graduate students”  

As you can see, these research aims provide a high-level description of what the study is about and what it seeks to achieve. They’re not hyper-specific or action-oriented, but they’re clear about what the study’s focus is and what is being investigated.

Need a helping hand?

Research Objectives: What are they?

The research objectives take the research aims and make them more practical and actionable . In other words, the research objectives showcase the steps that the researcher will take to achieve the research aims.

The research objectives need to be far more specific (higher resolution) and actionable than the research aims. In fact, it’s always a good idea to craft your research objectives using the “SMART” criteria. In other words, they should be specific, measurable, achievable, relevant and time-bound”.

Research Objectives: Examples  

Let’s look at two examples of research objectives. We’ll stick with the topic and research aims we mentioned previously.  

For the digital transformation topic:

To observe the retail HR employees throughout the digital transformation. To assess employee perceptions of digital transformation in retail HR. To identify the barriers and facilitators of digital transformation in retail HR.

And for the student wellness topic:

To determine whether student self-care predicts the well-being score of engineering graduate students. To determine whether student support predicts the well-being score of engineering students. To assess the interaction between student self-care and student support when predicting well-being in engineering graduate students.

  As you can see, these research objectives clearly align with the previously mentioned research aims and effectively translate the low-resolution aims into (comparatively) higher-resolution objectives and action points . They give the research project a clear focus and present something that resembles a research-based “to-do” list.

Research Questions: What are they?

Finally, we arrive at the all-important research questions. The research questions are, as the name suggests, the key questions that your study will seek to answer . Simply put, they are the core purpose of your dissertation, thesis, or research project. You’ll present them at the beginning of your document (either in the introduction chapter or literature review chapter) and you’ll answer them at the end of your document (typically in the discussion and conclusion chapters).  

The research questions will be the driving force throughout the research process. For example, in the literature review chapter, you’ll assess the relevance of any given resource based on whether it helps you move towards answering your research questions. Similarly, your methodology and research design will be heavily influenced by the nature of your research questions. For instance, research questions that are exploratory in nature will usually make use of a qualitative approach, whereas questions that relate to measurement or relationship testing will make use of a quantitative approach.  

Let’s look at some examples of research questions to make this more tangible.

Research Questions: Examples  

Again, we’ll stick with the research aims and research objectives we mentioned previously.  

For the digital transformation topic (which would be qualitative in nature):

How do employees perceive digital transformation in retail HR? What are the barriers and facilitators of digital transformation in retail HR?  

And for the student wellness topic (which would be quantitative in nature):

Does student self-care predict the well-being scores of engineering graduate students? Does student support predict the well-being scores of engineering students? Do student self-care and student support interact when predicting well-being in engineering graduate students?  

You’ll probably notice that there’s quite a formulaic approach to this. In other words, the research questions are basically the research objectives “converted” into question format. While that is true most of the time, it’s not always the case. For example, the first research objective for the digital transformation topic was more or less a step on the path toward the other objectives, and as such, it didn’t warrant its own research question.  

So, don’t rush your research questions and sloppily reword your objectives as questions. Carefully think about what exactly you’re trying to achieve (i.e. your research aim) and the objectives you’ve set out, then craft a set of well-aligned research questions . Also, keep in mind that this can be a somewhat iterative process , where you go back and tweak research objectives and aims to ensure tight alignment throughout the golden thread.

The importance of strong alignment 

Alignment is the keyword here and we have to stress its importance . Simply put, you need to make sure that there is a very tight alignment between all three pieces of the golden thread. If your research aims and research questions don’t align, for example, your project will be pulling in different directions and will lack focus . This is a common problem students face and can cause many headaches (and tears), so be warned.

Take the time to carefully craft your research aims, objectives and research questions before you run off down the research path. Ideally, get your research supervisor/advisor to review and comment on your golden thread before you invest significant time into your project, and certainly before you start collecting data .  

Recap: The golden thread

In this post, we unpacked the golden thread of research, consisting of the research aims , research objectives and research questions . You can jump back to any section using the links below.

As always, feel free to leave a comment below – we always love to hear from you. Also, if you’re interested in 1-on-1 support, take a look at our private coaching service here.

Psst... there’s more!

This post was based on one of our popular Research Bootcamps . If you're working on a research project, you'll definitely want to check this out ...

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38 Comments

Thank you very much for your great effort put. As an Undergraduate taking Demographic Research & Methodology, I’ve been trying so hard to understand clearly what is a Research Question, Research Aim and the Objectives in a research and the relationship between them etc. But as for now I’m thankful that you’ve solved my problem.

Well appreciated. This has helped me greatly in doing my dissertation.

An so delighted with this wonderful information thank you a lot.

so impressive i have benefited a lot looking forward to learn more on research.

I am very happy to have carefully gone through this well researched article.

Infact,I used to be phobia about anything research, because of my poor understanding of the concepts.

Now,I get to know that my research question is the same as my research objective(s) rephrased in question format.

I please I would need a follow up on the subject,as I intends to join the team of researchers. Thanks once again.

Thanks so much. This was really helpful.

I know you pepole have tried to break things into more understandable and easy format. And God bless you. Keep it up

i found this document so useful towards my study in research methods. thanks so much.

This is my 2nd read topic in your course and I should commend the simplified explanations of each part. I’m beginning to understand and absorb the use of each part of a dissertation/thesis. I’ll keep on reading your free course and might be able to avail the training course! Kudos!

Thank you! Better put that my lecture and helped to easily understand the basics which I feel often get brushed over when beginning dissertation work.

This is quite helpful. I like how the Golden thread has been explained and the needed alignment.

This is quite helpful. I really appreciate!

The article made it simple for researcher students to differentiate between three concepts.

Very innovative and educational in approach to conducting research.

I am very impressed with all these terminology, as I am a fresh student for post graduate, I am highly guided and I promised to continue making consultation when the need arise. Thanks a lot.

A very helpful piece. thanks, I really appreciate it .

Very well explained, and it might be helpful to many people like me.

Wish i had found this (and other) resource(s) at the beginning of my PhD journey… not in my writing up year… 😩 Anyways… just a quick question as i’m having some issues ordering my “golden thread”…. does it matter in what order you mention them? i.e., is it always first aims, then objectives, and finally the questions? or can you first mention the research questions and then the aims and objectives?

Thank you for a very simple explanation that builds upon the concepts in a very logical manner. Just prior to this, I read the research hypothesis article, which was equally very good. This met my primary objective.

My secondary objective was to understand the difference between research questions and research hypothesis, and in which context to use which one. However, I am still not clear on this. Can you kindly please guide?

In research, a research question is a clear and specific inquiry that the researcher wants to answer, while a research hypothesis is a tentative statement or prediction about the relationship between variables or the expected outcome of the study. Research questions are broader and guide the overall study, while hypotheses are specific and testable statements used in quantitative research. Research questions identify the problem, while hypotheses provide a focus for testing in the study.

Exactly what I need in this research journey, I look forward to more of your coaching videos.

This helped a lot. Thanks so much for the effort put into explaining it.

What data source in writing dissertation/Thesis requires?

What is data source covers when writing dessertation/thesis

This is quite useful thanks

I’m excited and thankful. I got so much value which will help me progress in my thesis.

where are the locations of the reserch statement, research objective and research question in a reserach paper? Can you write an ouline that defines their places in the researh paper?

Very helpful and important tips on Aims, Objectives and Questions.

Thank you so much for making research aim, research objectives and research question so clear. This will be helpful to me as i continue with my thesis.

Thanks much for this content. I learned a lot. And I am inspired to learn more. I am still struggling with my preparation for dissertation outline/proposal. But I consistently follow contents and tutorials and the new FB of GRAD Coach. Hope to really become confident in writing my dissertation and successfully defend it.

As a researcher and lecturer, I find splitting research goals into research aims, objectives, and questions is unnecessarily bureaucratic and confusing for students. For most biomedical research projects, including ‘real research’, 1-3 research questions will suffice (numbers may differ by discipline).

Awesome! Very important resources and presented in an informative way to easily understand the golden thread. Indeed, thank you so much.

Well explained

The blog article on research aims, objectives, and questions by Grad Coach is a clear and insightful guide that aligns with my experiences in academic research. The article effectively breaks down the often complex concepts of research aims and objectives, providing a straightforward and accessible explanation. Drawing from my own research endeavors, I appreciate the practical tips offered, such as the need for specificity and clarity when formulating research questions. The article serves as a valuable resource for students and researchers, offering a concise roadmap for crafting well-defined research goals and objectives. Whether you’re a novice or an experienced researcher, this article provides practical insights that contribute to the foundational aspects of a successful research endeavor.

A great thanks for you. it is really amazing explanation. I grasp a lot and one step up to research knowledge.

I really found these tips helpful. Thank you very much Grad Coach.

I found this article helpful. Thanks for sharing this.

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• Aims and Objectives – A Guide for Academic Writing
• Doing a PhD

One of the most important aspects of a thesis, dissertation or research paper is the correct formulation of the aims and objectives. This is because your aims and objectives will establish the scope, depth and direction that your research will ultimately take. An effective set of aims and objectives will give your research focus and your reader clarity, with your aims indicating what is to be achieved, and your objectives indicating how it will be achieved.

Introduction

There is no getting away from the importance of the aims and objectives in determining the success of your research project. Unfortunately, however, it is an aspect that many students struggle with, and ultimately end up doing poorly. Given their importance, if you suspect that there is even the smallest possibility that you belong to this group of students, we strongly recommend you read this page in full.

This page describes what research aims and objectives are, how they differ from each other, how to write them correctly, and the common mistakes students make and how to avoid them. An example of a good aim and objectives from a past thesis has also been deconstructed to help your understanding.

What Are Aims and Objectives?

Research aims.

A research aim describes the main goal or the overarching purpose of your research project.

In doing so, it acts as a focal point for your research and provides your readers with clarity as to what your study is all about. Because of this, research aims are almost always located within its own subsection under the introduction section of a research document, regardless of whether it’s a thesis , a dissertation, or a research paper .

A research aim is usually formulated as a broad statement of the main goal of the research and can range in length from a single sentence to a short paragraph. Although the exact format may vary according to preference, they should all describe why your research is needed (i.e. the context), what it sets out to accomplish (the actual aim) and, briefly, how it intends to accomplish it (overview of your objectives).

To give an example, we have extracted the following research aim from a real PhD thesis:

Example of a Research Aim

The role of diametrical cup deformation as a factor to unsatisfactory implant performance has not been widely reported. The aim of this thesis was to gain an understanding of the diametrical deformation behaviour of acetabular cups and shells following impaction into the reamed acetabulum. The influence of a range of factors on deformation was investigated to ascertain if cup and shell deformation may be high enough to potentially contribute to early failure and high wear rates in metal-on-metal implants.

Note: Extracted with permission from thesis titled “T he Impact And Deformation Of Press-Fit Metal Acetabular Components ” produced by Dr H Hothi of previously Queen Mary University of London.

Research Objectives

Where a research aim specifies what your study will answer, research objectives specify how your study will answer it.

They divide your research aim into several smaller parts, each of which represents a key section of your research project. As a result, almost all research objectives take the form of a numbered list, with each item usually receiving its own chapter in a dissertation or thesis.

Following the example of the research aim shared above, here are it’s real research objectives as an example:

Example of a Research Objective

• Develop finite element models using explicit dynamics to mimic mallet blows during cup/shell insertion, initially using simplified experimentally validated foam models to represent the acetabulum.
• Investigate the number, velocity and position of impacts needed to insert a cup.
• Determine the relationship between the size of interference between the cup and cavity and deformation for different cup types.
• Investigate the influence of non-uniform cup support and varying the orientation of the component in the cavity on deformation.
• Examine the influence of errors during reaming of the acetabulum which introduce ovality to the cavity.
• Determine the relationship between changes in the geometry of the component and deformation for different cup designs.
• Develop three dimensional pelvis models with non-uniform bone material properties from a range of patients with varying bone quality.
• Use the key parameters that influence deformation, as identified in the foam models to determine the range of deformations that may occur clinically using the anatomic models and if these deformations are clinically significant.

It’s worth noting that researchers sometimes use research questions instead of research objectives, or in other cases both. From a high-level perspective, research questions and research objectives make the same statements, but just in different formats.

Taking the first three research objectives as an example, they can be restructured into research questions as follows:

Restructuring Research Objectives as Research Questions

• Can finite element models using simplified experimentally validated foam models to represent the acetabulum together with explicit dynamics be used to mimic mallet blows during cup/shell insertion?
• What is the number, velocity and position of impacts needed to insert a cup?
• What is the relationship between the size of interference between the cup and cavity and deformation for different cup types?

Difference Between Aims and Objectives

Hopefully the above explanations make clear the differences between aims and objectives, but to clarify:

• The research aim focus on what the research project is intended to achieve; research objectives focus on how the aim will be achieved.
• Research aims are relatively broad; research objectives are specific.
• Research aims focus on a project’s long-term outcomes; research objectives focus on its immediate, short-term outcomes.
• A research aim can be written in a single sentence or short paragraph; research objectives should be written as a numbered list.

How to Write Aims and Objectives

Before we discuss how to write a clear set of research aims and objectives, we should make it clear that there is no single way they must be written. Each researcher will approach their aims and objectives slightly differently, and often your supervisor will influence the formulation of yours on the basis of their own preferences.

Regardless, there are some basic principles that you should observe for good practice; these principles are described below.

Your aim should be made up of three parts that answer the below questions:

• Why is this research required?
• What is this research about?
• How are you going to do it?

The easiest way to achieve this would be to address each question in its own sentence, although it does not matter whether you combine them or write multiple sentences for each, the key is to address each one.

The first question, why , provides context to your research project, the second question, what , describes the aim of your research, and the last question, how , acts as an introduction to your objectives which will immediately follow.

Scroll through the image set below to see the ‘why, what and how’ associated with our research aim example.

Note: Your research aims need not be limited to one. Some individuals per to define one broad ‘overarching aim’ of a project and then adopt two or three specific research aims for their thesis or dissertation. Remember, however, that in order for your assessors to consider your research project complete, you will need to prove you have fulfilled all of the aims you set out to achieve. Therefore, while having more than one research aim is not necessarily disadvantageous, consider whether a single overarching one will do.

Research Objectives

Each of your research objectives should be SMART :

• Specific – is there any ambiguity in the action you are going to undertake, or is it focused and well-defined?
• Measurable – how will you measure progress and determine when you have achieved the action?
• Achievable – do you have the support, resources and facilities required to carry out the action?
• Relevant – is the action essential to the achievement of your research aim?
• Timebound – can you realistically complete the action in the available time alongside your other research tasks?

In addition to being SMART, your research objectives should start with a verb that helps communicate your intent. Common research verbs include:

Table of Research Verbs to Use in Aims and Objectives

Last, format your objectives into a numbered list. This is because when you write your thesis or dissertation, you will at times need to make reference to a specific research objective; structuring your research objectives in a numbered list will provide a clear way of doing this.

To bring all this together, let’s compare the first research objective in the previous example with the above guidance:

Checking Research Objective Example Against Recommended Approach

Research Objective:

1. Develop finite element models using explicit dynamics to mimic mallet blows during cup/shell insertion, initially using simplified experimentally validated foam models to represent the acetabulum.

Checking Against Recommended Approach:

Q: Is it specific? A: Yes, it is clear what the student intends to do (produce a finite element model), why they intend to do it (mimic cup/shell blows) and their parameters have been well-defined ( using simplified experimentally validated foam models to represent the acetabulum ).

Q: Is it measurable? A: Yes, it is clear that the research objective will be achieved once the finite element model is complete.

Q: Is it achievable? A: Yes, provided the student has access to a computer lab, modelling software and laboratory data.

Q: Is it relevant? A: Yes, mimicking impacts to a cup/shell is fundamental to the overall aim of understanding how they deform when impacted upon.

Q: Is it timebound? A: Yes, it is possible to create a limited-scope finite element model in a relatively short time, especially if you already have experience in modelling.

Q: Does it start with a verb? A: Yes, it starts with ‘develop’, which makes the intent of the objective immediately clear.

Q: Is it a numbered list? A: Yes, it is the first research objective in a list of eight.

Mistakes in Writing Research Aims and Objectives

1. making your research aim too broad.

Having a research aim too broad becomes very difficult to achieve. Normally, this occurs when a student develops their research aim before they have a good understanding of what they want to research. Remember that at the end of your project and during your viva defence , you will have to prove that you have achieved your research aims; if they are too broad, this will be an almost impossible task. In the early stages of your research project, your priority should be to narrow your study to a specific area. A good way to do this is to take the time to study existing literature, question their current approaches, findings and limitations, and consider whether there are any recurring gaps that could be investigated .

Note: Achieving a set of aims does not necessarily mean proving or disproving a theory or hypothesis, even if your research aim was to, but having done enough work to provide a useful and original insight into the principles that underlie your research aim.

2. Making Your Research Objectives Too Ambitious

Be realistic about what you can achieve in the time you have available. It is natural to want to set ambitious research objectives that require sophisticated data collection and analysis, but only completing this with six months before the end of your PhD registration period is not a worthwhile trade-off.

3. Formulating Repetitive Research Objectives

Each research objective should have its own purpose and distinct measurable outcome. To this effect, a common mistake is to form research objectives which have large amounts of overlap. This makes it difficult to determine when an objective is truly complete, and also presents challenges in estimating the duration of objectives when creating your project timeline. It also makes it difficult to structure your thesis into unique chapters, making it more challenging for you to write and for your audience to read.

Fortunately, this oversight can be easily avoided by using SMART objectives.

Hopefully, you now have a good idea of how to create an effective set of aims and objectives for your research project, whether it be a thesis, dissertation or research paper. While it may be tempting to dive directly into your research, spending time on getting your aims and objectives right will give your research clear direction. This won’t only reduce the likelihood of problems arising later down the line, but will also lead to a more thorough and coherent research project.

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Writing the Research Objectives: 5 Straightforward Examples

The research objective of a research proposal or scientific article defines the direction or content of a research investigation. Without the research objectives, the proposal or research paper is in disarray. It is like a fisherman riding on a boat without any purpose and with no destination in sight. Therefore, at the beginning of any research venture, the researcher must be clear about what he or she intends to do or achieve in conducting a study.

How do you define the objectives of a study? What are the uses of the research objective? How would a researcher write this essential part of the research? This article aims to provide answers to these questions.

Table of Contents

Definition of a research objective.

A research objective describes, in a few words, the result of the research project after its implementation. It answers the question,

“ What does the researcher want or hope to achieve at the end of the research project.”  

The research objective provides direction to the performance of the study.

What are the Uses of the Research Objective?

The uses of the research objective are enumerated below:

• serves as the researcher’s guide in identifying the appropriate research design,
• identifies the variables of the study, and
• specifies the data collection procedure and the corresponding analysis for the data generated.

The research design serves as the “blueprint” for the research investigation. The University of Southern California describes the different types of research design extensively. It details the data to be gathered, data collection procedure, data measurement, and statistical tests to use in the analysis.

The variables of the study include those factors that the researcher wants to evaluate in the study. These variables narrow down the research to several manageable components to see differences or correlations between them.

Specifying the data collection procedure ensures data accuracy and integrity . Thus, the probability of error is minimized. Generalizations or conclusions based on valid arguments founded on reliable data strengthens research findings on particular issues and problems.

In data mining activities where large data sets are involved, the research objective plays a crucial role. Without a clear objective to guide the machine learning process, the desired outcomes will not be met.

How is the Research Objective Written?

A research objective must be achievable, i.e., it must be framed keeping in mind the available time, infrastructure required for research, and other resources.

Before forming a research objective, you should read about all the developments in your area of research and find gaps in knowledge that need to be addressed. Readings will help you come up with suitable objectives for your research project.

5 Examples of Research Objectives

The following examples of research objectives based on several published studies on various topics demonstrate how the research objectives are written:

• This study aims to find out if there is a difference in quiz scores between students exposed to direct instruction and flipped classrooms (Webb and Doman, 2016).
• This study seeks to examine the extent, range, and method of coral reef rehabilitation projects in five shallow reef areas adjacent to popular tourist destinations in the Philippines (Yeemin et al ., 2006).
• This study aims to investigate species richness of mammal communities in five protected areas over the past 20 years (Evans et al ., 2006).
• This study aims to clarify the demographic, epidemiological, clinical, and radiological features of 2019-nCoV patients with other causes of pneumonia (Zhao et al ., 2020).
• This research aims to assess species extinction risks for sample regions that cover some 20% of the Earth’s terrestrial surface.

Finally, writing the research objectives requires constant practice, experience, and knowledge about the topic investigated. Clearly written objectives save time, money, and effort.

Once you have a clear idea of your research objectives, you can now develop your conceptual framework which is a crucial element of your research paper as it guides the flow of your research. The conceptual framework will help you develop your methodology and statistical tests.

I wrote a detailed, step-by-step guide on how to develop a conceptual framework with illustration in my post titled “ Conceptual Framework: A Step by Step Guide on How to Make One. “

Evans, K. L., Rodrigues, A. S., Chown, S. L., & Gaston, K. J. (2006). Protected areas and regional avian species richness in South Africa.  Biology letters ,  2 (2), 184-188.

Thomas, C. D., Cameron, A., Green, R. E., Bakkenes, M., Beaumont, L. J., Collingham, Y. C., … & Hughes, L. (2004). Extinction risk from climate change. Nature, 427(6970), 145-148.

Webb, M., & Doman, E. (2016). Does the Flipped Classroom Lead to Increased Gains on Learning Outcomes in ESL/EFL Contexts?. CATESOL Journal, 28(1), 39-67.

Yeemin, T., Sutthacheep, M., & Pettongma, R. (2006). Coral reef restoration projects in Thailand.  Ocean & Coastal Management ,  49 (9-10), 562-575.

Zhao, D., Yao, F., Wang, L., Zheng, L., Gao, Y., Ye, J., Guo, F., Zhao, H. & Gao, R. (2020). A comparative study on the clinical features of COVID-19 pneumonia to other pneumonias, Clinical Infectious Diseases , ciaa247, https://doi.org/10.1093/cid/ciaa247

© 2020 March 23 P. A. Regoniel Updated 17 November 2020 | Updated 18 January 2024

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Conceptual Framework: A Step-by-Step Guide on How to Make One

Simplified explanation of probability in statistics, about the author, patrick regoniel.

Dr. Regoniel, a faculty member of the graduate school, served as consultant to various environmental research and development projects covering issues and concerns on climate change, coral reef resources and management, economic valuation of environmental and natural resources, mining, and waste management and pollution. He has extensive experience on applied statistics, systems modelling and analysis, an avid practitioner of LaTeX, and a multidisciplinary web developer. He leverages pioneering AI-powered content creation tools to produce unique and comprehensive articles in this website.

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• Writing Tips

How to Write Research Objectives

3-minute read

• 22nd November 2021

Writing a research paper, thesis, or dissertation ? If so, you’ll want to state your research objectives in the introduction of your paper to make it clear to your readers what you’re trying to accomplish. But how do you write effective research objectives? In this post, we’ll look at two key topics to help you do this:

• How to use your research aims as a basis for developing objectives.
• How to use SMART criteria to refine your research objectives.

For more advice on how to write strong research objectives, see below.

Research Aims and Objectives

There is an important difference between research aims and research objectives:

• A research aim defines the main purpose of your research. As such, you can think of your research aim as answering the question “What are you doing?”
• Research objectives (as most studies will have more than one) are the steps you will take to fulfil your aims. As such, your objectives should answer the question “How are you conducting your research?”

For instance, an example research aim could be:

This study will investigate the link between dehydration and the incidence of urinary tract infections (UTIs) in intensive care patients in Australia.

To develop a set of research objectives, you would then break down the various steps involved in meeting said aim. For example:

This study will investigate the link between dehydration and the incidence of urinary tract infections (UTIs) in intensive care patients in Australia. To achieve this, the study objectives w ill include:

• Replicat ing a small Singaporean study into the role of dehydration in UTIs in hospital patients (Sepe, 2018) in a larger Australian cohort.
• Trialing the use of intravenous fluids for intensive care patients to prevent dehydration.
• Assessing the relationship between the age of patients and quantities of intravenous fluids needed to counter dehydration.

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Note that the objectives don’t go into any great detail here. The key is to briefly summarize each component of your study. You can save details for how you will conduct the research for the methodology section of your paper.

Make Your Research Objectives SMART

A great way to refine your research objectives is to use SMART criteria . Borrowed from the world of project management, there are many versions of this system. However, we’re going to focus on developing specific, measurable, achievable, relevant, and timebound objectives.

In other words, a good research objective should be all of the following:

• S pecific – Is the objective clear and well-defined?
• M easurable – How will you know when the objective has been achieved? Is there a way to measure the thing you’re seeking to do?
• A chievable – Do you have the support and resources necessary to undertake this action? Are you being overly ambitious with this objective?
• R elevant – Is this objective vital for fulfilling your research aim?
• T imebound – Can this action be realistically undertaken in the time you have?

If you follow this system, your research objectives will be much stronger.

Expert Research Proofreading

Whatever your research aims and objectives, make sure to have your academic writing proofread by the experts!

Our academic editors can help you with research papers and proposals , as well as any other scholarly document you need checking. And this will help to ensure that your academic writing is always clear, concise, and precise.

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Crafting Clear Pathways: Writing Objectives in Research Papers

Struggling to write research objectives? Follow our easy steps to learn how to craft effective and compelling objectives in research papers.

Are you struggling to define the goals and direction of your research? Are you losing yourself while doing research and tend to go astray from the intended research topic? Fear not, as many face the same problem and it is quite understandable to overcome this, a concept called research objective comes into play here.

In this article, we’ll delve into the world of the objectives in research papers and why they are essential for a successful study. We will be studying what they are and how they are used in research.

What is a Research Objective?

A research objective is a clear and specific goal that a researcher aims to achieve through a research study. It serves as a roadmap for the research, providing direction and focus. Research objectives are formulated based on the research questions or hypotheses, and they help in defining the scope of the study and guiding the research design and methodology. They also assist in evaluating the success and outcomes of the research.

Types of Research Objectives

There are typically three main types of objectives in a research paper:

• Exploratory Objectives: These objectives are focused on gaining a deeper understanding of a particular phenomenon, topic, or issue. Exploratory research objectives aim to explore and identify new ideas, insights, or patterns that were previously unknown or poorly understood. This type of objective is commonly used in preliminary or qualitative studies.
• Descriptive Objectives: Descriptive objectives seek to describe and document the characteristics, behaviors, or attributes of a specific population, event, or phenomenon. The purpose is to provide a comprehensive and accurate account of the subject of study. Descriptive research objectives often involve collecting and analyzing data through surveys, observations, or archival research.
• Explanatory or Causal Objectives: Explanatory objectives aim to establish a cause-and-effect relationship between variables or factors. These objectives focus on understanding why certain events or phenomena occur and how they are related to each other. 

Also Read: What are the types of research?

Steps for Writing Objectives in Research Paper

1. identify the research topic:.

Clearly define the subject or topic of your research. This will provide a broad context for developing specific research objectives.

2. Conduct a Literature Review

Review existing literature and research related to your topic. This will help you understand the current state of knowledge, identify any research gaps, and refine your research objectives accordingly.

3. Identify the Research Questions or Hypotheses

Formulate specific research questions or hypotheses that you want to address in your study. These questions should be directly related to your research topic and guide the development of your research objectives.

4. Focus on Specific Goals

Break down the broader research questions or hypothesis into specific goals or objectives. Each objective should focus on a particular aspect of your research topic and be achievable within the scope of your study.

5. Use Clear and Measurable Language

Write your research objectives using clear and precise language. Avoid vague terms and use specific and measurable terms that can be observed, analyzed, or measured.

6. Consider Feasibility

Ensure that your research objectives are feasible within the available resources, time constraints, and ethical considerations. They should be realistic and attainable given the limitations of your study.

7. Prioritize Objectives

If you have multiple research objectives, prioritize them based on their importance and relevance to your overall research goals. This will help you allocate resources and focus your efforts accordingly.

8. Review and Refine

Review your research objectives to ensure they align with your research questions or hypotheses, and revise them if necessary. Seek feedback from peers or advisors to ensure clarity and coherence.

Tips for Writing Objectives in Research Paper

1. be clear and specific.

Clearly state what you intend to achieve with your research. Use specific language that leaves no room for ambiguity or confusion. This ensures that your objectives are well-defined and focused.

2. Use Action Verbs

Begin each research objective with an action verb that describes a measurable action or outcome. This helps make your objectives more actionable and measurable.

3. Align with Research Questions or Hypotheses

Your research objectives should directly address the research questions or hypotheses you have formulated. Ensure there is a clear connection between them to maintain coherence in your study.

4. Be Realistic and Feasible

Set research objectives that are attainable within the constraints of your study, including available resources, time, and ethical considerations. Unrealistic objectives may undermine the validity and reliability of your research.

5. Consider Relevance and Significance

Your research objectives should be relevant to your research topic and contribute to the broader field of study. Consider the potential impact and significance of achieving the objectives.

SMART Goals for Writing Research Objectives

To ensure that your research objectives are well-defined and effectively guide your study, you can apply the SMART framework. SMART stands for Specific, Measurable, Achievable, Relevant, and Time-bound. Here’s how you can make your research objectives SMART:

• Specific : Clearly state what you want to achieve in a precise and specific manner. Avoid vague or generalized language. Specify the population, variables, or phenomena of interest.
• Measurable : Ensure that your research objectives can be quantified or observed in a measurable way. This allows for objective evaluation and assessment of progress.
• Achievable : Set research objectives that are realistic and attainable within the available resources, time, and scope of your study. Consider the feasibility of conducting the research and collecting the necessary data.
• Relevant : Ensure that your research objectives are directly relevant to your research topic and contribute to the broader knowledge or understanding of the field. They should align with the purpose and significance of your study.
• Time-bound : Set a specific timeframe or deadline for achieving your research objectives. This helps create a sense of urgency and provides a clear timeline for your study.

Examples of Research Objectives

Here are some examples of research objectives from various fields of study:

• To examine the relationship between social media usage and self-esteem among young adults aged 18-25 in order to understand the potential impact on mental well-being.
• To assess the effectiveness of a mindfulness-based intervention in reducing stress levels and improving coping mechanisms among individuals diagnosed with anxiety disorders.
• To investigate the factors influencing consumer purchasing decisions in the e-commerce industry, with a focus on the role of online reviews and social media influencers.
• To analyze the effects of climate change on the biodiversity of coral reefs in a specific region, using remote sensing techniques and field surveys.

Importance of Research Objectives

Research objectives play a crucial role in the research process and hold significant importance for several reasons:

• Guiding the Research Process: Research objectives provide a clear roadmap for the entire research process. They help researchers stay focused and on track, ensuring that the study remains purposeful and relevant. 
• Defining the Scope of the Study: Research objectives help in determining the boundaries and scope of the study. They clarify what aspects of the research topic will be explored and what will be excluded. 
• Providing Direction for Data Collection and Analysis: Research objectives assist in identifying the type of data to be collected and the methods of data collection. They also guide the selection of appropriate data analysis techniques. 
• Evaluating the Success of the Study: Research objectives serve as benchmarks for evaluating the success and outcomes of the research. They provide measurable criteria against which the researcher can assess whether the objectives have been met or not. 
• Enhancing Communication and Collaboration: Clearly defined research objectives facilitate effective communication and collaboration among researchers, advisors, and stakeholders. 

Common Mistakes to Avoid While Writing Research Objectives

When writing research objectives, it’s important to be aware of common mistakes and pitfalls that can undermine the effectiveness and clarity of your objectives. Here are some common mistakes to avoid:

• Vague or Ambiguous Language: One of the key mistakes is using vague or ambiguous language that lacks specificity. Ensure that your research objectives are clearly and precisely stated, leaving no room for misinterpretation or confusion.
• Lack of Measurability: Research objectives should be measurable, meaning that they should allow for the collection of data or evidence that can be quantified or observed. Avoid setting objectives that cannot be measured or assessed objectively.
• Lack of Alignment with Research Questions or Hypotheses: Your research objectives should directly align with the research questions or hypotheses you have formulated. Make sure there is a clear connection between them to maintain coherence in your study.
• Overgeneralization : Avoid writing research objectives that are too broad or encompass too many variables or phenomena. Overgeneralized objectives may lead to a lack of focus or feasibility in conducting the research.
• Unrealistic or Unattainable Objectives: Ensure that your research objectives are realistic and attainable within the available resources, time, and scope of your study. Setting unrealistic objectives may compromise the validity and reliability of your research.

In conclusion, research objectives are integral to the success and effectiveness of any research study. They provide a clear direction, focus, and purpose, guiding the entire research process from start to finish. By formulating specific, measurable, achievable, relevant, and time-bound objectives, researchers can define the scope of their study, guide data collection and analysis, and evaluate the outcomes of their research.

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• A Research Guide
• Research Paper Guide

How to Write Research Objectives

• What are research objectives
• Step-by-step writing guide
• Helpful tips
• Research objectives examples

What are research objectives, and why are they important?

Step-by-step research objectives writing guide, step 1: provide the major background of your research, step 2: mention several objectives from the most to least important aspects, step 3: follow your resources and do not promise too much, step 4: keep your objectives and limitations mentioned, step 5: provide action verbs and tone, helpful tips for writing research objectives.

• Keep your content specific! It is necessary to narrow things down and leave no space for double meanings or confusion. If some idea cannot be supported with a piece of evidence, it’s better to avoid it in your objectives.
• Objectives must be measurable! It is crucial to make it possible to replicate your work in further research. Creating an outline as you strive for your goals and set the purpose is necessary.
• Keeping things relevant! Your research objectives should be related to your thesis statement and the subject that you have chosen to work with. It will help to avoid introducing ideas that are not related to your work.
• Temporal factor! Set deadlines to track your progress and provide a setting for your research if it is relevant. It will help your target audience to see your limitations and specifics.

Research objectives example

Research objective 1: The study aims to explore the origins and evolution of the youth movements in the Flemish provinces in Belgium, namely Chiro and KSA. This research evaluates the major differences during the post-WW2 period and the social factors that created differences between the movements. 

Research objective 2: This paper implements surveys and personal interviews to determine first-hand feedback from the youth members and the team leaders. 

Research objective 3: Aiming to compare and contrast, this study determines the positive outcomes of the unity project work between the branches of the youth movement in Belgium, aiming for statistical data to support it. 

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21 Research Objectives Examples (Copy and Paste)

Research objectives refer to the definitive statements made by researchers at the beginning of a research project detailing exactly what a research project aims to achieve.

These objectives are explicit goals clearly and concisely projected by the researcher to present a clear intention or course of action for his or her qualitative or quantitative study. 

Research objectives are typically nested under one overarching research aim. The objectives are the steps you’ll need to take in order to achieve the aim (see the examples below, for example, which demonstrate an aim followed by 3 objectives, which is what I recommend to my research students).

Research Objectives vs Research Aims

Research aim and research objectives are fundamental constituents of any study, fitting together like two pieces of the same puzzle.

The ‘research aim’ describes the overarching goal or purpose of the study (Kumar, 2019). This is usually a broad, high-level purpose statement, summing up the central question that the research intends to answer.

Example of an Overarching Research Aim:

“The aim of this study is to explore the impact of climate change on crop productivity.” 

Comparatively, ‘research objectives’ are concrete goals that underpin the research aim, providing stepwise actions to achieve the aim.

Objectives break the primary aim into manageable, focused pieces, and are usually characterized as being more specific, measurable, achievable, relevant, and time-bound (SMART).

Examples of Specific Research Objectives:

1. “To examine the effects of rising temperatures on the yield of rice crops during the upcoming growth season.” 2. “To assess changes in rainfall patterns in major agricultural regions over the first decade of the twenty-first century (2000-2010).” 3. “To analyze the impact of changing weather patterns on crop diseases within the same timeframe.”

The distinction between these two terms, though subtle, is significant for successfully conducting a study. The research aim provides the study with direction, while the research objectives set the path to achieving this aim, thereby ensuring the study’s efficiency and effectiveness.

How to Write Research Objectives

I usually recommend to my students that they use the SMART framework to create their research objectives.

SMART is an acronym standing for Specific, Measurable, Achievable, Relevant, and Time-bound. It provides a clear method of defining solid research objectives and helps students know where to start in writing their objectives (Locke & Latham, 2013).

Each element of this acronym adds a distinct dimension to the framework, aiding in the creation of comprehensive, well-delineated objectives.

Here is each step:

• Specific : We need to avoid ambiguity in our objectives. They need to be clear and precise (Doran, 1981). For instance, rather than stating the objective as “to study the effects of social media,” a more focused detail would be “to examine the effects of social media use (Facebook, Instagram, and Twitter) on the academic performance of college students.”
• Measurable: The measurable attribute provides a clear criterion to determine if the objective has been met (Locke & Latham, 2013). A quantifiable element, such as a percentage or a number, adds a measurable quality. For example, “to increase response rate to the annual customer survey by 10%,” makes it easier to ascertain achievement.
• Achievable: The achievable aspect encourages researchers to craft realistic objectives, resembling a self-check mechanism to ensure the objectives align with the scope and resources at disposal (Doran, 1981). For example, “to interview 25 participants selected randomly from a population of 100” is an attainable objective as long as the researcher has access to these participants.
• Relevance : Relevance, the fourth element, compels the researcher to tailor the objectives in alignment with overarching goals of the study (Locke & Latham, 2013). This is extremely important – each objective must help you meet your overall one-sentence ‘aim’ in your study.
• Time-Bound: Lastly, the time-bound element fosters a sense of urgency and prioritization, preventing procrastination and enhancing productivity (Doran, 1981). “To analyze the effect of laptop use in lectures on student engagement over the course of two semesters this year” expresses a clear deadline, thus serving as a motivator for timely completion.

You’re not expected to fit every single element of the SMART framework in one objective, but across your objectives, try to touch on each of the five components.

Research Objectives Examples

1. Field: Psychology

Aim: To explore the impact of sleep deprivation on cognitive performance in college students.

• Objective 1: To compare cognitive test scores of students with less than six hours of sleep and those with 8 or more hours of sleep.
• Objective 2: To investigate the relationship between class grades and reported sleep duration.
• Objective 3: To survey student perceptions and experiences on how sleep deprivation affects their cognitive capabilities.

2. Field: Environmental Science

Aim: To understand the effects of urban green spaces on human well-being in a metropolitan city.

• Objective 1: To assess the physical and mental health benefits of regular exposure to urban green spaces.
• Objective 2: To evaluate the social impacts of urban green spaces on community interactions.
• Objective 3: To examine patterns of use for different types of urban green spaces. 

3. Field: Technology

Aim: To investigate the influence of using social media on productivity in the workplace.

• Objective 1: To measure the amount of time spent on social media during work hours.
• Objective 2: To evaluate the perceived impact of social media use on task completion and work efficiency.
• Objective 3: To explore whether company policies on social media usage correlate with different patterns of productivity.

4. Field: Education

Aim: To examine the effectiveness of online vs traditional face-to-face learning on student engagement and achievement.

• Objective 1: To compare student grades between the groups exposed to online and traditional face-to-face learning.
• Objective 2: To assess student engagement levels in both learning environments.
• Objective 3: To collate student perceptions and preferences regarding both learning methods.

5. Field: Health

Aim: To determine the impact of a Mediterranean diet on cardiac health among adults over 50.

• Objective 1: To assess changes in cardiovascular health metrics after following a Mediterranean diet for six months.
• Objective 2: To compare these health metrics with a similar group who follow their regular diet.
• Objective 3: To document participants’ experiences and adherence to the Mediterranean diet.

6. Field: Environmental Science

Aim: To analyze the impact of urban farming on community sustainability.

• Objective 1: To document the types and quantity of food produced through urban farming initiatives.
• Objective 2: To assess the effect of urban farming on local communities’ access to fresh produce.
• Objective 3: To examine the social dynamics and cooperative relationships in the creating and maintaining of urban farms.

7. Field: Sociology

Aim: To investigate the influence of home offices on work-life balance during remote work.

• Objective 1: To survey remote workers on their perceptions of work-life balance since setting up home offices.
• Objective 2: To conduct an observational study of daily work routines and family interactions in a home office setting.
• Objective 3: To assess the correlation, if any, between physical boundaries of workspaces and mental boundaries for work in the home setting.

8. Field: Economics

Aim: To evaluate the effects of minimum wage increases on small businesses.

• Objective 1: To analyze cost structures, pricing changes, and profitability of small businesses before and after minimum wage increases.
• Objective 2: To survey small business owners on the strategies they employ to navigate minimum wage increases.
• Objective 3: To examine employment trends in small businesses in response to wage increase legislation.

9. Field: Education

Aim: To explore the role of extracurricular activities in promoting soft skills among high school students.

• Objective 1: To assess the variety of soft skills developed through different types of extracurricular activities.
• Objective 2: To compare self-reported soft skills between students who participate in extracurricular activities and those who do not.
• Objective 3: To investigate the teachers’ perspectives on the contribution of extracurricular activities to students’ skill development.

10. Field: Technology

Aim: To assess the impact of virtual reality (VR) technology on the tourism industry.

• Objective 1: To document the types and popularity of VR experiences available in the tourism market.
• Objective 2: To survey tourists on their interest levels and satisfaction rates with VR tourism experiences.
• Objective 3: To determine whether VR tourism experiences correlate with increased interest in real-life travel to the simulated destinations.

11. Field: Biochemistry

Aim: To examine the role of antioxidants in preventing cellular damage.

• Objective 1: To identify the types and quantities of antioxidants in common fruits and vegetables.
• Objective 2: To determine the effects of various antioxidants on free radical neutralization in controlled lab tests.
• Objective 3: To investigate potential beneficial impacts of antioxidant-rich diets on long-term cellular health.

12. Field: Linguistics

Aim: To determine the influence of early exposure to multiple languages on cognitive development in children.

• Objective 1: To assess cognitive development milestones in monolingual and multilingual children.
• Objective 2: To document the number and intensity of language exposures for each group in the study.
• Objective 3: To investigate the specific cognitive advantages, if any, enjoyed by multilingual children.

13. Field: Art History

Aim: To explore the impact of the Renaissance period on modern-day art trends.

• Objective 1: To identify key characteristics and styles of Renaissance art.
• Objective 2: To analyze modern art pieces for the influence of the Renaissance style.
• Objective 3: To survey modern-day artists for their inspirations and the influence of historical art movements on their work.

14. Field: Cybersecurity

Aim: To assess the effectiveness of two-factor authentication (2FA) in preventing unauthorized system access.

• Objective 1: To measure the frequency of unauthorized access attempts before and after the introduction of 2FA.
• Objective 2: To survey users about their experiences and challenges with 2FA implementation.
• Objective 3: To evaluate the efficacy of different types of 2FA (SMS-based, authenticator apps, biometrics, etc.).

15. Field: Cultural Studies

Aim: To analyze the role of music in cultural identity formation among ethnic minorities.

• Objective 1: To document the types and frequency of traditional music practices within selected ethnic minority communities.
• Objective 2: To survey community members on the role of music in their personal and communal identity.
• Objective 3: To explore the resilience and transmission of traditional music practices in contemporary society.

16. Field: Astronomy

Aim: To explore the impact of solar activity on satellite communication.

• Objective 1: To categorize different types of solar activities and their frequencies of occurrence.
• Objective 2: To ascertain how variations in solar activity may influence satellite communication.
• Objective 3: To investigate preventative and damage-control measures currently in place during periods of high solar activity.

17. Field: Literature

Aim: To examine narrative techniques in contemporary graphic novels.

• Objective 1: To identify a range of narrative techniques employed in this genre.
• Objective 2: To analyze the ways in which these narrative techniques engage readers and affect story interpretation.
• Objective 3: To compare narrative techniques in graphic novels to those found in traditional printed novels.

18. Field: Renewable Energy

Aim: To investigate the feasibility of solar energy as a primary renewable resource within urban areas.

• Objective 1: To quantify the average sunlight hours across urban areas in different climatic zones. 
• Objective 2: To calculate the potential solar energy that could be harnessed within these areas.
• Objective 3: To identify barriers or challenges to widespread solar energy implementation in urban settings and potential solutions.

19. Field: Sports Science

Aim: To evaluate the role of pre-game rituals in athlete performance.

• Objective 1: To identify the variety and frequency of pre-game rituals among professional athletes in several sports.
• Objective 2: To measure the impact of pre-game rituals on individual athletes’ performance metrics.
• Objective 3: To examine the psychological mechanisms that might explain the effects (if any) of pre-game ritual on performance.

20. Field: Ecology

Aim: To investigate the effects of urban noise pollution on bird populations.

• Objective 1: To record and quantify urban noise levels in various bird habitats.
• Objective 2: To measure bird population densities in relation to noise levels.
• Objective 3: To determine any changes in bird behavior or vocalization linked to noise levels.

21. Field: Food Science

Aim: To examine the influence of cooking methods on the nutritional value of vegetables.

• Objective 1: To identify the nutrient content of various vegetables both raw and after different cooking processes.
• Objective 2: To compare the effect of various cooking methods on the nutrient retention of these vegetables.
• Objective 3: To propose cooking strategies that optimize nutrient retention.

The Importance of Research Objectives

The importance of research objectives cannot be overstated. In essence, these guideposts articulate what the researcher aims to discover, understand, or examine (Kothari, 2014).

When drafting research objectives, it’s essential to make them simple and comprehensible, specific to the point of being quantifiable where possible, achievable in a practical sense, relevant to the chosen research question, and time-constrained to ensure efficient progress (Kumar, 2019). 

Remember that a good research objective is integral to the success of your project, offering a clear path forward for setting out a research design , and serving as the bedrock of your study plan. Each objective must distinctly address a different dimension of your research question or problem (Kothari, 2014). Always bear in mind that the ultimate purpose of your research objectives is to succinctly encapsulate your aims in the clearest way possible, facilitating a coherent, comprehensive and rational approach to your planned study, and furnishing a scientific roadmap for your journey into the depths of knowledge and research (Kumar, 2019). 

Kothari, C.R (2014). Research Methodology: Methods and Techniques . New Delhi: New Age International.

Kumar, R. (2019). Research Methodology: A Step-by-Step Guide for Beginners .New York: SAGE Publications.

Doran, G. T. (1981). There’s a S.M.A.R.T. way to write management’s goals and objectives. Management review, 70 (11), 35-36.

Locke, E. A., & Latham, G. P. (2013). New Developments in Goal Setting and Task Performance . New York: Routledge.

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Frequently asked questions

What is a research objective.

Research objectives describe what you intend your research project to accomplish.

They summarise the approach and purpose of the project and help to focus your research.

Your objectives should appear in the introduction of your research paper , at the end of your problem statement .

Frequently asked questions: Dissertation

The acknowledgements are generally included at the very beginning of your thesis or dissertation, directly after the title page and before the abstract .

If you only used a few abbreviations in your thesis or dissertation, you don’t necessarily need to include a list of abbreviations .

If your abbreviations are numerous, or if you think they won’t be known to your audience, it’s never a bad idea to add one. They can also improve readability, minimising confusion about abbreviations unfamiliar to your reader.

A list of figures and tables compiles all of the figures and tables that you used in your thesis or dissertation and displays them with the page number where they can be found.

A thesis or dissertation outline is one of the most critical first steps in your writing process. It helps you to lay out and organise your ideas and can provide you with a roadmap for deciding what kind of research you’d like to undertake.

Generally, an outline contains information on the different sections included in your thesis or dissertation, such as:

• Your anticipated title
• Your abstract
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An abstract for a thesis or dissertation is usually around 150–300 words. There’s often a strict word limit, so make sure to check your university’s requirements.

The abstract appears on its own page, after the title page and acknowledgements but before the table of contents .

While it may be tempting to present new arguments or evidence in your thesis or disseration conclusion , especially if you have a particularly striking argument you’d like to finish your analysis with, you shouldn’t. Theses and dissertations follow a more formal structure than this.

All your findings and arguments should be presented in the body of the text (more specifically in the discussion section and results section .) The conclusion is meant to summarize and reflect on the evidence and arguments you have already presented, not introduce new ones.

For a stronger dissertation conclusion , avoid including:

• Generic concluding phrases (e.g. “In conclusion…”)
• Weak statements that undermine your argument (e.g. “There are good points on both sides of this issue.”)

Your conclusion should leave the reader with a strong, decisive impression of your work.

The conclusion of your thesis or dissertation shouldn’t take up more than 5-7% of your overall word count.

The conclusion of your thesis or dissertation should include the following:

• A restatement of your research question
• A summary of your key arguments and/or results
• A short discussion of the implications of your research

Don’t feel that you have to write the introduction first. The introduction is often one of the last parts of the research paper you’ll write, along with the conclusion.

This is because it can be easier to introduce your paper once you’ve already written the body ; you may not have the clearest idea of your arguments until you’ve written them, and things can change during the writing process .

In a thesis or dissertation, the discussion is an in-depth exploration of the results, going into detail about the meaning of your findings and citing relevant sources to put them in context.

The conclusion is more shorter and more general: it concisely answers your main research question and makes recommendations based on your overall findings.

A dissertation prospectus or proposal describes what or who you plan to research for your dissertation. It delves into why, when, where, and how you will do your research, as well as helps you choose a type of research to pursue. You should also determine whether you plan to pursue qualitative or quantitative methods and what your research design will look like.

It should outline all of the decisions you have taken about your project, from your dissertation topic to your hypotheses and research objectives , ready to be approved by your supervisor or committee.

Note that some departments require a defense component, where you present your prospectus to your committee orally.

A research project is an academic, scientific, or professional undertaking to answer a research question . Research projects can take many forms, such as qualitative or quantitative , descriptive , longitudinal , experimental , or correlational . What kind of research approach you choose will depend on your topic.

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Research Aims and Objectives: The dynamic duo for successful research

Picture yourself on a road trip without a destination in mind — driving aimlessly, not knowing where you’re headed or how to get there. Similarly, your research is navigated by well-defined research aims and objectives. Research aims and objectives are the foundation of any research project. They provide a clear direction and purpose for the study, ensuring that you stay focused and on track throughout the process. They are your trusted navigational tools, leading you to success.

Understanding the relationship between research objectives and aims is crucial to any research project’s success, and we’re here to break it down for you in this article. Here, we’ll explore the importance of research aims and objectives, understand their differences, and delve into the impact they have on the quality of research.

Understanding the Difference between Research Aims and Objectives

In research, aims and objectives are two important components but are often used interchangeably. Though they may sound similar, they are distinct and serve different purposes.

Research Aims:

Research aims are broad statements that describe the overall purpose of your study. They provide a general direction for your study and indicate the intended achievements of your research. Aims are usually written in a general and abstract manner describing the ultimate goal of the research.

Research Objectives:

Research objectives are specific, measurable, and achievable goals that you aim to accomplish within a specified timeframe. They break down the research aims into smaller, more manageable components and provide a clear picture of what you want to achieve and how you plan to achieve it.

In the example, the objectives provide specific targets that must be achieved to reach the aim. Essentially, aims provide the overall direction for the research while objectives provide specific targets that must be achieved to accomplish the aims. Aims provide a broad context for the research, while the objectives provide smaller steps that the researcher must take to accomplish the overall research goals. To illustrate, when planning a road trip, your research aim is the destination you want to reach, and your research objectives are the specific routes you need to take to get there.

Aims and objectives are interconnected. Objectives play a key role in defining the research methodology, providing a roadmap for how you’ll collect and analyze data, while aim is the final destination, which represents the ultimate goal of your research. By setting specific goals, you’ll be able to design a research plan that helps you achieve your objectives and, ultimately, your research aim.

Importance of Well-defined Aims and Objectives

The impact of clear research aims and objectives on the quality of research cannot be understated. But it’s not enough to simply have aims and objectives. Well-defined research aims and objectives are important for several reasons:

• Provides direction: Clear aims and well-defined objectives provide a specific direction for your research study, ensuring that the research stays focused on a specific topic or problem. This helps to prevent the research from becoming too broad or unfocused, and ensures that the study remains relevant and meaningful.
• Guides research design: The research aim and objectives help guide the research design and methodology, ensuring that your study is designed in a way that will answer the research questions and achieve the research objectives.
• Helps with resource allocation: Clear research aims and objectives helps you to allocate resources effectively , including time, financial resources, human resources, and other required materials. With a well-defined aim and objectives, you can identify the resources required to conduct the research, and allocate them in a way that maximizes efficiency and productivity.
• Assists in evaluation: Clearly specified research aims and objectives allow for effective evaluation of your research project’s success. You can assess whether the research has achieved its objectives, and whether the aim has been met. This evaluation process can help to identify areas of the research project that may require further attention or modification.
• Enhances communication: Well-defined research aims and objectives help to enhance communication among the research team, stakeholders, funding agencies, and other interested parties. Clear aims and objectives ensure that everyone involved in your research project understands the purpose and goals of the study. This can help to foster collaboration and ensure that everyone is working towards the same end goal.

How to Formulate Research Aims and Objectives

Formulating effective research aims and objectives involves a systematic process to ensure that they are clear, specific, achievable, and relevant. Start by asking yourself what you want to achieve through your research. What impact do you want your research to have? Once you have a clear understanding of your aims, you can then break them down into specific, achievable objectives. Here are some steps you can follow when developing research aims and objectives:

• Identify the research question : Clearly identify the questions you want to answer through your research. This will help you define the scope of your research. Understanding the characteristics of a good research question will help you generate clearer aims and objectives.
• Conduct literature review : When defining your research aim and objectives, it’s important to conduct a literature review to identify key concepts, theories, and methods related to your research problem or question. Conducting a thorough literature review can help you understand what research has been done in the area and what gaps exist in the literature.
• Identify the research aim: Develop a research aim that summarizes the overarching goal of your research. The research aim should be broad and concise.
• Develop research objectives: Based on your research questions and research aim, develop specific research objectives that outline what you intend to achieve through your research. These objectives should be specific, measurable, achievable, relevant, and time-bound (SMART).
• Use action verbs: Use action verbs such as “investigate,” “examine,” “analyze,” and “compare” to describe your research aims and objectives. This makes them more specific and measurable.
• Ensure alignment with research question: Ensure that the research aim and objectives are aligned with the research question. This helps to ensure that the research remains focused and that the objectives are specific enough to answer your research question.
• Refine and revise: Once the research aim and objectives have been developed, refine and revise them as needed. Seek feedback from your colleagues, mentors, or supervisors to ensure that they are clear, concise, and achievable within the given resources and timeframe.
• Communicate: After finalizing the research aim and objectives, they should be communicated to the research team, stakeholders, and other interested parties. This helps to ensure that everyone is working towards the same end goal and understands the purpose of the study.

Common Pitfalls to Avoid While Formulating Aims and Objectives

There are several common mistakes that researchers can make when writing research aims and objectives. These include:

• Being too broad or vague: Aims and objectives that are too general or unclear can lead to confusion and lack of focus. It is important to ensure that the aims and objectives are concise and clear.
• Being too narrow or specific: On the other hand, aims and objectives that are too narrow or specific may limit the scope of the research and make it difficult to draw meaningful conclusions or implications.
• Being too ambitious: While it is important to aim high, being too ambitious with the aims and objectives can lead to unrealistic expectations and can be difficult to achieve within the constraints of the research project.
• Lack of alignment: The aims and objectives should be directly linked to the research questions being investigated. Otherwise, this will lead to a lack of coherence in the research project.
• Lack of feasibility: The aims and objectives should be achievable within the constraints of the research project, including time, budget, and resources. Failing to consider feasibility may cause compromise of the research quality.
• Failing to consider ethical considerations: The aims and objectives should take into account any ethical considerations, such as ensuring the safety and well-being of study participants.
• Failing to involve all stakeholders: It’s important to involve all relevant stakeholders, such as participants, supervisors, and funding agencies, in the development of the aims and objectives to ensure they are appropriate and relevant.

To avoid these common pitfalls, it is important to be specific, clear, relevant, and realistic when writing research aims and objectives. Seek feedback from colleagues or supervisors to ensure that the aims and objectives are aligned with the research problem , questions, and methodology, and are achievable within the constraints of the research project. It’s important to continually refine your aims and objectives as you go. As you progress in your research, it’s not uncommon for research aims and objectives to evolve slightly, but it’s important that they remain consistent with the study conducted and the research topic.

In summary, research aims and objectives are the backbone of any successful research project. They give you the ability to cut through the noise and hone in on what really matters. By setting clear goals and aligning them with your research questions and methodology, you can ensure that your research is relevant, impactful, and of the highest quality. So, before you hit the road on your research journey, make sure you have a clear destination and steps to get there. Let us know in the comments section below the challenges you faced and the strategies you followed while fomulating research aims and objectives! Also, feel free to reach out to us at any stage of your research or publication by using #AskEnago  and tagging @EnagoAcademy on Twitter , Facebook , and Quora . Happy researching!

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A Practical Guide to Writing Quantitative and Qualitative Research Questions and Hypotheses in Scholarly Articles

Edward barroga.

1 Department of General Education, Graduate School of Nursing Science, St. Luke’s International University, Tokyo, Japan.

Glafera Janet Matanguihan

2 Department of Biological Sciences, Messiah University, Mechanicsburg, PA, USA.

The development of research questions and the subsequent hypotheses are prerequisites to defining the main research purpose and specific objectives of a study. Consequently, these objectives determine the study design and research outcome. The development of research questions is a process based on knowledge of current trends, cutting-edge studies, and technological advances in the research field. Excellent research questions are focused and require a comprehensive literature search and in-depth understanding of the problem being investigated. Initially, research questions may be written as descriptive questions which could be developed into inferential questions. These questions must be specific and concise to provide a clear foundation for developing hypotheses. Hypotheses are more formal predictions about the research outcomes. These specify the possible results that may or may not be expected regarding the relationship between groups. Thus, research questions and hypotheses clarify the main purpose and specific objectives of the study, which in turn dictate the design of the study, its direction, and outcome. Studies developed from good research questions and hypotheses will have trustworthy outcomes with wide-ranging social and health implications.

INTRODUCTION

Scientific research is usually initiated by posing evidenced-based research questions which are then explicitly restated as hypotheses. 1 , 2 The hypotheses provide directions to guide the study, solutions, explanations, and expected results. 3 , 4 Both research questions and hypotheses are essentially formulated based on conventional theories and real-world processes, which allow the inception of novel studies and the ethical testing of ideas. 5 , 6

It is crucial to have knowledge of both quantitative and qualitative research 2 as both types of research involve writing research questions and hypotheses. 7 However, these crucial elements of research are sometimes overlooked; if not overlooked, then framed without the forethought and meticulous attention it needs. Planning and careful consideration are needed when developing quantitative or qualitative research, particularly when conceptualizing research questions and hypotheses. 4

There is a continuing need to support researchers in the creation of innovative research questions and hypotheses, as well as for journal articles that carefully review these elements. 1 When research questions and hypotheses are not carefully thought of, unethical studies and poor outcomes usually ensue. Carefully formulated research questions and hypotheses define well-founded objectives, which in turn determine the appropriate design, course, and outcome of the study. This article then aims to discuss in detail the various aspects of crafting research questions and hypotheses, with the goal of guiding researchers as they develop their own. Examples from the authors and peer-reviewed scientific articles in the healthcare field are provided to illustrate key points.

DEFINITIONS AND RELATIONSHIP OF RESEARCH QUESTIONS AND HYPOTHESES

A research question is what a study aims to answer after data analysis and interpretation. The answer is written in length in the discussion section of the paper. Thus, the research question gives a preview of the different parts and variables of the study meant to address the problem posed in the research question. 1 An excellent research question clarifies the research writing while facilitating understanding of the research topic, objective, scope, and limitations of the study. 5

On the other hand, a research hypothesis is an educated statement of an expected outcome. This statement is based on background research and current knowledge. 8 , 9 The research hypothesis makes a specific prediction about a new phenomenon 10 or a formal statement on the expected relationship between an independent variable and a dependent variable. 3 , 11 It provides a tentative answer to the research question to be tested or explored. 4

Hypotheses employ reasoning to predict a theory-based outcome. 10 These can also be developed from theories by focusing on components of theories that have not yet been observed. 10 The validity of hypotheses is often based on the testability of the prediction made in a reproducible experiment. 8

Conversely, hypotheses can also be rephrased as research questions. Several hypotheses based on existing theories and knowledge may be needed to answer a research question. Developing ethical research questions and hypotheses creates a research design that has logical relationships among variables. These relationships serve as a solid foundation for the conduct of the study. 4 , 11 Haphazardly constructed research questions can result in poorly formulated hypotheses and improper study designs, leading to unreliable results. Thus, the formulations of relevant research questions and verifiable hypotheses are crucial when beginning research. 12

CHARACTERISTICS OF GOOD RESEARCH QUESTIONS AND HYPOTHESES

Excellent research questions are specific and focused. These integrate collective data and observations to confirm or refute the subsequent hypotheses. Well-constructed hypotheses are based on previous reports and verify the research context. These are realistic, in-depth, sufficiently complex, and reproducible. More importantly, these hypotheses can be addressed and tested. 13

There are several characteristics of well-developed hypotheses. Good hypotheses are 1) empirically testable 7 , 10 , 11 , 13 ; 2) backed by preliminary evidence 9 ; 3) testable by ethical research 7 , 9 ; 4) based on original ideas 9 ; 5) have evidenced-based logical reasoning 10 ; and 6) can be predicted. 11 Good hypotheses can infer ethical and positive implications, indicating the presence of a relationship or effect relevant to the research theme. 7 , 11 These are initially developed from a general theory and branch into specific hypotheses by deductive reasoning. In the absence of a theory to base the hypotheses, inductive reasoning based on specific observations or findings form more general hypotheses. 10

TYPES OF RESEARCH QUESTIONS AND HYPOTHESES

Research questions and hypotheses are developed according to the type of research, which can be broadly classified into quantitative and qualitative research. We provide a summary of the types of research questions and hypotheses under quantitative and qualitative research categories in Table 1 .

Research questions in quantitative research

In quantitative research, research questions inquire about the relationships among variables being investigated and are usually framed at the start of the study. These are precise and typically linked to the subject population, dependent and independent variables, and research design. 1 Research questions may also attempt to describe the behavior of a population in relation to one or more variables, or describe the characteristics of variables to be measured ( descriptive research questions ). 1 , 5 , 14 These questions may also aim to discover differences between groups within the context of an outcome variable ( comparative research questions ), 1 , 5 , 14 or elucidate trends and interactions among variables ( relationship research questions ). 1 , 5 We provide examples of descriptive, comparative, and relationship research questions in quantitative research in Table 2 .

Hypotheses in quantitative research

In quantitative research, hypotheses predict the expected relationships among variables. 15 Relationships among variables that can be predicted include 1) between a single dependent variable and a single independent variable ( simple hypothesis ) or 2) between two or more independent and dependent variables ( complex hypothesis ). 4 , 11 Hypotheses may also specify the expected direction to be followed and imply an intellectual commitment to a particular outcome ( directional hypothesis ) 4 . On the other hand, hypotheses may not predict the exact direction and are used in the absence of a theory, or when findings contradict previous studies ( non-directional hypothesis ). 4 In addition, hypotheses can 1) define interdependency between variables ( associative hypothesis ), 4 2) propose an effect on the dependent variable from manipulation of the independent variable ( causal hypothesis ), 4 3) state a negative relationship between two variables ( null hypothesis ), 4 , 11 , 15 4) replace the working hypothesis if rejected ( alternative hypothesis ), 15 explain the relationship of phenomena to possibly generate a theory ( working hypothesis ), 11 5) involve quantifiable variables that can be tested statistically ( statistical hypothesis ), 11 6) or express a relationship whose interlinks can be verified logically ( logical hypothesis ). 11 We provide examples of simple, complex, directional, non-directional, associative, causal, null, alternative, working, statistical, and logical hypotheses in quantitative research, as well as the definition of quantitative hypothesis-testing research in Table 3 .

Research questions in qualitative research

Unlike research questions in quantitative research, research questions in qualitative research are usually continuously reviewed and reformulated. The central question and associated subquestions are stated more than the hypotheses. 15 The central question broadly explores a complex set of factors surrounding the central phenomenon, aiming to present the varied perspectives of participants. 15

There are varied goals for which qualitative research questions are developed. These questions can function in several ways, such as to 1) identify and describe existing conditions ( contextual research question s); 2) describe a phenomenon ( descriptive research questions ); 3) assess the effectiveness of existing methods, protocols, theories, or procedures ( evaluation research questions ); 4) examine a phenomenon or analyze the reasons or relationships between subjects or phenomena ( explanatory research questions ); or 5) focus on unknown aspects of a particular topic ( exploratory research questions ). 5 In addition, some qualitative research questions provide new ideas for the development of theories and actions ( generative research questions ) or advance specific ideologies of a position ( ideological research questions ). 1 Other qualitative research questions may build on a body of existing literature and become working guidelines ( ethnographic research questions ). Research questions may also be broadly stated without specific reference to the existing literature or a typology of questions ( phenomenological research questions ), may be directed towards generating a theory of some process ( grounded theory questions ), or may address a description of the case and the emerging themes ( qualitative case study questions ). 15 We provide examples of contextual, descriptive, evaluation, explanatory, exploratory, generative, ideological, ethnographic, phenomenological, grounded theory, and qualitative case study research questions in qualitative research in Table 4 , and the definition of qualitative hypothesis-generating research in Table 5 .

Qualitative studies usually pose at least one central research question and several subquestions starting with How or What . These research questions use exploratory verbs such as explore or describe . These also focus on one central phenomenon of interest, and may mention the participants and research site. 15

Hypotheses in qualitative research

Hypotheses in qualitative research are stated in the form of a clear statement concerning the problem to be investigated. Unlike in quantitative research where hypotheses are usually developed to be tested, qualitative research can lead to both hypothesis-testing and hypothesis-generating outcomes. 2 When studies require both quantitative and qualitative research questions, this suggests an integrative process between both research methods wherein a single mixed-methods research question can be developed. 1

FRAMEWORKS FOR DEVELOPING RESEARCH QUESTIONS AND HYPOTHESES

Research questions followed by hypotheses should be developed before the start of the study. 1 , 12 , 14 It is crucial to develop feasible research questions on a topic that is interesting to both the researcher and the scientific community. This can be achieved by a meticulous review of previous and current studies to establish a novel topic. Specific areas are subsequently focused on to generate ethical research questions. The relevance of the research questions is evaluated in terms of clarity of the resulting data, specificity of the methodology, objectivity of the outcome, depth of the research, and impact of the study. 1 , 5 These aspects constitute the FINER criteria (i.e., Feasible, Interesting, Novel, Ethical, and Relevant). 1 Clarity and effectiveness are achieved if research questions meet the FINER criteria. In addition to the FINER criteria, Ratan et al. described focus, complexity, novelty, feasibility, and measurability for evaluating the effectiveness of research questions. 14

The PICOT and PEO frameworks are also used when developing research questions. 1 The following elements are addressed in these frameworks, PICOT: P-population/patients/problem, I-intervention or indicator being studied, C-comparison group, O-outcome of interest, and T-timeframe of the study; PEO: P-population being studied, E-exposure to preexisting conditions, and O-outcome of interest. 1 Research questions are also considered good if these meet the “FINERMAPS” framework: Feasible, Interesting, Novel, Ethical, Relevant, Manageable, Appropriate, Potential value/publishable, and Systematic. 14

As we indicated earlier, research questions and hypotheses that are not carefully formulated result in unethical studies or poor outcomes. To illustrate this, we provide some examples of ambiguous research question and hypotheses that result in unclear and weak research objectives in quantitative research ( Table 6 ) 16 and qualitative research ( Table 7 ) 17 , and how to transform these ambiguous research question(s) and hypothesis(es) into clear and good statements.

a These statements were composed for comparison and illustrative purposes only.

b These statements are direct quotes from Higashihara and Horiuchi. 16

a This statement is a direct quote from Shimoda et al. 17

The other statements were composed for comparison and illustrative purposes only.

CONSTRUCTING RESEARCH QUESTIONS AND HYPOTHESES

To construct effective research questions and hypotheses, it is very important to 1) clarify the background and 2) identify the research problem at the outset of the research, within a specific timeframe. 9 Then, 3) review or conduct preliminary research to collect all available knowledge about the possible research questions by studying theories and previous studies. 18 Afterwards, 4) construct research questions to investigate the research problem. Identify variables to be accessed from the research questions 4 and make operational definitions of constructs from the research problem and questions. Thereafter, 5) construct specific deductive or inductive predictions in the form of hypotheses. 4 Finally, 6) state the study aims . This general flow for constructing effective research questions and hypotheses prior to conducting research is shown in Fig. 1 .

Research questions are used more frequently in qualitative research than objectives or hypotheses. 3 These questions seek to discover, understand, explore or describe experiences by asking “What” or “How.” The questions are open-ended to elicit a description rather than to relate variables or compare groups. The questions are continually reviewed, reformulated, and changed during the qualitative study. 3 Research questions are also used more frequently in survey projects than hypotheses in experiments in quantitative research to compare variables and their relationships.

Hypotheses are constructed based on the variables identified and as an if-then statement, following the template, ‘If a specific action is taken, then a certain outcome is expected.’ At this stage, some ideas regarding expectations from the research to be conducted must be drawn. 18 Then, the variables to be manipulated (independent) and influenced (dependent) are defined. 4 Thereafter, the hypothesis is stated and refined, and reproducible data tailored to the hypothesis are identified, collected, and analyzed. 4 The hypotheses must be testable and specific, 18 and should describe the variables and their relationships, the specific group being studied, and the predicted research outcome. 18 Hypotheses construction involves a testable proposition to be deduced from theory, and independent and dependent variables to be separated and measured separately. 3 Therefore, good hypotheses must be based on good research questions constructed at the start of a study or trial. 12

In summary, research questions are constructed after establishing the background of the study. Hypotheses are then developed based on the research questions. Thus, it is crucial to have excellent research questions to generate superior hypotheses. In turn, these would determine the research objectives and the design of the study, and ultimately, the outcome of the research. 12 Algorithms for building research questions and hypotheses are shown in Fig. 2 for quantitative research and in Fig. 3 for qualitative research.

EXAMPLES OF RESEARCH QUESTIONS FROM PUBLISHED ARTICLES

• EXAMPLE 1. Descriptive research question (quantitative research)
• - Presents research variables to be assessed (distinct phenotypes and subphenotypes)
• “BACKGROUND: Since COVID-19 was identified, its clinical and biological heterogeneity has been recognized. Identifying COVID-19 phenotypes might help guide basic, clinical, and translational research efforts.
• RESEARCH QUESTION: Does the clinical spectrum of patients with COVID-19 contain distinct phenotypes and subphenotypes? ” 19
• EXAMPLE 2. Relationship research question (quantitative research)
• - Shows interactions between dependent variable (static postural control) and independent variable (peripheral visual field loss)
• “Background: Integration of visual, vestibular, and proprioceptive sensations contributes to postural control. People with peripheral visual field loss have serious postural instability. However, the directional specificity of postural stability and sensory reweighting caused by gradual peripheral visual field loss remain unclear.
• Research question: What are the effects of peripheral visual field loss on static postural control ?” 20
• EXAMPLE 3. Comparative research question (quantitative research)
• - Clarifies the difference among groups with an outcome variable (patients enrolled in COMPERA with moderate PH or severe PH in COPD) and another group without the outcome variable (patients with idiopathic pulmonary arterial hypertension (IPAH))
• “BACKGROUND: Pulmonary hypertension (PH) in COPD is a poorly investigated clinical condition.
• RESEARCH QUESTION: Which factors determine the outcome of PH in COPD?
• STUDY DESIGN AND METHODS: We analyzed the characteristics and outcome of patients enrolled in the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA) with moderate or severe PH in COPD as defined during the 6th PH World Symposium who received medical therapy for PH and compared them with patients with idiopathic pulmonary arterial hypertension (IPAH) .” 21
• EXAMPLE 4. Exploratory research question (qualitative research)
• - Explores areas that have not been fully investigated (perspectives of families and children who receive care in clinic-based child obesity treatment) to have a deeper understanding of the research problem
• “Problem: Interventions for children with obesity lead to only modest improvements in BMI and long-term outcomes, and data are limited on the perspectives of families of children with obesity in clinic-based treatment. This scoping review seeks to answer the question: What is known about the perspectives of families and children who receive care in clinic-based child obesity treatment? This review aims to explore the scope of perspectives reported by families of children with obesity who have received individualized outpatient clinic-based obesity treatment.” 22
• EXAMPLE 5. Relationship research question (quantitative research)
• - Defines interactions between dependent variable (use of ankle strategies) and independent variable (changes in muscle tone)
• “Background: To maintain an upright standing posture against external disturbances, the human body mainly employs two types of postural control strategies: “ankle strategy” and “hip strategy.” While it has been reported that the magnitude of the disturbance alters the use of postural control strategies, it has not been elucidated how the level of muscle tone, one of the crucial parameters of bodily function, determines the use of each strategy. We have previously confirmed using forward dynamics simulations of human musculoskeletal models that an increased muscle tone promotes the use of ankle strategies. The objective of the present study was to experimentally evaluate a hypothesis: an increased muscle tone promotes the use of ankle strategies. Research question: Do changes in the muscle tone affect the use of ankle strategies ?” 23

EXAMPLES OF HYPOTHESES IN PUBLISHED ARTICLES

• EXAMPLE 1. Working hypothesis (quantitative research)
• - A hypothesis that is initially accepted for further research to produce a feasible theory
• “As fever may have benefit in shortening the duration of viral illness, it is plausible to hypothesize that the antipyretic efficacy of ibuprofen may be hindering the benefits of a fever response when taken during the early stages of COVID-19 illness .” 24
• “In conclusion, it is plausible to hypothesize that the antipyretic efficacy of ibuprofen may be hindering the benefits of a fever response . The difference in perceived safety of these agents in COVID-19 illness could be related to the more potent efficacy to reduce fever with ibuprofen compared to acetaminophen. Compelling data on the benefit of fever warrant further research and review to determine when to treat or withhold ibuprofen for early stage fever for COVID-19 and other related viral illnesses .” 24
• EXAMPLE 2. Exploratory hypothesis (qualitative research)
• - Explores particular areas deeper to clarify subjective experience and develop a formal hypothesis potentially testable in a future quantitative approach
• “We hypothesized that when thinking about a past experience of help-seeking, a self distancing prompt would cause increased help-seeking intentions and more favorable help-seeking outcome expectations .” 25
• “Conclusion
• Although a priori hypotheses were not supported, further research is warranted as results indicate the potential for using self-distancing approaches to increasing help-seeking among some people with depressive symptomatology.” 25
• EXAMPLE 3. Hypothesis-generating research to establish a framework for hypothesis testing (qualitative research)
• “We hypothesize that compassionate care is beneficial for patients (better outcomes), healthcare systems and payers (lower costs), and healthcare providers (lower burnout). ” 26
• Compassionomics is the branch of knowledge and scientific study of the effects of compassionate healthcare. Our main hypotheses are that compassionate healthcare is beneficial for (1) patients, by improving clinical outcomes, (2) healthcare systems and payers, by supporting financial sustainability, and (3) HCPs, by lowering burnout and promoting resilience and well-being. The purpose of this paper is to establish a scientific framework for testing the hypotheses above . If these hypotheses are confirmed through rigorous research, compassionomics will belong in the science of evidence-based medicine, with major implications for all healthcare domains.” 26
• EXAMPLE 4. Statistical hypothesis (quantitative research)
• - An assumption is made about the relationship among several population characteristics ( gender differences in sociodemographic and clinical characteristics of adults with ADHD ). Validity is tested by statistical experiment or analysis ( chi-square test, Students t-test, and logistic regression analysis)
• “Our research investigated gender differences in sociodemographic and clinical characteristics of adults with ADHD in a Japanese clinical sample. Due to unique Japanese cultural ideals and expectations of women's behavior that are in opposition to ADHD symptoms, we hypothesized that women with ADHD experience more difficulties and present more dysfunctions than men . We tested the following hypotheses: first, women with ADHD have more comorbidities than men with ADHD; second, women with ADHD experience more social hardships than men, such as having less full-time employment and being more likely to be divorced.” 27
• “Statistical Analysis
• ( text omitted ) Between-gender comparisons were made using the chi-squared test for categorical variables and Students t-test for continuous variables…( text omitted ). A logistic regression analysis was performed for employment status, marital status, and comorbidity to evaluate the independent effects of gender on these dependent variables.” 27

EXAMPLES OF HYPOTHESIS AS WRITTEN IN PUBLISHED ARTICLES IN RELATION TO OTHER PARTS

• EXAMPLE 1. Background, hypotheses, and aims are provided
• “Pregnant women need skilled care during pregnancy and childbirth, but that skilled care is often delayed in some countries …( text omitted ). The focused antenatal care (FANC) model of WHO recommends that nurses provide information or counseling to all pregnant women …( text omitted ). Job aids are visual support materials that provide the right kind of information using graphics and words in a simple and yet effective manner. When nurses are not highly trained or have many work details to attend to, these job aids can serve as a content reminder for the nurses and can be used for educating their patients (Jennings, Yebadokpo, Affo, & Agbogbe, 2010) ( text omitted ). Importantly, additional evidence is needed to confirm how job aids can further improve the quality of ANC counseling by health workers in maternal care …( text omitted )” 28
• “ This has led us to hypothesize that the quality of ANC counseling would be better if supported by job aids. Consequently, a better quality of ANC counseling is expected to produce higher levels of awareness concerning the danger signs of pregnancy and a more favorable impression of the caring behavior of nurses .” 28
• “This study aimed to examine the differences in the responses of pregnant women to a job aid-supported intervention during ANC visit in terms of 1) their understanding of the danger signs of pregnancy and 2) their impression of the caring behaviors of nurses to pregnant women in rural Tanzania.” 28
• EXAMPLE 2. Background, hypotheses, and aims are provided
• “We conducted a two-arm randomized controlled trial (RCT) to evaluate and compare changes in salivary cortisol and oxytocin levels of first-time pregnant women between experimental and control groups. The women in the experimental group touched and held an infant for 30 min (experimental intervention protocol), whereas those in the control group watched a DVD movie of an infant (control intervention protocol). The primary outcome was salivary cortisol level and the secondary outcome was salivary oxytocin level.” 29
• “ We hypothesize that at 30 min after touching and holding an infant, the salivary cortisol level will significantly decrease and the salivary oxytocin level will increase in the experimental group compared with the control group .” 29
• EXAMPLE 3. Background, aim, and hypothesis are provided
• “In countries where the maternal mortality ratio remains high, antenatal education to increase Birth Preparedness and Complication Readiness (BPCR) is considered one of the top priorities [1]. BPCR includes birth plans during the antenatal period, such as the birthplace, birth attendant, transportation, health facility for complications, expenses, and birth materials, as well as family coordination to achieve such birth plans. In Tanzania, although increasing, only about half of all pregnant women attend an antenatal clinic more than four times [4]. Moreover, the information provided during antenatal care (ANC) is insufficient. In the resource-poor settings, antenatal group education is a potential approach because of the limited time for individual counseling at antenatal clinics.” 30
• “This study aimed to evaluate an antenatal group education program among pregnant women and their families with respect to birth-preparedness and maternal and infant outcomes in rural villages of Tanzania.” 30
• “ The study hypothesis was if Tanzanian pregnant women and their families received a family-oriented antenatal group education, they would (1) have a higher level of BPCR, (2) attend antenatal clinic four or more times, (3) give birth in a health facility, (4) have less complications of women at birth, and (5) have less complications and deaths of infants than those who did not receive the education .” 30

Research questions and hypotheses are crucial components to any type of research, whether quantitative or qualitative. These questions should be developed at the very beginning of the study. Excellent research questions lead to superior hypotheses, which, like a compass, set the direction of research, and can often determine the successful conduct of the study. Many research studies have floundered because the development of research questions and subsequent hypotheses was not given the thought and meticulous attention needed. The development of research questions and hypotheses is an iterative process based on extensive knowledge of the literature and insightful grasp of the knowledge gap. Focused, concise, and specific research questions provide a strong foundation for constructing hypotheses which serve as formal predictions about the research outcomes. Research questions and hypotheses are crucial elements of research that should not be overlooked. They should be carefully thought of and constructed when planning research. This avoids unethical studies and poor outcomes by defining well-founded objectives that determine the design, course, and outcome of the study.

Disclosure: The authors have no potential conflicts of interest to disclose.

Author Contributions:

• Conceptualization: Barroga E, Matanguihan GJ.
• Methodology: Barroga E, Matanguihan GJ.
• Writing - original draft: Barroga E, Matanguihan GJ.
• Writing - review & editing: Barroga E, Matanguihan GJ.

This paper is in the following e-collection/theme issue:

Published on 18.4.2024 in Vol 26 (2024)

The Alzheimer’s Knowledge Base: A Knowledge Graph for Alzheimer Disease Research

Authors of this article:

Original Paper

• Joseph D Romano 1, 2, 3 , MA, MPhil, PhD   ; 
• Van Truong 1, 4, 5 , MS   ; 
• Rachit Kumar 1, 4, 5, 6 , BS   ; 
• Mythreye Venkatesan 7 , BE, MS   ; 
• Britney E Graham 7 , PhD   ; 
• Yun Hao 1, 4 , PhD   ; 
• Nick Matsumoto 7 , BA   ; 
• Xi Li 7 , MS   ; 
• Zhiping Wang 7 , MS, PhD   ; 
• Marylyn D Ritchie 1, 3, 5 , PhD   ; 
• Li Shen 1, 3 , PhD   ; 
• Jason H Moore 7 , PhD  

1 Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

2 Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

3 Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

4 Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

5 Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

6 Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

7 Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Corresponding Author:

Joseph D Romano, MA, MPhil, PhD

Institute for Biomedical Informatics

Perelman School of Medicine

University of Pennsylvania

403 Blockley Hall

423 Guardian Drive

Philadelphia, PA, 19104

United States

Phone: 1 2155735571

Email: [email protected]

Background: As global populations age and become susceptible to neurodegenerative illnesses, new therapies for Alzheimer disease (AD) are urgently needed. Existing data resources for drug discovery and repurposing fail to capture relationships central to the disease’s etiology and response to drugs.

Objective: We designed the Alzheimer’s Knowledge Base (AlzKB) to alleviate this need by providing a comprehensive knowledge representation of AD etiology and candidate therapeutics.

Methods: We designed the AlzKB as a large, heterogeneous graph knowledge base assembled using 22 diverse external data sources describing biological and pharmaceutical entities at different levels of organization (eg, chemicals, genes, anatomy, and diseases). AlzKB uses a Web Ontology Language 2 ontology to enforce semantic consistency and allow for ontological inference. We provide a public version of AlzKB and allow users to run and modify local versions of the knowledge base.

Results: AlzKB is freely available on the web and currently contains 118,902 entities with 1,309,527 relationships between those entities. To demonstrate its value, we used graph data science and machine learning to (1) propose new therapeutic targets based on similarities of AD to Parkinson disease and (2) repurpose existing drugs that may treat AD. For each use case, AlzKB recovers known therapeutic associations while proposing biologically plausible new ones.

Conclusions: AlzKB is a new, publicly available knowledge resource that enables researchers to discover complex translational associations for AD drug discovery. Through 2 use cases, we show that it is a valuable tool for proposing novel therapeutic hypotheses based on public biomedical knowledge.

Introduction

Alzheimer disease (AD) is a progressive, neurodegenerative disease affecting an estimated 6.5 million Americans aged ≥65 years and represents a significant clinical, economic, and emotional burden worldwide [ 1 ]. AD is often cited as one of the greatest health care problems of the 21st century, particularly in high-income nations with an increasing proportion of older adults. Despite its societal impact, effective pharmaceutical treatments for AD remain notoriously elusive. The US Food and Drug Administration has approved 5 drugs for the treatment of AD, 4 of which (donepezil, rivastigmine, galantamine, and memantine) only temporarily treat symptoms but do not alter the overall progression of the disease [ 2 ], whereas the fifth (aducanumab) is highly controversial in terms of evidence of effectiveness and its safety profile [ 3 ]. AD researchers have prioritized the discovery and approval of new therapies for the disease both in terms of newly discovered compounds and by repurposing drugs that are already approved to treat other (non-AD) human diseases.

AD is associated with substantial changes in pathology, including the presence of neuritic plaques associated with the amyloid-β protein, extracellular deposition of amyloid-β, and neurofibrillary tangles. Previous research has shown that these neuropathological changes begin to occur years before clinical symptoms are apparent [ 4 , 5 ]. Despite decades of research, why this pathology begins to develop remains largely unknown [ 6 ]. Current consensus is that AD risk is multifactorial. The most well-established risk factors include age; family history; and certain genetic factors, especially the presence of the σ4 allele of the apolipoprotein E gene, which is involved in fat metabolism and cholesterol transport. However, the exact mechanism through which these factors—including APOE -σ4 presence—cause or contribute to AD risk is unknown [ 7 ].

Of the many techniques used in AD therapeutics research, there is a wealth of computer-aided approaches that leverage recent advances in bioinformatics, epidemiology, artificial intelligence (AI), and machine learning (ML). For example, Rodriguez et al [ 8 ] developed an ML framework to assess gene lists constructed by differential gene expression data in response to drug treatment to determine whether those drugs would be candidates for repurposing in AD. Tsuji et al [ 9 ] used an autoencoder neural network to perform dimensionality reduction of a high-density protein interaction network to identify new possible drug targets and then found drugs associated with those targets. Genome-wide association studies have long been used for the identification of genes that confer AD risk, particularly for rare genes or genes with small (but statistically significant) contributions to disease risk [ 10 ].

In this paper, we describe the design and deployment of a major new knowledge resource for computational AD research—named The Alzheimer’s Knowledge Base (AlzKB) [ 11 ]—with a particular focus on drug discovery and drug repurposing. The overall structure and contents of AlzKB are summarized in Figure 1 . At its core, AlzKB consists of a large, heterogeneous graph database describing entities related to AD at multiple levels of biological organization, with rich semantic relationships describing how those entities are linked to one another. To demonstrate its value, we present two data-driven analyses involving ML on AlzKB’s knowledge graph: (1) predicting Parkinson disease (PD) genes that may also be associated with AD and (2) generating and explaining drug repurposing hypotheses for treating AD, both of which replicate existing knowledge while proposing entirely novel directions for future experimental validation. AlzKB is free, open source, and publicly available [ 11 ] and consists entirely of publicly sourced knowledge integrated from 22 diverse web-based biomedical databases. We hypothesized that the relationships and entities in AlzKB contain valuable knowledge that cannot be effectively captured in existing data resources, with the additional advantage of improving the explainability of new predictions.

Existing Graph-Based Approaches to AD Research

Due to the increased popularity and success of analyses using integrated knowledge, previous efforts have used knowledge graphs in AD research for a variety of purposes, including drug repurposing [ 12 - 14 ] and gene identification [ 15 ] and as general informational resources [ 16 ]. Similar to AlzKB, these bodies of work draw from a variety of sources to construct the underlying knowledge graphs, including scientific literature and formally structured biomedical databases. Some, including the Alzheimer Disease Knowledge Graph [ 14 ] and the Heterogeneous network-based data set for AD [ 16 ], have been released as publicly accessible resources similar to AlzKB. Other studies have used existing resources not specifically intended for AD research (such as the Semantic MEDLINE Database [ 13 ]) to answer questions related to AD. To our knowledge, AlzKB is the largest graph-based knowledge representation that focuses solely on AD and draws from the greatest number of source databases. For comparison, the next largest AD-specific knowledge graph that we are aware of is AD-KG, which contains 30,729 nodes and 398,544 edges (compared to AlzKB’s 118,902 nodes and 1,309,527 edges). Our emphasis on merging similar nodes or edges and cleaning the graph structure using an underlying biomedical ontology reduces the amount of noise that tends to be associated with many different node or edge types in a single graph, enabling more robust inference about relationships in AD, especially when used with emerging graph ML algorithms. Furthermore, AlzKB offers a public, web interface that allows for easy access and application to new research questions, whereas existing resources have either restricted access or are entirely unavailable for reuse. Given the challenge of identifying new or repurposed drugs for etiologically complex diseases such as AD, AlzKB represents a major step forward by improving both quantitatively and structurally on existing resources.

AlzKB Ontology

Graph databases are renowned for their flexibility in representing data that do not conform to a rigid, tabular structure, but this comes at the expense of implicitly enforcing consistency and semantic standardization [ 17 ]. To mitigate this issue, we designed a Web Ontology Language (OWL) 2 ontology—describing the types of entities relevant to AD and treatment of AD, as well as the types of relationships that link those entities—that serves as a template for nodes and edges in the knowledge graph. Ontologies (including OWL 2 ontologies) are formal representations of knowledge that are frequently used in biomedicine to computationally structure, retrieve, and make inferences about knowledge within a domain of interest [ 18 ]. Briefly, as many of the components of a graph database have a 1-to-1 correspondence with components of an OWL 2 ontology (eg, OWL 2 classes are equivalent to graph database node labels, and OWL 2 object properties are equivalent to edge types in a graph database), it is possible to populate the ontology using biomedical knowledge and translate the contents of the populated ontology into an equivalent graph database. Therefore, enforcing consistency in the ontology becomes equivalent to enforcing consistency in the graph database.

We constructed the ontology manually using the Protégé ontology editor (version 5.5.0; Stanford Center for Biomedical Informatics Research) [ 19 ] following an iterative process guided by expert domain knowledge. First, we prototyped a class hierarchy containing the types of nodes (eg, gene, disease, pathway, and drug) desired in the knowledge base. We then annotated these classes with data properties (eg, drugs can be assigned a property value corresponding to molecular weight) and object properties (relationship types that link 2 entities, such as “drug treats disease”). A thorough description of the components of OWL 2 ontologies is provided by Hitzler et al [ 20 ]. Finally, we placed restrictions on the ontology to reflect biology and clinical practice. For example, we specified restrictions stating that all pathways must contain one or more genes or that all drugs in the knowledge base must have a valid DrugBank ID. We repeated these steps several times, making revisions on previous iterations until several domain experts agreed that the semantic contents of the ontology were consistent with current AD knowledge and systems biology processes involved in AD etiology. After collecting the data sources used to populate the ontology (see the following section), we included additional data properties corresponding to identifiers in those source databases, enabling data provenance and facilitating both interoperability and validation. The final ontology structure consists of entity types involved in AD etiology (modeled as OWL 2 classes), types of semantic relationships that can link those entity types (modeled as OWL 2 object properties), and properties that can be annotated onto entities of specific types (modeled as OWL 2 data properties). Both before and after populating the ontology with individuals (see the Implementing AlzKB section), we validated its contents and structure by running FaCT++—an ontology inference engine that identifies errors by evaluating all assertions in the ontology against the ontology’s class or property hierarchy and other restrictions [ 21 ].

Collecting and Assembling Third-Party Data Sources

Using the AlzKB ontology’s class hierarchy as a starting point, we determined a set of the most important entity types to include in the first release of the knowledge base. For example, we prioritized inclusion of entities representing diseases (specifically AD and its various subtypes), genes, and drugs, among others. Similarly, we identified important relationship types (eg, “DRUG_BINDS_GENE” or “GENE_ASSOCIATED_WITH_DISEASE”) to include in the knowledge base. For each of these entity and relationship types, we identified a third-party, public data source that would serve as a collection of “ground truth knowledge” for that entity or relationship type. In the assembled knowledge base, there is roughly a 1-to-1 correspondence between a data record in the original “ground truth” data source and its corresponding entity or relationship in AlzKB, with some important exceptions. For example, we made the decision to only include neurological diseases in AlzKB rather than all diseases described in the “ground truth” data source (in this case, the Disease Ontology). We also identified instances in which properties from additional data sources could be used to augment the “ground truth” entities. For example, while DrugBank is used to specify the drugs described in AlzKB, we also used fields from Distributed Structure-Searchable Toxicity and PubChem to augment the properties annotated onto drugs (such as molecular weight, chemical fingerprint, and synonyms).

Implementing AlzKB

We populated the ontology by sequentially carrying out the following steps:

• Import distinct entities from each data source corresponding to the corresponding ontology class and define those entities as ontology individuals (ie, instances of that class). For example, the drug memantine is defined as an instance of the ontology class Drug.
• Populate data properties for all instances of each ontology class using data from relevant sources. For example, memantine is annotated with the Chemical Abstracts Service Registry number 19982-08-2.
• Populate object properties as the semantic relationships linking pairs of entities using the appropriate data source. For example, an object property of type “DRUG_TREATS_DISEASE” links memantine to the instance of Disease named Alzheimer’s Disease.

After populating the AlzKB ontology with entities, relationships, and data properties, we serialized the ontology into the Resource Description Framework (RDF) or XML graph data format, which is compatible with modern graph database software as an input format. A complete list of the data sources used in AlzKB at the time of writing is provided in Table 1 . We then populated a Neo4j graph database (version 4.4.5; Neo4j, Inc) [ 22 ] with the contents of the RDF or XML file using the neosemantics library [ 23 ], which parses the RDF data, inserting semantic triples into the graph database corresponding to each entity or relationship. Finally, we stripped the newly populated graph database of unnecessary artifacts that are components of the OWL 2 standard, leaving only nodes, relationships, and properties defined within the hierarchy. For the publicly hosted version of AlzKB, we created a web server that hosts both the static AlzKB website (containing information, documentation, and use details) and the Neo4j graph database, which is available by navigating to a subdomain [ 24 ] of the main website [ 11 ]. For reproducibility, this entire pipeline (including mappings to source databases) is provided as a single Python script available on GitHub (the most recent version) [ 25 ] or Zenodo (an archived version of the code at the time of publication) [ 26 ].

a As source data elements do not correspond in a 1-to-1 manner with entities in the graph (eg, entities may be merged, filtered, or used as edges rather than nodes), actual counts for entities in AlzKB stratified by source are not available. The sizes are the best available estimates at the time of publication. Table 2 and Table S1 in Multimedia Appendix 1 [ 50 - 56 ] provide actual node and edge type counts in AlzKB.

b AOP-DB: Adverse Outcome Pathway Database.

c The derived data are structured in part using Hetionet.

d AD: Alzheimer disease.

e EPA: Environmental Protection Agency.

f DSSTox: Distributed Structure-Searchable Toxicity.

g ACToR: Aggregated Computational Toxicology Resource.

h GWAS: genome-wide association studies.

i LINCS: Library of Integrated Network-Based Cellular Signatures.

j NCBI: National Center for Biotechnology Information.

k MeSH: Medical Subject Headings.

l SIDER: Side Effect Resource.

m Counts not applicable (TISSUES associations map to edges rather than nodes in the graph).

Validating AlzKB Using Real-World Use Cases

After building AlzKB’s knowledge graph, we designed two ML-based use cases that resemble real-world tasks for which AlzKB was originally designed: (1) proposing genetic targets for new drugs based on disease similarity and topological graph features and (2) predicting new edges in the knowledge graph linking AD to repurposed drugs via a graph completion model. These 2 use cases are intended to assess the external validity of AlzKB—for the ML models to perform well on tasks defined using real-world evaluation end points (eg, effective drugs or etiologically important genes), the informative patterns and phenomena underlying those end points need to be adequately captured in the knowledge graph.

In the first use case (identifying genetic targets via graph topology measures), we trained a random forest (RF) classifier (implemented in the scikit-learn library [Python Software Foundation] for the Python programming language) using the following topological graph features, which are computed for every node pair in the graph (regardless of whether an edge does or does not exist between them): common neighbors, total neighbors, preferential attachment, Adamic-Adar, and resource allocation [ 57 - 60 ]. Each feature gives a different measure of network “relatedness” for a pair of nodes, which are then used as predictive features in the RF model. For a given node pair ( n 1 , n 2 ), these metrics are defined as follows:

where N(n 1 ) is the set of neighbor (adjacent) nodes of node i . Our training procedure for the RF model included 3-fold grid search cross-validation to optimize hyperparameters, an 80%/20% train/test split, and repeating the procedure 10 times with random sampling.

To accomplish the second use case (drug repurposing via graph completion models), we implemented and compared the performance of 5 graph completion algorithms applied to the entire AlzKB knowledge graph. These models learn low-dimensional representations of graph nodes as vector embeddings. The embeddings are then combined to propose all possible triples in the graph (source node, edge, and target node), and scores are generated to indicate the plausibility of the triple. The 5 models we evaluated are TransE, RotatE, DistMult, ComplEx, and ConvE [ 60 ].

We implemented the 5 models using PyKEEN—a Python library for knowledge graph embeddings [ 50 ]. We randomly split the data set of all triples into 80/10/10 training/validation/testing sets and used grid search to empirically set embedding dimensions to 256 and the number of epochs to 100 with early stopping allowed. All remaining hyperparameters were set to the PyKEEN defaults. We trained the models on Google Colab using a single Tesla T4 graphics processing unit and evaluated the results using the rank-based evaluation metrics hits@k ( k =1, 3, and 10) and mean reciprocal rank (MRR) [ 61 ]. Ranking-based evaluation sorts the scores of triples in descending order and sets their rank as the index in the sorted list. In the case of multiple “true” triples having an equal score, we used the average of the most optimistic (best) and pessimistic (worst) ranks across the metrics. Briefly, hits@k is the ratio of true triples in the test set that have been ranked within the top k predictions of the model. Higher values indicate better performance. The MRR, also known as inverse harmonic mean rank, is the arithmetic mean of the inverse rank of the true triples. We performed evaluation on both left- and right-side predictions (ie, how well they can predict missing entities in partial triples without either the head [source] or tail [target] entities).

Ethical Considerations

No human participants were involved in this research. All data used to build and evaluate AlzKB were derived from publicly available biomedical knowledge retrieved from open access databases. None of the data included were derived from individual human participants. Similarly, AlzKB is entirely open source and publicly available and complies with the licensing terms of all 22 source databases used to build the knowledge base.

Knowledge Base Description

The first release of AlzKB (version 1.0) [ 26 ] contains 118,902 distinct nodes (representing biomedical entities) and 1,309,527 relationships linking those nodes. A full summary of node and relationship types with counts, respectively, is provided in Table 2 and Table S1 in Multimedia Appendix 1 . Users can interact with AlzKB in their web browser using the built-in Neo4j interface or programmatically by connecting to the graph database over the internet. We also provide instructions for installing a local copy of the graph database as well as how to build the database from its original data sources.

Proposing New Therapeutic Targets for AD

As a proof of concept, we performed an analysis to predict whether known PD genes are also linked to AD etiology. PD is a chronic, progressive neurological disorder characterized by uncontrollable movements and possible mental and behavioral changes. Similar to AD, the precise etiology of PD is not fully understood, but the disease is characterized by the death or dysfunction of basal ganglia neurons. A growing body of work has established physiological and genetic similarities between PD and AD [ 62 ], and it has been proposed that drugs targeting PD genes could potentially treat AD as well. To approach this hypothesis computationally, we defined a binary classification task to predict whether gene nodes in the AlzKB knowledge graph are or are not AD genes [ 63 ]. To assemble the data set, we considered all gene nodes adjacent to AD as positive (n=101) and all gene nodes not adjacent to AD as negative (n=62,306). The negative samples are assumed to contain a mixture of true negatives and false negatives; in link prediction tasks, the goal is to recover the false negatives. We further filtered the negative nodes to omit PD genes (n=73) and orphan gene nodes (n=43,032) and down sampled the remaining genes to 303 (ie, 3 times the number of positive samples). To evaluate the performance, we used accuracy, balanced accuracy, precision, recall, F 1 -score, area under the receiver operating characteristic curve, and area under the precision-recall curve, as shown in Figure 2 .

The RF model predicted gene-disease relationships with an average balanced accuracy of 96.2% (precision=0.88; recall=0.98). We applied the trained models to predict PD genes that are likely to also be AD genes. Of the 73 PD genes in AlzKB, 8 (11%; FYN , DCTN1 , SNCA , SYNJ1 , RSP12 , ATXN2 , KCNIP3 , and CHRNB1 ; described in Table 3 ) were predicted to be AD genes. A total of 10% (7/73) of the genes were predicted to be AD genes in all 10 models, whereas CHRNB1 was predicted in 7 of the 10 models.

Drug Repurposing via Graph Data Science

As a second use case, we considered the task of repurposing existing drugs—currently used to treat other diseases—based on patterns in the knowledge graph that suggest that they may also treat AD. To do this, we trained 5 state-of-the-art knowledge graph completion methods (TransE, RotatE, DistMult, ComplEx, and ConvE) [ 51 ] on AlzKB and selected the highest-performing one to predict links between drugs and AD. Additional details about the differences between these methods are provided in Multimedia Appendix 1 .

The performance of the 5 different knowledge graph completion models is shown in Table 4 . Among them, RotatE performed best, with the highest MRR and hits@k values. Therefore, we used RotateE to make predictions on the test set to obtain missing head entities with the template ([ drug ], DRUG_TREATS_DISEASE, AD). The top 10 predicted drugs are listed in Table 5 along with their current approved use and relevant clinical trial status pertaining to AD efficacy. Of the top 10 predictions, 3 (30%) have been investigated in clinical trials to treat symptoms of AD. To further explore these predictions, we generated visualizations of a minimum spanning tree linking the 10 drugs to AD in AlzKB’s knowledge graph, as shown in Figure 3 . The visualization shows that the shortest paths between the drugs and AD are mediated by a small set of AD-associated genes, each of which is associated with one or more of the proposed drugs. The visualization is suggestive of interpretable biological mechanisms through which the drugs could act on AD etiology and provides hypotheses to further explore their validity.

a MRR: mean reciprocal rank.

b Italicized values indicate maximum scores within a given column.

a No known AD-related clinical trials for the given drug.

b ER+: estrogen-receptor positive.

Principal Findings

AlzKB is a freely available resource for the biomedical research community, with the primary goal of expanding the repertoire of therapies for AD via drug repurposing. In the previous sections, we described the current contents of AlzKB, the process of constructing it, and 2 specific data-driven use cases that illustrate how it can be applied to drug repurposing tasks. These use cases consisted of predicting the shared genetic architecture of AD and PD (potentially allowing for PD therapies to be repurposed for AD) and directly proposing drugs to repurpose for treating AD by predicting new links between drug and disease nodes in the knowledge graph. In both cases, the results are both biologically plausible and supported by quantitative metrics, yielding new hypotheses that merit experimental validation. AlzKB is a flexible resource that is not limited to these analyses, and we encourage other research teams to use it for different and complementary knowledge discovery tasks.

The Role of AlzKB in Biomedical Knowledge Discovery

AD and other neurodegenerative diseases present one of the greatest challenges in modern biomedicine. AD is by and large a disease of old age, and as improvements to health care continue to increase the overall global life expectancy, we can expect the number of people with various forms of dementia to also increase. As the etiology and pathophysiology of AD are highly multifactorial, there is likely no single “cure” for the disease. Instead, researchers and public health officials have shifted much of their focus toward finding therapies that reduce risk, slow the progression of the disease, or reverse neuronal damage. In addition, as there are various subtypes of AD with underlying mechanisms, any therapy might be effective for only some patients with AD. Therefore, an essential step for reducing global disease burden is to propose many new therapeutic agents that target various aspects of AD pathology. This is precisely the motivating use case for AlzKB. As we have demonstrated, AlzKB provides a rich representation of existing knowledge about AD and the biological context in which it acts. The 2 ML-based use cases we presented previously use real-world end points to demonstrate that the knowledge captured in AlzKB is meaningful and representative of the biological processes underlying the disease. AlzKB stands to become a major resource in the AD research community, where pattern analysis and integration with observational data can be used to propose a diverse array of new therapeutic hypotheses along with interpretable mechanistic explanations of how those therapies may act in the human body.

Building the initial release of AlzKB was a highly interdisciplinary effort involving contributions from experts in translational bioinformatics, data science, and clinical informatics as well as medical scientists. Although each of these domains was essential in delivering a knowledge base that reflects important biomedical patterns describing AD etiology and treatment, a key need during the design and implementation phases was data literacy. To support future work in this and related areas, we encourage the inclusion of informatics and data analysis techniques in all types of biomedical curricula. Beyond AlzKB, our approach for building the knowledge graph is generalizable to practically any domain and depends on (1) defining an ontology using expert knowledge that formally describes the domain of interest and (2) identifying source databases that provide the entities and relationships described in the ontology. We are directly involved in the ongoing development of other knowledge bases using this same approach, including ComptoxAI—a knowledge base that supports AI research in toxicology [ 64 ]. As both knowledge bases share many of the same “core” entities (genes, diseases, pathways, and anatomical structures), the knowledge graphs are already semantically harmonized and ready for integration in larger, cross-disciplinary biomedical knowledge applications.

Discovering Putative Therapies Through Graph Data Science

Of the PD genes predicted to also be AD genes (see the Proposing New Therapeutic Targets for AD section; Table 3 ), some are involved in neuronal signaling and structure, and some are known to be involved in a wide range of neurological disorders. FYN has seen recent attention and investigation into its possible link to AD due to its broad expression in brain tissue and known interactions with tau proteins [ 65 , 66 ]. Among the other identified genes, one ( CHRNB1 ) is known to be involved in acetylcholine signaling [ 67 , 68 ], and another ( KCNIP3 ) codes a protein that interacts with presenilin, and mutations in presenilin are causal for hereditary AD [ 69 , 70 ]. Some of these gene hits ( ATXN2 and DCTN1 ) have limited or no current research directly linking them to AD but are biologically plausible. As such, they may represent novel therapeutic targets or targets for further research and investigation [ 71 ]. For example, DCTN1 encodes the dynactin-1 protein, and deficits in dynactin are connected to several neurodegenerative diseases; however, there is limited research linking this gene to AD [ 72 , 73 ].

Among the drug repurposing predictions (see the Drug Repurposing via Graph Data Science section; Table 5 ) are some agents that have previously been proposed for the treatment of AD (risperidone and sertraline) or for symptoms associated with AD (nicotine). Sumatriptan has been the subject of several studies focused on AD [ 74 ] and is connected to a strong comorbidity of migraine headaches and dementia in women [ 75 ]. Pimozide has been shown to reduce the aggregation of tau protein in mice [ 76 ] and is linked to AD in a number of unrelated in silico models [ 77 ]. The inclusion of nicotine is also noteworthy as it has seen recent interest among AD researchers and is the subject of an ongoing clinical trial to improve memory [ 78 ]. Other drugs listed in Table 5 have not yet been identified as AD treatments and represent novel repurposing candidates. Each can be considered a testable hypothesis meriting further investigation, giving credence to the increased detective power of AlzKB’s knowledge graph approach over existing AD data resources. It should be noted that this approach can only propose new indications for existing drugs and is based on existing knowledge and derived from known biological associations with those drugs. Other approaches (including emerging techniques in graph ML) could be used to propose entirely new drugs that could treat AD.

Future Directions With AlzKB

AlzKB is a growing resource, and we have plans for adding new features and data types that are in various stages of implementation. As a central hypothesis of AD pathogenesis revolves around the atypical accumulation of proteins within and around brain cells, an important step will be to adequately distinguish and differentiate genes from the proteins that those genes code for. Existing data resources available for inclusion in AlzKB largely fail to make this distinction in a way that is accepted by the scientific community, so we are currently evaluating options to use either postprocessing of existing knowledge sources or synthesis of new knowledge to achieve a good representation of genes, proteins, and functional or structural variants that are key to understanding AD.

Current ML models often do not generalize well to heterogeneous graphs such as the one that constitutes AlzKB’s knowledge graph. This is largely because traditional models cannot use the network structure and heterogeneous nature of different entity types. Several promising algorithms can be used for prediction on heterogeneous graphs—including GraphSAGE [ 79 ] and metapath2vec [ 80 ]—but most fail to scale effectively when the number of node or edge types increases. As any effective therapy must be accompanied by a mechanistic understanding of how it functions, we also need to ensure that new heterogeneous graph ML models are explainable . With this in mind, we are using AlzKB as a motivating resource for designing new, cutting-edge algorithms that produce interpretable predictions from highly heterogeneous knowledge graphs. Furthermore, the increasing popularity of large language models (LLMs; such as GPT-4) presents a wealth of opportunities for incorporating knowledge graphs such as AlzKB into diverse AI applications [ 81 ]. One application we are considering is using AlzKB to provide LLMs with formalized knowledge about AD that allows them to more effectively produce informative outputs about AD etiology. Currently, LLMs can perform poorly on technically complex or poorly understood domains due to a scarcity of relevant content in their training corpora, and augmenting their performance using domain-specific knowledge graphs is an emerging strategy for fixing that issue. As we do so, these will be released alongside AlzKB with educational resources that facilitate ease of use and adoptability by various stakeholders.

Knowledge graphs—including AlzKB—come with several important limitations that will be crucial to address in coming years. One of these is the subjective nature of determining what does and does not constitute “knowledge,” implying broad acceptance by the scientific community (as opposed to “data,” which consist of individual observations). Currently, we use expert domain knowledge and careful screening of source databases to accomplish this, but with the advent of broadly accessible generative AI tools, there may be emerging strategies that minimize sources of human bias [ 82 ]. Furthermore, new predictions made using knowledge graphs still necessitate costly and time-consuming experimental or observational follow-up studies to validate those predictions. This is due in part to the absence of negative samples for training predictive models. While the presence of an edge between 2 nodes in a knowledge graph is interpreted as a “positive sample” for model training, the absence of an edge simply means that we do not know whether a relationship does or does not exist, and therefore, it may not in fact be a negative sample. New methods, including self-supervised contrastive learning, show promise in alleviating this issue [ 83 ], but further work is needed to determine whether these generalize well to AlzKB and similar highly heterogeneous biomedical knowledge graphs. Nonetheless, these are active areas of research in the AI, informatics, and computer science communities, and in spite of them, our results are still robust enough to provide compelling evidence demonstrating AlzKB’s scientific value.

Ultimately, we aim to provide AlzKB as a robust resource that helps unravel the etiology of AD. It is already a large, high-quality knowledge base from which graph-based AI or ML approaches can be developed for drug repurposing and drug discovery. As we and the rest of the biomedical research community make these discoveries in the coming years, they will be included and publicized on the AlzKB website as a public resource to drive innovation and scientific progress.

Obtaining AlzKB for Local Use and Extending the Knowledge Graph

As it is a public and open-source resource for scientific discovery, we provide AlzKB through a variety of interfaces with distinct advantages for different use cases and user types. Casual users who wish to browse the knowledge base or perform simple analyses can do so directly through the Neo4j browser interface [ 24 ]. However, for more advanced use cases (or when computational needs exceed those available on the public version of the knowledge base), AlzKB can be either downloaded and populated locally into a Neo4j installation or built from the original source data files via the tools included on the AlzKB GitHub repository [ 25 ]. The latter of these options also allows users to extend the knowledge base to include additional data sources, entity types, or relationships beyond those provided in the official knowledge base distribution. We also encourage users who make modifications to the knowledge base to submit their changes for review to be included in the main code distribution. Instructions for how to contribute to AlzKB are also available on the GitHub repository.

As the data sources included in AlzKB are all, themselves, from open-source databases, we urge users to ensure that any new data sources they merge into AlzKB similarly comply with open-source standards. In brief, AlzKB can only be maintained under the most restrictive license terms of its included third-party sources, so restrictive license terms in a database being considered decrease that database’s suitability for inclusion. We hope for AlzKB to be recognized as a community effort for aggregating and democratizing the discovery of new AD therapeutics and, therefore, encourage public discussion of new methods and data sources to be included.

Conclusions

In this work, we introduced AlzKB as a free, publicly available toolkit and data resource for novel discoveries in AD research, with a particular focus on therapeutic approaches to treating AD. AlzKB is both new and continually growing, and we aim to cultivate a community of researchers to collaboratively increase the impact, speed, and throughput of AD research, along with rapid dissemination to health care, academia, and the pharmaceutical industry. In the future, we will develop new AI and data science methods to continually extract knowledge from AlzKB, but in this study, we already demonstrate through graph data science that AlzKB can both replicate existing AD knowledge and generate entirely new, testable hypotheses to drive the future of drug repurposing and drug discovery.

Acknowledgments

The Alzheimer’s Knowledge Base is supported by US National Institutes of Health grants U01-AG066833, R01-LM010098, R01-LM013463 (principal investigator [PI]: JHM), and R00-LM013646 (PI: JDR).

Data Availability

The data sets generated during and analyzed during this study are available in the GitHub and Zenodo repositories [ 25 , 26 ].

Conflicts of Interest

None declared.

Supplemental information providing expanded details on the knowledge graph completion methods used to validate Alzheimer’s Knowledge Base, as well as counts for relationship types in the knowledge graph.

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Abbreviations

Edited by T de Azevedo Cardoso; submitted 24.02.23; peer-reviewed by P Dabas, N Mungoli, B Xie, C Sun; comments to author 21.04.23; revised version received 23.06.23; accepted 07.11.23; published 18.04.24.

©Joseph D Romano, Van Truong, Rachit Kumar, Mythreye Venkatesan, Britney E Graham, Yun Hao, Nick Matsumoto, Xi Li, Zhiping Wang, Marylyn D Ritchie, Li Shen, Jason H Moore. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 18.04.2024.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.

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A Dear Colleague Letter (DCL) is an informal correspondence which is written by a Requesting Office and distributed to communities within a specific program area, to attract individuals eligible under a Visiting Scientist, Engineer, and Educator (VSEE) appointment, an Intergovernmental Personnel Act (IPA) assignment and/or a Federal Temporary appointment. These letters may be circulated in paper form through internal mail, distributed electronically using listservs or accessed through NSF.gov’s Career Page.

Science Advisor for Public Access (Program Director)

Application timeline, position summary.

The Office of Integrative Activities (OIA) within the Office of the Director at the National Science Foundation (NSF) announces a nationwide search to fill the Science Advisor for Public Access position.  The position coordinates agency responses to federal public access mandates, oversees development of the NSF Public Access Repository, coordinates with other agencies via involvement in the NSTC and other cross-agency groups, and contributes to the NSF Knowledge Management activity.

Formal consideration of interested applications will begin immediately and continue until a selection is made.

OIA works across disciplinary boundaries to lead and coordinate strategic programs and opportunities that: advance research excellence and innovation; develop human and infrastructure capacity critical to the U.S. science and engineering enterprise; and promote engagement of scientists and engineers at all career stages and the personnel who support them.

For more information on the NSF Public Access Initiative, see: https://new.nsf.gov/public-access  

Position Description

Serves as the primary representative and point of contact for the NSF Public Access Initiative and Open Science matters, in consultation with other concerned entities within the Foundation (e.g., Office of the Director, Office of General Counsel, etc.) and the members of the cross-agency Public Access and Open Science Working Group (PAOSWG).  Creates and maintains linkages to other NSF units and other Federal agencies in pursuit of the overall NSF mission.

Works closely with the NSF Chief Information Officer staff on implementation and refinement of NSF's public access policies and systems (e.g., NSF-PAR, see: http://par.nsf.gov ).  Provides oversight and direction to system developers at NSF and DOE in the collaborative development and maintenance of the subsystems comprising NSF-PAR.

Contributes to the NSF Knowledge Management activity (e.g., change management) and its work with internal, enterprise-wide policies.

Assists the Office of Legislative and Public Affairs (OLPA) in communicating NSF’s Public Access and Open Science goals to the range of research communities served by NSF. 

Provides strategic and technical advice to the PAOSWG and the Office of the Director on policy development and implementation regarding public access to the outcomes of federally funded research, and other related science policy issues as they arise.

Analyzes and integrates scientific input and policy guidance from OMB, OSTP, Congress, the National Academy of Sciences, professional societies, the National Science Board, NSF policy groups, the Advisory Committee for Cyberinfrastructure, and other agencies and organizations into the Foundation’s plans for implementing public access and other science policy issues.

Advises OIA on advanced technology for knowledge management, including but not limited to taxonomy, ontology, machine learning, artificial intelligence, and semantic search.

Applies contemporary methods of organizing data, information, and knowledge to internal NSF information.

Provides leadership and support for the NSF Public Access Working Group. The NSF Public Access Working Group is charged with oversight of the implementation of the NSF Public Access Plan 2.0 (NSF 23-104, see: https://www.nsf.gov/pubs/2023/nsf23104/nsf23104.pdf ) and is comprised of senior leadership from across the Foundation. 

Serves on or leads NSF-wide groups addressing public access and other policy issues.  Serves on or leads teams of experts on interagency studies and, working with the Public Access working group and the Office of the Director, helps to coordinate NSF involvement in relevant interagency activities. 

Working with the Office of the Director and other NSF leadership, works to coordinate with the international science community on public access (and related policy issues as they arise) with the appropriate units within NSF, and to facilitate NSF interaction/participation in international science policy bodies.

Represents NSF as appropriate on internal committees, interagency committees, at meetings of other Federal agencies, professional organizations, and universities; participating, providing advice, and drafting recommendations and reports representing the outcome of such meetings.

Prepares background papers, presentations, and reports for use by senior NSF leadership in discussions with the National Science Board and for hearings and congressional testimony, as needed. Initiates, conducts, and manages studies and analyses to assess the scientific and technological contributions of public access to the achievement of national goals and objectives, as needed.

Serves as liaison with other Federal agencies, particularly in interagency programs involving public access policy development and implementation, and conducts other duties as assigned.

Appointment options

The position recruited under this announcement will be filled under the following appointment option(s):

Intergovernmental Personnel Act (IPA) Assignment: Individuals eligible for an IPA assignment with a Federal agency include employees of State and local government agencies or institutions of higher education, Indian tribal governments, and other eligible organizations in instances where such assignments would be of mutual benefit to the organizations involved. Initial assignments under IPA provisions may be made for a period up to two years, with a possible extension for up to an additional two-year period. The individual remains an employee of the home institution and NSF provides the negotiated funding toward the assignee's salary and benefits. Initial IPA assignments are made for a one-year period and may be extended by mutual agreement. 

Eligibility information

It is NSF policy that NSF personnel employed at or IPAs detailed to NSF are not permitted to participate in foreign government talent recruitment programs.  Failure to comply with this NSF policy could result in disciplinary action up to and including removal from Federal Service or termination of an IPA assignment and referral to the Office of Inspector General. https://www.nsf.gov/careers/Definition-of-Foreign-Talent-HRM.pdf .

Applications will be accepted from U.S. Citizens. Recent changes in Federal Appropriations Law require Non-Citizens to meet certain eligibility criteria to be considered. Therefore, Non-Citizens must certify eligibility by signing and attaching this Citizenship Affidavit to their application. Non-Citizens who do not provide the affidavit at the time of application will not be considered eligible. Non-Citizens are not eligible for positions requiring a security clearance.

To ensure compliance with an applicable preliminary nationwide injunction, which may be supplemented, modified, or vacated, depending on the course of ongoing litigation, the Federal Government will take no action to implement or enforce the COVID-19 vaccination requirement pursuant to Executive Order 14043 on Requiring Coronavirus Disease 2019 Vaccination for Federal Employees. Federal agencies may request information regarding the vaccination status of selected applicants for the purposes of implementing other workplace safety protocols, such as protocols related to masking, physical distancing, testing, travel, and quarantine.

Qualifications

Candidates must have a Ph.D. in an appropriate field plus after award of the Ph.D., six or more years of successful research, research administration, and/or managerial experience pertinent to the position; OR a Master's degree in an appropriate field plus after award of the degree, eight or more years of successful research, research administration, and/or managerial experience pertinent to the position.

Knowledge of current and historical developments in federal public access policies and mandates is highly desirable, as is familiarity with scientific communication practices and research data practices. Candidates must be able to communicate and interact with senior science, engineering and managerial personnel throughout the Foundation, with other agencies, and the general science and engineering community, and are expected to know and diplomatically express the views and goals of the NSF on Public Access topics in many situations both within and outside of the National Science Foundation. Candidates must also be skilled and experienced in operating both independently and interdependently with others. Outstanding oral and writing skills and the capability to deal with a wide variety of materials, frequently changing venues, and tight deadlines is imperative.

How to apply

To apply, email the following (i) a cover letter outlining qualifications and interest in the position, and (ii) an up-to-date curriculum vitae, to [email protected] .