Respiratory Therapy- Prof. Sparaco AHS 112: Suggested Paper Topics

  • Term Paper Guidelines
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Prof. Sparaco's Suggested Term Paper Topics

SUGGESTED TERM PAPER TOPICS – Spring 2016

1. Acute Respiratory Distress Syndrome (ARDS): Pathology & Current Clinical Management

2. Non-Invasive Positive Pressure Ventilation

3. Ventilator Associated Events, Ventilator Associated Conditions, Infection-Related Ventilator Associated Complications, and Ventilator Associated Pneumonia (VAEs, VACs, IVACs, VAPs)

4. Discontinuing (Weaning) Ventilation - Acute Care Setting

5. Discontinuing (Weaning) Prolonged Mechanical Ventilation  

6. Asthma: Pathology & Current Clinical Management

7. Heliox Therapy: Theory & Clinical Application for Intubated & Non-Intubated Patients

8. Chronic Obstructive Pulmonary Disease: Pathology & Current Clinical Management

9. Aerosol Therapy: Traditional & New Drugs in Aerosol Medicine 

10. Aerosol Therapy: SVNs, MDIs, DPIs & Evolving Aerosol Technologies

11. High Frequency Jet Ventilation: History & Current Use

12. High Frequency Oscillatory Ventilation: History & Current Use

13. Inhaled Nitric Oxide in Respiratory Care

14. Lung Volume Reduction Surgery

15. Sleep Apnea: Obstructive vs. Central

16. Emergency Airway Management: Tubes & Techniques

17. Smoking, Health & Cessation Programs

18. Infant Respiratory Distress Syndrome: Pathology & Current Clinical Management

19. Protective Lung Strategies & Permissive Hypercapnea in ARDS

20. Systemic Inflammatory Response Syndrome and the Lung

21. Aerosolized Antibiotics: Efficacy and Delivery Systems

22. Cystic Fibrosis: Pathogenesis and Pulmonary Implications

23. Long-Term Oxygen Therapy

24. Capnography in Respiratory Care

25. Surfactant Therapy: New & Evolving Agents & Delivery Systems

26. Recruitment Maneuvers & PEEP in ARDS

27. Patient-Ventilator Interactions

28. Inhaled Carbon Monoxide as a Therapeutic Gas

29. Alpha 1 Antitrypsin Deficiency & Pulmonary Disease

Search Techniques to Find Specific Information on Suggested Topics

Where do you begin to find the information you need on specific topics?

  • Select Databases from the Library's homepage.

dissertation topics in respiratory medicine

2. The Databases are arranged in alphabetical order. The most relevant to Respiratory Therapy are CINAHL and MEDLINE .  The interfaces for CINAHL and MEDLINE are similar.

3. Click on Advanced Search .

4.   Enter your keyword search terms in each box.  Each term can be combined with the term above it.

dissertation topics in respiratory medicine

This search will result in articles that have information about both asthma AND its pathology.

4. If you conducted your search here, you would probably get too many results, and several of them would be irrelevant.  To make your results more accurate, it's a good idea to select limiters.  Limiters,  let you narrow your search.   The more you choose, the less results you will get.

dissertation topics in respiratory medicine

After you select the limiters you need, click  Search.

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Home > Nursing and Health Professions > Respiratory Therapy > RT_THESES

Respiratory Therapy Theses

Theses from 2024 2024.

Prevalence and Determinants of Perceived Stress among Undergraduate Respiratory Therapy Students in Saudi Arabia , Abdulmajeed Baogbah

The Perception of Asthma Management Among Healthcare Student Programs at an Urban University , Yazeed Felemban

THE PERCEPTION OF ABG INTERPRETATION AMONG NURSING AND RESPIRATORY THERAPY STUDENTS AT AN URBAN UNIVERSITY , Hams Shrourou

Theses from 2023 2023

Prevalence, and Attitudes among Respiratory Therapists in Saudi Arabia toward Using Airway Pressure Release Ventilation Mode with Pediatric Acute Respiratory Distress Syndrome Patients , Fawaz Alamri

Prevalence of Insomnia and Its Impact on Academic Performance Among Respiratory Therapy Students in Saudi Arabia (SA) and the United States of America (USA). , Ahmed H. Alasimi

The Perception of Skills for Maximizing Patient Comfort During Non-Invasive Ventilation Among Respiratory Therapists at KFSH&RC , Ahmed Albaqawi

Evaluation of Smoking Prevalence, Secondhand Smoke Exposure, and Perceptions of Smoking Cessation among Respiratory Therapy Students in Saudi Arabia , Abdulrahman Alharbi

Prevalence of Anxiety and Depression Among Respiratory Therapy Professionals in The Western Region of Saudi Arabia , Ali S. AlQahtani

Perception and prevalence of utilizing APRV mode with Covid-19 cases among Respiratory Therapists in Saudi Arabia , Jihad Alrehaili

Respiratory Therapy Students' Perception on Online Learning During COVID-19 in the Kingdom of Saudi Arabia , Faisal A. Alshehri

Perceptions of Healthcare Students toward Pulmonary Rehabilitation Programs for COPD Patients , Amani Assiry

The prevalence of sleep disturbance and anxiety among Saudi respiratory therapists during the COVID-19 winter of 2022. , Asim Madkhali

Theses from 2022 2022

An Assessment of Perception, Prevalence, And Attitudes Toward Using ECMO among Respiratory Therapists in Saudi Arabia , Fatimah Shaker Alkhamis

Evaluating the Impact of Trikafta on the Quality of Life for Cystic Fibrosis Patients , Yzeed Alrwaili

Theses from 2021 2021

The Impact of Body Mass Index and Waist Circumference on Lung Volumes in the Adult Population , Sarah B. Al Ahmed

The Perceptions of Junior Intensive Care Unit Respiratory Therapists Toward Ventilator-Associated Pneumonia Preventive Strategies , Wayil Alanazi

Level of Implementation and Beliefs about Evidence-Based Practice among Respiratory Therapists in Clinical Setting in Saudi Arabia. , Ahmad M. Alharbi

The Importance and Needs for a Standardized Preceptor Training Program in Respiratory Therapy Departments in Riyadh City, Saudi Arabia , Ahmed Y. Aljoni

The Effects of an Asthma Action Plan and Asthma Self-efficacy on Asthma Control , Abdullah Alkhthlan

Perceptions of E-cigarettes and Tobacco-Related Harm Among U.S. Adolescents: Findings From the 2020 National Youth Tobacco Survey , Reem Alluhibi

Attitudes, Practices, and Perceptions towards Covid-19 Patients among Respiratory Therapists in Saudi Arabia. , Rayan Almadni

The Perceptions of Healthcare Students toward the Evidence-Based Practice of Asthma Management , Fatimah N. Alobaidi

An Assessment of the Knowledge, Perception, and Prevalence of Using APRV on ARDS Patients among Respiratory Therapists in the Eastern Province, Saudi Arabia , Mohammad Al Obead

Evaluating The Effective Teaching Characteristic of Saudi Arabian Preceptors in Clinical Education , Abdulaziz Alolayan

Job Satisfaction among Saudi Arabian Respiratory Therapists , Saleh M. Alosaimi

A Survey of Prevalence and Experience of the Adaptive Support Ventilation (ASV) Mode among Respiratory Care Practitioners in the Eastern Province of Saudi Arabia , Zainab Alrastem

Survey of COPD Knowledge, Skills, and Attitudes Among Saudi Arabian Respiratory Therapists , Ziyad Mubarak Alshahrani

Prevalence of Burnout Syndrome Among Respiratory Therapists in Saudi Arabia , Waleed Abdullah Asiri

The Impact Of Diabetes Mellitus On Length Of Stay And Mechanical Ventilation Among Motor Vehicle Accident Patients In A Level-1 Trauma Center , Olyvia Branch

Examining the Prevalence of Self-Reported Respiratory Symptoms and Respiratory Infection amongst Firefighters in the Presence or Absence of Asthma , Juliana K. Cartwright

Comparison Of Different Exhalation Filters In Protection Against Fugitive Aerosol During Nebulizer Treatments: An In-vitro Study , Li Sheng Chen

Survey of Respiratory Therapy Students’ Perceptions of Appropriate Vibrating Mesh Nebulizer Placement for Inline Mechanical Ventilator Circuits , Jordan Kenney

Does Increasing Flow to a High-flow Nasal Cannula Affect Mean Airway Pressure in a Pediatric In Vitro Model? , James Liu

Theses from 2020 2020

Perceptions, Attitudes, and Compliance of Health Care Undergraduate and Graduate Students Regarding Infection Control Practices , Raghad A. Alherbish

Measuring Muscle Fatigue associated with tourniquet use using Accelerometer-Based Mechanomyography: A Pilot Study , Erica Armstrong

Theses from 2018 2018

When to Initiate Pulmonary Rehabilitation Program for Chronic Obstructive Pulmonary Disease Patients , Samar Alosaimi

The Impact of Aerosol Devices and Delivery Interfaces on Aerosol Deposition in Children Receiving Noninvasive Ventilation , Malak Obaid Alshlowi

The Perception of Adherence to Cystic Fibrosis Guidelines by Respiratory Therapist in Saudi Arabia , Jameel Zaid Hakeem

A Survey of Research Productivity in Respiratory Therapy Educational Programs , Melinda Register and Melinda L. Register

Theses from 2017 2017

Healthcare Students' Perceptions of Simulation Education at an Urban University , Fahad H. Al Enazi

Prediction Equations for Pulmonary Diffusing Capacity for Nitric Oxide in Healthy African-American Adults , Ahmad Almamary

Developing A Prediction Equation for the Six-Minute Walk Test in Healthy African-American Adults , Mobarak Alqahtani

Prevalence, Knowledge, Beliefs, and Attitude of Hookah (Waterpipe) Smoking among Health Care Students at a Southeastern Urban Research University , Mohammed Alqahtani

Healthcare Professional Students' Perceptions toward Interprofessional Education , Bandar Faqihi

Theses from 2016 2016

The Perceived Impact of International Educational Experiences in the United States on Saudi Respiratory Therapists , Hassan Y. AbuNurah

The Prevalence of Use, Awareness and Beliefs of Electronic Cigarettes Among College-Based Health Care Students At A Southeastern Urban University , Abdullah Mayof Alanazi

Evaluation of Clinical Facilities in term of Clinical Learning Environment, Supervisory Relationship,and Roles of Clinical Instructor , Saeed M. Alghamdi

Knowledge of Asthma and the Utilization of Certified Asthma Educators in a Health Law Partnership Legal Services Clinic and a Metropolitan Children?s Hospital , A Needs Assessment , Laura Miller

Theses from 2015 2015

Perceptions of Clinical Instructors and Respiratory Therapy Students on Effective Teaching Characteristics of Clinical Instructors in Saudi Arabian Universities , Fahad Alahmadi

Clinical Instructors' Perceptions of Effective Student Behavioral Characteristics Among Respiratory Therapy Students in the State of Georgia , Yousef Saad Aldabayan

Respiratory Therapy Administrators' Perceptions of Effective Teaching Characteristics of Clinical Preceptors in Metro-Atlanta Hospitals , Abdulelah Aldhahir

Students' Perceptions of Using Simulation In Respiratory Therapy Program , Ahmad Alhaykan

Respiratory Therapy Student Perception of Patient Simulation Education at a Large Urban University , Abdullah Alqarni

Respiratory Therapists' Knowledge, Skills, and Attitudes Regarding MERS-CoV Disasters , Naif Alruwaili

Cultural Competency Among Undergraduate and Graduate Respiratory Therapy Students , Ziyad Alshehri

A Needs and Value Assessment in Developing a Saudi Board of Respiratory Therapy , Khalid S. Alwadeai

Respiratory Therapy Faculty' Perceptions of Effective Teaching Characteristics of Clinical Instructors in the State of Georgia , Rayan Siraj

Theses from 2014 2014

Respiratory Therapy Students' Perceptions of Effective Teaching Characteristics of Clinical Instructors at an Urban University , Ali M. Alasmari

Theses from 2013 2013

The Effect of Aerosol Devices and Administration Techniques on Drug Delivery in a Simulated Spontaneously Breathing Pediatric Model with a Tracheostomy , Bshayer R. Alhamad

Survey of the Knowledge and Confidence of Respiratory Therapy Students Regarding Tobacco Smoking and Respiratory Diseases , Delano S. DuCasse

Correlational Study for Predictor Variables Affecting Length of Stay in Pediatric Sickle Cell Patients , Jenny Schott

Comparison of HFNC, Bubble CPAP, and SiPAP on Aerosol Delivery in Neonates: An In-Vitro Study , Fatemah S. Sunbul

Theses from 2012 2012

In Vitro Evaluation oF Aerosol Drug Delivery With And Without High Flow Nasal Cannula Using Pressurized Metered Dose Inhaler And Jet Nebulizer in Pediatrics , Mahmood A. Alalwan

A Survey of Preceptor Training in Clinical Education of Respiratory Care Departments in Selected Hospitals in Metropolitan Atlanta , Tariq Aljasser

Problem-Based Learning as a Teaching Method Versus Lecture-Based Teaching in Respiratory Therapy Education , Bandar M. Almasoudi

In-Vitro Comparison of Aerosol Drug Delivery in Pediatrics Using Pressurized Metered Dose Inhaler, Jet Nebulizer, and Vibrating Mesh Nebulizers , Huriah A. Al Sultan

Theses from 2011 2011

Efficiency of Aerosol Therapy through Jet Nebulizer, Breath-Actuated Nebulizer, and Pressurized Metered Dose Inhaler in a Simulated Spontaneous Breathing Adult , Abdullah ALQarni

The Effect of Using Different Aerosol Devices and Masks on Aerosol Deposition during Noninvasive Positive Pressure Ventilation in an Adult Lung Model , Maher M. AlQuaimi

Cost-Benefit Analysis of a Dosimetric Nebulizer Using Circulaire and aTraditional Vixone Nebulizer , Nwakaego C. Okere Ms

The Independent Effect of Three Inline Suction Adapters and Lung Compliance change on Amplitude and delivered Tidal Volume during High Frequency Oscillatory Ventilation in an adult patient with ARDS: Bench Model , Shreya Thacker

Theses from 2010 2010

Comparison of Albuterol Delivery between High Frequency Oscillatory Ventilation and Conventional Mechanical Ventilation in a Simulated Adult Lung Model using Different Compliance Levels , Waleed A. Alzahrani

Effects of Heat and Moisture Exchangers Designed to Allow Aerosol Delivery on Airflow Resistance and Aerosol Deposition , William Sonny Bowers II

The Effect of Different Interfaces on Aerosol Delivery in Simulated Spontaneously Breathing Adult with Tracheostomy , Alaa Ahmed Bugis

Theses from 2009 2009

How Does Alteration of Airway Resistance Affect Delivered Tidal Volume in Adult Patients Receiving High-Frequency Oscillatory Ventilation? , Essam Ali Aljamhan

The Effect of Compliance Changes on Delivered Volumes in an Adult Patient Ventilated with High Frequency Oscillatory Ventilation: A Bench Model , John England

The Effects of Aerosol Drug Delivery on Airway Resistance through Heat-Moisutre Exchangers , Matthew Thomas Hart

Does Increasing Flow to a High Flow Nasal Cannula Affect Mean Airway Pressure in an In Vitro Model? , Robert Brent Murray

Correlational Study for Predictor Variables Affecting Duration on Bubble CPAP , Alison Louise Stoeri

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Explore the broad range of research subjects you can undertake with the guidance of dedicated, enthusiastic faculty.

Topics for research projects with specific investigators include:

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  • Effect of acetoxycoumarins and calcium channel blocking dihydropyrimidone derivatives on protein kinase C activity of and lymphocytes in COPD patients.
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Home » Pay Someone to Write My Medical Thesis » Dissertation Topics For MD Respiratory Medicine

Dissertation Topics For MD Respiratory Medicine Dissertation & Thesis Writing Service & Help

Because theses are required by law, it is recommended that you select your thesis topic for MD respiratory medicine with care and consideration. As with any subject, you need to decide what you are good at and then narrow it down to two or three topics that can be done in two to three years.

You should also make sure that the topic that you choose is something that you are interested in and will be interesting to you. If the topic you are considering is not something you are interested in then you should consider someone else who is interested in the same area. It is important to make sure that you and your adviser do not have too many topics on which to work on as this could slow down the completion time and make it difficult for you to focus on your work.

When you choose your topic for MD, you need to remember that it does not have to be strictly research papers or any other type of writing. Even though you need to complete your research papers, you should consider using articles and even journal articles when you can write them because these types of papers often require little to no research at all.

In the same way that research papers do not have to be strictly research papers, an article does not have to be solely about a doctor. For instance, if you are interested in medical communication, then you should consider including articles written about topics such as communicating with patients, using medical charts, developing patient communication skills, and creating medical reports. In addition to the article, you can also include a few pages of your own personal research paper in addition to the doctor’s research paper.

It is always a good idea to include a section on why you chose your doctor. This is often an important part of the thesis, because it allows your advisor to see why you selected that doctor over others. If you were attracted to a particular doctor due to a physical attribute that the doctor had, then it may be appropriate to include that information in your personal research paper. For example, if you like doctors that are outgoing and fun, then you may want to include in your personal writing some information about what it was that drew you to your chosen doctor.

Although the dissertation is not required by law, it is always good to include in your dissertation, an analysis of a doctor’s work. It is always nice to include your research paper with the doctor’s work for MD but if you do not have the time or if the doctor is retired, then you may want to discuss in your personal writing how you believe his or her work is important.

When you review your doctor’s work, you should consider the fact that there are many things that you do not know and this is where you can gain insight from. For example, when studying anatomy and physiology you may not fully understand the concept behind the methods that the doctor uses in treating patients so you may want to discuss this in your personal paper.

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Home > MAHE Student Work > KMCMLR

Kasturba Medical College, Mangalore Theses and Dissertations

Theses/dissertations from 2021 2021.

“The Impact of Self-Stigma of Seeking Help and Perceived Social Support on Burnout among Clinical Psychologists” , Aavrita A

The impact of self-stigma of seeking help &percieved social support on burnout among clinical psychologists. , Aavrita .

Immediate Effects of Novel Hand Rehabilitation Board on Fine Motor Skills in Children with Cerebral Palsy. , Romita Fernandes. Abraham

"COMPARISON OF THREE SCORING CRITERIA TO ASSESS RECOVERY FROM GENERAL ANAESTHESIA IN THE POST-ANAESTHESIA CARE UNIT- A LONGITUDINAL OBSERVATIONAL STUDY " , Shagun Aggarwal

Comparative predictive validity of Alberta Infant Motor Scale and Infant Neurological International Battery in Low Birth Weight Infants- A Prospective Longitudinal Study. , Polisetti Siva Sai Anand

Antagonistic Asynchrony in Muscle Recruitment Pattern of Forward Reach Movement In Children With Cerebral Palsy. , Sanya Anklesaria

Muscle fatigue response of rotator cuff muscles in sitting and standing postures , Lisanne Aranha

Effectiveness of static weight bearing versus modified constraint induced movement therapy on improving hand function in hemiplegic cerebral palsy- A Randomized Clinical Trial. , Ruth Bavighar

How informed are our patients about generic medicines? – A study from coastal South India , Darshan BB

Morphological variants of the human spleen, a cadaveric study , Murlimanju BV

Association between cervical breast cancer and Diabtetes mellitus among women seeking health care in tertiary hospitals od south India: A cross sectional study , Pratik Kumar Chatterjee

Carcinoma Breast in among Women with Diabetes Mellitus: A Case Control Study , Pratik Kumar Chatterjee

Perception of Empathy among medical students: A cross sectional study , Pratik Kumar Chatterjee

CLINICOMYCOLOGICAL PROFILE OF DERMATOPHYTOSIS IN A TERTIARY CARE HOSPITAL IN SOUTH INDIA , Adyashree Dalai

Study of outcome of Ponseti technique of management for idiopathic clubfoot in a tertiary center in south India , Lulu Damsas

Comparative study of emotional labour &burnout on life satisfaction among school teachers across different educational settings , Meghana Dharampalan

“Comparative Study of Emotional Labor and Burnout on Life Satisfaction Among School Teachers Across Different Educational Settings” , Meghana V. Dharmapalan

“Relationship Between Sexual Fantasy, Sexual Communication, Personality Traits and Sexual Satisfaction in Married Individuals” , Rhea Dhir

Comparing the efficacy of USG guided supraclavicular brachial plexus block with or without intercostobrachial nerve block for forearm surgeries – an observational study , DIKSHA D’MELLO

Does Quality of Sitting influence Functional Mobility in Cerebral Palsy? A cross-sectional study , Kaiorisa N. Doctor

Factors effecting gait velocity in osteoarthritis knee-An observational study. , Lisha Gretal D’silva

Effect of Inspiratory Muscle Training on Pulmonary Function, Functional Capacity, Quality Of Life And Length Of Stay in individuals undergoing Cardiac Surgery , Fiona Verdine Dsouza

Relationship of Academic Resilience with Self-Efficacy, and Perceived Social Support; Among Civil Service Aspirants , Neha Eldho

EFFICACY, FEASIBILITY, AND SAFETY OF PERCUTANEOUS IMAGE-GUIDED CATHETER DRAINAGE OF THORACIC, ABDOMINAL, AND PELVIC FLUID COLLECTION , Aishwarya Gadwal

Comparison of efficacy of two different bolus doses of norepinephrine as prophylac-tic to prevent post-spinal hypotension during elective caesarean section , PRANATHI GARAPATI

Trends in Frailty and its Associated factors in Community Dwelling Elderly Indian Population during COVID-19 Pandemic- A Prospective Analytical Study , Karan Gautam

Speech Sound acquisition in some south Indian Dravidian languages: A systematic review , Jesica George

Comparison of Femoral nerve block with Dexmedetomidine and Adductor canal block with Dexmedetomidine for postoperative analgesia for Total Knee Arthroplasty . , NEHA GEORGE

Assessment Of Cardiovascular Risk Factors In Patients With Osteoarthritis Knee , Sagar Goel

Effectiveness of Intermittent Cervical Traction with and without Neural Mobilization in Discogenic Cervical Radiculopathy , Aditi Goyal

Study of maternal and cord blood vitamin B12 levels with anthropometry in term neonates born to normal and malnourished mothers: a hospital based cross sectional study , Sugapradha a. GR

Development of a Questionnaire to Determine the Intervention and Service Delivery Practices of Speech-Language Pathologists for Children with Speech Sound Disorders in India , Shaily Gupta

Relationship between Physical Activity, Objective Sleep Parameters and Circadian Rhythm in Patients with Head and Neck Cancer receiving Chemoradiotherapy- A Longitudinal Study , Rachita Gururaj

“Emotional Contagion, Perceived Stress and Coping Strategies Among Nurses” , Saumya Hariharan

Assessment of knowledge and belief about stuttering among undergraduate medical students , Anushree Harihar

Association of serum lipid levels and other systemic risk factors with retinal hard exudates in diabetic retinopathy patients. , Harshita Mukesh Hiran

Assessment of risk of Diabetes Mellitus by using Indian Diabetes Risk Score among Housekeeping staff , Ramesh Holla

“Emotional Intelligence, Self-compassion, and Life-Satisfaction In Clinical Psychologists” , Vania Jacob

UPPER-CROSSED SYNDROME AND DISABILITY IN SHOULDER ADHESIVE CAPSULITIS. , Aishwarya Jaideep

Study to assess the role of doppler ultrasound in evaluation of arteriovenous hemodialysis fistula and the complications of hemodialysis access , Ishank Jain

Relationship between burnout compassion fatigue, work environment & mindfulness in medical residents , Pranay Javeri

“Relationship Between Burnout, Compassion Fatigue, Work Environment and Mindfulness in Medical Residents” , Pranay Harichandra Javeri

“Dating Anxiety in Emerging Adults” , Jisha V. Jayaprakash

“Relationship Between Tolerance for Disagreement and Mindfulness in Married Males and Married Females” , Jahnavi Jha

Antibiotic usage and susceptibility patterns in Uncomplicated UTI in a Tertiary Hospital in South India , Christy John

Association of bed rise difficulty scale with trunk impairment and functional scales among stroke patients , Leena G. John

Is there a correlation between Pediatric Berg Balance Scale and Centre of Pressure Excursion measured through Dual Axis Static Force Plate™ to assess Balance in Children with Spastic Cerebral Palsy and Typically Developing? , Niharika Joshi

Comparison of Sensory Processing Responses in Cerebral Palsy Subtypes and Typically Developing Children (7-36 months): A Cross Sectional Study. , Archana Antony K

‘A study on the Role of Learned Helplessness, Selfefficacy and Perceived Social Support in Determining Resilience in Parents of Children with Neurodevelopmental Disorders’ , Benaisha Khurshed Katrak

A study of correlation of maternal serum zinc levels with breast milk and cord blood of late preterm neonates , Rashmi Katti

Correlation of histopathology and direct immunofluorescence findings in clinically diagnosed prurigo nodularis , Haritha K

Difference in proximal femur loading due to muscle activity during partial weight bearing and NWB standing- A cross-sectional study. , Smital Kshirsagar

Effect of Sesamol on neurobiochemical changes in diet induced (DIO) obesity model of Zebra fish (Danio rerio) , Rashmii K.S.

Importance of integration of medical ethics with undergraduate medical curriculum- Instructors and student’s perspectives. , Rashmii K.S.

Long-term potentiation (LTP): A simple yet powerful cellular process in learning and memory , Rashmii K.S.

Parkinson's Disease Overview: Alternative Potential Curcumin Treatment, Current Treatment and Prevalence Among Ethnic Groups , Rashmii K.S.

Smart brain of India vs. tricky drugs , Rashmii K.S.

The Role of Professionalism and Ethics Training: Instructor’s and Student’s perspectives in a medical College , Rashmii K.S.

Violence Against Doctors: A Qualitative Study On This Rising Predicament , Rashmii K.S.

Morphometric study of the gracilis muscle and its pedicles , Chettiar Ganesh Kumar

Comparative study of bed side tests to assess difficult airway in paediatric patients , S.Abinandha Kumar

Euphorbia thymifolia (Linn.)- A review on ethno pharmacological properties , Vasavi Kumblekar

COMPARISON OF KNOWLEDGE, ATTITUDE, AND PRACTICE TOWARDS THE USE OF SUNSCREEN IN DAILY LIFE BETWEEN FIRST -AND THIRD -YEAR MEDICAL STUDENTS , Aarushi Lall

‘Feminist Identity, Socio-cultural Attitude Towards Appearance, and Body Images issues in Emerging Adult Women’ , Sheena Lonappan

A novel approach to quantify the Dynamic Windlass Mechanism , Ishita Mahajan

METFORMIN VERSUS INSULIN IN THE MANAGEMENT OF GESTATIONAL DIABETES , Varikuti Manogna

Cognitive abilities among employed and unemployed middle-aged women – a systematic review , Aswini M

‘Emotional Intelligence, Job Satisfaction and Psychological Well-being Among Nurses’ , Chetna M

RELATIONSHIP OF COMPUTER AIDED DESIGN(CAD)-BASED PHOTOGRAMMETRY FOR FACIAL DYSFUNCTION WITH FACIAL GRADING SYSTEMS FOR BELL’S PALSY: A PROSPECTIVE OBSERVATIONAL STUDY , Ankita Mehendale

“Effect of Sensation Seeking and Anxious Traits on Suicidal Ideation Among Adults by Birth Order” , Haripriya G. M

Clinical & radiological assessment of intertrochanteric fractures treated with PFN A2 , Harish M

Effect of a home-based pulmonary rehabilitation programme on respiratory function, functional capacity, and quality of life in patients with chronic obstructive pulmonary disease , Vaibhavi Mhatre

Profiling Communication Characteristics of Individuals with Acquired Neuro-communication Disorder in a Tertiary Care Setup , Nikita Subudhi M

Relationship between weight bearing symmetry, trunk control and fear of fall amongst subjects with stroke: A cross sectional study , VIVIAN NEHAL MONIS

Lower extremity muscle recruitment pattern during sit to stand transfer in children with cerebral palsy as compared to typically developing children- a cross sectional study. , Kiran P. Nadgauda

Knowledge, attitudes and practices of Indian classical singers towards vocal healthcare , Raveena Muralidharan Nair

"Perspectives of Indian Speech Language Pathologists on Adolescent Language Assessment" , Rohana Muralidharan Nair

Effect Of Yoga On Perceived Stress And Pulmonary Function In High Stressed Postmenopausal Women , Vinodini NA

Refractory errors, blood groups & diabetes mellitus: A corrleative study in south Indian population , Vinodini NA

Comparison of Functional outcomes for displaced extra-articular distal radius fractures managed by Conservative versus Operative methods: A Prospective cohort study , Muhammed Ehsan Nazeer

COMPARATIVE STUDYOF THE EFFECTIVENESS OF VAPOCOOLANT SPRAY VERSUS EMLA®® CREAM IN REDUCING PAIN DURING INTRAVENOUS CANNULATION IN ADULT POPULATION , Sisla Nazer P

Assessment of attitude among public towards stuttering in a coastal city of Southern Karnataka , Prithvi N

"Severity assessment of acute pancreatitis using ct severity index and modified ct severity index: association with clinical outcomes and ranson’s criteria. " , GEETANJALI PARMAR

“The Effect of Culture Shock on Adjustment and Psychological Wellbeing Among College Going Students” , Akanksha Patra

‘Effect of Religiosity on Attitude Towards Euthanasia in Medical Students’ , Sumedha Pawar

Development Of A Questionnaire To Determine The Clinical Assessment Practices Of Speech-Language Pathologists For Children With Speech Sound Disorders In India , Prasila Elsa Philip

Correlation of oxidised LDL with oxidant and antioxidant enzymes in subjects with elevated LDL levels , Pooja p

Association of emotional intelligence of primigravida mothers with breastfeeding self efficacy in the early postpartum period and exclusive breastfeeding rates up to 6 months. , Priyanka Reddy p

Morphometric study of the Sartorius muscle and its vascular pedicles , M.D. Prameela

Comparison of the analgesic duration using ultrasound guided popliteal sciatic nerve block between diabetics with neuropathy and non-diabetics without neuropathy , GANESH PRASAD

Early follicular and Mid-luteal phase associated changes in Lower extremity Muscle strength , length and Agility in amateur female athletes – a Prospective Analytical study , Vishnu Priya

Assessment of mobile device based educational intervention on breastfeeding technique in multigravida mothers and its effect on early infant feeding pattern- A randomized controlled trial. , Keerthi Raj

THERMAL ULTRASOUND, MANIPULATION AND EXERCISE ON PAIN AND MOUTH OPENING IN CHRONIC TEMPOROMANDIBULAR JOINT DISORDER: A CASE REPORT , Suchita S. Rao

Correlation of Histopathology and Direct Immunofluorescence: Findings in clinically diagnosed Prurigo nodularis in a Tertiary care hospital , Haritha Reddy

EFFECT OF POSITIONING ON THE PAIN RESPONSE OF INFANTS VACCINATED WITH IPV AND PENTAVALENT (dtwp-HEPATITIS B-HEMOPHILUS INFLUENZA B) VACCINES , Sontosh Reddy

Assessment of the acceptable length of Right internal jugular central venous catheters. , Nivedhitha R

PRELEVANCE OF WORK RELATED DERMATOLOGICAL SYMPTOMS IN HEALTH CARE WORKERS IN COVID-19 ERA , Rana R

COMPARISON OF TWO ROUTINE FACIAL EXERCISE PROTCOLS FOR BELL’S PALSY- A RANDOMIZED CONTROLLED TRIAL , Stephanie Santiago

Profiling selected speech characteristics in individuals with Chronic Cough , Nawal Palakkal Sathar

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Thesis topics.

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dissertation topics in respiratory medicine

Role of atopy in the etiology of non-smoker chronic bronchitis.

Airway response to provocation with methacholine aerosol in different kinds of smokers.

Relative contribution of the parasympathetic and sympathetic mechanisms in airway obstruction in bronchial asthma.

Assessment Airway response to broncho-constricting agents in leprosy.

Tuberculin sensitivity in patients with sarcoidosis. Predicting outcome in respiratory intensive care: comparative evaluation of three severity scoring systems.

Incidence of tuberculosis during corticosteroid therapy.

Evaluation of predictors of duration of mechanical ventilation.

Airway resistance in subjects exposed to environmental tobacco smoke.

Profile of method and criteria used for weaning from mechanical ventilation in Respiratory Critical Care Unit.

Spectrum and outcome of acute lung injury in Respiratory Critical Care Unit.

Asbestos induced changes in some cellular and molecular function in rat alveolar macrophages.

Status of reactive oxygen species and antioxidant defense system in alveolar macrophages of lung cancer patients.

Study of the occurrence and mechanisms of programmes cell death (apoptosis) in peripheral blood mononuclear cells of pulmonary tuberculosis patients.

Oxygen free radicals: their role in mycobacterial killing and the mechanism of action.

Immunoregulatory effects mediated by CD4+ and gamma/delta T-cells in pulmonary tuberculosis.

Determination of ventilatory minute volumes required to maintain normocapnia in adult North Indian health subjects under anaesthesia.

Factors influencing survival time of Bronchogenic Carcinoma in a tertiary Care Centre

The clinical, Radiological and function profile in diffuse Parenchymal Lung Disease.

Cardio Pulmonary Exercise testing in asymptomatic smokers v/s Nonsmokers

A prospective study comparing the outcome of chemical Pleurodesis using TALC or Tetracycline in Patients with Pneumothorax.

Prevalence of components of Metabolic Syndrome in pregnant women with obstructive sleep apnoea / hypopnoea Syndrome.

A study on Pulmonary function abnormalities in patients with Carcinoma Breast following external radiation treatment.

A study of the measurement of quality of life of lung cancer patients.

Inspiratory muscle training in chronic obstructive pulmonary disease.

Airway response to fenoterol in hypothyroid patients before and after treatment.

Socio-demographic profile and B.M.I. characteristic of patients with pulmonary tuberculosis attending chest clinic.

Measurement of bronchial hyperreactivity in patients with idiopathic pulmonary fibrosis.

Tuberculin sensitivity in patients with pulmonary sarcoidosis.

Hematological abnormalities in patients with sarcoidosis.

Predictors of Oxygen derived - free radicals in non smoker women exposed to environmental tobacco smoke.

A study of the smoking habits in patients of pulmonary tuberculosis.

Diurnal variations of peak expiratory flow and its correlation with different morbidity indices in bronchial asthma.

Study of relationship of endobronchial and transbronchial lung lesions in patients with clinical diagnosis of sarcoidosis.

Arm span to height relationship for assessment of spirometric functions.

Sensitivity and specificity of tuberculin skin test for the diagnosis of pulmonary tuberculosis in patients seeking treatment for respiratory problems.

To test the reliability of a Hindi questionnaire designed and validated for diagnosis of asthma for prevalence studies.

A study of familial aggregation of cancer in the first degree relatives of lung cancer patients.

Indices of morbidity and control of asthma in non smoking women exposed to combustion of biomass fuels.

Assessment of airway responsiveness in asymptomatic asthmatic women exposed to environmental smoke.

Study of cellular composition of bronchoalveolar lavage fluid in patients with pulmonary tuberculosis using flow-cytometry.

Visual analogue scales in assessing severity of bronchial asthma.

Diurnal variations in pulmonary function tests in normal healthy individuals.

Influence of environmental tobacco smoke exposure on acute exacerbations in known asthmatics.

Validity of new study questionnaire in Hindi for diagnosis of asthma for epidemiological studies.

Production of reactive nitrogen intermediates and L-cirtrulline by peripheral blood polymorphonuclear leukocytes in bronchial asthma.

Nebulized salbutamol for acute hyperkalemia in renal failure patients.

Significance of the reactive nitrogen intermediates in the pathophysiology of human pulmonary tuberculosis.

Serodiagnosis of tuberculosis in adults using ELISAS test with antigen - 5.

Production of oxygen derived free radicals by peripheral blood polymorphonuclear leukocytes in different stages of Asthma in adults.

Bronchial provocation with Parthenium hysterophorus pollen extract in patients of bronchial asthma.

Diagnostic evaluation of cholesterol and various lipoproteins in the pleural effusions.

Transbronchial lung biopsy in sarcoidosis and relationship of histological changes with pulmonary function tests.

Assessment of lung function in health natives of Bhutan.

Airway response to acid application in oesophagus (simulating gastro-esophageal reflux) in patients of bronchial asthma.

Prediction of blood carboxy-haemoglobin from expired air carbon monoxide samples in "bidi" and cigarette smokers.

Determination of maximal inspiratory and expiratory muscle pressure at mouth in healthy Indian adults.

A study of serum-fluid albumin gradient in evaluation of pleural effusions.

Study of non-specific airway responsiveness in patients of rheumatoid arthritis.

Influence of environmental tobacco smoke exposure on different morbidity indices in adult asthmatic women.

Nifedipine in bronchial asthma.

Enalapril and bronchial responsiveness.

Bronchodilator mediated airway response in health.

Comparative airway response to bronchodilators in patients of leprosy with normoreactivity and hyporeactivity to methacholine.

Status of reactive oxygen species and anti-oxidant defense system in alveolar macrophages and peripheral blood neutrophils of lung cancer patients.

Pulmonary function changes after large volume paracentesis in patients with cirrhosis of liver and ascites.

Effect of mechanical ventilation on surfactant levels in patients with ARDS.

Surfactant protein-A and nitric oxide derivatives in lung lavage obtained from patients with idiopathic pulmonary fibrosis.

Effect of esophageal variceal sclerotherapy on lung function.

Estimation of nitrate production by alveolar macrophages in bronchogenic carcinoma.

Respiratory symptoms among the farmers.

Role of domestic fuels on the course of bronchial asthma in nonsmoking women.

Neutrophil superoxide (free radical) levels and total neutrophil count in peripheral blood of smokers (asymptomatic and symptomatic with chronic obstructive pulmonary disease) of cigarette, bidi, hookah and mixed product. Vitamin A, beta-carotene and vitamin C in patients of lung cancer.

Study of carcinoembryonic antigen and sialic acid levels (total and lipid bound) in patients with lung cancer.

Hypothalmo-pituitary-adrenocortical axis in inhaled corticosteroid users, not an oral corticosteroid: a longitudinal study.

Production of anti-oxidant enzymes by pulmonary alveolar macrophages in patients with lung cancer.

Erythrocyte (RBC) antioxidant enzyme levels in patients with primary lung cancer.

Production of oxygen free radicals by pulmonary alveolar macrophages in patients with lung cancer.

Lung functions with relation to the fuels (biomass, LPG, kerosene and mixed) used in the houses of children in the age group of 7-15 years.

Non-invasive evaluation of cardiac abnormalities in rheumatoid arthritis.

Spectrum of changes in computed tomography in chest in pulmonary tuberculosis.

Effect of ciprofloxacin and ibuprofen on blood levels of rifampicin in patients receiving antitubercular treatment.

Evaluation of pulmonary changes in patients of psoriasis on methotrexate therapy.

A study of broncho-alveolar lavage cytology in patients of rheumatoid arthritis.

Neutrophil count and myeloperoxidase activity in smokers.

Pulmonary function in patients of idiopathic ulcerative colitis.

Blood carboxyhemoglobin levels in different types of smoking.

Effect of domestic fuels on lung functions in females.

Effect of irradiated lung volume on the pulmonary functions following postoperative radiotherapy in carcinoma breast.

Studies on T-Lymphocytes in tubercular pleural effusion.

Immunohistological studies in tubercular lymphadenitis.

Quantification of cells recovered by bronchoalveolar lavage in pulmonary tuberculosis.

Hepatoxicity with INH and Rifampicin.

Skin hypersensitivity and precipitating antibodies against Aspergillus fumigatus in patients of bronchial asthma.

Thyroid function in smokers.

Radiologic evaluation of total lung capacity.

Correlation between morphological changes and impairment of ventilatory function in patients suffering from bronchiectesis.

Study of respiratory tract involvement in leprosy.

A study of peak-expiratory flow rate in healthy school children, 6-16 years of age.

Study of effects of 6 months' therapy with methotrexate on pulmonary functions in patients of rheumatoid arthritis.

Echocardiographic evaluation of right and left ventricular functions in corpulmonale with chronic obstructive pulmonary disease in acute respiratory failure.

Cough reflex threshold and diabetic autonomic neuropathy : correlation with ECG parameters of vagal involvement.

Echocardiographic evaluation of cardiac involvement in sarcoidosis.

Suspicious nodules in asymptomatic smokers with greater than 30 pack years of smoking by low dose CT screening

Narrow band Imaging guided bronchial biopsy vs white light bronchoscopy guided bronchial biopsy

Endobronchial ultrasound vs Positron Emission tomography in the evaluation of malignant mediastinal masses

Socioeconomic class and compliance with asthma medications

Retrospective study of road traffic accidents in patients diagnosed with severe obstructive sleep apnea

The usefulness of Heliox in acute severe asthma

Case series of mediastinal masses.

The effect of socioeconomic upbringing on the lung function

Reference values for Maximum Voluntary Ventilation for the Indian adults.

Prevalence of obstructive sleep apnea in patients admitted for bariatric surgery

Indications and Outcomes of Non invasive Ventilation in a tertiary care hospital

Profile of 50 consequent interstitial lung disease patient attending tertiary care center.

Analysis of CT-chest of smokers with greater than 10 pack years of smoking

Commonest side effects complained by the patients initiated on HAART therapy

The incidence of cavities in 5000 chest x rays taken in a medical college hospital. (Mass miniature radiography was used to detect TB earlier)

Diabetes in chronic liver disease

The incidence of HIV in patients admitted for elective surgery.

Success rate of nicotine patch is a hospital based smoking cessation program

Post op pulmonary complications in patient undergoing liver transplant surgery

Incidence of laryngeal involvement in sputum positive pulmonary TB

Pulmonary hypertension in patients diagnosed with severe obstructive sleep apnea.

Asthma and Obesity – Comparing the pulmonary function of obese and non- obese asthmatics

The usefulness of bronchoscopic brush specimen versus biopsy in the diagnosis of carcinoma of lung

Role of NIV in severe type 2 respiratory failure. Predictors of success and failure with NIV use.

Post bronchodilator reversibility in COPD and its correlation with the stage of COPD as per GOLD guidelines and BODE score

Compliance with asthma medications. The common cause of non-adherence and predictor of compliance with recommended medications.

Spirometry in athletes versus normal individuals of same height

Role of bronchoscopy in smear negative pulmonary tuberculosis.

Pulmonary function tests before and after transhiatal oesophagectomy for carcinoma oesophagus.

Occurrence of nasobronchial hypersensitivity in patients having contact dermatitis to Parthenium hysterophorus.

Comparative study of high resolution CT versus bronchography in the diagnosis of bronchiectasis.

Prediction of pulmonary function for lung resection.

Assessment of radiologically guided fine needle aspiration cytology of mediastinal masses.

Drug interactions between rifampicin and cotrimoxazole/ aspirin in patients on antituberculosis treatment.

Determination of ventilatory minute volumes, required to maintain normocapnia under anaesthesia in adult North Indian subjects.

Pulmonary insufficiency after skeletal trauma.

Role of HRCT in management of pulmonary infections in renal transplant recipients.

HRCT in heavy smokers with normal chest X-ray.

A study of prevalence of hepatopulmonary syndrome in patients with NCPF. ATT induced hepatitis: a study on prevalence and outcome after re-introduction of drugs.

A study of prevalence of hepatopulmonary syndrome in patients with cirrhosis.

Rapid molecular typing and Th1-Th2 cytokine profiling in patients suffering from tubercular lymphadenopathy.

A clinical study to compare the efficacy, safety and plasma levels of two doses of theophylline in patients of bronchial asthma.

Role of epithelium in the airway responses to hyperosmotic solutions in normal and sensitised guinea pigs

To determine the occurrence and effect of nasal polyps in patients with bronchial asthma and / or allergic rhinitis.

Effect of ipratropium and salbutamol on heart rate variability in chronic obstructive pulmonary disease.

Effect of pulmonary rehabilitation on systemic inflammation, muscle mass and functional status in post tuberculosis sequelae.

Study of sinonasal involvement in patients of interstitial lung diseases.

Sensitisation with selected fungi in patients of asthma and chronic obstructive pulmonary disease and its correlation with skin prick testing and clinical presentation.

Role of some inflammatory markers in obstructive sleep apnoea: effects of grape seed extract.

A clinical study to evaluate the safety and efficacy of theophylline and its modulation by ascorbic acid in patients of bronchial asthma.

Phenotypic and molecular characterisation of clinical isolates of Acinetobacter spp.

Adenosine metabolism in bronchial asthma: a study on adenosine deaminase and 5'-nucleotidase activity and adenosine level in serum, lymphocytes and erythrocytes.

Antimicrobial drug prescribing pattern in hospitalised patients of community-acquired pneumonia: a retrospective study.

Phenotypic and molecular characterisation of clinical isolates of Candida species with special reference to Candida dubliniensis.

Role of TLR expression in innate activity during virus infection in acute asthma.

Detection, identification and profiling of mycobacterial isolates from patients of pulmonary and lymph node tuberculosis in Delhi.

A study to correlate the activity of ADAM33 gene protein with oxidative stress in asthma.

Correlation of fractional exhaled nitric oxide, nasal nitric oxide with atopic status in bronchial asthma, allergic rhinitis.

Evaluation of vitamin D in asthma: its effect on inflammatory markers and impact on management.

International guidelines for pneumococcal vaccination and the Indian scenario. Pneumococcal vaccination status of COPD patients presenting to a medical college hospital. Possible strategies to improve the vaccination coverage.

Use of inhaled steroids and Inhaler technique among asthmatics admitted with acute exacerbation.

Role of Omalizumab in the management of asthma. Outcomes in 20 patients who were administered omalizumab

Incidence of TB among rheumatoid arthritis patients on TNF-alpha antagonists

Endobronchial tuberculosis – presentation, diagnosis, management and complications in 30 consecutive patients

Adverse symptoms reported by patients with HIV/TB co-infection and taking both ATT and HAART

Percentage of HIV seropositivity in smear positive tuberculosis patients in a medical college hospital in western india

Factors associated with primary drug resistance in tuberculosis

Lung abscess – presentation, predisposing factors, organisms isolated and management in 50 consecutive patients

Lung volumes in healthy non smoking adults belonging to ethnic Punjabi population by CT volumetry

Empyema thoracis – Outcomes in a medical college hospital

Reversibility of FEV1 and FEV in COPD post bronchodilation and its correlation with COPD stages.

Respiratory complications in 50 HIV seropositive patients followed over a period of one year

Profile of hospital acquired pneumonia over a one year period in a tertiary care hospital. The predisposing factors, organisms isolated, antibiotics used and outcomes.

Role of cardiopulmonary exercise testing (C-PET) in pre op evaluation

Alveolar haemorrhage due to pulmonary renal syndrome. A case series of 30 patients

Foreign bodies in airways – Profile of 30 consecutive patients, interventions and outcomes

Pre-op spirometry and post op pulmonary complications in patients undergoing elective upper abdominal surgeries.

Diaphragmatic palsies – profile of 25 consecutive patients

Mediastinal pathologies – 50 consecutive cases in a tertiary care hospital

Presence of pulsus paradoxus in a population of severe COPD as assessed by pulse oximetry.

Cardiorespiratory responses to exercise in patients with mild to moderate bronchial asthma.

Gender differences in perception of dyspnoea, quality of life and pattern of lung function abnormalities in asthma.

A study of sleep-related breathing disorders in chronoc obstructive pulmonary disease patients with or eithout cor-pulmonale.

A study to monitor adverse drug reactions in patients of chronic obstructive pulmonary disease.

Breath carbon monoxide levels as a marker of clinical severity and control of asthma.

The occurrence of rhinosinusitis in patients with bronchial asthma and/or allergic rhinitis.

Characterisation of lower respiratory tract inflammation and its relationship with changes in pulmonary patho-physiology and thoracic imaging in bronchial asthma.

A Comparative Study Of Inhaled and Intravenous Magnesium Sulphate As An Adjunct To Standard Treatment Protocol For Management Of Severe Exacerbation Of Bronchial Asthma.

Predictors Of Emergency Department Use In Asthmatics.

Diagnostic Yield Of Induced Sputum And Various Bronchoscopic Samples in Sputum Smear Negative Tuberculosis.

A Study to Monitor Adverse Drug Reactions in Patients of Bronchial Asthma.

Drug Resistance Profiling and Molecular Typing of Mycobacterium tuberculosis Isolates from a DOTS center and a Private Hospital in Delhi.

Biochemical Studies on Protein Kinase C In Peripheral Blood Lymphocytes Of COPD Patients.

Evaluation of systemic inflammatory markers, oxidant-antioxidant status and sputum cytology in stages of chronic obstructive pulmonary and diseases.

Obstructive sleep apnoea, oxidative stress and renal function.

Acute effects of tiotropium alone and in combination with formoterol in patients with COPD: comparision of three regimens.

Evaluation of the effect of inhaled ciclesonide on the allergic and inflammatory markers in and bronchial asthma.

Effect of glycemic control on outcome of acute exacerbation of COPD.

Factors affecting attainment of control in asthma.

Occurrence of upper airway symptoms and their impact on quality of life (QoL) in patients with COPD.

Airway obstruction, bronchial hyper-reactivity and sensitivity to commonaeroallergen in allergic rhinitis.

A comparative study of the efficacy and safety of theophylline and doxofylline in patients of obstructive lung disease.

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To compare the inflammatory mediator profiles, pulmonary function tests and skin and reactivity in obese and non-obese bronchial asthma patients.

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Common antibiotic may be helpful in fighting respiratory viral infections.

Transparent human head illustration with nasal cavity highlighted.

(© stock.adobe.com)

A new, Yale-led study suggests that a range of respiratory viral infections — including COVID-19 and influenza — may be preventable or treatable with a generic antibiotic that is delivered to the nasal passageway.

A team led by Yale’s Akiko Iwasaki and former Yale researcher Charles Dela Cruz successfully tested the effectiveness of neomycin, a common antibiotic, to prevent or treat respiratory viral infections in animal models when given to the animals via the nose. The team then found that the same nasal approach — this time applying the over-the-counter ointment Neosporin — also triggers a swift immune response by interferon-stimulated genes (ISGs) in the noses of healthy humans.

The findings were published in the journal Proceedings of the National Academy of Sciences.

“ This is an exciting finding, that a cheap over-the-counter antibiotic ointment can stimulate the human body to activate an antiviral response,” said Iwasaki, the Sterling Professor of Immunobiology and professor of dermatology at Yale School of Medicine and co-senior author of the new study.

“ Our work supports both preventative and therapeutic actions of neomycin against viral diseases in animal models, and shows effective blocking of infection and transmission,” said Iwasaki, who is also professor of molecular, cellular, and developmental biology in Yale’s Faculty of Arts and Sciences, professor of epidemiology at Yale School of Public Health, and an investigator at the Howard Hughes Medical Institute.

Respiratory viruses affect millions of people each year. The global COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has led to 774.5 million cases worldwide as of February 2024, with global mortality of 6.9 million people. Influenza viruses account for up to 5 million cases of severe illness and 500,000 deaths annually worldwide.

Currently, most therapies used to fight respiratory viral infections — including antivirals, monoclonal antibodies, and convalescent plasma therapy — are delivered intravenously or orally. They focus on stopping the progression of existing infections.

A nasal-centered therapy has a much better chance of stopping infections before they can spread to the lower respiratory tract and cause severe diseases, the researchers said.

“ This collaborative multi-disciplinary work combined important insights from animal pulmonary infection modeling experiments with human study evaluation of this intranasal approach to stimulate antiviral immunity,” said Dela Cruz, former associate professor of pulmonary, critical care, and sleep medicine, and of microbial pathogenesis at Yale School of Medicine and former director of the Center for Pulmonary Infection Research and Treatment. Dela Cruz is currently at the University of Pittsburgh.

In their study, the researchers found that mice treated intranasally with neomycin showed a robust ISG line of defense against both SARS-CoV- 2 and a highly virulent strain of influenza A virus. The researchers also found that an intranasal treatment of neomycin strongly mitigated contact transmission of SARS-CoV-2 in hamsters.

In healthy humans, intranasal application of Neosporin (containing neomycin) also initiated a strong expression of ISGs in a subset of volunteers, the researchers said.

“ Our findings suggest that we might be able to optimize this cheap and generic antibiotic to prevent viral diseases and their spread in human populations, especially in global communities with limited resources,” Iwasaki said. “This approach, because it is host-directed, should work no matter what the virus is.”

The co-first authors of the new study, all from Yale, are Tianyang Mao, Jooyoung Kim, and Mario Peña-Hernández.

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Effect of steplike high-temperature treatment on the composition and structure of the primary carbides in R6M5 high-speed steel ingots

  • Published: 25 May 2011
  • Volume 2011 , pages 29–32, ( 2011 )

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  • I. V. Doronin 1 ,
  • Yu. A. Lukina 2 ,
  • I. O. Bannykh 3 &
  • P. L. Alekseev 1  

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The effect of steplike high-temperature treatment (SHTT) on the composition and structure of carbides in the ledeburite eutectic of R6M5 high-speed steel ingots is studied. It is shown that SHTT processes lead to fragmentation and a change in the composition of the primary carbides, which causes their disintegration and a decrease in the carbide size during hot deformation.

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Structural and phase changes in carbides of the high-speed steel upon heat treatment

Optimization of the process of carburizing and heat treatment of low-carbon martensitic steels.

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Effect of Melting Rate of Electroslag Rapid Remelting on the Microstructure and Carbides in a Hot Work Tool Steel

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Original Russian Text © I.V. Doronin, Yu.A. Lukina, I.O. Bannykh, P.L. Alekseev, 2011, published in Metally, 2011, No. 1, pp. 35–38.

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Doronin, I.V., Lukina, Y.A., Bannykh, I.O. et al. Effect of steplike high-temperature treatment on the composition and structure of the primary carbides in R6M5 high-speed steel ingots. Russ. Metall. 2011 , 29–32 (2011). https://doi.org/10.1134/S0036029511010071

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19th Edition of Global Conference on Catalysis, Chemical Engineering & Technology

Victor Mukhin

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Victor Mukhin, Speaker at Chemical Engineering Conferences

Title : Active carbons as nanoporous materials for solving of environmental problems

However, up to now, the main carriers of catalytic additives have been mineral sorbents: silica gels, alumogels. This is obviously due to the fact that they consist of pure homogeneous components SiO2 and Al2O3, respectively. It is generally known that impurities, especially the ash elements, are catalytic poisons that reduce the effectiveness of the catalyst. Therefore, carbon sorbents with 5-15% by weight of ash elements in their composition are not used in the above mentioned technologies. However, in such an important field as a gas-mask technique, carbon sorbents (active carbons) are carriers of catalytic additives, providing effective protection of a person against any types of potent poisonous substances (PPS). In ESPE “JSC "Neorganika" there has been developed the technology of unique ashless spherical carbon carrier-catalysts by the method of liquid forming of furfural copolymers with subsequent gas-vapor activation, brand PAC. Active carbons PAC have 100% qualitative characteristics of the three main properties of carbon sorbents: strength - 100%, the proportion of sorbing pores in the pore space – 100%, purity - 100% (ash content is close to zero). A particularly outstanding feature of active PAC carbons is their uniquely high mechanical compressive strength of 740 ± 40 MPa, which is 3-7 times larger than that of  such materials as granite, quartzite, electric coal, and is comparable to the value for cast iron - 400-1000 MPa. This allows the PAC to operate under severe conditions in moving and fluidized beds.  Obviously, it is time to actively develop catalysts based on PAC sorbents for oil refining, petrochemicals, gas processing and various technologies of organic synthesis.

Victor M. Mukhin was born in 1946 in the town of Orsk, Russia. In 1970 he graduated the Technological Institute in Leningrad. Victor M. Mukhin was directed to work to the scientific-industrial organization "Neorganika" (Elektrostal, Moscow region) where he is working during 47 years, at present as the head of the laboratory of carbon sorbents.     Victor M. Mukhin defended a Ph. D. thesis and a doctoral thesis at the Mendeleev University of Chemical Technology of Russia (in 1979 and 1997 accordingly). Professor of Mendeleev University of Chemical Technology of Russia. Scientific interests: production, investigation and application of active carbons, technological and ecological carbon-adsorptive processes, environmental protection, production of ecologically clean food.   

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