bipolar disorder research studies

"This is an important step towards the kind of research into disease mechanisms that, across the history of medicine, has underwritten successful therapeutics." Big study, big effect. Bipolar disorder is a severe, heritable mood disorder that affects approximately 1 percent of people and often begins in early adulthood.

The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression. Rochester, MN. The purpose of this research study is to find out if the medication known as ketamine can help the symptoms of depression. This drug is approved by the Food and ...

September 29, 2021 • Research Highlight. In the largest genome-wide association study of bipolar disorder to date, researchers found about twice as many genetic locations associated with bipolar disorder as reported in previous studies.

Bipolar disorder is a complex and heritable psychiatric condition that affects millions of people worldwide. This article reviews the current knowledge on the genetic factors that contribute to bipolar disorder, and discusses the challenges and opportunities for future research. The article also explores the implications of genetic findings for the diagnosis, treatment and prevention of ...

Bipolar disorder is a recurrent illness, but its longitudinal course is heterogeneous and difficult to predict.46 66 The few available long term studies of BD-I and BD-II have found a consistent average rate of recurrence of 0.40 mood episodes per year in historical studies67 and 0.44 mood episodes per year in more recent studies.68 The median ...

Results: We synthesized evidence from 157 unique studies, 108 studies for 28 drugs, 49 studies for nondrug interventions. All drug study findings with at least low-strength evidence were based almost exclusively on adults with bipolar I disorder (BD-I).Asenapine, cariprazine, quetiapine, and olanzapine improved acute mania symptoms compared to placebo (low-strength evidence).

Human and animal studies reveal a neurobiological pathway that connects polygenic risks and behavioural changes that are shared between schizophrenia and bipolar mood disorder. Jake Rogers ...

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which ...

A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research. Am J Psychiatry. 2014;8:829 ...

Longitudinal studies of bipolar patients and their families: translating findings to advance individualized risk prediction, treatment and research. Bipolar disorder is a broad diagnostic construct associated with significant phenotypic and genetic heterogeneity challenging progress in clinical practice and discovery research.

ment) Strategic Research Centre, School of Medicine, Barwon Health, Deakin Uni - ... risk factors for bipolar disorder in observational studies, although few of these findings are sup-

Call or text (650) 600-1609 or email [email protected]. Having Sleep Problems? Insomnia Related to Bipolar Disorder Study at VA Palo Alto Healthcare System. People with bipolar disorder (manic depression) often have trouble sleeping. This can lead to worsening problems with mood and functioning.

The use of cognitive-behavioral therapy (CBT) in four areas makes a significant contribution to the treatment process: 1. Easing the symptoms of the disease (intervention in depressive, dysphoric (irritable) and elevated mood episodes) 2. Enhancing adherence to drug treatment 3. Learning early signs and preventing episodes 4.

The Bipolar and Depression Research Program is a clinical research program focused on treatment of individuals with bipolar and major depressive disorders directed by Drs. Trisha Suppes and ... All studies are open to the general public as well as veterans and active duty military personnel. Our research focuses on Bipolar Disorder, including ...

To bridge the gap between research and clinical practice, patients' perspectives should be used in health care and research. This study aimed to understand the challenges people with bipolar disorder (BD) experience and examine what these challenges imply for health care and research needs. Two qualitative studies were used, one to formulate ...

Bipolar disorder (formerly called manic-depressive illness or manic depression) is a mental illness that causes unusual shifts in a person's mood, energy, activity levels, and concentration. These shifts can make it difficult to carry out day-to-day tasks. There are three types of bipolar disorder. All three types involve clear changes in ...

Bipolar disorder is a broad diagnostic construct associated with significant phenotypic and genetic heterogeneity challenging progress in clinical practice and discovery research. Prospective studies of well-characterized patients and their family members have identified lithium responsive (LiR) and lithium non-responsive (LiNR) subtypes that hold promise for advancement.

Scientific Reports (2024) Bipolar disorders are chronic and recurrent disorders that affect >1% of the global population. Bipolar disorders are leading causes of disability in young people as they ...

This research study is to evaluate if educational and motivational text messages might help patients take their medication for high blood pressure and bipolar disorder more regularly. Participants must have bipolar disorder and high blood pressure, be between the ages of 21 and 80, have a cell phone, take medication for high blood pressure, and ...

Learn about participating in the Mayo Clinic Bipolar Disorder Biobank and how the biobank has been advancing bipolar disorder research since 2009. ... The Bipolar Disorder Biobank makes it much easier to study bipolar disorder. This is because researchers can find blood samples and data from thousands of people all in one place.

Enrolling nationally from around the country. National Institute of Mental Health (NIMH) researchers seek adults 18 to 70, who have a history of attempted suicide but are not currently suicidal, for a study of suicide and brain function. Participation includes up to seven days as an inpatient at the NIH Clinical Center in Bethesda, Maryland.

Abstract. Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the disease process and as a drug target.

Background. Bipolar Disorder (BD) is a mental disorder marked by alternating episodes of mania or hypomania and depression. It affects approximately 1%-4% of the population ().The correlation between diet and various physical diseases is well-established and documented, and in recent years, this has extended to the exploration within psychiatric disciplines (2, 3).

Here, we critically review recent neuroimaging research on bipolar disorder using a network‐based approach. Methods A systematic search was conducted on studies published from 2009 through 2019 ...

Clinical Trials. A listing of 57 Bipolar Disorder clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas. There are currently 57 active clinical trials seeking participants for Bipolar Disorder research studies. The states with the highest number of trials for Bipolar Disorder ...

The aetiology of bipolar is not well understood and research into the disorder lags behind disorders such as psychosis. ... Epidemiology of bipolar disorder. Epidemiological studies have suggested a lifetime prevalence of around 1% for bipolar type I in the general population. 54,55 A large cross-sectional survey of 11 countries found the ...

In a new study, researchers looked at whether lonely people are more prone to problems such as depression and psychosis. Based on medication use, the correlation is clear.

Psychiatric Research and Clinical Practice; Psychiatric Services; The American Journal of Psychotherapy; All Journals; ... Bipolar Disorder; Depression (MDD) Gun Violence; Schizophrenia; International; My POL; More. Sign In. ... Conditions for Further Study.

Research in psychology and medicine has linked mental health disorders, and particularly bipolar disorder (BD), to employment in creative professions. Little is known, however, about the ...

In addition, HCMV has been associated with depressive disorder, bipolar disorder, anxiety, and autism-spectrum disorder, although the available findings are likewise inconsistent. Given associations between HCMV and a variety of neurocognitive and neuropsychiatric disorders, additional research investigating reasons for the considerable ...