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- 11 March 2020
How artificial kidneys and miniaturized dialysis could save millions of lives
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Kidney dialysis is inefficient and exhausting for patients such as this person in Yemen. Credit: Mohammed Huwais/AFP/Getty
From the start, Mat Risher swore that dialysis wouldn’t upend his life. He had been working at a software company, conducting research on a car-racing simulator, when kidney damage from lupus forced him to start the blood-filtering treatments three times a week.
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Artificial Kidney
- First Online: 20 July 2016
Cite this chapter
- Maria Cristina Annesini 5 ,
- Luigi Marrelli 6 ,
- Vincenzo Piemonte 6 &
- Luca Turchetti 7
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This chapter is mainly focused on the engineering aspects of the design of the dialysis systems. After a short overview of the functions and pathologies of the renal system, aimed at defining the medical requirements of the artificial devices, a summary of the historical development of the artificial kidney is reported. Subsequently, the different implementations of membrane separation operations in renal replacement therapies, as well as the characteristics of the membrane modules used, are reported. On the basis of this information, mathematical models are then developed to describe the behaviour of these systems and optimize their design. Patient-device models are also considered to predict the evolution in time of toxin levels in patient blood and optimize the dialysis protocol. The chapter ends with a survey on the latest technological developments in terms of portable or wearable devices as well as on bio-artificial devices aimed at best replacing the functions of natural kidneys.
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This and the following section were authored by Sergio Morini—Center for Integrated Biomedical Research (CIR), University “Campus Bio-Medico” of Rome, Italy.
A small secretion of creatinine in proximal tubule occurs, and this affects the evaluation of the GFR.
In medical literature, the sieving coefficient \(\mathscr {S}=1-\sigma \) is also used. Therefore, for an unhindered solute \(\mathscr {S}=1\) , while for a component completely rejected \(\mathscr {S}=0\) .
It is worth noting that \(\mathrm {CL}_{0}\) and \(\mathrm {DL}_{0}\) are different from the clearance and dialysance obtained with the same device in the absence of ultrafiltration.
The term “sorbent dialysis” is widely used in the literature; as it is reported below, it must be pointed out that regeneration is not exclusively carried out by sorption processes.
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Department of Chemical Engineering Materials and Environment, University “La Sapienza” of Rome, Rome, Italy
Maria Cristina Annesini
Faculty of Engineering, University “Campus Bio-medico” of Rome, Rome, Italy
Luigi Marrelli & Vincenzo Piemonte
ENEA- Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Rome, Italy
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Annesini, M.C., Marrelli, L., Piemonte, V., Turchetti, L. (2017). Artificial Kidney. In: Artificial Organ Engineering. Springer, London. https://doi.org/10.1007/978-1-4471-6443-2_7
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DOI : https://doi.org/10.1007/978-1-4471-6443-2_7
Published : 20 July 2016
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IMAGES
VIDEO
COMMENTS
But there's hope of a new option in the not-too-distant future: an artificial kidney implant. Scientists have developed a bioreactor device that uses human kidney cells cultured in the lab and mimics some of the key functions of a kidney. It's been successfully tested in pigs for a week with no obvious side effects or issues.
This review aims to outline the developments, the current status of the artificial kidney and explore its future potential. Go to: Chronic kidney disease (CKD) affects about 10% of the world population, including about 1 in 4 men and 1 in 5 women aged 65-74. [ 1] End-stage renal disease (ESRD) is increasing worldwide, and its incidence and ...
By Levi Gadye Photo of Shuvo Roy holding early prototype of an artificial kidney by Steve Babuljak. Scientists at UC San Francisco are working on a new approach to treating kidney failure that could one day free people from needing dialysis or having to take harsh drugs to suppress their immune system after a transplant.
Need for an Artificial Kidney. From 1990 onwards, the prevalence of patients needing renal replacement therapy (RRT) has doubled and is expected to rise even further.[1,2] With an increase in lifestyle diseases such as diabetes, hypertension, and metabolic syndrome and a growing proportion of the elderly in the general population, the shortage of donor kidneys for transplantation is only going ...
INTRODUCTION. Chronic kidney disease (CKD) affects about 10% of the world population, including about 1 in 4 men and 1 in 5 women aged 65-74.[] End-stage renal disease (ESRD) is increasing worldwide, and its incidence and prevalence differ in various parts of the world.[] In the USA, the age-gender-race adjusted incidence of ESRD is 384.6 per million/year in 2018.[]
A wearable artificial kidney is a wearable dialysis machine that a person with end-stage kidney disease could use daily or even continuously. A wearable artificial kidney (WAK) is not available, but research teams are in the process of developing such a device. The goal is to develop a portable device that will be able to imitate the functions ...
In contrast to artificial kidney devices that use synthetic membranes and components to filter blood, bioartificial kidneys incorporate living cells to enhance the performance of the device and ...
The method can remove 15 grams of urea in 24 hours, sufficient for most people with kidney failure, and requires only 750 millilitres of solution, Himmelfarb says. The team's standalone ...
Abstract. The artificial kidney, one of the greatest medical inventions in the 20th century, has saved innumerable lives with end stage renal disease. Designs of artificial kidney evolved dramatically in decades of development. A hollow-fibered membrane with well controlled blood and dialysate flow became the major design of the modern ...
The developments, the current status of the artificial kidney and its future potential are outlined and the future potential is explored. End-stage renal disease (ESRD) is increasing worldwide. In India, diabetes mellitus and hypertension are the leading causes of chronic kidney disease and ESRD. Hemodialysis is the most prevalent renal replacement therapy (RRT) in India. The ideal RRT must ...
1 INTRODUCTION. When kidney function decreases below a glomerular filtration rate (GFR) of 10 ml/1.73 m 2 a consideration has to be taken on how to compensate for the lost kidney function to avoid death by uremia. 1 Such a decrease in kidney failure can either appear acute within a few hours 2 or slowly over many years of suffering from progressively worsening CKD. 1
Despite limited organ availability and post-transplant complications, kidney transplantation remains the optimal treatment for End-Stage Kidney Disease (ESKD). However, innovative dialysis technologies such as portable, wearable, and implantable bioartificial kidney systems are being developed with the aim of addressing these issues and improving patient care. An ideal implantable device could ...
3.2 The Kidney. The known functions of the kidney can be separated into four main categories: excretory, regulatory, endocrine, and metabolic (Table 3-1 ). The principle role is the elimination of waste material and the regulation of the volume and composition of body fluid. Table 3-1 The Functions of the Kidney.
Artificial kidney: a chemical engineering challenge. Luisa Di Paola. Unit of Chemical physics Fundamentals in Chemical Engineering, Department of Engineering, Università Campus. Bio -Medico di ...
Abstract. This chapter is mainly focused on the engineering aspects of the design of the dialysis systems. After a short overview of the functions and pathologies of the renal system, aimed at defining the medical requirements of the artificial devices, a summary of the historical development of the artificial kidney is reported.
Bioartificial kidneys provide an extension to conventional artificial kidneys and dialysis systems, by incorporating aspects of living cellular and tissue function, in an attempt to better mimic normal kidneys. Recent advancements in genomic, cellular, and tissue engineering technologies are facilitating the improved design of these systems.
The artificial kidney, one of the greatest medical inventions in the 20th century, has saved innumerable lives with end stage renal disease. Designs of artificial kidney evolved dramatically in decades of development. A hollow-fibered membrane with well controlled blood and dialysate flow became the major design of the modern artificial kidney. Although they have been well established to ...
Summary. Chronic kidney disease (CKD) is associated with an increased risk of kidney failure, cardiovascular events and all-cause mortality. A treatment option for CKD is dialysis, both haemodialysis and peritoneal, that obliges the patient to undergo a 4-hour treatment three or four days a week. This affects their social life, their work and ...
Essay on the Artificial Kidney Essay on the Hormones of the Kidney; Essay # 1. Introduction to Kidney: ADVERTISEMENTS: A large number of waste products are produced in the body as a result of metabolic activities. The main waste products are carbon dioxide, water, and nitrogenous compounds. ... The short renal artery arising from the abdominal ...
Artificial intelligence (AI) has emerged as a promising tool in the field of healthcare, with an increasing number of research articles evaluating its applications in the domain of kidney disease. To comprehend the evolving landscape of AI research in kidney disease, a bibliometric analysis is essential. The purposes of this study are to systematically analyze and quantify the scientific ...
Abstract. Artificial intelligence (AI), as an advanced science technology, has been widely used in medical fields to promote medical development, mainly applied to early detections, disease diagnoses, and management. Owing to the huge number of patients, kidney disease remains a global health problem. Challenges remain in its diagnosis and ...
Conclusion. An artificial kidney is a man-made kidney. When a kidney fails or stops working an artificial kidney is physically incorporated into the host. It is also called haemodialysis, a procedure performed to filter out waste products and water from the body. A haemodialyser apparatus or an artificial kidney has a reusable dialyzer membrane.
The applications of AI kidney disease can be broadly subdivided into three main topics: (a) predicting events in the future; (b) treatment and decision aids; and (c) identification of existing, but unrecognized, patterns. Table 2 shows a summary of key AI‐related studies that have been published in the field of kidney disease. Currently, only ...
Feature papers represent the most advanced research with significant potential for high impact in the field. A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. ... Artificial Intelligence in ...