mark burton phd

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Meet the team.

Mark S. Burton, PhD

PE Consultant Trainer

Dr. Burton is a postdoctoral fellow at Emory University School of Medicine, where he receives mentorship from Dr. Rauch and Dr. Rothbaum within the Emory Healthcare Veterans Program.   He earned his PhD from Case Western Reserve University and completed his predoctoral internship at the Charleston Consortium.

Sheila A. M. Rauch, PhD, ABPP

PE Consultant Trainer, VA PE Roll-Out Trainer, and Co-author of PE Manual and Workbook

Dr. Rauch has provided PTSD and anxiety disorders treatment for over 20 years. She is currently Principal Investigator of two PTSD treatment outcomes and mechanisms trials including a DOD funded, multi-site PTSD treatment trial comparing prolonged exposure and sertraline and a VA/DOD collaboratively-funded trial examining biomarkers in active duty military service members completing psychotherapy.  Her research focuses on translational treatment outcomes and modifications of proven treatments for use in alternate settings, such as primary care.  She has published scholarly articles and book chapters in the areas of anxiety disorders and PTSD focusing on neurobiology and factors involved in the development, maintenance and treatment of anxiety disorders, psychosocial factors in medical settings and the relation between physical health and anxiety.

Barbara O. Rothbaum, PhD, ABPP

PE Consultant Trainer, PE Trainer, and Co-author of PE Manual and Workbook

Dr. Rothbaum has devoted her career to developing and testing new treatments for PTSD. Dr. Rothbaum is an inventor of virtual reality exposure therapy and pioneered applying the treatment for PTSD in combat veterans. She has authored over 300 scientific papers and chapters and co-authored the manuals for prolonged exposure therapy that are disseminated throughout the VA hospital system. She has published five books on the treatment of PTSD and edited three others on anxiety, as well as received the Diplomate in Behavioral Psychology from the American Board of Professional Psychology.

Andrew M. Sherrill, PhD

Program Manager and PE Consultant Trainer (Conference Call Leader)

Dr. Sherrill is an assistant professor of psychiatry and behavioral sciences at Emory University School of Medicine, where he previously completed his postdoctoral fellowship under the mentorship of Drs. Rauch and Rothbaum.  He earned his PhD from Northern Illinois University and completed his predoctoral internship at the VA Puget Sound Health Care System, American Lake Division.  Dr. Sherrill has authored papers in the areas of mindfulness, aggression and PTSD.  His current research aims to understand effective implementation of evidence-based interventions for trauma-exposed populations (e.g., prolonged exposure and virtual reality exposure therapy).

Liza C. Zwiebach, PhD

Dr. Zwiebach is Associate Clinical Director of the Emory Healthcare Veterans Program and a faculty member in the Department of Psychiatry and Behavioral Sciences at Emory University School of Medicine. She received her PhD from the University of Massachusetts. Dr. Zwiebach completed clinical training at the Edith Nourse Rogers Memorial VA Medical Center and Bellevue Hospital Center.  In her career she has provided evidence-based treatment for PTSD to active military and veteran personnel, as well as to law-enforcement personnel.

Advisory Board of Training Program

Afsoon Eftekhari, PhD Veterans Affairs National Center for PTSD  

Elizabeth Hembree, PhD University of Pennsylvania  

David Riggs, PhD Uniformed Services University of the Health Sciences  

Edward Shafranske, PhD Pepperdine University  

Peter Tuerk, PhD University of Virginia  

Lindsey Zimmerman, PhD Veterans Affairs National Center for PTSD

Mark Burton, PhD

I have been adjunct faculty at the University of Utah where I taught graduate students in counseling psychology about family and relationship counseling, and have appeared on television and radio as a relationship expert. I am a member of the Utah Psychological Association and the American Psychological Association.

If you have questions, please feel free to call me at 801-581-0422 Ext. 1, or email me at [email protected]

Lindy Burton, LCSW

What happens in our childhood has a tremendous impact on how we form our coping patterns. We can change our lives when we are able to understand the reasons for our behaviors, and so I specialize in helping you heal from childhood wounds.

I work with clients across a large range of issues including depression, anxiety, trauma recovery, eating disorders, and relationship issues. I also work with parents to increase their parenting skills.

If you have questions, feel free to call me at 801-581-0422 Ext. 2, or email me at [email protected] .

Our Colleagues

*all are independent practitioners

Angela Jette Swanson, PhD

Lee Beckstead, PhD

Adryon Burton Denmark, PhD

Ejay Jack, LCSW

Location and directions.

1433 South 1100 East Salt Lake City Utah, 84105.

Aspen Grove Counseling

• Email info@aspengrovecounseling.com
• Phone 801-581-0422
• Address 1433 South 1100 East Salt Lake City Utah, 84105

Liberation psychology: An interview with Mark Burton

2016, OPen Learn: Free Learning from the Open University

Related Papers

PSYCHOLOGIST-LEICESTER-

Mark Burton

in press in Parker, I. (ed) Handbook of Critical Psychology

Psychology of Liberation

Carolyn Kagan , Mark Burton

Carolyn Kagan

Journal of community & applied social …

Mark Burton , Carolyn Kagan

Liberation Practices

Herbert Giron

Maria Castro Romero

We have known each other personally for over a decade and although we were developing our praxis in similar directions, we connected professionally at the Eighth European Congress of Community Psychology. Maria was leading a roundtable discussion with Mark Burton, Raquel Guzzo, Steve Melluish and clinical psychology trainees, on what European community psychology can learn from Latin America, where Taiwo was participating. This was the starting point of conversations and Maria inviting Taiwo to teach liberation psychology together. This chapter is based on our experience of joint teaching on a London-based Professional Doctorate in Clinical Psychology course since 2011 (brief excerpts from the tapes of our teaching session in October 2013 appear in quotation marks and italics), and recorded dialogues between us taking place over meetings between November 2013 and February 2014. This chapter has offered us the opportunity to reflect and build on this shared teaching journey and to sh...

Wayne Dykstra, PhD

Analysis of the historical conditions in El Salvador and Latin America that contributed to the emergence of Latin American Liberation Psychology, most notably the work of Ignacio Martin-Baro. A broad survey of the sociopolitical trends during that time helps locate Liberation Psychology alongside a variety of critical responses in Psychology and other academic disciplines.

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Mark Barton, Ph.D.

Dr. Mark Barton is Professor of Geology and Geochemistry at the University of Arizona and Co-Director of the Lowell Institute for Mineral Resources.  Mark earned BS and MS degrees from Virginia Tech (1977, 1978) and a PhD from the University of Chicago (1981). Following a post-doctoral fellowship at the Geophysical Laboratory (Carnegie Institution of Washington), he taught at the University of California, Los Angeles (UCLA) before joining the faculty at the University of Arizona. His research interests and span many aspects of energy and mass transfer in the Earth's lithosphere and their applications to mineral deposits. Mark has published over 90 papers and advised over 70 MS, PSM, and PhD students. His research is on wide-ranging topics from mineralogy to physical modeling has emphasized ore deposit studies with a focus on porphyry, IOCG, sediment-hosted Cu, and various precious metal systems, and their broader geologic and environmental context. Ongoing collaborative studies involve many mining companies and the USGS and were supported by these groups, the US National Science Foundation, Keck Foundation, National Institutes of Health, and Science Foundation Arizona.

Mark is a fellow of and has been active in several professional societies including SGA, the Society of Economic Geologists, the Geological Society of America, and the Mineralogical Society of America; he has received awards from several of these including the Lindgren (SEG) and MSA (MSA). He has served in various capacities including on editorial boards, on U.S. National Research Council Committees, and in other roles for professional societies and government panels. Since joining the UA faculty he has worked actively at the local and national levels to help secure the long term vitality of minerals-related research and education in the United States. After 15 years directing the geology-focused, research-oriented "Center for Mineral Resources," he co-founded the Lowell Institute for Mineral Resources which is a state-, industry-, and privately-funded interdisciplinary organization that catalyzes and facilitates research and education related to mineral resources spanning science and engineering to public health and policy. In the early 2000s, he collaborated with his former PhD students David Johnson and Eric Jensen in developing Bronco Creek Exploration, a successful minerals exploration company which is now part of EMX Royalty.

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College of Arts and Sciences

Ptsd research and treatment program, research team members.

We hope that this page gives you a sense of the kind of work that we are doing in our lab here, the PTSD Treatment and Research Program – and the opportunities for students that are available. Our work is focused on intervention studies, primarily in the area of PTSD, but also in mood disorders. We are a busy, productive group. Below are the names of everyone currently working in the lab, with introductions from some of the lab members.

Our Current Team

Current Undergraduate Research Assistants:

Hana Thamer Halle Deericks Talya Waxenberg Anna Isberg Carsten Torgeson Ashleigh Bahadur

Previous case graduate students and postdoctoral fellows that we have worked/published with:

Allison Baier, PhD Alexandra Klein, PhD Alice Coyne, PhD Alex Rothbaum, PhD, MPH Alexander Kline, PhD Mark Burton, PhD Hannah Bergman, PhD Andrew Cooper, PhD Erin Clifton, PhD Stephanie Keller, PhD Loren Post, PhD Shoshana Kahana, PhD Carla Kmett Danielson, PhD Teresa Linares, PhD Victoria Miller, PhD Lisa Schwartz, PhD AnnaMaria Aguirre, PhD Jeannie Duax, PhD

Are you interested in working with our group? We have positions available for interested, enthusiastic students who would like to work as research assistants in our lab for credit or as volunteers. Research assistants in the PTSD Treatment & Research Program are involved in many aspects of the day-to-day functioning of the ongoing treatment studies, assist with writing and editing manuscripts, conduct literature reviews, and participate in our bi-weekly PTSD Journal Club meetings during the academic year.

If you are interested, please contact Dr. Norah Feeny or Sinan Payat .

2018-2019 Research Team L-R: Kathy Benhamou, Allison Baier, Norah Feeny, Alex Rothbaum, Alexandra Klein, Alexandra Bowling

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Dr Mark Burton

Connect with mark.

Email: [email protected]

Tel: +44 23 8120 8664

Dr Burton completed an Undergraduate degree in Biomedical Sciences at the University of Southampton, followed by an MSc in Molecular Neurosciences at the University of Bristol. He returned to Southampton to study for his PhD investigating the effect of folic acid intake on the regulation of genes that modulate breast cancer development and how epigenetic regulation plays a role. This established an interest in the epigenetics of disease and how intervention at different periods of the life-course can modulate disease trajectories. Dr Burton has worked on a number of research projects within the EpiGen Research Group including investigating the links between methylation adiposity and non-alcoholic fatty liver disease in adolescence, in collaboration with the University of Western Australia. He has also participated in a number of large cohort studies investigating the cellular and molecular regulation of sarcopenia, testing novel pharmacological compounds in collaboration with a UK-based artificial intelligence industry partner (BenevolentAI). Furthermore, he has worked on three pioneering projects investigating the regulation of non-coding RNA’s in serum from the Hertfordshire sarcopenia cohort, and in sperm from the PREPARE cohort, characterising for the first time the small ncRNA populations. He recently ran a project investigating the single cell transcriptomes of nuclei from cultured primary myoblasts from older people with sarcopenia. Dr Burton hopes to continue with research which will enable the discovery of biomarkers that are predictive of disease risk, to enable molecular targeting through nutritional or pharmacological intervention in order to improve health trajectories.

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• Centre for Developmental Origins of Health and Disease
• Interdisciplinary Musculoskeletal Health

Current research

Understanding the molecular mechanisms assoicated with Sarcopenia and muscle dysregulation in older adults.

Publications

Lecturer BIOL 3015, Regulation of Gene Expression–Long non-coding RNAs. 

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Apixaban to Prevent Recurrence After Cryptogenic Stroke

• 1 Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, New York
• 2 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York
• 3 Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut
• Original Investigation Apixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy Hooman Kamel, MD; W. T. Longstreth Jr, MD; David L. Tirschwell, MD; Richard A. Kronmal, PhD; Randolph S. Marshall, MD; Joseph P. Broderick, MD; Rebeca Aragón García, BS; Pamela Plummer, MSN; Noor Sabagha, RPH; Qi Pauls, MS; Christy Cassarly, PhD; Catherine R. Dillon, MS; Marco R. Di Tullio, MD; Eldad A. Hod, MD; Elsayed Z. Soliman, MD; David J. Gladstone, MD; Jeff S. Healey, MD; Mukul Sharma, MD; Seemant Chaturvedi, MD; L. Scott Janis, PhD; Balaji Krishnaiah, MD; Fadi Nahab, MD; Scott E. Kasner, MD; Robert J. Stanton, MD; Dawn O. Kleindorfer, MD; Matthew Starr, MD; Toni R. Winder, MD; Wayne M. Clark, MD; Benjamin R. Miller, MD; Mitchell S. V. Elkind, MD; ARCADIA Investigators; Ganesh Asaithambi; Maxwell  Klaiman; Konark Malhotra; Mary Fetter; Anna Wanahita; Stacie Merritt; Rehan Sajjad; Kate McPolin; Bruce Coull; Shriya Kavathia; Murali Kolikonda; Sara Calhoun; Felipe de los Rios la Rosa; Ian Del Conde; Josette Elysée; Amin Aghaebrahim; Melissa Stratoberdha; Andria Ford; James Giles; Yan Wang; Jennifer Babka; Rahul Damani; Barbara Gutierrez-Flores; Sandeep Kumar; Sarah Marchina; Marc Swerdloff; Margaret Scott; Amandeep Sangha; Kelly Patterson; Julie Shulman; Steven Feske; Jose Rafael Romero; Hugo Aparicio; David Greer; Rebecca Stafford; Arturo Tamayo; Leanne Anderson; Stelios Smirnakis; Quinn Rademaker; Maurice Hourihane; Robert Sawyer; Marilou Ching; Amit Kandel; Rakesh Magun; Annemarie Crumlish; Annaliese Bosco; Sanjay Singh; Abhishek Singh; Elizabeth Traynor; Ram Sankaraneni; Toufik Haddad.; Carly Isder; Lois Rasmussen; Dustin Rochestie; Nancy Brunetti; Dhruvil Pandya; Rosemarie Baligod; Dan Capampangan; Allegra Sahelian; Jason Nomura; Kimberly Gannon; Jonathan Raser-Schramm; Kathleen Murphy; Ahmed Itrat; Debra Hudock; Dolora Wisco; Laura Sweeney; William Likosky; Rebekah Garcia; Hermann Schumacher; Lindsey Colman; Benjamin Lisle; Uriah Atkinson; Wady Aude; Cassandra Trevino; Kevin Attenhoffer; Claudia Fortiche; Kumar Rajamani; Amanda Reyes; Hasnain Arshad; Julie Weidman; Peter Adamczyk; Leah Galvez; Fadi Nahab; Michael Frankel; Alicia Escobar; Kiva Schindler; Megan Schultz; Lori Bhadsavle; Leah Craft; Ariane Mackey; Steve Verreault; Marie-Christine Camden; Stéphanie Gosselin-Lefebvre; Suzy Lavoie; Nirav Patel; Richard Bailey; Marc Lazzaro; Marek Cierny; Ann Helms; Caitlin Moore; Diane Book; Hatim Attar; Tiffany Morse; Sophia Aboagye; Lakiesha Coleman; Katie Alter-Troilo; Rodney Short; Desyree Weakley; Jana Wold; Kinga Aitken; Harmeet Sachdev; Audrey Paulson; Nicolas Bianchi; Kelvin Ng; Kanchana Ratnayake; David Tirschwell; Mary Asirot; Allison Kunze; Yan Hou; Reena Patel; Laura Greiner; Benjamin Miller; Julie Scherber; Angelos Katramados; Teresa Wiegand; Scott Kasner; Rebecca Burdett; Brett Cucchiara; Steven Messe; Qingyang Yuan; Donna Kurowski George; Jens Witsch; Laura Stein; Christopher Favilla; James Siegler; Jesse Thon; Michael Mullen; Aaron Rothstein; Ossama Khaazal; Daniel Cristancho; Emily Grodinsky; Farhan Khan; Christopher Renner; Jonah Zuflacht; Kelley Humbert; Arooshi Kumar; Judy Dawod; Gbambele Kone; Sahily Reyes-Esteves; Nino Kvantaliani; Mary Liz De Santo; Nichole Gallatti; Devin Keating; Mauricio Concha; Robynn Pannell; Nick Murray; Jacki Anderson; Lindsay Bosh; Erika Marulanda-Londono; Andrea Escobar; Zahra Ajani; Nathalie Gonzalez; William Neil; Michael Fechter; Nerses Sanossian; Jesus Pena; Clare Binley; Elsadig Elamin; Meghan GEREIN; Susan Law; Monique Tita; Shirin Jalini; Andrew Nguyen; Siddharth Sehgal; Collin Culbertson; Penhleakhena Ou; Kaitlyn Kirchhoffer; Danielle Cross; Louise Kruse; Martin Gizzi; Karla Kummer; Hussam Yacoub; Andrew Orzel; Salman Azhar; Ronnie Elsaadany; Luciano Sposato; Jennifer Mandzia; Lauren Mai; Alexander Khaw; Sebastian Fridman; Beth Beauchamp; Lindsay Lambourn; Nima Ramezan-Arab; Deysi Caballero; Omid Omidvar; Michael Thompson; Melanie Altamirano; Svetlana Pundik; Manda Double; Oladi Bentho; Christopher Streib; Muhammad Affan; Haitham Hussein; Margy McCullough-Hicks; Praveen Hariharan; Amelia Solei; Kate Bard; Amanda Weller; Kathleen Miller; Anna Brauch; Chloe Lawyer; Deb Quigley; Abbey Staugaitis; Qingliang Wang; Maryna Mootoo; Aneesh Singhal; Rhianna Carr; Alejandro Rabinstein; Eugene Scharf; Amy Headlee; Michelle Lin; Meredith McDonald; Taylor Reid; Aniel Majjhoo; Roberts Marci; Mahmoud Rayes; Emily Paschall; Karl Meisel; Colleen Shaw; Andrew Stemer; Emma Waldon; Amie Hsia; Chandni Kalaria; Shannon Burton; Yongwoo Kim; Sana Somani; Veronica Craft; Jamal Smith; Juby Matthews; Megan Grainger; Cassidy Anderson; Christine Holmstedt; Caitlan Lematty; Anjail Sharrief; Gabretta Cooksey; Yazan Alderazi; Chad Tremont; Lucian Maidan; Danielle Hornbuckle; Osama Zaidat; Cynthia Upham; Balaji Krishnaiah; Andrei Alexandrov; Cheran Elangovan; Mark Rubin; Quentin Thacker; Joseph Hanna; Dana Cook; Bradley Jacobs; Christina Weller; Kathryn Kirchoff-Torres; Mellanie Springer; Khadean Moncrieffe; Tanzina Islam; Pramod Sethi; Jamil Ahmed; Steven Rudolph; Holly Morhaim; Carolyn Brockington; Naresh Poondla; Calvin Hansen; Heather Banker; Imama Naqvi; Eliza Miller; Carmen Castillo; Rebeca Aragon Garcia; Kevin Slane; Neal Parikh; Babak Navi; Saad Mir; Alan Segal; Halina White; Ava Liberman; Dana Leifer; Hooman Kamel; Carla Sherman; Jed Kaiser; Vanessa Liao; Natalie LeMoss; Kelsey Lansdale; Aaron Lord; Maria Cotrina; Jose Torres; Danika Anganoo-Khan; Toni Winder; Jill Elliot; Yahya Atalay; Courtney Stathis; Jeffrey Katz; Erin Schwartz; Kayla Stanton; Sandra Anghel; Ahmad Ballout; Alicia Dee; Morteza Modaber; Neisha Patel; Rohan Arora; Ina Teron; Richard Libman; Kirendra Pasram; Fan Caprio; Rachel Vincent; Arun Talkad; Ashwath Ravisankar; Alicia Zha; Mohammad Hamed; Evgeny SIdorov; Danny Samkutty; David Gordon; Robert Hamilton; Faddi Velez; Jason King; Bappaditya Ray; April Vaughn; Blair Hill; Jason Sharps; Richard Zweifler; Jessica Henry; Wayne Clark; Hormozd Bozorgchami; Parker Miller; Rachel Laursen; Sonesh Amin; Megan Pattle; Jon Foley; Monica Dolan; Emilie Nagle; Paulo Zortea; Reilly Leonard; Souvik Sen; Nishanth Kodumuri; Justin Lowe; Makenzie Logue; Amanda Kabetso; Phil Fleming; Corey White; Damon Gates; Amytis Towfighi; Monica Ayala-Rivera; Raul Guisado; Karen De La Cuest; Maria Pyle; Tina Burton; Karen Furie; Shadi Yaghi; Narendra Kala; Ashley Schomer; Scott Moody; Deepica Chaudhry; Catrina Elizardo; Nirav Vora; Katy Groezinger; Deviyani Mehta; Michelle Moccio; Edward Stenroos; Jeffrey Saver; Daisy Mercado; Brett Graham; Gary Hunter; Lissa Peeling; Michael Kelly; Regan Cooley; Sanchea Wasyliw; Cassandra Tyson; Emily Junk; Kaitlyn Foster; Kala Bolt; Lilian Urroz; Ruth Whelan; Aaron Gardner; Shrijal Bhavsar; Laurel Cherian; James Conners; Sarah Song; Rima Dafer; Alejandro Vargas; Henna McCoy; Karin Olds; Debbie Summers; Rene Colorado; Terri Nielsen; Juan Morales; Claude Hemphill; Dominica Randazzo; Destini Spaeth; Jason Neal; Melissa Zdroik; Royya Modir; Theresa McQuaid; Yu Cheng; Cary Murphy; Henrik Manassarians; Fazeel Siddiqui; Laura Reiser; Muhib Khan; Heidi Taylor; Stephanie Mueller; Naim Khoury; Lauren Bainter; Supreet Kaur; Guadalupe Calzadillas; Randall Edgell; Benjamin Cummins; Logan McDaneld; Lisa Bertrand; Kelly Matmati; Nabil Matmati; Nirali Vora; Madelleine Garcia; David Spence; Tisha Mabb; Curtis Benesch; Emily Prentiss; Julia Hopyan; David Gladstone; Idris Fatakdawala; Manoj Mittal; Tammy Donnel; Dawn Lenakakis; Katharyn Gelinas; Alicia Bennett; William Burgin; Marla Hairston; Paul Katz; Hannah Reimer; Rony Salem; Tracy Stern; Robin Dharia; Sasha Paglione; Christopher Goshgarian; Stacy Smith; Emiliya Melkumova; Nikolas Melkumyan; Sanjeeva Onteddu; Lisa Richardson; Mohammad Shafie; Wengui Yu; Julia Fong; Josue Prado; Karen Rapp; Wade Smith; Christina Wilson; Neringa May; Sophia Sundararajan; Mary Andrews; Richard Goddeau; Brian Silver; Christina Manxhari; Meaghan Demers-Peel; Cynthia Kenmuir; Kristen Kerfoot; Christy Ireland; Matthew Starr; Ty Shang; Mark Johnson; Erica Jones; Mehari Gebreyohannas; Jessica Clark; Andrew Southerlandc; Bradford Worrallc; Matthew Gusler; Keri JohnsonN; Necrisha Roach; Sherita Chapman; Nina Solenski; Rohini Bhole; Amna Sohail; Karen Johnston; Andrew Weko; Miah Perch; Cheyenne Batton; Allison Ramsey; Sonya Gunter; Jane Monita; Marie Meyer; Jennifer Murwin; Kaitlin Lundell; Nimco Essa; Michael Lyerly; Tammy Davis; Ashfaq Shuaib; Lori Piquette; Michael Hill; Shelagh Coutts; Supriya Save; Karla Ryckborst; Carol Kenney; Lana Toussaint; James Brorson; Elisheva Coleman; Emma Hall; Robert Stanton; Dawn Kleindorfer; Stacie Demel; Jennifer Powers; Fernando Testai; Maureen Hillmann; Enrique Leira; Heena Olalde; Jorge Kawano-Castillo; Aparna Pendurthi; Margaret Houghton; Justin Moore; Joel Maruthanal; Alissa Fugate; Saurav Das; Creed Pettigrew; Pattricia Arnold; Tracy Ander; Ann Jerde; Seemant Chaturvedi; Christina Spadafora; Joseph Carrera; Christopher Becker; Devin Brown; James Burke; Frank Conyers; Anthony Harrington; Christopher Hill; Jessica Roberts; Patty Johnson; Shashank Shekhar; Shreyas Gangadhara; Margaret Smith; Pierre Fayad; Helen Obaro; Tarun Girotra; Jacqueline Morales; Erin Rael; Muhammad-Adeel Saleemi; Rebecca Sugg; Tamekia Grissett; Stefanie White; Reza Behrouz; Jody Richardson; Lee Chung; Jennifer Majersik; Dana DeWitt; Stephanie Lyden; Vivek Reddy; Peter Tekiela; Peter Hannon; Adam de Havenon; Brian Marcus; Knut Hoversten; Chelsea Meyer; Jerdan Ruff; Theodore Rock; Michael Dela Cruz; Edward Bradbury; Jenna Bock; Kevin Call; Ryan McQuivey; Karen Belanger; Andrew Huffer; Sharon McRae; Ameer Hassan; Raza Khan; Olive Sanchez; Thalia Field; Laura Wilson; John Gorman; Stephen Van Gaal; Samuel Yip; Philip Teal; Oscar Benavente; Sharanpal Mann; Princess King-Azote; Genoveva Maclean; Carson Ma; Karina Villaluna; Michael Froehler; Hemangi Rajpal; Muhammad Alvi; Sara Dobrzynski; Jay Sherman; Cheryl Bushnell; Krystal Schmidt; Roi Wallis; Kimberly Panizzon; Reshma Narula; Lindsey Kuohn; Sara Jasak; Michael Kampp; Melissa Pish JAMA
• Comment & Response Apixaban to Prevent Recurrence After Cryptogenic Stroke—Reply Hooman Kamel, MD; David L. Tirschwell, MD; Mitchell S. V. Elkind, MD; ARCADIA Investigators JAMA

To the Editor The recent Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke (ARCADIA) trial 1 did not demonstrate superiority of apixaban over aspirin for secondary prevention in patients with cryptogenic stroke and atrial cardiopathy. In this study, atrial cardiopathy was defined by meeting any of the following criteria: serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels greater than 250 pg/mL, P-wave terminal force in electrocardiography lead V 1 greater than 5000 μV × ms, or left atrial diameter index of 3 cm/m 2 or greater. Notably, approximately 46% of participants were enrolled based on the serum NT-proBNP criterion alone. While serum NT-proBNP levels are positively correlated with left atrial remodeling and dysfunction, they are not robust predictors of atrial fibrillation and are influenced by various noncardiac factors such as age, obesity, and kidney function. 2 Thus, use of this criterion alone may not have accurately represented atrial cardiopathy and may have affected the precision of effect estimates of desired interventions. We speculate that the negative results in ARCADIA may be partially attributed to within-study variance because participants could be enrolled solely based on the NT-proBNP criterion. It would be helpful if the authors could provide more information about participants recruited based on electrocardiographic and echocardiographic criteria, which more accurately reflect atrial pathology.

Chi K , Nanna M , Nanna MG. Apixaban to Prevent Recurrence After Cryptogenic Stroke. JAMA. Published online May 13, 2024. doi:10.1001/jama.2024.6851

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