thesis statement about animal testing

Animal Testing Thesis Statement

Animal experimentation has been a controversial topic for many years. Some people believe that it is necessary in order to advance medical research, while others argue that it is cruel and inhumane.

There are pros and cons to both sides of the argument. On one hand, animal testing can be vital in developing new treatments and medications for diseases. Without animal testing, many life-saving drugs would not be available today. On the other hand, animal testing is often criticized because it can be cruel and inhumane. Animals in experiments are often subjected to pain and suffering, and sometimes they do not survive.

Ultimately, the decision of whether or not to support animal experimentation is a personal one. There are valid arguments on both sides of the issue, and it is up to each individual to decide what they believe is right.

There has been a dispute between animal rights activists and scientists about the morality of using animals in laboratory testing. It is also contentious whether utilizing animals for such research aids in the discovery of cures. If there are no other options and if it is probable that this will advance medical research, I believe that animals may be used for experimental study.

Animal testing is the use of animals in experiments and development projects to determine the toxicity, efficacy or side effects of substances such as drugs, chemicals, cosmetics, vaccines and other products. In many countries around the world animals are still suffering in laboratories with little hope for relief. According to the Animal Welfare Act (AWA), federal law regulates the treatment of animals in research, exhibition, transport, and by dealers.

The AWA does not extend to birds, rats of the genus Rattus, and mice of the genus Mus, which together account for more than 95% of all animals used in research.(1)Animal Experimentation Up 80 Percent In Last Decade) There has been an increase in the use of animals in experiments, although the number of rats and mice used has decreased slightly.

While animal rights advocates argue that people and animals are equivalent, I believe that people and animals cannot be compared; as a result, the death of an animal can never be the same as that of a person. As a result, causing animals to die for science in order to save human lives may be considered ethical to some extent if it aids scientific progress and is beneficial to humanity in general.

Animal testing has been a controversial issue for many years. Some people believe that animal testing is cruel and inhumane, and that it should be stopped immediately. Others believe that animal testing is necessary in order to continue making progress in medical research.

There are pros and cons to both sides of the argument, but I believe that the pros of animal testing outweigh the cons. The main reason I believe this is because animal testing has led to significant medical advances over the years, and has helped save countless lives.

One example of how animal testing has led to a medical breakthrough is the development of penicillin. Penicillin is an antibiotic used to treat bacterial infections, and it was first discovered in 1928 by Alexander Fleming. Fleming’s discovery of penicillin was accidental; he was studying bacteria in a petri dish when he noticed that a fungus had contaminated the dish.

Fleming observed that the bacteria were not growing near the fungus, and he realized that the fungus must be producing a substance that was inhibiting the growth of the bacteria. He isolated this substance, which we now know as penicillin, and found that it was effective at killing bacteria.

Fleming’s discovery of penicillin was a major medical breakthrough, and it would not have been possible without animal testing. In order to test whether or not penicillin was effective at treating bacterial infections, Fleming injected it into mice. He found that the mice who were injected with penicillin survived, while the mice who were not injected with penicillin died.

This experiment proved that penicillin was effective at treating bacterial infections in animals, and it paved the way for further research into the drug’s effects on humans. In 1942, penicillin was used to treat a patient with a serious bacterial infection for the first time, and it was found to be effective.

Since then, penicillin has been used to treat millions of people with bacterial infections, and has saved countless lives. Animal testing played a vital role in the development of this life-saving drug, and without it, we would not have the medical advances that we do today.

Animal testing has also played a role in the development of vaccines. Vaccines are used to prevent diseases, and they work by causing the body to develop immunity to a particular disease.

The first vaccine was developed in 1796 by Edward Jenner, and it was used to prevent smallpox. Jenner observed that milkmaids who had contracted cowpox (a mild form of smallpox) were immune to smallpox. He vaccinate people with cowpox in order to give them immunity to smallpox, and his experiment was successful.

Since then, vaccines have been developed for many other diseases, including polio, measles, mumps, rubella, and chickenpox. Animal testing has played a vital role in the development of these life-saving vaccines.

For example, the polio vaccine was developed in 1952 by Jonas Salk. In order to test whether or not the vaccine was safe and effective, Salk injected it into monkeys. He found that the monkeys who were injected with the vaccine did not develop polio, while the monkeys who were not vaccinated developed the disease.

This experiment proved that the polio vaccine was safe and effective, and it paved the way for further research into the vaccine. In 1955, the polio vaccine was declared safe for use in humans, and it has since been used to vaccinate millions of people around the world.

Furthermore, animal rights advocates accuse scientists of being ” barbarous” for causing animals to die in medical research, yet they do not object to people, particularly farmers, who kill animals for food. Even though they are aware that 99 percent of deaths are caused by farmers and only 1 percent by scientists, the reason for that is that they find scientists simpler to attack and have no strategy against farmers who are organized and powerful.

Animal testing has been a controversial issue for many years. Is it necessary? Does it save lives? These are the questions that people ask when they think about animal testing. Animal testing is the use of animals in experiments and development projects usually to determine toxicity, dosing and efficacy of test drugs before proceeding to human clinical trials (1).

Approximately 26 million vertebrate animals are used for research each year around the world (2). The animals used in research vary from mice and rats, which make up 85-90% of all laboratory animals, to larger mammals such as dogs, primates and farm animals.

The United States currently uses the most animals for research, with approximately 1.2 million animals used per year. This is followed by China, Japan, the United Kingdom and Canada (3).

Animal testing has been used for centuries to test products before they are made available to the public. It is only in recent years that animal rights groups have started to question the necessity of animal testing.

Animal testing is necessary in order to ensure the safety of products before they are made available to consumers. Without animal testing, many products would be released that could potentially be harmful to humans. Animal testing allows scientists to test the safety of products before they are used on human subjects.

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Animal Testing Essay Guide + Topics

Whether you are taking a position for or against animal testing in your essay, here are some helpful hacks, tips, and tricks you can use to ace your paper.

Animal testing is a controversial issue of global scope. However, with pandemics and outbreaks being a common phenomenon and the rise of the cosmetics industry, many animals are used in scientific research. Also known as in-vivo, animal experimentation, or animal research, animal testing entails using animals in different levels of experiments to investigate the reactions, performance, and potency of various medications, drugs, cosmetic products, and foods.

Use in both biological, medical, and now beauty studies, animal testing has gained comprehensive coverage. When writing persuasive or argumentative essays, you are likely to be given an animal testing research topic for your essay. The interest of commercial bodies and pharmaceutical companies and the ethics surrounding everything that occurs around us makes writing an animal testing argumentative or persuasive essay interesting.

When we asked 100 students who had ordered custom persuasive or argumentative animal testing essays from our website, they confessed that writing the essay only seems easy at its face value. However, it becomes complicated as they plan, conduct research, and write animal research papers. Do not fear, though because, you can either get an argumentative essay expert to write your essay or a model essay for you. Alternatively, use this guide to write a paper that will check all the boxes that your professor or instructor supposes you cannot.

What to include in your introduction?

When writing an animal testing introduction, avoid wasting too many words. Instead, write an introduction that attracts your readers, piques their interest, and keeps them glued to the end. This means that you should have: (a) hook , (b)background statement (where you explore the problem at hand), and (c) your animal-testing thesis statement.

Most of the top essay writers on our website revealed that they usually search for animal testing essay examples online for inspiration : it helps get a general atmosphere surrounding a controversial topic. With such a background, they can develop a thesis statement that defines their stance and the scope of their animal research essay.

Here are some excellent ideas for your first sentence or the hook:

• Statistics of animals killed annually for research
• Facts on animals are mostly used
• The position of the society
• Catchy facts
• Controversial statements on animal research
• Shocking facts about animal testing, e.g., Surprisingly, as People for the Ethical Treatment of Animal reports, almost 100 million animals are killed in just the laboratories in the U.S. for research such as biology lessons, experimentation, food, drug, and cosmetic testing. Imagine how the statistics will skew upwards if we considered the entire world's population of animals killed every hour.
• Rhetorical questions : you use this to make the reader intrigued to read more about the topic. For example, Would you rather use a drug tested on a volunteer human or other animal-safe alternative research approaches, and one that is effective or use a drug tested on animals whose failure rate is slightly high? or Do you believe that morality should be enforced in medical research, especially when animal rights are infringed?

The background of your animal testing research paper introduction can include:

• Definition of animal testing
• The extent of animal testing.'
• The historical context of animal testing
• Breakthroughs of animal testing
• Expert opinion over animal testing
• Description of the problem
• The debate surrounding animal testing

Animal Testing Essay Outline/Structure

Your outline will depend on whether you are writing pro-animal testing or against animal testing research paper. Here is a generalized example of the outline for an animal testing essay.

A well-structured animal testing essay will automatically earn you marks. In most cases, it follows the conventional five-paragraph essay format divided into the introduction, main body, and conclusion.

The introduction and conclusion are each 10% of the word count, while the main body is 80%. You have to format your paper in APA, MLA, or Harvard format as your professor requires. To understand the formatting requirements, read the prompt and rubric of the animal testing essay keenly.

Remember to maintain a single idea per every body paragraph. That idea must reflect in the topic sentence of the paragraph to enable your audience to distinguish your major arguments.

The contents of the body paragraphs must also support the thesis. If there is a counterargument, make it known in your second last paragraph that precedes the conclusion.

Introduction

• 10% of the word count
• Begin with a stellar hook sentence
• Provide background to your chosen topic
• Have an outstanding thesis statement
• Transition to the main body of your essay
• Comprises 80% of the word count
• It can be three paragraphs for short essays or more for a long-form research paper
• Provide the history of animal testing, if necessary.
• Look at the roles of regulation and legislation in preventing animal cruelty.
• Explore the different bodies involved in preventing or lobbying against animal testing.
• Explore the breakthroughs of animal testing
• Explore the different alternatives to animal testing: why they can work or why they cannot
• Each paragraph should have its idea
• Transition to your conclusion
• Provide a summary of the paper
• Highlight your significant arguments and counterarguments
• Offer recommendations, if necessary
• Rephrase your thesis statement and show how evidence has supported it in your essay.

Alternative Methods to Animal Testing to include in your paper

Cruelty-Free International argues that non-animal testing methods are cheaper, reliable, and more effective. You can recommend some of these alternatives in your animal testing research paper or essay, considering they elongate the discussion on this seemingly controversial topic.

• Computer modeling
• Cell cultures
• Human tissues
• Volunteer studies
• Use of egg embryo
• Use of unicellular organisms
• The LAL tests
• In vitro methods

Now, when writing an argumentative essay about animal testing, especially if you take a stance against it, listing these alternatives can strengthen your arguments. Look at this model animal testing essay and craft yours along the same line.

Tips for Concluding your Animal Testing Essay

There is no different way to end an animal testing essay, as it is the same as ending any essay. Thus, when you read our cheat sheet for ending an argumentative essay , you will understand that the main thing is to have a definitive conclusion.

The conclusion is not the place to introduce new ideas. Instead, you will summarize the main points of the essay and restate the thesis in a revamped version. Show your writers the connection between your main arguments and the recommendations you are making. If there is a counterstatement, explain your rationale for it.

When writing the conclusion, make it clear, concise, and coherent. For example, an excellent animal-testing essay conclusion will have the introduction sentence, the summary of the main body, and the closing sentence.

Strive to leave your reader yearning for more : you get to tickle the best grades even from that stingy professor. Weave together the concluding paragraph with appropriate sentence transitions and do not overdo it. Keep everything simple, and you will win the main marks assigned to a reasonable conclusion.

Now that we have everything explained, we can look at some of the main topics you can use as titles for animal testing papers.

Examples of Controversial and Latest Animal Testing Essay Topics

We asked our top writers to suggest some topics they think fit well for an animal testing essay. We got a total of fifty entries that you can select and write something about. If you are stuck and want an essay sample urgently, we can write such an essay for you in a few hours, thanks to our website that helps students write essays ASAP . You can choose from these animal testing essay titles:

• Animal testing should be banned
• Animal testing is not ethical
• Pros and cons of animal testing
• Alternative methods to using animals in drugs development
• Controversy in using animal testing in medical and cosmetic research
• Neglected interests and inhuman practices during animal testing
• The cruelty of animal testing
• Horrors of animal testing
• Accidents during animal testing
• Ethics of transporting caged animals for animal research
• The future of animal testing, given the advancement in biotechnology
• Medical animal testing should be banned
• Should guinea pigs be used for lab work research?
• New, better, and innovative treatments for humanity
• Using animals in medical research is ethical and essential
• Science and the murder of one hundred million animals annually
• Importance of animals in clinical trials
• Importance of animal testing in vaccine development
• Is animal testing necessary for human survival?
• Animal testing as an experimentation industry
• Effectiveness of animal testing
• Exploring the role of Cruelty-Free International Organization
• Role of religious bodies in advocating for animal-testing-free society
• The Americans for the Prevention of Cruelty to Animals (ASPCA) organization
• Ethical issues in animal experimentation
• How animal cruelty affects the ecosystem
• Animal models in vaccine development
• Defining animal cruelty
• Treatment versus rights of animals
• Are animal model results safe for humans?
• Migraine Treatment and Animal testing
• Dinitrophenol drug for overweight and Animal testing
• Anti-arthritis Treatment and Animal Testing
• Animal use in unmanned war drones
• Positive and negative outcomes of animal testing
• Role of media in influencing animal testing
• The politics of deception in animal testing
• Problems associated with animal testing
• Animal testing should be controlled and not stopped
• Licenses that are required for one to conduct animal testing
• Role of Big Pharma in advancing animal testing.
• Can plants be used as an alternative to animal testing?
• Impacts of animal testing on ecology
• How does animal testing affect the economy?
• Can animal testing result in bioweapons?
• Use of technology to predict diseases and outcomes rather than animal testing.
• Are the rights and feelings of animals considered in animal experimentation?
• Are animals used in tests free?
• Reasons rats, rabbits, and pigs are widely used in animal testing
• Can volunteer human beings replace animals in medical research?
• The best approach to take care of animals used in experimentation
• Breakthroughs after animal testing
• Animal testing and the cosmetics industry
• History of animal testing
• Role of CDC in animal testing research
• Role of WHO on animal testing authorization

Where and how to get help with your Animal Testing Essays?

In our article, we have extensively referenced our custom essay writers who can help you ace your animal testing essays. If you feel that the guide cannot help you break down the essay or are short of time, you can pay someone on our website to write one for you. When you buy an argumentative essay from our website, we assign it to a pro writer who will research, draft, and write the paper from scratch.

Our bespoke essay service ensures that every paper is done as though you would have done it. This means that the writer cites every animal testing journal article, credible website, or relevant scholarly resources as you would have done. They do this when they summarize, paraphrase, or quote from the sources.

Therefore, you are guaranteed 100% original and plagiarism-free animal testing essays. Furthermore, whether you are for or against animal testing, we have a writer who can write your argumentative essay outline, annotated bibliography, research paper, and essay.

They can take an ethical stance or argue based on what society or professionals/experts think about the issue.

Trust us with your paper because we have done this time and again : written untraceable papers for students. Our writers are fast, accurate, respectable, and experienced. They know how to score the top grade on the rubric. All the papers we have done have been used as best argumentative essay samples on should animal testing be banned? yours could be the next one.

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Gradecrest is a professional writing service that provides original model papers. We offer personalized services along with research materials for assistance purposes only. All the materials from our website should be used with proper references. See our Terms of Use Page for proper details.

Home — Essay Samples — Social Issues — Animal Testing

Argumentative Essays on Animal Testing

Hook examples for animal testing essays, the ethical dilemma hook.

Begin your essay by presenting the ethical dilemma surrounding animal testing. Explore the moral questions it raises and the conflicting viewpoints of proponents and opponents.

The Historical Perspective Hook

Take your readers on a journey through the history of animal testing. Discuss its origins, evolution, and its role in scientific and medical advancements over time.

The Scientific Advancements Hook

Highlight the scientific breakthroughs and discoveries that have resulted from animal testing. Discuss how it has contributed to medical treatments, vaccines, and the understanding of diseases.

The Alternatives and Innovations Hook

Explore alternative methods and innovations in research that aim to replace or reduce the use of animals in testing. Discuss advancements like in vitro testing and computer modeling.

The Animal Welfare Hook

Focus on the welfare and ethical treatment of animals used in testing. Discuss regulations, guidelines, and efforts to minimize harm and suffering in research.

The Legal and Regulatory Landscape Hook

Examine the legal and regulatory framework surrounding animal testing in different countries. Discuss laws, restrictions, and their enforcement.

The Public Opinion and Activism Hook

Discuss public perceptions of animal testing and the role of animal rights activists in advocating for change. Highlight notable campaigns and their impact.

The Unintended Consequences Hook

Explore unintended consequences or risks associated with animal testing, such as potential harm to humans due to species differences or the limitations of animal models.

The Future of Research Hook

Discuss the future of scientific research and the possibilities for reducing or eliminating animal testing. Explore emerging technologies and trends in biomedical research.

The Personal Story Hook

Share a personal or anecdotal story related to animal testing, such as the experiences of a researcher, activist, or someone affected by medical advancements achieved through animal testing.

Ethical Statement for Animal Testing

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The Use of Animals in Scientific Research

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Discussion Whether Animals Testing is Necessary

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The Ethics of Animal Testing: an Argument Against Its Practice

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Animal testing, referred to as animal experimentation, animal research, or in vivo testing, involves the utilization of animals other than humans in scientific experiments aimed at manipulating the factors influencing the behavior or biological processes being investigated.

Throughout history, the practice of animal testing has deep roots dating back centuries. The earliest recorded instances can be traced back to ancient civilizations, where animals were used for various scientific and medical purposes. The Greek physician Galen, during the second century AD, conducted experiments on animals to understand human anatomy and physiology. However, the formal establishment of animal testing as a systematic approach began to take shape during the 19th century with the emergence of modern medical research. In the late 1800s, advances in scientific knowledge and technology led to an increased demand for animal testing in various fields, including medicine, toxicology, and physiology. The development of anesthesia further facilitated the experimentation on animals by reducing pain and discomfort. Throughout the 20th century, animal testing became more widespread and institutionalized, particularly in the pharmaceutical industry.

Public opinion on animal testing is a complex and diverse topic, with viewpoints spanning a wide spectrum. While there are those who support the use of animals in scientific research for the advancement of human knowledge and medical breakthroughs, others express strong opposition due to ethical concerns and the perceived mistreatment of animals. Some people argue that animal testing is necessary for the development of life-saving treatments and the improvement of human health. They believe that animals provide valuable insights into human biology and the effectiveness of potential therapies. On the other hand, opponents of animal testing argue that it is cruel and unnecessary, advocating for alternative methods such as in vitro testing, computer modeling, and human cell-based assays. Public opinion on animal testing often hinges on the balance between scientific progress and animal welfare. The growing awareness of animal rights and ethical considerations has fueled debates and discussions surrounding the topic. As society becomes more conscious of animal welfare, there is an increasing demand for alternative testing methods and greater transparency in the treatment of animals involved in research. Ultimately, public opinion plays a crucial role in shaping policies and regulations surrounding animal testing.

1. Scientific advancement. 2. Human health and safety. 3. Understanding diseases. 4. Regulatory requirements. 5. Animal welfare improvements.

1. Ethical concerns. 2. Inadequate human relevance. 3. Availability of alternatives. 4. Animal welfare. 5. Speciesism and moral status.

One example of media representation is the documentary "Earthlings" directed by Shaun Monson. This influential film explores different aspects of animal exploitation, including animal testing, and highlights the ethical concerns surrounding the practice. It has garnered widespread attention and prompted discussions about the treatment of animals in scientific research. Social media platforms have also become powerful tools for activists and organizations to share information and advocate for alternatives to animal testing. Hashtags like #StopAnimalTesting and #CrueltyFree have gained traction, raising awareness and encouraging conversations on the topic.

The topic of animal testing is important due to its ethical, scientific, and societal implications. From an ethical standpoint, it raises profound questions about the treatment of sentient beings and the moral responsibility we have towards animals. It prompts us to consider the balance between scientific progress and animal welfare, urging us to explore alternative methods that minimize harm. Scientifically, animal testing has been instrumental in advancing medical knowledge and developing treatments for various diseases. However, it is essential to continually evaluate its effectiveness, limitations, and potential alternatives to ensure both human and animal well-being. Furthermore, the issue of animal testing has societal implications as it reflects our values and priorities as a society. It prompts discussions about our relationship with animals, the extent of their rights, and the importance of promoting more humane practices.

The topic of animal testing is worth writing an essay about due to its complex nature and the multitude of perspectives it encompasses. It is a subject that elicits strong emotions and raises critical ethical, scientific, and social questions. Writing an essay on animal testing allows for an in-depth exploration of these issues and encourages critical thinking and analysis. By delving into the topic, one can examine the ethical considerations surrounding the use of animals in experiments, weighing the potential benefits against the moral implications. Additionally, it provides an opportunity to evaluate the scientific validity and reliability of animal testing as a method for understanding human biology and developing medical treatments. Furthermore, an essay on animal testing opens avenues for discussing alternative approaches and advancements in technology that can reduce or replace animal experimentation. It allows for an exploration of the societal impact of animal testing, including public opinion, legislation, and the influence of media.

1. Each year, millions of animals are used in scientific experiments worldwide. According to estimates, over 100 million animals, including rabbits, mice, rats, dogs, and primates, are subjected to testing for various purposes, such as biomedical research, drug development, and toxicity testing. 2. Animal testing is not always reliable in predicting human outcomes. Studies have shown that there can be significant differences between animals and humans in terms of anatomy, physiology, and drug metabolism. This raises concerns about the validity and relevance of using animal models for understanding human diseases and developing treatments. 3. Alternatives to animal testing are emerging and gaining traction. Scientists and researchers are actively exploring innovative methods, such as in vitro cell cultures, computer modeling, and organ-on-a-chip technology, to simulate human biology and predict human responses more accurately. These alternative approaches aim to reduce or eliminate the need for animal testing while still ensuring the safety and efficacy of new products and treatments.

1. Abbott, A. (2005). Animal testing: more than a cosmetic change. Nature, 438(7065), 144-147. (https://go.gale.com/ps/i.do?id=GALE%7CA185466349&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=00280836&p=AONE&sw=w&userGroupName=anon%7E513ffe31) 2. Doke, S. K., & Dhawale, S. C. (2015). Alternatives to animal testing: A review. https://www.sciencedirect.com/science/article/pii/S1319016413001096 Saudi Pharmaceutical Journal, 23(3), 223-229. 3. Hajar, R. (2011). Animal testing and medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123518/ Heart views: the official journal of the Gulf Heart Association, 12(1), 42. 4. Bottini, A. A., & Hartung, T. (2009). Food for thought… on the economics of animal testing. ALTEX-Alternatives to animal experimentation, 26(1), 3-16. (https://www.altex.org/index.php/altex/article/view/633) 5. Valappil, S. P., Misra, S. K., Boccaccini, A. R., & Roy, I. (2006). Biomedical applications of polyhydroxyalkanoates, an overview of animal testing and in vivo responses. Expert Review of Medical Devices, 3(6), 853-868. (https://www.tandfonline.com/doi/abs/10.1586/17434440.3.6.853) 6. File, S. E., Lippa, A. S., Beer, B., & Lippa, M. T. (2004). Animal tests of anxiety. Current protocols in neuroscience, 26(1), 8-3. (https://currentprotocols.onlinelibrary.wiley.com/doi/abs/10.1002/0471142301.ns0803s26) 7. Madden, J. C., Enoch, S. J., Paini, A., & Cronin, M. T. (2020). A review of in silico tools as alternatives to animal testing: principles, resources and applications. Alternatives to Laboratory Animals, 48(4), 146-172. (https://journals.sagepub.com/doi/pdf/10.1177/0261192920965977) 8. Donnellan, L. (2006). Animal testing in cosmetics: recent developments in the European Union and the United States. Animal L., 13, 251. (https://heinonline.org/HOL/LandingPage?handle=hein.journals/anim13&div=18&id=&page=)

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Essays on animal testing – write them like a pro.

Animal testing essays are often required by instructors due to the controversial nature of the topic. Over the years there has been a long-standing debate about animal testing. One camp thinks that animal testing is inhumane while another camp suggests that it is essential for the advancement of research. If you’ve been asked to write animal testing essays for the first time, you may be conflicted about the topic. While you can always seek out a professional to write an animal testing essay for you, some tips can help you write it yourself. Keep reading to find out more.

Top Tips For Writing Perfect Animal Testing Essays

• Understand The Requirements Of Your Animal Testing Essay

First of all, you need to understand the requirements. This is the only way you can figure out what you’re expected to write. What is animal testing? Animal testing involves using animals for experiments. It could involve injecting them with harmful substances and observing how their body reacts. They may also inject these animals with antidotes while trying to find the cure to diseases. Irrespective of how you feel about it, you need to do the animal testing research paper according to the requirements. If you’ve been asked to write a descriptive essay, your job will be to describe what the subject is without being against animal testing or for animal testing. If it an expository essay, you need to state the facts. If it’s a persuasive essay, you need to convince the reader of what your opinion is on animal testing. If you’ve been asked to write an argumentative essay on animal testing, speak for or against. Make sure you know what you’ve been asked to do and stick to it.

• Research The Topic

When you’re asked to write an animal testing research paper, you need to do your homework to make sure that the content you provide is accurate. Your research should come from credible sources only. Thanks to the Internet, you don’t need to go to a library when you want to work on your animal testing thesis. There are many online libraries with detailed information about the subject. You can also check reliable news archives online to get statistics when necessary. Make sure that the information you use is up to date and verifiable.

• Prepare Your Animal Testing Thesis Statement

Your thesis statement is an important part of your essay. It should come just before the animal testing essay introduction. You can also make it part of the introduction. It should be one or two sentences that serve as a premise for your essay. By reading the thesis statement on essays on animal testing, your reader should be able to know what type of essay you’ve been asked to write and what direction you’re leaning towards.

• Stick To The Topic And Type Of Essay

Whether some animal research topics are assigned to you or you pick a topic yourself, make sure that you stick to the topic from the beginning to the end. If you’ve been asked to write a particular kind of essay, make sure you stick to it. For example, if you’ve been asked to write a why animal testing should be banned essay, this means that you’re writing an against animal testing essay. In this case, you need to give animal testing facts and examples that will persuade the reader that animal testing is not a good idea and it should be banned. You can offer alternatives to animal testing in your essay. You can search for an animal rights research paper to get an insight into the subject. If you’re asked to write an essay that supports animal testing, make sure you use facts to convince your audience. You can state how animal testing has been used to produce treatment for several illnesses over the years.  

• Stay Objective From Start To Finish

Remaining objective when you’re writing your animal rights research paper might be challenging if you have a soft spot for animals. You need to do everything you can to remain objective. Providing emotional writing when you’re working on animal experimentation essays is only going to irritate your reader. This is especially so when there are no facts included. When you want to appeal to emotions, make sure you use facts and examples to get the reader’s attention.

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Writing an animal testing essay is like writing any other essay. Make sure that you follow the basic principles of essay writing, stick to the facts. Apart from sticking to the facts, make sure your content is free of grammatical and typographical errors. Your content also has to be free of plagiarism. You can use premium tools to verify that the content is ideal for submission. However, you can ask a professional writer to proofread the content for you. These experts can give your essay a professional touch. Better still, they can write an essay for you from the beginning to the end.

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Writing Animal Testing Argumentative Essay & Thesis Statement

writing animal testing essay

Animal testing is a global debate, not only in science but also in the ethical concerns of the general public. Understanding this is important in writing an animal testing argumentative essay and formulating the appropriate thesis statements and arguments.

Animal testing is the practice of using animals to conduct tests and experiments to control variables affecting both the behavior and the biological system being studied.

It is also known as Vivo testing or animal experiment and is a problem that has bothered people worldwide.

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How to Write an Animal Testing Essay?

When writing essays on animal testing, there are specific approaches that you need to consider. These approaches are:

1. Consider the Historical Context

In this approach, what you write about in your essay does not require your own point of view.

Methods of testing and other aspects of the experiment can be borrowed from different sources.

In order to write a good essay in this approach, you need not have a prior opinion or judgment before knowing the facts involved in the experiment.

You should have objectives when searching for relevant information and explore animal testing as a scientist.

2. Take one side of the Argumentative Debate

In this approach, you need to make your own point of view known and convince the reader to be in line with your essay. You can also come up with your own topic on animal testing and stick to it.

When writing an animal testing essay, there are several sides concerning animal testing that you may wish to write on. These may include;

Arguments that can be made in an essay on animal testing

This can be done by writing essays that strongly oppose animal testing. You have to choose an argument showing the bad side of animal testing.

These arguments may include the following.

• Not all testing requires the use of animals.
• Killing animals for unsuccessful experiments is inhumane.
• Products made or approved by animal testing are harmful to human beings.
• This experiment method is far more expensive than the natural one.
• Most of the testing causes animal suffering.
• Most religions are for the notion that we should take care of our animals.
• You can also support animal testing in your essay by being persuasive in your arguments that the modern-day world needs animal testing. You can choose to support your views by:
• Arguing that animal experiments prevent people from going through the experiment.
• It shows that using an animal with similar organisms to humans is preferable to the human himself.
• Arguing that successful animal testing has saved a lot of people by providing the needed treatment.
•  Proving that testing products new to humans are more dangerous than using animals.
• Arguing that scientists prefer animals in doing tests and that humans have complete authority over animals.
• You can argue that scientist sees medical progression as more important than the life of a mere animal.
• Arguing that it is very hard to find other ways of testing an organism that is fully functioning.

3. Formulate a Thesis Statement

You will need to formulate and write a good thesis statement that will present your main idea. This statement is your stand and is what will guide the writing of the animal testing essay introduction, body paragraphs, and conclusions.

How to Write an Animal Testing Thesis Statement

The sentence(s) capturing the main point or central message, in this case concerning the animal experiment topic, is a thesis statement. In order to write a good thesis statement on animal testing, you have to consider the following:

• Be specific

You need to be very specific when writing a thesis statement in your animal testing essay. Focus on the main points of discussion. Your thesis statement should not be too general.

• Announce the topic

This is a very critical aspect of a thesis statement.

This is where you should present your view and position of the animal testing issue you are writing about.

• Be original

Make sure that the thesis statement is your real work. A thesis statement plays a huge part on the reader of your text.

Do not rely on or quote the thesis statements of other peoples’ animal testing essays because the reader is likely to get uninterested.

Write a thesis statement in a language that the reader can easily understand. Avoid vague and abstract words to give the reader a clear meaning of the animal testing topic you have written about.

4. Write a Good Introduction to Animal Testing

In the introductory part of an animal testing essay, you define the topic of your essay and give any further background information related to the topic to make the reader understand better.

Apart from the definitions, you can provide statistics, describe a problem, talk about some important relative facts, and include the thesis statement, the position of the society, and the views from experts in the introduction of the animal testing essay.

A hook sentence and a sentence linking the introduction to the main body must also be in the introduction. You can check a comprehensive essay guide on writing introduction paragraphs for your essays.

5. Write Proper Body Paragraphs with Points on Animal Testing

This is where you present all the ideas and information on the topic, with each idea in its own paragraph. Ideas and information on animal testing topics may include:

• Great discoveries on the topic of study.
• What is the historical background of the animal testing topic?
• What are the effects and benefits of animal testing in detail?
• Intensive explanation of ethics that govern animal testing.

After writing down several paragraphs, make sure you include a statement that will link the body to the conclusion. This is the main part of the essay, which gives people problems.

6. Write a Good Conclusion on Animal Testing Points

This is the part where you draw deductions on the content of the essay without suggesting anything new that has not been talked about in the introduction and the body.

In this part, you write a brief summary of your work that can include a final argument, an unexpected twist related to the work written, and anything that warrants serious consideration.

Writing good conclusions is one of the challenges in writing essays , and you can check how to solve it in that article.

Once a good conclusion is done, you will be safe to proofread your paper and submit it confidently to get a good grade. Read more tips on how to write good essays on any topic in our more general guide.

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35 Topics for Writing an Animal Testing Essay

Animal testing is a broad area of study. The following are some of the 15 best topics that one can write animal testing essays about:

• The history of animal testing.
• Ethics that guide animal experiments.
• Alternatives to animal testing.
• How to take care of and use animals in animal testing?
• Advantages and disadvantages of animal testing.
• What are the best discoveries of animal testing?
• The practice of animal testing in your country.
• Comparison of animal testing in your country with neighboring countries and the world.
• The rights of animals in the context of animal testing.
• Changes in animal testing with the recent advancement of technology.
• What does the future of animal testing hold?
• Good and bad outcomes of animal testing.
• Horrors associated with animal testing.
• Relation of animal testing with cosmetics.
• Contribution of research in animal testing.

Other Good Topics for Animal Testing Essays Include

• Why animal testing should be stopped.
• Human diseases and animal testing.
• Is animal testing free from external control?
• Which animals, between vertebrates and invertebrates, are suitable for animal testing?
• The truth about animal testing.
• Should scientific reasons be the reasons for animal testing?
• What role does the media play in spreading the message about animal experimentation?
• Problems associated with animal testing.
• Do animals really have feelings?
• Can testing on plants be an alternative for animal testing?
• How can animal testing be made more animal-friendly?
• Why are rabbits and rats the most used animals in animal testing?
• Should we stop taking medicines to save animals from animal testing?
• Do scientists have an obligation to respect the animals they are experimenting on?
• How can we improve the lives of the animals that experiments are done?
• Impact of animal testing on the economy.
• What are the side effects of testing on animals?
• Is animal testing the leading creation of human viruses?
• Are there better alternatives to animal testing than animals?
• How can scientists use technology to reduce the impact of animal testing?

Check some of the recent debates and news regarding animal testing, experimenting with monkeys

With over 10 years in academia and academic assistance, Alicia Smart is the epitome of excellence in the writing industry. She is our managing editor and is in charge of the writing operations at Grade Bees.

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Animal Testing Argumentative Essay: Guidelines

How to Write a Great Animal Testing Argumentative Essay?

Animal testing sample.

According to the statistical data, testing in the US is conducted on 26 million animals. Those animals are used for research in the field of commercial products and various scientific advancements. Besides, animals are used to test the latest medical treatment, check on the toxicity of drugs, and verify the level of safety that the products aimed at people will have. Animal testing is also in demand in the commercial industry and the area of health care. Since it is an issue of intense arguments whether it is ethically correct to use the animals in experiments, an animal testing argumentative essay is among the most popular topics at schools, colleges, and universities.

The idea to use animals in experiments is not new. Actually, it is a practice that dates back to 500 BC; and even at that time, there were those who supported this idea and those who were against it. The latter claim that it is cruel and inhumane to test the products using animals, and they call for the development of the new alternative techniques which will eliminate the need for animal testing.

Such organizations as PETA campaign in order to increase the range of relevant research and make the process of developing alternative testing methods faster and more efficient. It is reasonable that an animal testing essay of a student who supports this point of view will state the requirement to alleviate testing on animals. It will also contain an argument that animal testing does not ensure absolutely valid results as tests conducted on animals are different from those done to humans; that is why the question is whether animal testing has any practical sense at all.

Good Argumentative Essay Topics

On the other hand, an argumentative essay on animal testing can be written from the point of view of the advantages of the use of animals in medicine. It is wrong to hurt living beings, but it is necessary to test the safety of new products before using them for the benefit of people. Typically, rats are the first animals used for research. In case the tests prove to be effective, monkeys are the next subjects for a series of tests. Only if these experiments are successful, the product can be given to people.

An animal testing argumentative essay always mentions the benefit of reducing the number of errors and fatal mistakes owing to a round of tests on animals. It also mentions that the number of saved people’s lives is enormous owing to the sacrificed lives of animals. Actually, there is hardly any effective alternative to animal testing. Furthermore, it is subject to following strict regulations to ensure the prevention of all kinds of animal mistreatment.

In general, the debates over the use of animals in testing for medical research testing have been historically known for centuries. After the animal testing essay introduction, it is typical to present the claims of the proponents. They imply that there is no intentional harm in animal testing; moreover, the animals are well kept, fed, and treated nicely. Besides, they state that the absence of effective alternatives makes it impossible to eliminate this practice. They also emphasize the benefit of saving lives owing to animal testing. Nevertheless, certain environmental organizations aimed at the protection of animals call for no more animals in research and testing because of the cruel and inhumane practices.

Writing an animal testing argumentative essay outline , one should take into consideration that animal testing is a matter of various discussions. Thus, it is important to choose a certain position and focus the whole assignment on this point of view. A common task for the students is to work on an argumentative paper; thus, it is essential to determine and specify a definite position and then develop a thesis statement with the supporting arguments appropriately. For instance, if you make up your mind to look at the animal testing from the angle of supporting position, it is recommended to use the following arguments or similar ones.

Writing Prompts for Animal Testing Essays

Advantages to Write About in Animal Testing Essay

It is impossible to eliminate animal testing as it saves people’s lives.

According to medical researchers, the contribution of testing on animals in the advancement of health care and medicine cannot be overestimated. It is owing to the experiments conducted on animals, people can be treated for breast cancer, tuberculosis, diabetics, malaria, brain injury, and other diseases. Physicians also emphasize the role of chimpanzees in experiments aimed at looking for treatment for Hepatitis B and Hepatitis C.

There Is No Alternative to Experimenting with Animals Because Its the Safest Testing Method Known

An animal testing essay conclusion always refers to the fact that the structure of animals’ organisms that resembles that of humans makes them the most suitable material for research in product testing in the fields of medicine and cosmetics. Animal and human bodies have identical or similar processes. There is an assumption that testing can be conducted on cell organisms, but it is doubtful that it will work, as those tissues cannot be tested for blindness or blood pressure issues.

Currently, animal testing is used as a model for computer programs that will probably substitute it in the future. The provided data prove to be accurate; however, living organisms cannot be replaced with less complex computer programs that do not ensure stimulation of the brain activity.

The Biological Similarity between Animal Species and People Is the Best

The organs of the mammals are identical to those of people; besides, there is a striking genetic closeness between them. The statistical data prove that the genetic similarity between the people and mammals can be up to 98%. Animals have the same bloodstream and central nervous systems with humans; that is why the susceptibility to diseases of both of them is similar.

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Ethical Side of Animal Testing

Each essay about animal testing contains an argument about checking of medical treatment for toxicity during the animal testing procedures. It is against all ethical norms to test a new medicine on people and risk their lives. Helsinki Medical Association claims that animal testing should always go before human experiments

Additional Benefits for Animals

As a result of vaccine testing on animals, not only people but animals are saved from terminal diseases. Besides, the development of new medical products contributes to the prevention of species extinction.

Animal Testing Has the Strict Regulations

Various animal testing essay examples demonstrate that there are strict regulations for experimenting with animals nowadays. A topical issue of present-day life is the protection of animal rights, and numerous organizations control the situation. It is important to make sure that there is neither violation of animal rights not the suffering of animals from abuse.

Further Advantages of Animal Testing

The life cycles of animals are shorter than those of people; thus, the experiments on them are more reasonable than those on humans. It is possible to observe all consequences and effects of certain drugs owing to short life cycles in the course of several years or even months.

Animal Testing Implies Humane Treatment

Some students even use the fact of humane treatment of animals in the animal testing essay title. Researchers always take into account the conditions and consequences of experiments and care about animals.

Disadvantages to Write About in Animal Testing Essay

A variety of animal testing essay topics implies considering different opinions of the pros and cons of those experiments. It is important to ensure the presence of alternative ideas to prevent all kinds of bias and ensure having different perspectives on the same issue.

Human societies have always been oriented at innovation and adaptability as desired features. On the other hand, old practices have the tendency of being kept by the researchers and organizations for a number of reasons. In an animal testing argumentative essay, the aspects should be explored in detail.

First of all, let us talk about the benefits.

Ethics in Animal Testing

If the essay is written in support of animal testing, this is one of the easiest points. Animals used for testing lack moral capabilities and conscious mind despite having their DNA equal to the human one in 98 %. A good animal testing essay title always mentions this somehow. Nevertheless, animals suffer and their agony can lead to death in some serious cases.

Try to explore the issues philosophically. Touch upon attributing value to people and animals. Mention the patients with mental illnesses who have no morality or consciousness. Consider the appropriateness of experimenting on such people along with the animals.

An efficient animal testing pros and cons essay should be based on a broad topic and numerous implications for analysis.

Availability of Alternatives

The progress cannot be stopped in the present-day world. It is normal now to get rid of outdated things and introduce innovations. In a perfect why animal testing should be banned essay, try to note that there are and there will be other ways to experiment on new products. For example, it is possible to cultivate human cells and do organ replication in the laboratories to use the obtained organs for testing of biological processes.

Right, all challenges in modern research cannot be addressed via cell testing; besides, the immune system, endocrine system, blood pressure issues and other aspects of the human body cannot be analyzed using cells. On the other hand, testing practices in the laboratories can substitute some animal alternatives, if possible.

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Reduction, Refinement, and Replacement

The mentioned three RRRs (reduction, refinement, and replacement) represent a plan developed by numerous countries to ensure the decrease in the testing with the use of animals. A cosmetic animal testing essay should contain this argument for explanations of why it is important to eradicate the common practice.

• What is the reduction ?

It is the minimization of the animal testing practice by research centers, laboratories, and companies, and regulation of the affected living creatures via introducing innovative practices and improving the experimental techniques.

• What is refinement ?

It is changing the lives of tested animals, ensuring good living conditions, the introduction of obligatory anesthesia, and the provision of necessary medical treatment.

• What is the replacement ?

It is a procedure of transition to innovative methods of conducting experiments with the use of computers, cell culture, micro-dosing by volunteers, human tissue tissues, and other methods.

Overrating of the Contribution

An argument that animal testing should be illegal is used by numerous researchers against the current testing practices. The supporters of the theory cite examples to prove the inevitability of animal experiments for the progress of humans. Nevertheless, it is complicated to make a prediction on how the discoveries can be made without animal testing, but the ideas of progress cannot be based on outdated practices.

It cannot be denied that the development of insulin was made owing to the dogs that had pancreases injected. On the other hand, a medical student from Germany, Paul Langerhans, saw the strange pancreatic tissue cells and encouraged Frederick Banting to make a discovery without any animal testing. Thus, there is a question of whether the disadvantages of animal testing outweigh the benefits obtained. The use of dogs sped up the process but kills many innocent animals. Insulin helped many people survive, but it is complicated to determine how the studies will be affected by animal testing results.

Insufficient Reliability

The efficiency of the animal tests on people is 95% because of the 2% genome divergence between animals and people. The European Union banned the use of animals in testing cosmetics for two reasons. Firstly, the eyes of humans are less sensitive than the eyes of rats and some other animals, thus the experiment results are unreliable. Secondly, other alternatives, for example, tissue testing, can be more effective.

Some researchers claim that animal testing should be allowed, but insufficient reliability may result in tragedies. For instance, tension, anxiety, and insomnia were treated with thalidomide medication in West Germany, and in 1957, as many as 5,000 infants died, and many lost sights, hearing or suffered severe deformities. It is not always right to use the products suitable for animals on humans. Another example is Rezulin that was a trigger of liver failure in people but treated rats with diabetes type 2 perfectly.

High Price of Animal Tests

It is common to pay no attention to this fact. It is assumed that more innovative technology will be even more expensive; however, progress always implies durability, and that should be noted. Financial losses are huge even for common dissection classes. Reliable results require numerous life forms, but computer models can use the required data for analysis in a different way.

Leaving out the Rights

The governments adopted a number of regulations in different countries of the world to ensure the protection of animals’ rights; however, it is a common practice to forget about the animals used for testing when it goes about laws.

Thinking about a good title for an essay on animal testing for medical purposes, do not forget to take into consideration this debatable point. How can it happen that the Animal Welfare Act omits fish, mice, and rats? The researchers are allowed to treat those animals in the way they need for their experiments. Try to explore how moral this situation is.

Global Progress

Your essay should emphasize the crucial importance of certain practices and lack of alternatives; however, it is also essential to touch upon the better options, available now o expected in the future. Every year, the development of technologies causes the emergence of new experimenting methods, making science more efficient and more humane. Mention the subjective opinions of the researchers and limitations of the control samples when talking about animal testing. On the other hand, note the advantages of new computer models that avoid bias and manipulation of data. Animals are less close to people than in cell cultures. All in all, it is more ethical to try alternative testing techniques as they not only protect the animals but also increase the efficiency of science.

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Please notice.

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Reproduced with permission from student

January 26, 2004

Public Speaking 220

Katherine E. Oleson

Title: “The importance of understanding the controversy around animal testing”

Topic: animal testing

General Purpose: to inform

Specific Purpose: to inform the audience about what animal testing is, and explain the alternative practices to it

Thesis Statement: Animal testing is a highly controversial topic that has divided people into group that either support animal testing or oppose it altogether, and another one that advocates the use of alternatives.

Organizational plan: Categorical

I. Introduction

• Attention getter: How many of you use here use razors to shave? How many of you wear makeup? How many of you have been on antibiotics at some time in your life? If you raised your hand or answered “yes” in your head to any of these questions, then this speech concerns you. Animal testing has been used as a mechanism in the advancement of medicine, household products, and the cosmetic industry in the United State s for nearly 60 years. With between 17 and 70 million animals killed each year in U.S. laboratories, the growth in animal experimentation has sparked much debate.
• Thesis: Animal testing is a high controversial topic that has divided people into groups that support animal experimentation, oppose it altogether, or advocate the use of available alternatives.
• Preview: Today I am going to tell you about some of the main ideas that are involved in the debate surrounding animal experimentation. Along with providing you a background about animal testing, I will educate you with information about both the benefits of animal testing and the disadvantages of animal testing.

<Transition> I will start out by illustrating the historical background of and the legislative reasons behind its use.

• While there is a law in effect that regulates the condition of animals used in experiments, the legality of these tests is not enforced.
• The Animal Welfare Act (AWA) is the federal law that governs the humane care, handling, treatment, and transportation of animals used in laboratories (PETA, 2004).
• No law requires animal testing for cosmetics and household products, and both the Consumer Product Safety Commission and the Food and Drug Administration does not require any particular product test.

<Transition> Even though there is not strict regulation that can force companies into using animals as their means of testing, proponents of animal testing support its use for the efficiency it offers that other types of testing do not.

• Supporters of animal testing feel that because the animals are handled in a civilized manner, their use in making medical breakthroughs and guaranteeing product safety justifies animal testing.
• Various medical advances have been made thanks to animal testing that would otherwise have not been achieved.

a.        Barbara Davies, deputy director of the Research Defense Society, reports that “All you have to do is think of any major medical advances of the last 100 years to see the benefit of animal testing,” (Morrison, 2001).

b.       Because of animal research we have anesthesia, hip replacement, kidney dialysis, and a vaccine for acute Hepatitis B, and without animal testing doctors would not have the chemotherapy to save 70% of children who now survive acute lymphatic leukemia (Americans for Medical Progress Educational Alliance, 2002).

• Advocates of animal experimentation argue that laboratory testing is not as common or cruel as it is conveyed by the common public.

a.        Of all the areas in animal use, including agriculture, pet, sports, and animal research, the standards of welfare and veterinary care laid down are the highest for animals kept in labs for research (Haugen, 2000).

b.       In 1999, 57 percent of vertebrate animals in labs covered by the Animal Welfare Act experienced no pain or distress, and of those that do undergo moderate to severe pain, 34 percent were relieved by anesthesia or analgesia, and only 9 percent tested suffered from unrelieved pain or stress. (The Center for Laboratory Animal Welfare, 2004).

3. Product testing is crucal to guaranteeing consumers that they can securely use everyday products without experiencing side effects.

a. Scientists defend testing on animals because they are conducted in the name of protecting consumers, while manufacturers rely on animal testing to verify the safety of the product and protect them from lawsuits (McCoy, 1993).

b.  Researchers call attention to the fact that only 20 percent of animals used in laboratories are used to evaluate the safety of consumer products (The Center for Laboratory Animal Welfare, 2004).

c. If no testing is performed on a product, the producer is legally responsible to print a warning on the product label reading: THE SAFETY OF THIS PRODUCT HAS NOT BEEN DETERMINED, which may turn away potential buyers and in a snowball effect the manufacturers, scientists, and researchers are left without jobs (McCoy, 1993).

<Transition> Although I have presented several reasons in support of animal experimentation, there are also a number of strong arguments that oppose it.

• Those against the current means of animal testing undermine it as a malicious procedure of yielding inaccurate results that could be more effective and scientific with the use of alternatives.
• Opponents allege testing on animals leads to unreliable and unscientific findings that harm or kill humans 61% of the time after being deemed safe (Americans for Medical Progress Educational Alliance, 2003).

a.        Plavix, which is taken by more than three million patients, passed all required animal tests and was considered safe for humans. Now it is causing bleeding, anemia, and kidney failure in some clients (Cohen, 2001).

b.       Medications such as aspirin kill cats, and penicillin kills guinea pigs, yet guinea pigs can safely eat strychnine, one of the deadliest poisons for humans that is safe for monkeys to consume (Haugen, 2000).

• Animal testing is a vicious process that inflicts stress and physical pain that can very well be avoided.

a.        The Eye Irritancy Test involves immobilizing rabbits from stocks where only their heads project and dropping different substances into their eyes usually with no anesthesia to test the damage to the eye tissue over a course of generally 72 hours (PETA, 2004).

b.       With the Acute Toxicity Test a substance is usually forced by tube into the animals stomachs or through holes cut into their throats to determine the amount of a substance that will kill a percentage, even up to 100 percent, of a group of test animals (PETA, 2004).

• Challengers of animal testing say alternatives are the future, and that since they are available they should be persued.

a.        A study by the American Medical Association found that 75 percent of Americans are against using animals to test cosmetics (Haugen, 2000).

b.       While the expansion and recognition of using alternatives is slowly growing, over 500 companies have already shunned animal testing (PETA, 2004).

i.                      Colgate-Palmolive is one of the largest companies that’s reduced its use of animal testing and their research facility has reduced the use of animals for experimentation by as much as 90 percent (McCoy, 1993).

c.        Through epidemiology (population research), in vitro experimentation, and clinical studies we have discovered our most valuable information about the origins of cancer, the efficiency of treatments, and the prevention of cancer (Cohen, 2001).

<Transition> Both sides of this debate have valuable arguments that should be taken into consideration when shaping your opinion and when deciding the future of animal testing.

III. Conclusion

• Signal: Considering how detailed and supported the statements of the challengers and advocates of animal testing are, the outlook of animal testing will take much time and deliberation to make an educated decision. It is important that we the public stay informed and active as we are the consumers of these products.
• Summary/Review: As you have seen, those who agree with animal testing cite the medical breakthroughs, the necessity of animal testing in determining safety, and the humane treatment of animals as reasons to support their position. In contrast, those who disagree with animal experimentation see it as unreliable and unscientific, cruel physical harm, and want alternative practices to be more widely used.
• Closure: Billions of dollars are funded each year in the animal testing industry, so next time you go to the store to buy makeup, medication, or even toothpaste, make a well-informed decision about whether or not you support animal experimentation.

Americans for Medical Progress Educational Alliance. (2003). Animal Research . Retrieved

January 25, 2004, from Americans for Medical Progress Educational Alliance Web site: http://www.amprogress.org/Issues/issuesmain.cfm

Cohen, M. (2001 April). Human lives not saved by lab animals . Seattle Post-Intelligencer . A19.

Retrieved January 22, 2003, from UMI Proquest Direct.

Haugen, D.M. (2000). Animal experimentation . San Diego: Greenhaven Press.

McCoy, J.J. (1993). Animals in research, issues, and conflicts . United States: Impact.

Morrison, N. (2001, February). Animal rights and wrongs. Northern Echo . 08. Retrieved January

21, 2004, from UMI Proquest Direct database.

People for the Ethical Treatment of Animals (PETA). (2004). Factsheets . Retrieved January 21,

2004, from People for the Ethical Treatment of Animals Web site: http://www.peta.org/mc/facts.html

The Center for Laboratory Animal Welfare. (2004). Laboratory Animal Welfare . Retrieved

January 21, 2004, from the Massachusetts Society for the Prevention of Cruelty to Animals. Web site: http://www.labanimalwelfare.org/

Ethical care for research animals

WHY ANIMAL RESEARCH?

The use of animals in some forms of biomedical research remains essential to the discovery of the causes, diagnoses, and treatment of disease and suffering in humans and in animals., stanford shares the public's concern for laboratory research animals..

Many people have questions about animal testing ethics and the animal testing debate. We take our responsibility for the ethical treatment of animals in medical research very seriously. At Stanford, we emphasize that the humane care of laboratory animals is essential, both ethically and scientifically.  Poor animal care is not good science. If animals are not well-treated, the science and knowledge they produce is not trustworthy and cannot be replicated, an important hallmark of the scientific method .

There are several reasons why the use of animals is critical for biomedical research: 

••  Animals are biologically very similar to humans. In fact, mice share more than 98% DNA with us!

••  Animals are susceptible to many of the same health problems as humans – cancer, diabetes, heart disease, etc.

••  With a shorter life cycle than humans, animal models can be studied throughout their whole life span and across several generations, a critical element in understanding how a disease processes and how it interacts with a whole, living biological system.

The ethics of animal experimentation

Nothing so far has been discovered that can be a substitute for the complex functions of a living, breathing, whole-organ system with pulmonary and circulatory structures like those in humans. Until such a discovery, animals must continue to play a critical role in helping researchers test potential new drugs and medical treatments for effectiveness and safety, and in identifying any undesired or dangerous side effects, such as infertility, birth defects, liver damage, toxicity, or cancer-causing potential.

U.S. federal laws require that non-human animal research occur to show the safety and efficacy of new treatments before any human research will be allowed to be conducted.  Not only do we humans benefit from this research and testing, but hundreds of drugs and treatments developed for human use are now routinely used in veterinary clinics as well, helping animals live longer, healthier lives.

It is important to stress that 95% of all animals necessary for biomedical research in the United States are rodents – rats and mice especially bred for laboratory use – and that animals are only one part of the larger process of biomedical research.

Our researchers are strong supporters of animal welfare and view their work with animals in biomedical research as a privilege.

Stanford researchers are obligated to ensure the well-being of all animals in their care..

Stanford researchers are obligated to ensure the well-being of animals in their care, in strict adherence to the highest standards, and in accordance with federal and state laws, regulatory guidelines, and humane principles. They are also obligated to continuously update their animal-care practices based on the newest information and findings in the fields of laboratory animal care and husbandry.  

Researchers requesting use of animal models at Stanford must have their research proposals reviewed by a federally mandated committee that includes two independent community members.  It is only with this committee’s approval that research can begin. We at Stanford are dedicated to refining, reducing, and replacing animals in research whenever possible, and to using alternative methods (cell and tissue cultures, computer simulations, etc.) instead of or before animal studies are ever conducted.

Organizations and Resources

There are many outreach and advocacy organizations in the field of biomedical research.

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How To Write An Animal Testing Essay?

Table of Contents

Animal testing is a long-standing problem, which bothers people all around the world. It is also known as in vivo testing or animal research; it’s the use of animals in experiments to explore the reactions of their bodies and biological systems to various irritants.

From the beginning of the scientific revolution, this method was often used in medical and biological studies. However, nowadays it is also used in commercial facilities and pharmaceutical companies to test cosmetics, hygiene products, and foods before selling them to people.

Animal testing essay approaches

Basically, there are two approaches to writing essays on animal testing.

You may choose a topic that considers the historical context, as methods of testing and other aspects that don’t require your personal point of view. When writing such an essay, remember that you need to be unprejudiced and objective, to explore the topic as a scientist.

The other approach is an argumentative essay. There’s also a vast quantity of sides to choose from but you’ll need to express your point of view or compose the topic for an essay sticking to it. Here you will have to be persuasive to convince the reader in your rightness.

Position against animal testing essay

If you are an opponent to animal testing, you may want to choose the topic, that would highlight the negative sides of the issue. Here are some arguments against animal testing for you to start off:

• Experiments on animals are inhumane and cause animal suffering.
• There are different alternatives for testing, that can replace animals.
• People differ from animals. Thus, the results of animal testing might be unjustified.
• Some products that have passed animal testing were dangerous to people.
• Alternative methods of research are cheaper than animal testing.
• Lots of failed experiments are useless to expend of animals’ lives.
• Religion induces us to be merciful to all living creatures including animals.

Position pro-animal testing essay

In case you support the idea of animal testing and decided to prove that it is needed in the modern world, you’d need to be very persuasive. There are thousands of people who won’t share your opinion.

Below you can find some ideas to support animal testing:

• Animal testing produced dozens of treatments and saved millions of people’s lives.
• There still are no equivalent alternatives to test a fully functioning organism.
• Some animals are similar to the human organism.
• Animal testing prevents dangerous and harmful experiments on people.
• There’s legislation which aims to prevent animals’ mistreatment.
• The majority of scientists endorse the practice of animal testing.
• Some of the products must be first tested on animals to prove humans can use them.
• Religion establishes human domination.
• Animals’ lives is a small price for scientific and medical progress.

Ideas on animal testing essay structure

Each essay has to be well-structured and animal testing essay is not an exception. As a rule, an essay consists of three parts: introduction, main body, and conclusion.

In the introduction , you present the problem and the topic of your essay. Provide your reader with some definitions and background information for a better understanding.

In the main body , you represent all the information, ideas and statements for your topic. Don’t forget to structure the text and break it into paragraphs, this will make your essay more readable. Ideally, you write each idea or statement in the new paragraph.

The conclusion is put at the very end when everything is already said. Here you make an inference of the whole essay without adding any new information.

Here is an example of the outline for a pro-animal testing research paper:

Introduction

• Hook sentence.
• Thesis statement.
• Transition to Main Body.
• History of the animal testing practice.
• The role of legislation in preventing mistreatment.
• Great discoveries, which would be impossible without animal testing.
• Why alternatives to animal testing won’t work?
• Transition to Conclusion.
• Unexpected twist or a final argument.
• Food for thought.

Writing an animal testing essay introduction

To write a successful introduction, and the whole essay as well, you need to be aware of the topic. So first of all, you need to do a lot of research work for a good start.

Searching for some animal testing essay examples might appear to be a great idea. Once you gain some background you will surely get to know what is needed to be said.

Here are some hints on what to include in your introduction:

• Definition of animal testing.
• Statistics.
• Description of the problem.
• Experts’ point of view.
• Society’s position.
• Some catchy facts.
• Thesis statement – the main idea of your essay.

Best animal testing essay titles

Lack of ideas for a good title? Here’s a list of topics for the essay on animal testing.

Choose any. Each of them is catchy.

• Pros and cons of animal testing.
• Animal testing in cosmetics.
• Great discoveries of animal testing.
• Alternatives to animal testing.
• Animal testing in your country.
• The ethical side of animal testing.
• Positive and negative outcomes of animal testing.
• Horrors of animal testing.
• Future of animal testing.
• Animal testing and animal rights.

Crafting an animal testing essay hook

When it comes to writing, the introduction is almost a half of success. If you manage to write a good beginning, the reader will surely have a more positive vision of the whole work.

… How to grab the reader’s attention and compose a catchy beginning?

These two basic techniques are often used by speakers, but can also be applied when writing:

• Rhetorical question. Make the reader think, ask something ambiguous or nippy, like: “Is morality valuable when it comes to medical progress and saving lives?” or “Would you kill an animal with your own hands?”
• Shocking fact. Something like: “More than 100 million animals are abused and killed in the US yearly” or “88% of Nobel Prizes in Physiology and Medicine involved animal testing.

All in all, animal testing is newsworthy and up to date topic to discover and highlight. There are many aspects of the problem to explore and what is important – you can’t be right or wrong with your point of view.

This coin has two sides and it is for you to decide which one to stick to. Remember that your essay will benefit from honesty with yourself and the reader.

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• v.63(2 Suppl 3); 2022 Jun

Ethical considerations regarding animal experimentation

Aysha karim kiani.

1 Allama Iqbal Open University, Islamabad, Pakistan

2 MAGI EUREGIO, Bolzano, Italy

DEREK PHEBY

3 Society and Health, Buckinghamshire New University, High Wycombe, UK

GARY HENEHAN

4 School of Food Science and Environmental Health, Technological University of Dublin, Dublin, Ireland

RICHARD BROWN

5 Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada

PAUL SIEVING

6 Department of Ophthalmology, Center for Ocular Regenerative Therapy, School of Medicine, University of California at Davis, Sacramento, CA, USA

PETER SYKORA

7 Department of Philosophy and Applied Philosophy, University of St. Cyril and Methodius, Trnava, Slovakia

ROBERT MARKS

8 Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel

BENEDETTO FALSINI

9 Institute of Ophthalmology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy

NATALE CAPODICASA

10 MAGI BALKANS, Tirana, Albania

STANISLAV MIERTUS

11 Department of Biotechnology, University of SS. Cyril and Methodius, Trnava, Slovakia

12 International Centre for Applied Research and Sustainable Technology, Bratislava, Slovakia

LORENZO LORUSSO

13 UOC Neurology and Stroke Unit, ASST Lecco, Merate, Italy

DANIELE DONDOSSOLA

14 Center for Preclincal Research and General and Liver Transplant Surgery Unit, Fondazione IRCCS Ca‘ Granda Ospedale Maggiore Policlinico, Milan, Italy

15 Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy

GIANLUCA MARTINO TARTAGLIA

16 Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy

17 UOC Maxillo-Facial Surgery and Dentistry, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milan, Italy

MAHMUT CERKEZ ERGOREN

18 Department of Medical Genetics, Faculty of Medicine, Near East University, Nicosia, Cyprus

MUNIS DUNDAR

19 Department of Medical Genetics, Erciyes University Medical Faculty, Kayseri, Turkey

SANDRO MICHELINI

20 Vascular Diagnostics and Rehabilitation Service, Marino Hospital, ASL Roma 6, Marino, Italy

DANIELE MALACARNE

21 MAGI’S LAB, Rovereto (TN), Italy

GABRIELE BONETTI

Astrit dautaj, kevin donato, maria chiara medori, tommaso beccari.

22 Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy

MICHELE SAMAJA

23 MAGI GROUP, San Felice del Benaco (BS), Italy

STEPHEN THADDEUS CONNELLY

24 San Francisco Veterans Affairs Health Care System, University of California, San Francisco, CA, USA

DONALD MARTIN

25 Univ. Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAG, SyNaBi, Grenoble, France

ASSUNTA MORRESI

26 Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy

ARIOLA BACU

27 Department of Biotechnology, University of Tirana, Tirana, Albania

KAREN L. HERBST

28 Total Lipedema Care, Beverly Hills California and Tucson Arizona, USA

MYKHAYLO KAPUSTIN

29 Federation of the Jewish Communities of Slovakia

LIBORIO STUPPIA

30 Department of Psychological, Health and Territorial Sciences, School of Medicine and Health Sciences, University "G. d'Annunzio", Chieti, Italy

LUDOVICA LUMER

31 Department of Anatomy and Developmental Biology, University College London, London, UK

GIAMPIETRO FARRONATO

Matteo bertelli.

32 MAGISNAT, Peachtree Corners (GA), USA

Animal experimentation is widely used around the world for the identification of the root causes of various diseases in humans and animals and for exploring treatment options. Among the several animal species, rats, mice and purpose-bred birds comprise almost 90% of the animals that are used for research purpose. However, growing awareness of the sentience of animals and their experience of pain and suffering has led to strong opposition to animal research among many scientists and the general public. In addition, the usefulness of extrapolating animal data to humans has been questioned. This has led to Ethical Committees’ adoption of the ‘four Rs’ principles (Reduction, Refinement, Replacement and Responsibility) as a guide when making decisions regarding animal experimentation. Some of the essential considerations for humane animal experimentation are presented in this review along with the requirement for investigator training. Due to the ethical issues surrounding the use of animals in experimentation, their use is declining in those research areas where alternative in vitro or in silico methods are available. However, so far it has not been possible to dispense with experimental animals completely and further research is needed to provide a road map to robust alternatives before their use can be fully discontinued.

How to cite this article: Kiani AK, Pheby D, Henehan G, Brown R, Sieving P, Sykora P, Marks R, Falsini B, Capodicasa N, Miertus S, Lorusso L, Dondossola D, Tartaglia GM, Ergoren MC, Dundar M, Michelini S, Malacarne D, Bonetti G, Dautaj A, Donato K, Medori MC, Beccari T, Samaja M, Connelly ST, Martin D, Morresi A, Bacu A, Herbst KL, Kapustin M, Stuppia L, Lumer L, Farronato G, Bertelli M. Ethical considerations regarding animal experimentation. J Prev Med Hyg 2022;63(suppl.3):E255-E266. https://doi.org/10.15167/2421-4248/jpmh2022.63.2S3.2768

Introduction

Animal model-based research has been performed for a very long time. Ever since the 5 th century B.C., reports of experiments involving animals have been documented, but an increase in the frequency of their utilization has been observed since the 19 th century [ 1 ]. Most institutions for medical research around the world use non-human animals as experimental subjects [ 2 ]. Such animals might be used for research experimentations to gain a better understanding of human diseases or for exploring potential treatment options [ 2 ]. Even those animals that are evolutionarily quite distant from humans, such as Drosophila melanogaster , Zebrafish ( Danio rerio ) and Caenorhabditis elegans , share physiological and genetic similarities with human beings [ 2 ]; therefore animal experimentation can be of great help for the advancement of medical science [ 2 ].

For animal experimentation, the major assumption is that the animal research will be of benefit to humans. There are many reasons that highlight the significance of animal use in biomedical research. One of the major reasons is that animals and humans share the same biological processes. In addition, vertebrates have many anatomical similarities (all vertebrates have lungs, a heart, kidneys, liver and other organs) [ 3 ]. Therefore, these similarities make certain animals more suitable for experiments and for providing basic training to young researchers and students in different fields of biological and biomedical sciences [ 3 ]. Certain animals are susceptible to various health problems that are similar to human diseases such as diabetes, cancer and heart disease [ 4 ]. Furthermore, there are genetically modified animals that are used to obtain pathological phenotypes [ 5 ]. A significant benefit of animal experimentation is that test species can be chosen that have a much shorter life cycle than humans. Therefore, animal models can be studied throughout their life span and for several successive generations, an essential element for the understanding of disease progression along with its interaction with the whole organism throughout its lifetime [ 6 ].

Animal models often play a critical role in helping researchers who are exploring the efficacy and safety of potential medical treatments and drugs. They help to identify any dangerous or undesired side effects, such as birth defects, infertility, toxicity, liver damage or any potential carcinogenic effects [ 7 ]. Currently, U.S. Federal law, for example, requires that non-human animal research is used to demonstrate the efficacy and safety of any new treatment options before proceeding to trials on humans [ 8 ]. Of course, it is not only humans benefit from this research and testing, since many of the drugs and treatments that are developed for humans are routinely used in veterinary clinics, which help animals live longer and healthier lives [ 4 ].

COVID-19 AND THE NEED FOR ANIMAL MODELS

When COVID-19 struck, there was a desperate need for research on the disease, its effects on the brain and body and on the development of new treatments for patients with the disease. Early in the disease it was noticed that those with the disease suffered a loss of smell and taste, as well as neurological and psychiatric symptoms, some of which lasted long after the patients had “survived” the disease [ 9-15 ]. As soon as the pandemic started, there was a search for appropriate animal models in which to study this unknown disease [ 16 , 17 ]. While genetically modified mice and rats are the basic animal models for neurological and immunological research [ 18 , 19 ] the need to understand COVID-19 led to a range of animal models; from fruit flies [ 20 ] and Zebrafish [ 21 ] to large mammals [ 22 , 23 ] and primates [ 24 , 25 ]. And it was just not one animal model that was needed, but many, because different aspects of the disease are best studied in different animal models [ 16 , 25 , 26 ]. There is also a need to study the transmission pathways of the zoonosis: where does it come from, what are the animal hosts and how is it transferred to humans [ 27 ]?

There has been a need for animal models for understanding the pathophysiology of COVID-19 [ 28 ], for studying the mechanisms of transmission of the disease [ 16 ], for studying its neurobiology [ 29 , 30 ] and for developing new vaccines [ 31 ]. The sudden onset of the COVID-19 pandemic has highlighted the fact that animal research is necessary, and that the curtailment of such research has serious consequences for the health of both humans and animals, both wild and domestic [ 32 ] As highlighted by Adhikary et al. [ 22 ] and Genzel et al. [ 33 ] the coronavirus has made clear the necessity for animal research and the danger in surviving future such pandemics if animal research is not fully supported. Genzel et al. [ 33 ], in particular, take issue with the proposal for a European ban on animal testing. Finally, there is a danger in bypassing animal research in developing new vaccines for diseases such as COVID-19 [ 34 ]. The purpose of this paper is to show that, while animal research is necessary for the health of both humans and animals, there is a need to carry out such experimentation in a controlled and humane manner. The use of alternatives to animal research such as cultured human cells and computer modeling may be a useful adjunct to animal studies but will require that such methods are more readily accessible to researchers and are not a replacement for animal experimentation.

Pros and cons of animal experimentation

Arguments against animal experimentation.

A fundamental question surrounding this debate is to ask whether it is appropriate to use animals for medical research. Is our acceptance that animals have a morally lower value or standard of life just a case of speciesism [ 35 ]? Nowadays, most people agree that animals have a moral status and that needlessly hurting or abusing pets or other animals is unacceptable. This represents something of a change from the historical point of view where animals did not have any moral status and the treatment of animals was mostly subservient to maintaining the health and dignity of humans [ 36 ].

Animal rights advocates strongly argue that the moral status of non-human animals is similar to that of humans, and that animals are entitled to equality of treatment. In this view, animals should be treated with the same level of respect as humans, and no one should have the right to force them into any service or to kill them or use them for their own goals. One aspect of this argument claims that moral status depends upon the capacity to suffer or enjoy life [ 37 ].

In terms of suffering and the capacity of enjoying life, many animals are not very different from human beings, as they can feel pain and experience pleasure [ 38 ]. Hence, they should be given the same moral status as humans and deserve equivalent treatment. Supporters of this argument point out that according animals a lower moral status than humans is a type of prejudice known as “speciesism” [ 38 ]. Among humans, it is widely accepted that being a part of a specific race or of a specific gender does not provide the right to ascribe a lower moral status to the outsiders. Many advocates of animal rights deploy the same argument, that being human does not give us sufficient grounds declare animals as being morally less significant [ 36 ].

ARGUMENTS IN FAVOR OF ANIMAL EXPERIMENTATION

Those who support animal experimentation have frequently made the argument that animals cannot be elevated to be seen as morally equal to humans [ 39 ]. Their main argument is that the use of the terms “moral status” or “morality” is debatable. They emphasize that we must not make the error of defining a quality or capacity associated with an animal by using the same adjectives used for humans [ 39 ]. Since, for the most part, animals do not possess humans’ cognitive capabilities and lack full autonomy (animals do not appear to rationally pursue specific goals in life), it is argued that therefore, they cannot be included in the moral community [ 39 ]. It follows from this line of argument that, if animals do not possess the same rights as human beings, their use in research experimentation can be considered appropriate [ 40 ]. The European and the American legislation support this kind of approach as much as their welfare is respected.

Another aspect of this argument is that the benefits to human beings of animal experimentation compensate for the harm caused to animals by these experiments.

In other words, animal harm is morally insignificant compared to the potential benefits to humans. Essentially, supporters of animal experimentation claim that human beings have a higher moral status than animals and that animals lack certain fundamental rights accorded to humans. The potential violations of animal rights during animal research are, in this way, justified by the greater benefits to mankind [ 40 , 41 ]. A way to evaluate when the experiments are morally justified was published in 1986 by Bateson, which developed the Bateson’s Cube [ 42 ]. The Cube has three axes: suffering, certainty of benefit and quality of research. If the research is high-quality, beneficial, and not inflicting suffering, it will be acceptable. At the contrary, painful, low-quality research with lower likelihood of success will not be acceptable [ 42 , 43 ].

Impact of experimentations on animals

Ability to feel pain and distress.

Like humans, animal have certain physical as well as psychological characteristics that make their use for experimentation controversial [ 44 ].

In the last few decades, many studies have increased knowledge of animal awareness and sentience: they indicate that animals have greater potential to experience damage than previously appreciated and that current rights and protections need to be reconsidered [ 45 ]. In recent times, scientists as well as ethicists have broadly acknowledged that animals can also experience distress and pain [ 46 ]. Potential sources of such harm arising from their use in research include disease, basic physiological needs deprivation and invasive procedures [ 46 ]. Moreover, social deprivation and lack of the ability to carry out their natural behaviors are other causes of animal harm [ 46 ]. Several studies have shown that, even in response to very gentle handling and management, animals can show marked alterations in their physiological and hormonal stress markers [ 47 ].

In spite of the fact that suffering and pain are personalized experiences, several multi-disciplinary studies have provided clear evidence of animals experiencing pain and distress. In particular, some animal species have the ability to express pain similarly to human due to common psychological, neuroanatomical and genetic characteristics [ 48 ]. Similarly, animals share a resemblance to humans in their developmental, genetic and environmental risk factors for psychopathology. For instance, in many species, it has been shown that fear operates within a less organized subcortical neural circuit than pain [ 49 , 50 ]. Various types of depression and anxiety disorders like posttraumatic stress disorder have also been reported in mammals [ 51 ].

PSYCHOLOGICAL CAPABILITIES OF ANIMALS

Some researchers have suggested that besides their ability to experience physical and psychological pain and distress, some animals also exhibit empathy, self-awareness and language-like capabilities. They also demonstrate tools-linked cognizance, pleasure-seeking and advanced problem-solving skills [ 52 ]. Moreover, mammals and birds exhibit playful behavior, an indicator of the capacity to experience pleasure. Other taxa such as reptiles, cephalopods and fishes have also been observed to display playful behavior, therefore the current legislation prescribes the use of environmental enrichers [ 53 ]. The presence of self-awareness ability, as assessed by mirror self-recognition, has been reported in magpies, chimpanzees and other apes, and certain cetaceans [ 54 ]. Recently, another study has revealed that crows have the ability to create and use tools that involve episodic-like memory formation and its retrieval. From these findings, it may be suggested that crows as well as related species show evidence of flexible learning strategies, causal reasoning, prospection and imagination that are similar to behavior observed in great apes [ 55 ]. In the context of resolving the ethical dilemmas about animal experimentation, these observations serve to highlight the challenges involved [ 56 , 57 ].

Ethics, principles and legislation in animal experimentation

Ethics in animal experimentation.

Legislation around animal research is based on the idea of the moral acceptability of the proposed experiments under specific conditions [ 58 ]. The significance of research ethics that ensures proper treatment of experimental animals [ 58 ]. To avoid undue suffering of animals, it is important to follow ethical considerations during animal studies [ 1 ]. It is important to provide best human care to these animals from the ethical and scientific point of view [ 1 ]. Poor animal care can lead to experimental outcomes [ 1 ]. Thus, if experimental animals mistreated, the scientific knowledge and conclusions obtained from experiments may be compromised and may be difficult to replicate, a hallmark of scientific research [ 1 ]. At present, most ethical guidelines work on the assumption that animal experimentation is justified because of the significant potential benefits to human beings. These guidelines are often permissive of animal experimentation regardless of the damage to the animal as long as human benefits are achieved [ 59 ].

PRINCIPLE OF THE 4 RS

Although animal experimentation has resulted in many discoveries and helped in the understanding numerous aspects of biological science, its use in various sectors is strictly controlled. In practice, the proposed set of animal experiments is usually considered by a multidisciplinary Ethics Committee before work can commence [ 60 ]. This committee will review the research protocol and make a judgment as to its sustainability. National and international laws govern the utilization of animal experimentation during research and these laws are mostly based on the universal doctrine presented by Russell and Burch (1959) known as principle of the 3 Rs. The 3Rs referred to are Reduction, Refinement and Replacement, and are applied to protocols surrounding the use of animals in research. Some researchers have proposed another “R”, of responsibility for the experimental animal as well as for the social and scientific status of the animal experiments [ 61 ]. Thus, animal ethics committees commonly review research projects with reference to the 4 Rs principles [ 62 ].

The first “R”, Reduction means that the experimental design is examined to ensure that researchers have reduced the number of experimental animals in a research project to the minimum required for reliable data [ 59 ]. Methods used for this purpose include improved experimental design, extensive literature search to avoid duplication of experiments [ 35 ], use of advanced imaging techniques, sharing resources and data, and appropriate statistical data analysis that reduce the number of animals needed for statistically significant results [ 2 , 63 ].

The second “R”, Refinement involves improvements in procedure that minimize the harmful effects of the proposed experiments on the animals involved, such as reducing pain, distress and suffering in a manner that leads to a general improvement in animal welfare. This might include for example improved living conditions for research animals, proper training of people handling animals, application of anesthesia and analgesia when required and the need for euthanasia of the animals at the end of the experiment to curtail their suffering [ 63 ].

The third “R”, Replacement refers to approaches that replace or avoid the use of experimental animals altogether. These approaches involve use of in silico methods/computerized techniques/software and in vitro methods like cell and tissue culture testing, as well as relative replacement methods by use of invertebrates like nematode worms, fruit flies and microorganisms in place of vertebrates and higher animals [ 1 ]. Examples of proper application of these first “3R2 principles are the use of alternative sources of blood, the exploitation of commercially used animals for scientific research, a proper training without use of animals and the use of specimen from previous experiments for further researches [ 64-67 ].

The fourth “R”, Responsibility refers to concerns around promoting animal welfare by improvements in experimental animals’ social life, development of advanced scientific methods for objectively determining sentience, consciousness, experience of pain and intelligence in the animal kingdom, as well as effective involvement in the professionalization of the public discussion on animal ethics [ 68 ].

OTHER ASPECTS OF ANIMAL RESEARCH ETHICS

Other research ethics considerations include having a clear rationale and reasoning for the use of animals in a research project. Researchers must have reasonable expectation of generating useful data from the proposed experiment. Moreover, the research study should be designed in such a way that it should involve the lowest possible sample size of experimental animals while producing statistically significant results [ 35 ].

All individual researchers that handle experimental animals should be properly trained for handling the particular species involved in the research study. The animal’s pain, suffering and discomfort should be minimized [ 69 ]. Animals should be given proper anesthesia when required and surgical procedures should not be repeated on same animal whenever possible [ 69 ]. The procedure of humane handling and care of experimental animals should be explicitly detailed in the research study protocol. Moreover, whenever required, aseptic techniques should be properly followed [ 70 ]. During the research, anesthetization and surgical procedures on experimental animals should only be performed by professionally skilled individuals [ 69 ].

The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines that are issued by the National Center for the Replacement, Refinement, and Reduction of Animals in Research (NC3Rs) are designed to improve the documentation surrounding research involving experimental animals [ 70 ]. The checklist provided includes the information required in the various sections of the manuscript i.e. study design, ethical statements, experimental procedures, experimental animals and their housing and husbandry, and more [ 70 ].

It is critical to follow the highest ethical standards while performing animal experiments. Indeed, most of the journals refuse to publish any research data that lack proper ethical considerations [ 35 ].

INVESTIGATORS’ ETHICS

Since animals have sensitivity level similar to the human beings in terms of pain, anguish, survival instinct and memory, it is the responsibility of the investigator to closely monitor the animals that are used and identify any sign of distress [ 71 ]. No justification can rationalize the absence of anesthesia or analgesia in animals that undergo invasive surgery during the research [ 72 ]. Investigators are also responsible for giving high-quality care to the experimental animals, including the supply of a nutritious diet, easy water access, prevention of and relief from any pain, disease and injury, and appropriate housing facilities for the animal species [ 73 ]. A research experiment is not permitted if the damage caused to the animal exceeds the value of knowledge gained by that experiment. No scientific advancement based on the destruction and sufferings of another living being could be justified. Besides ensuring the welfare of animals involved, investigators must also follow the applicable legislation [ 74 , 75 ].

To promote the comfort of experimental animals in England, an animal protection society named: ‘The Society for the Preservation of Cruelty to Animals’ (now the Royal Society for the Prevention of Cruelty to Animals) was established (1824) that aims to prevent cruelty to animal [ 76 ].

ANIMAL WELFARE LAWS

Legislation for animal protection during research has long been established. In 1876 the British Parliament sanctioned the ‘Cruelty to Animals Act’ for animal protection. Russell and Burch (1959) presented the ‘3 Rs’ principles: Replacement, Reduction and Refinement, for use of animals during research [ 61 ]. Almost seven years later, the U.S.A also adopted regulations for the protection of experimental animals by enacting the Laboratory Animal Welfare Act of 1966 [ 60 ]. In Brazil, the Arouca Law (Law No. 11,794/08) regulates the animal use in scientific research experiments [ 76 ].

These laws define the breeding conditions, and regulate the use of animals for scientific research and teaching purposes. Such legal provisions control the use of anesthesia, analgesia or sedation in experiments that could cause distress or pain to experimental animals [ 59 , 76 ]. These laws also stress the need for euthanasia when an experiment is finished, or even during the experiment if there is any intense suffering for the experimental animal [ 76 ].

Several national and international organizations have been established to develop alternative techniques so that animal experimentation can be avoided, such as the UK-based National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) ( www.caat.jhsph.edu ), the European Centre for the Validation of Alternative Methods (ECVAM) [ 77 ], the Universities Federation for Animal Welfare (UFAW) ( www.ufaw.org.uk ), The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) [ 78 ], and The Center for Alternatives to Animal Testing (CAAT) ( www.caat.jhsph.edu ). The Brazilian ‘Arouca Law’ also constitutes a milestone, as it has created the ‘National Council for the Control of Animal Experimentation’ (CONCEA) that deals with the legal and ethical issues related to the use of experimental animals during scientific research [ 76 ].

Although national as well as international laws and guidelines have provided basic protections for experimental animals, the current regulations have some significant discrepancies. In the U.S., the Animal Welfare Act excludes rats, mice and purpose-bred birds, even though these species comprise almost 90% of the animals that are used for research purpose [ 79 ]. On the other hand, certain cats and dogs are getting special attention along with extra protection. While the U.S. Animal Welfare Act ignores birds, mice and rats, the U.S. guidelines that control research performed using federal funding ensure protections for all vertebrates [ 79 , 80 ].

Living conditions of animals

Choice of the animal model.

Based on all the above laws and regulations and in line with the deliberations of ethical committees, every researcher must follow certain rules when dealing with animal models.

Before starting any experimental work, thorough research should be carried out during the study design phase so that the unnecessary use of experimental animals is avoided. Nevertheless, certain research studies may have compelling reasons for the use of animal models, such as the investigation of human diseases and toxicity tests. Moreover, animals are also widely used in the training of health professionals as well as in training doctors in surgical skills [ 1 , 81 ].

Researcher should be well aware of the specific traits of the animal species they intend to use in the experiment, such as its developmental stages, physiology, nutritional needs, reproductive characteristics and specific behaviors. Animal models should be selected on the basis of the study design and the biological relevance of the animal [ 1 ].

Typically, in early research, non-mammalian models are used to get rapid insights into research problems such as the identification of gene function or the recognition of novel therapeutic options. Thus, in biomedical and biological research, among the most commonly used model organisms are the Zebrafish, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans . The main advantage of these non-mammalian animal models is their prolific reproducibility along with their much shorter generation time. They can be easily grown in any laboratory setting, are less expensive than the murine animal models and are somewhat more powerful than the tissue and cell culture approaches [ 82 ].

Caenorhabditis elegans is a small-sized nematode with a short life cycle and that exists in large populations and is relatively inexpensive to cultivate. Scientists have gathered extensive knowledge of the genomics and genetics of Caenorhabditis elegans ; but Caenorhabditis elegans models, while very useful in some respects, are unable to represent all signaling pathways found in humans. Furthermore, due to its short life cycle, scientists are unable to investigate long term effects of test compounds or to analyze primary versus secondary effects [ 6 ].

Similarly, the fruit fly Drosophila melanogaster has played a key role in numerous biomedical discoveries. It is small in size, has a short life cycle and large population size, is relatively inexpensive to breed, and extensive genomics and genetics information is available [ 6 ]. However, its respiratory, cardiovascular and nervous systems differ considerably from human beings. In addition, its immune system is less developed when compared to vertebrates, which is why effectiveness of a drug in Drosophila melanogaster may not be easily extrapolated to humans [ 83 ].

The Zebrafish ( Danio rerio ) is a small freshwater teleost, with transparent embryos, providing easy access for the observation of organogenesis and its manipulation. Therefore, Zebrafish embryos are considered good animal models for different human diseases like tuberculosis and fetal alcohol syndrome and are useful as neurodevelopmental research models. However, Zebrafish has very few mutant strains available, and its genome has numerous duplicate genes making it impossible to create knockout strains, since disrupting one copy of the gene will not disrupt the second copy of that gene. This feature limits the use of Zebrafish as animal models to study human diseases. Additionally they are rather expensive, have long life cycle, and genomics and genetics studies are still in progress [ 82 , 84 ].

Thus, experimentation on these three animals might not be equivalent to experimentation on mammals. Mammalian animal model are most similar to human beings, so targeted gene replacement is possible. Traditionally, mammals like monkey and mice have been the preferred animal models for biomedical research because of their evolutionary closeness to humans. Rodents, particularly mice and rats, are the most frequently used animal models for scientific research. Rats are the most suitable animal model for the study of obesity, shock, peritonitis, sepsis, cancer, intestinal operations, spleen, gastric ulcers, mononuclear phagocytic system, organ transplantations and wound healing. Mice are more suitable for studying burns, megacolon, shock, cancer, obesity, and sepsis as mentioned previously [ 85 ].

Similarly, pigs are mostly used for stomach, liver and transplantation studies, while rabbits are suitable for the study of immunology, inflammation, vascular biology, shock, colitis and transplantations. Thus, the choice of experimental animal mainly depends upon the field of scientific research under consideration [ 1 ].

HOUSING AND ENVIRONMENTAL ENRICHMENT

Researchers should be aware of the environment and conditions in which laboratory animals are kept during research, and they also need to be familiar with the metabolism of the animals kept in vivarium, since their metabolism can easily be altered by different factors such as pain, stress, confinement, lack of sunlight, etc. Housing conditions alter animal behavior, and this can in turn affect experimental results. By contrast, handling procedures that feature environmental enrichment and enhancement help to decrease stress and positively affect the welfare of the animals and the reliability of research data [ 74 , 75 ].

In animals, distress- and agony-causing factors should be controlled or eliminated to overcome any interference with data collection as well as with interpretation of the results, since impaired animal welfare leads to more animal usage during experiment, decreased reliability and increased discrepancies in results along with the unnecessary consumption of animal lives [ 86 ].

To reduce the variation or discrepancies in experimental data caused by various environmental factors, experimental animals must be kept in an appropriate and safe place. In addition, it is necessary to keep all variables like humidity, airflow and temperature at levels suitable for those species, as any abrupt variation in these factors could cause stress, reduced resistance and increased susceptibility to infections [ 74 ].

The space allotted to experimental animals should permit them free movement, proper sleep and where feasible allow for interaction with other animals of the same species. Mice and rats are quite sociable animals and must, therefore, be housed in groups for the expression of their normal behavior. Usually, laboratory cages are not appropriate for the behavioral needs of the animals. Therefore, environmental enrichment is an important feature for the expression of their natural behavior that will subsequently affect their defense mechanisms and physiology [ 87 ].

The features of environmental enrichment must satisfy the animals’ sense of curiosity, offer them fun activities, and also permit them to fulfill their behavioral and physiological needs. These needs include exploring, hiding, building nests and gnawing. For this purpose, different things can be used in their environment, such as PVC tubes, cardboard, igloos, paper towel, cotton, disposable masks and paper strips [ 87 ].

The environment used for housing of animals must be continuously controlled by appropriate disinfection, hygiene protocols, sterilization and sanitation processes. These steps lead to a reduction in the occurrence of various infectious agents that often found in vivarium, such as Sendai virus, cestoda and Mycoplasma pulmonis [ 88 ].

Euthanasia is a term derived from Greek, and it means a death without any suffering. According to the Brazilian Arouca Law (Article 14, Chapter IV, Paragraphs 1 and 2), an animal should undergo euthanasia, in strict compliance with the requirements of each species, when the experiment ends or during any phase of the experiment, wherever this procedure is recommended and/or whenever serious suffering occurs. If the animal does not undergo euthanasia after the intervention it may leave the vivarium and be assigned to suitable people or to the animal protection bodies, duly legalized [ 1 ].

Euthanasia procedures must result in instant loss of consciousness which leads to respiratory or cardiac arrest as well as to complete brain function impairment. Another important aspect of this procedure is calm handling of the animal while taking it out of its enclosure, to reduce its distress, suffering, anxiety and fear. In every research project, the study design should include the details of the appropriate endpoints of these experimental animals, and also the methods that will be adopted. It is important to determine the appropriate method of euthanasia for the animal being used. Another important point is that, after completing the euthanasia procedure, the animal’s death should be absolutely confirmed before discarding their bodies [ 87 , 89 ].

Relevance of animal experimentations and possible alternatives

Relevance of animal experiments and their adverse effects on human health.

One important concern is whether human diseases, when inflicted on experimental animals, adequately mimic the progressions of the disease and the treatment responses observed in humans. Several research articles have made comparisons between human and animal data, and indicated that the results of animals’ research could not always be reliably replicated in clinical research among humans. The latest systematic reviews about the treatment of different clinical conditions including neurology, vascular diseases and others, have established that the results of animal studies cannot properly predict human outcomes [ 59 , 90 ].

At present, the reliability of animal experiments for extrapolation to human health is questionable. Harmful effects may occur in humans because of misleading results from research conducted on animals. For instance, during the late fifties, a sedative drug, thalidomide, was prescribed for pregnant women, but some of the women using that drug gave birth to babies lacking limbs or with foreshortened limbs, a condition called phocomelia. When thalidomide had been tested on almost all animal models such as rats, mice, rabbits, dogs, cats, hamsters, armadillos, ferrets, swine, guinea pig, etc., this teratogenic effect was observed only occasionally [ 91 ]. Similarly, in 2006, the compound TGN 1412 was designed as an immunomodulatory drug, but when it was injected into six human volunteer, serious adverse reactions were observed resulting from a deadly cytokine storm that in turn led to disastrous systemic organ failure. TGN 1412 had been tested successfully in rats, mice, rabbits, and non-human primates [ 92 ]. Moreover, Bailey (2008) reported 90 HIV vaccines that had successful trial results in animals but which failed in human beings [ 93 ]. Moreover, in Parkinson disease, many therapeutic options that have shown promising results in rats and non-human primate models have proved harmful in humans. Hence, to analyze the relevance of animal research to human health, the efficacy of animal experimentation should be examined systematically [ 94 , 95 ]. At the same time, the development of hyperoxaluria and renal failure (up to dialysis) after ileal-jejunal bypass was unexpected because this procedure was not preliminarily evaluated on an animal model [ 96 ].

Several factors play a role in the extrapolation of animal-derived data to humans, such as environmental conditions and physiological parameters related to stress, age of the experimental animals, etc. These factors could switch on or off genes in the animal models that are specific to species and/or strains. All these observations challenge the reliability and suitability of animal experimentation as well as its objectives with respect to human health [ 76 , 92 ].

ALTERNATIVE TO ANIMAL EXPERIMENTATION/DEVELOPMENT OF NEW PRODUCTS AND TECHNIQUES TO AVOID ANIMAL SACRIFICE IN RESEARCH

Certainly, in vivo animal experimentation has significantly contributed to the development of biological and biomedical research. However it has the limitations of strict ethical issues and high production cost. Some scientists consider animal testing an ineffective and immoral practice and therefore prefer alternative techniques to be used instead of animal experimentation. These alternative methods involve in vitro experiments and ex vivo models like cell and tissue cultures, use of plants and vegetables, non-invasive human clinical studies, use of corpses for studies, use of microorganisms or other simpler organism like shrimps and water flea larvae, physicochemical techniques, educational software, computer simulations, mathematical models and nanotechnology [ 97 ]. These methods and techniques are cost-effective and could efficiently replace animal models. They could therefore, contribute to animal welfare and to the development of new therapies that can identify the therapeutics and related complications at an early stage [ 1 ].

The National Research Council (UK) suggested a shift from the animal models toward computational models, as well as high-content and high-throughput in vitro methods. Their reports highlighted that these alternative methods could produce predictive data more affordably, accurately and quickly than the traditional in vivo or experimental animal methods [ 98 ].

Increasingly, scientists and the review boards have to assess whether addressing a research question using the applied techniques of advanced genetics, molecular, computational and cell biology, and biochemistry could be used to replace animal experiments [ 59 ]. It must be remembered that each alternative method must be first validated and then registered in dedicated databases.

An additional relevant concern is how precisely animal data can mirror relevant epigenetic changes and human genetic variability. Langley and his colleagues have highlighted some of the examples of existing and some emerging non-animal based research methods in the advanced fields of neurology, orthodontics, infectious diseases, immunology, endocrine, pulmonology, obstetrics, metabolism and cardiology [ 99 ].

IN SILICO SIMULATIONS AND INFORMATICS

Several computer models have been built to study cardiovascular risk and atherosclerotic plaque build-up, to model human metabolism, to evaluate drug toxicity and to address other questions that were previously approached by testing in animals [ 100 ].

Computer simulations can potentially decrease the number of experiments required for a research project, however simulations cannot completely replace laboratory experiments. Unfortunately, not all the principles regulating biological systems are known, and computer simulation provide only an estimation of possible effects due to the limitations of computer models in comparison with complex human tissues. However, simulation and bio-informatics are now considered essential in all fields of science for their efficiency in using the existing knowledge for further experimental designs [ 76 ].

At present, biological macromolecules are regularly simulated at various levels of detail, to predict their response and behavior under certain physical conditions, chemical exposures and stimulations. Computational and bioinformatic simulations have significantly reduced the number of animals sacrificed during drug discovery by short listing potential candidate molecules for a drug. Likewise, computer simulations have decreased the number of animal experiments required in other areas of biological science by efficiently using the existing knowledge. Moreover, the development of high definition 3D computer models for anatomy with enhanced level of detail, it may make it possible to reduce or eliminate the need for animal dissection during teaching [ 101 , 102 ].

3D CELL-CULTURE MODELS AND ORGANS-ON-CHIPS

In the current scenario of rapid advancement in the life sciences, certain tissue models can be built using 3D cell culture technology. Indeed, there are some organs on micro-scale chip models used for mimicking the human body environment. 3D models of multiple organ systems such as heart, liver, skin, muscle, testis, brain, gut, bone marrow, lungs and kidney, in addition to individual organs, have been created in microfluidic channels, re-creating the physiological chemical and physical microenvironments of the body [ 103 ]. These emerging techniques, such as the biomedical/biological microelectromechanical system (Bio-MEMS) or lab-on-a-chip (LOC) and micro total analysis systems (lTAS) will, in the future, be a useful substitute for animal experimentation in commercial laboratories in the biotechnology, environmental safety, chemistry and pharmaceutical industries. For 3D cell culture modeling, cells are grown in 3D spheroids or aggregates with the help of a scaffold or matrix, or sometimes using a scaffold-free method. The 3D cell culture modeling conditions can be altered to add proteins and other factors that are found in a tumor microenvironment, for example, or in particular tissues. These matrices contain extracellular matrix components such as proteins, glycoconjugates and glycosaminoglycans that allow for cell communication, cell to cell contact and the activation of signaling pathways in such a way that the morphological and functional differentiation of these cells can accurately mimic their environment in vivo . This methodology, in time, will bridge the gap between in vivo and in vitro drug screening, decreasing the utilization of animal models during research [ 104 ].

ALTERNATIVES TO MICROBIAL CULTURE MEDIA AND SERUM-FREE ANIMAL CELL CULTURES

There are moves to reduce the use of animal derived products in many areas of biotechnology. Microbial culture media peptones are mostly made by the proteolysis of farmed animal meat. However, nowadays, various suppliers provide peptones extracted from yeast and plants. Although the costs of these plant-extracted peptones are the same as those of animal peptones, plant peptones are more environmentally favorable since less plant material and water are required for them to grow, compared with the food grain and fodder needed for cattle that are slaughtered for animal peptone production [ 105 ].

Human cell culture is often carried out in a medium that contains fetal calf serum, the production of which involves animal (cow) sacrifice or suffering. In fact, living pregnant cows are used and their fetuses removed to harvest the serum from the fetal blood. Fetal calf serum is used because it is a natural medium rich in all the required nutrients and significantly increases the chances of successful cell growth in culture. Scientists are striving to identify the factors and nutrients required for the growth of various types of cells, with a view to eliminating the use of calf serum. At present, most cell lines could be cultured in a chemically-synthesized medium without using animal products. Furthermore, data from chemically-synthesized media experiments may have better reproducibility than those using animal serum media, since the composition of animal serum does change from batch to batch on the basis of animals’ gender, age, health and genetic background [ 76 ].

ALTERNATIVES TO ANIMAL-DERIVED ANTIBODIES

Animal friendly affinity reagents may act as an alternative to antibodies produced, thereby removing the need for animal immunization. Typically, these antibodies are obtained in vitro by yeast, phage or ribosome display. In a recent review, a comparative analysis between animal friendly affinity reagents and animal derived-antibodies showed that the affinity reagents have superior quality, are relatively less time consuming, have more reproducibility and are more reliable and are cost-effective [ 106 , 107 ].

Conclusions

Animal experimentation led to great advancement in biological and biomedical sciences and contributed to the discovery of many drugs and treatment options. However, such experimentation may cause harm, pain and distress to the animals involved. Therefore, to perform animal experimentations, certain ethical rules and laws must be strictly followed and there should be proper justification for using animals in research projects. Furthermore, during animal experimentation the 4 Rs principles of reduction, refinement, replacement and responsibility must be followed by the researchers. Moreover, before beginning a research project, experiments should be thoroughly planned and well-designed, and should avoid unnecessary use of animals. The reliability and reproducibility of animal experiments should also be considered. Whenever possible, alternative methods to animal experimentation should be adopted, such as in vitro experimentation, cadaveric studies, and computer simulations.

While much progress has been made on reducing animal experimentation there is a need for greater awareness of alternatives to animal experiments among scientists and easier access to advanced modeling technologies. Greater research is needed to define a roadmap that will lead to the elimination of all unnecessary animal experimentation and provide a framework for adoption of reliable alternative methodologies in biomedical research.

Acknowledgements

This research was funded by the Provincia Autonoma di Bolzano in the framework of LP 15/2020 (dgp 3174/2021).

Conflicts of interest statement

Authors declare no conflict of interest.

Author's contributions

MB: study conception, editing and critical revision of the manuscript; AKK, DP, GH, RB, Paul S, Peter S, RM, BF, NC, SM, LL, DD, GMT, MCE, MD, SM, Daniele M, GB, AD, KD, MCM, TB, MS, STC, Donald M, AM, AB, KLH, MK, LS, LL, GF: literature search, editing and critical revision of the manuscript. All authors have read and approved the final manuscript.

Contributor Information

INTERNATIONAL BIOETHICS STUDY GROUP : Derek Pheby , Gary Henehan , Richard Brown , Paul Sieving , Peter Sykora , Robert Marks , Benedetto Falsini , Natale Capodicasa , Stanislav Miertus , Lorenzo Lorusso , Gianluca Martino Tartaglia , Mahmut Cerkez Ergoren , Munis Dundar , Sandro Michelini , Daniele Malacarne , Tommaso Beccari , Michele Samaja , Matteo Bertelli , Donald Martin , Assunta Morresi , Ariola Bacu , Karen L. Herbst , Mykhaylo Kapustin , Liborio Stuppia , Ludovica Lumer , and Giampietro Farronato

Animal Testing and Environmental Protection Essay

Introduction, animal testing is obsolete, progress has its price, animal testing is necessary, individualism beats environmentalism, conclusions.

The use of animals in biomedical research has a long history alongside the ongoing debates regarding the ethics of experimentation on animals. With the increasing popularity of domestic pets, the moral consensus surrounding the use of animals in biomedical studies has become less clear. While the proponents of animal use in research argued that the sacrifice of animals’ lives is crucial for advancing the sphere of medicine, the argument this essay will defend relates to the availability of modern and humane non-animal research methods that have become faster, cheaper, and more accurate, thus making animal testing obsolete.

The discussion about the preservation of the environment and natural resources goes hand-in-hand with the issue of animal use in biomedical research since both of them are associated with “destroying” something that was not created by humans in the first place, making either pro or against arguments even more complex. Despite the fact that the majority of anti-environmentalists argue that nature is just a resource for living, the discoveries made by modern scientists suggest that the abuse of natural resources will be worth a lot in the future.

In this paper, I will argue against the usage of animals in biomedical research as well as to oppose the devastation of natural resources for the sake of industrialization and globalization. The paper will be divided into the following sections: the elaboration on the thesis statement (animal testing is obsolete, and there are consequences of destroying the environment), the presentation of the counter-arguments for the thesis (progress is impossible without animal testing and the usage of natural resources), and making conclusions by forming an objection to the counter-arguments.

For many, the opposition of animal testing in biomedical research has become synonymous with common sense (LaFollette, 2014) because of the availability of alternatives that could potentially be more reliable. For example, the newly developed Vitro testing (Harvard’s Wyss Institute) allowed researchers to use “organs-on-chips” with human cells for mimicking the function and the responses of human systems of organs. The chips have been shown to be more effective in replicating human diseases, responses to drugs, and physiology compared to animal experiments. Currently, companies are working on turning the “organs-on-chips” into accessible products that scientists can use in their research thus making animal testing unnecessary and obsolete.

Despite the fact that the proponents of animal testing in biomedical research may argue that animals do not have the same moral rights as humans and thus should not be excluded from experiments, it is important to note that the relationships between animals and humans have dramatically evolved. With animals becoming members of millions of families across the globe, it is becoming more and more difficult to agree with the viewpoint that animal testing can bring more benefits than harm (Hajar, 2011). Furthermore, there is a certain level of moral responsibility that lies on the shoulders of humans to protect species that cannot protect themselves. From the efforts to increase the population of giant pandas to the prevention of oil spills in the places of penguin inhabitance, humans are responsible for protecting those that suffer from the devastating effects of globalization.

The preservation of natural resources and environmental sustainability ties in with the protection of animals against human-made threats. Environmentalists may argue that those who continuously contribute to the destruction of nature and the devastation of resources do not value their place in the universe and lack the perspective of looking at themselves as parts of nature (Sandler, 2014) rather than its mere users. This idea is associated with the fact that too many people possess enough knowledge about the negative impact of their activities as well as the implications of the destruction of nature but brush it off with the thought that someone else would do everything for them. Lack of appreciation for one’s place in the natural environment dies not simply mean that a human being should be intellectually appreciative (Sandler, 2014); rather, the appreciation should be reflected in one’s attitude towards nature and the respect for the abundance of resources it provides to humans.

With air pollution indicators in large cities exceeding the norm and with sea level being the highest it has ever been, the argument supporting the exhaustion of the environment for the sake of human progress becomes invalid. What so many anti-environmentalists fail to take into consideration is that there would be a time when the planet’s citizens will encounter human-caused natural disasters so severe, that no money on the planet will be enough to restore the damage. While the Earth provides so many people with resources for life, there is no “giving back” on the part of humans to minimize the impact of resource devastation.

To oppose the view that experiments on animals are unethical and obsolete in this day and age, some scientists argued that the animal rights movement which opposes the usage of animals in biomedical research presents a threat to continuous discovery and the development of new medication, treatments, and prevention practices for a broad range of conditions and illnesses. The argument for the use of animals in research stands on the idea that animals have no rights (Cohen, 2014). In this context, the concept of right refers to a claim that a party exercises against another, making them intelligibly defendable among beings that can make moral claims against one another. Animals do not have such ability nor do they have enough capacity for independent moral judgment; thus, they have no right to exercise against humans. While humans owe a degree of proper regard to other humans, they cannot have the same attitude towards other species that do not have the same level of moral autonomy (Cohen, 2014). Although this argument may be classified as “speciesist” (Cohen, 2014), the proponents of animal testing in biomedical research state that it is necessary to be a speciesist to make morally relevant distinctions between animals and human beings.

Despite the fact that the opponents of animal testing contend that the benefits for human beings rarely justify the harm caused to animals (Hajar, 2011), it is important to remember that no biomedical research without the use of animals was successful and innovative enough to get awarded a Noble Prize. The crucial role of animals in research can be illustrated by the example of Dr. Thomas Starzl (2012) who pioneered kidney and liver transplants. By using dogs in his studies, he managed to figure out the patterns of his techniques that allowed some animals to survive operations, leading to the last group of subjects to survive completely (Starzl, 2012). Most notably, the last group was made up of human babies. Had he not tested on dogs, Starzl could have been responsible for the deaths of children. Yet the animal rights activists claim that animal testing is unethical.

Many anti-environmentalists may argue that nature exists for the sake of being used and enjoyed by humans who constitute the pinnacle of development. To counter the position held by many nature activists and idealists, the proponents of the individualistic view on the usage of natural resources state that any limitations would impede the further development of the humankind. While today not many can argue against the importance of preservation of nature and its resources, there is a view that environmentalism does not take into account the legacy of individualism that lies in the requirements and principles of human life on earth. Despite the fact that environmentalism has been falsely accused of being junk science, it rather rests on junk philosophy that lacks the understanding of the moral value of human life and well-being.

Overcoming self-importance and individualism can be challenged by the idea that there may be other ways of developing humility and respect for nature (Schmidtz, 2014). It is important to note that an anti-environmentalist may value and enjoy nature in the same way as everybody else; however, he or she does not see any connections to preserving it independently from human enjoyment (Schmidtz, 2014). From the perspective of logic, anti-environmentalists take into consideration the benefits and costs of preserving natural resources, like, for example, maintaining a park or planting a garden. Environmentalists, on the other hand, rarely make a cost-benefit analysis arguing that no money is worth the destruction of nature, which is a point that lacks a logical perspective and is too idealistic.

The ethical discussion about animal testing in biomedical research rested on two arguments: technologies made animal usage obsolete and no progress is possible without animal testing. Nevertheless, with the current state of technologies and the development of fresh and innovative perspectives on biomedical research, the public may soon witness a Nobel Prize given to scientists that did not resort to animal testing. Reliability and cost-effectiveness cannot be fully associated with animal testing (LaFollette, 2014) since there are differences in the way human and animal organisms respond to diseases and their treatments. While there could be some exceptions to the rule, in the majority of instances, animal testing can be substituted for other methods of experimentation in biomedical research, as shown by the example of “organs-on-chips” developed at Harvard’s Wyss Institute.

With regards to the exhaustion of natural resources and the preservation of the environment, there is some logic in the cost-benefit analysis of maintaining environmental sustainability; however, if humans choose to withhold from paying for it today, it is possible that no money could save the nature in the future. The individualistic views that focus on the wellbeing of humans rarely take into account the consequences of progress and development with regards to how the environment could transform. Therefore, while the comfortable life of human beings on this planet is important, there should be some boundaries set on the extent to which we all can “enjoy” the resources provided by nature.

Cohen, C. (2014). The case for the use of animals in biomedical research. In H. LaFollette (Ed.), Ethics in practice: An anthology (pp. 198-203). Chichester, UK: John Wiley & Sons.

Hajar, R. (2011). Animal testing and medicine. Heart Views, 12 (1), 42.

LaFollette, H. (2014). Why Cohen is mistaken. In H. LaFollette (Ed.), Ethics in practice: An anthology (pp. 204-214). Chichester, UK: John Wiley & Sons.

Sandler, R. (2014). The value of nature. In H. LaFollette (Ed.), Ethics in practice: An anthology (pp. 594-601). Chichester, UK: John Wiley & Sons.

Schmidtz, D. (2014). A place for cost-benefit analysis. In H. LaFollette (Ed.), Ethics in practice: An anthology (pp. 602-610). Chichester, UK: John Wiley & Sons.

Starzl, T. (2012). The long reach of liver transplantation. Nature Medicine, 18 (10), 19-22.

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1. IvyPanda . "Animal Testing and Environmental Protection." September 16, 2020. https://ivypanda.com/essays/animal-testing-and-environmental-protection/.

Bibliography

IvyPanda . "Animal Testing and Environmental Protection." September 16, 2020. https://ivypanda.com/essays/animal-testing-and-environmental-protection/.

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• Anthropocentrism vs Biocentrism in Environmentalism
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• The Rise of Environmentalism in Australia
• Environmentalism and Human Behavior: A Literature Review
• Environmentalism: The Role of Design Activism
• The Concept of Environmentalism: Review of Studies
• Natural Gas and Environmentalists Views
• Animal Testing for Scientific Research
• Animal Rights Protection in the United States
• Food Production and Animals Suffering
• The Animal Rights and Welfare Debates
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Arguments against animal testing

Animal experiments are cruel, unreliable, and even dangerous

The harmful use of animals in experiments is not only cruel but also often ineffective. Animals do not naturally get many of the diseases that humans do, such as major types of heart disease, many types of cancer, HIV, Parkinson’s disease or schizophrenia. Instead, signs of these diseases are artificially induced in animals in laboratories in an attempt to mimic the human disease. Yet, such experiments belittle the complexity of human conditions which are affected by wide-ranging variables such as genetics, socio-economic factors, deeply-rooted psychological issues and different personal experiences.

It is not surprising to find that treatments showing “promise” in animals rarely work in humans.  Not only are time, money and animals’ lives being wasted (with a huge amount of suffering), but effective treatments are being mistakenly discarded and harmful treatments are getting through. The support for animal testing is based largely on anecdote and is not backed up, we believe, by the scientific evidence that is out there.

Despite many decades of studying cancer, Alzheimer’s disease, Parkinson’s disease, diabetes, stroke and AIDS in animals, none of these conditions have reliable and fully effective cures and some don’t even have effective treatments.

The history of cancer research has been the history of curing cancer in the mouse. We have cured mice of cancer for decades and it simply didn’t work in human beings.

Unreliable animal testing

• 92% of drugs fail in human clinical trials despite appearing safe and effective in animal tests, often on safety grounds or because they do not work.
• Urology drugs have the lowest success rate (only 4% are approved after entering clinical trials) followed by heart drugs (5% success rate), cancer drugs (5% success rate) and neurology drugs (6% success rate).
• Our research has shown that using dogs, rats, mice and rabbits to test whether or not a drug will be safe for humans provides statistically little useful insight. Our study also revealed that drug tests on monkeys are just as poor as those using any other species in predicting the effects on humans.
• A recent study found that out of 93 dangerous drug side effects, only 19% could have been predicted by animal tests.
• Another study showed that over 1,000 potential stroke treatments have been “successful” in animal tests, but of the approximately 10% that progressed to human trials, none worked sufficiently well in humans.
• One review of 101 high impact discoveries based on basic animal experiments found that only 5% resulted in approved treatments within 20 years. More recently, we conducted an analysis of 27 key animal-based ‘breakthroughs ’ that had been reported by the UK press 25 years earlier. Mirroring the earlier study, we found only one of the 27 “breakthroughs” had been realised in humans, and that was subject to several caveats.

Dangerous animal testing

• Vioxx, a drug used to treat arthritis, was found to be safe when tested in monkeys (and five other animal species) but has been estimated to have caused around 140,000 heart attacks and strokes and 60,000 deaths worldwide.
• Human volunteers testing a new monoclonal antibody treatment (TGN1412) at Northwick Park Hospital, UK, in 2006 suffered a severe immune reaction and nearly died. Testing on monkeys at 500 times the dose given to the volunteers totally failed to predict the dangerous side effects.
• A drug trial in France resulted in the death of one volunteer and left four others severely brain damaged in 2016. The drug, which was intended to treat a wide range of conditions including anxiety and Parkinson’s disease, was tested in four different species of animals (mice, rats, dogs and monkeys) before being given to humans.
• A clinical trial of Hepatitis B drug fialuridine had to be stopped because it caused severe liver damage in seven patients, five of whom died. It had been tested on animals first.

Animals are different

• Animals do not get many of the diseases we do, such as Parkinson’s disease, major types of heart disease, many types of cancer, Alzheimer’s disease, HIV or schizophrenia.
• An analysis of over 100 mouse cell types found that only 50% of the DNA responsible for regulating genes in mice could be matched with human DNA.
• The most commonly used species of monkey to test drug safety (Cynomolgous macaque monkeys) is resistant to doses of paracetamol (acetaminophen) that would be deadly in humans.
• Chocolate, grapes, raisins, avocados and macadamia nuts are harmless in humans but toxic to dogs.
• Aspirin is toxic to many animals and would not be on our pharmacy shelves if it had been tested according to current animal testing standards.

The science relating to animal experiments can be extremely complicated and views often differ. What appears on this website represents Cruelty Free International expert opinion, based on a thorough assessment of the evidence.

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subtitle: Established in 1898, Cruelty Free International is firmly rooted in the early social justice movement and has a long and inspiring history.

Animals used in laboratories are deliberately harmed, not for their own good, and are usually killed at the end of the experiment.

What is animal testing?

subtitle: Animals used in laboratories are deliberately harmed, not for their own good, and are usually killed at the end of the experiment.

Animal testing is carried out in a wide range of areas, including biological research, and testing medicines and chemicals.

Types of animal testing

subtitle: Animal testing is carried out in a wide range of areas, including biological research, and testing medicines and chemicals.

Millions of animals are used and killed in the name of progress every year.

Facts and figures on animal testing

subtitle: Millions of animals are used and killed in the name of progress every year.

Science Publications