"This is an important step towards the kind of research into disease mechanisms that, across the history of medicine, has underwritten successful therapeutics." Big study, big effect. Bipolar disorder is a severe, heritable mood disorder that affects approximately 1 percent of people and often begins in early adulthood.
Bipolar Disorder Clinical Trials
The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression. Rochester, MN. The purpose of this research study is to find out if the medication known as ketamine can help the symptoms of depression. This drug is approved by the Food and ...
Genomic Data From More Than 41,000 People Shed New Light on Bipolar
September 29, 2021 • Research Highlight. In the largest genome-wide association study of bipolar disorder to date, researchers found about twice as many genetic locations associated with bipolar disorder as reported in previous studies.
Genetic contributions to bipolar disorder: current status and future
Bipolar disorder is a complex and heritable psychiatric condition that affects millions of people worldwide. This article reviews the current knowledge on the genetic factors that contribute to bipolar disorder, and discusses the challenges and opportunities for future research. The article also explores the implications of genetic findings for the diagnosis, treatment and prevention of ...
Articles
The aim of this study was to examine differences between patients with bipolar I a... Giulio Emilio Brancati, Abraham Nunes, Katie Scott, Claire O'Donovan, Pablo Cervantes, Paul Grof and Martin Alda. International Journal of Bipolar Disorders 2023 11 :25. Research Published on: 14 July 2023.
Current Studies
Call or text (650) 600-1609 or email [email protected]. Having Sleep Problems? Insomnia Related to Bipolar Disorder Study at VA Palo Alto Healthcare System. People with bipolar disorder (manic depression) often have trouble sleeping. This can lead to worsening problems with mood and functioning.
Diagnosis and management of bipolar disorders
Bipolar disorder is a recurrent illness, but its longitudinal course is heterogeneous and difficult to predict.46 66 The few available long term studies of BD-I and BD-II have found a consistent average rate of recurrence of 0.40 mood episodes per year in historical studies67 and 0.44 mood episodes per year in more recent studies.68 The median ...
Epidemiology and risk factors for bipolar disorder
The aetiology of bipolar is not well understood and research into the disorder lags behind disorders such as psychosis. ... Epidemiology of bipolar disorder. Epidemiological studies have suggested a lifetime prevalence of around 1% for bipolar type I in the general population. 54,55 A large cross-sectional survey of 11 countries found the ...
Genome-wide association study of more than 40,000 bipolar disorder
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which ...
Bipolar disorder
Human and animal studies reveal a neurobiological pathway that connects polygenic risks and behavioural changes that are shared between schizophrenia and bipolar mood disorder. Jake Rogers ...
Treatment for Bipolar Disorder in Adults: A Systematic Review
Results: We synthesized evidence from 157 unique studies, 108 studies for 28 drugs, 49 studies for nondrug interventions. All drug study findings with at least low-strength evidence were based almost exclusively on adults with bipolar I disorder (BD-I).Asenapine, cariprazine, quetiapine, and olanzapine improved acute mania symptoms compared to placebo (low-strength evidence).
Bipolar Research
The Bipolar and Depression Research Program is a clinical research program focused on treatment of individuals with bipolar and major depressive disorders directed by Drs. Trisha Suppes and ... All studies are open to the general public as well as veterans and active duty military personnel. Our research focuses on Bipolar Disorder, including ...
The challenges of living with bipolar disorder: a qualitative study of
To bridge the gap between research and clinical practice, patients' perspectives should be used in health care and research. This study aimed to understand the challenges people with bipolar disorder (BD) experience and examine what these challenges imply for health care and research needs. Two qualitative studies were used, one to formulate ...
Bipolar Disorder
Bipolar disorder (formerly called manic-depressive illness or manic depression) is a mental illness that causes unusual shifts in a person's mood, energy, activity levels, and concentration. These shifts can make it difficult to carry out day-to-day tasks. There are three types of bipolar disorder. All three types involve clear changes in ...
About Us
At her time with the clinic, Ms. Robbins has worked on multiple research studies on Bipolar and Depression. Currently Ms. Robbins is the lead study coordinator for a study on Posttraumatic Stress Disorder (PTSD); a Smoking cessation in individuals with Bipolar Disorder, and is a coordinator on a genomic trials of veterans with depression.
Current Research Studies
This research study is to evaluate if educational and motivational text messages might help patients take their medication for high blood pressure and bipolar disorder more regularly. Participants must have bipolar disorder and high blood pressure, be between the ages of 21 and 80, have a cell phone, take medication for high blood pressure, and ...
Immunogenetics of lithium response and psychiatric phenotypes ...
The link between bipolar disorder (BP) and immune dysfunction remains controversial. While epidemiological studies have long suggested an association, recent research has found only limited ...
New Research into Treatment for Bipolar Depression
Psychiatry researchers are embarking on a pilot study to see if a novel form of transcranial magnetic stimulation (TMS) can yield more rapid improvements for patients with treatment-resistant depression in the setting of a bipolar 1 disorder diagnosis. TMS is a noninvasive method of brain stimulation that uses an insulated coil placed over the ...
New Research Looks at Link Between Cortisol and Mood Timescales in
Bipolar disorder is marked by fluctuating mood states over months to years. Which biological mechanism can give rise to these long fluctuations is not well understood. In a recent study, researchers combined longitudinal hair cortisol, individual hair cortisol measurements over a year, and mood measurements with mathematical modeling to provide a potential link between
Bipolar depression: a major unsolved challenge
Current status of depression in bipolar disorder. Depression in bipolar disorder (BD) is the major residual psychiatric morbidity with available treatments, accounting for three-quarters of the 40-50% long-term time-ill. Unresolved morbidity, and especially depression, is associated with excess medical morbidity, including metabolic syndrome ...
Bipolar Disorder Clinical Trials & Research Studies Near You (Updated 3/24)
A listing of 56 Bipolar Disorder clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas. There are currently 56 active clinical trials seeking participants for Bipolar Disorder research studies. The states with the highest number of trials for Autism participants are California, Florida ...
Adults: Bipolar Disorder
Enrolling nationally from around the country. National Institute of Mental Health (NIMH) researchers seek adults 18 to 70, who have a history of attempted suicide but are not currently suicidal, for a study of suicide and brain function. Participation includes up to seven days as an inpatient at the NIH Clinical Center in Bethesda, Maryland.
Diagnostic conversion to bipolar disorder among adolescents ...
Although several studies have examined a diagnostic conversion from major depressive disorder (MDD) to bipolar disorder (BD), only a few studies specifically focused on adolescents and young adults who are at the peak ages of BD onset. Data from participants (N = 130,793) aged 10-29 years who were diagnosed with MDD were extracted from the Taiwan National Health Insurance Research Database ...
Episode 2: Exploring Cognition in Patients With Bipolar Disorder
Functionality is a little better in bipolar II from the large Swedish studies, for example, though. ... How Patient-Centered Research Is Transforming Bipolar Disorder Care and Dispelling Stigma;
Participate in Research
The Bipolar Disorders Clinic is a research clinic, and patients generally participate in one or more studies. Criteria for participating in research are the same as that for becoming a patient. Being part of a research clinic provides patients access to the latest treatments, some of which may not yet be generally available.
The Emerging Neurobiology of Bipolar Disorder
Abstract. Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the disease process and as a drug target.
Disclosing Bipolar Disorder in Romantic Relationships
Interpersonal communication is central to the experience of illness for individuals and their relational partners (Hogan & Brashers, 2009). As such, many studies have explored the theoretical and p...
Associations between breakfast skipping and outcomes in
Utilizing data from genome-wide association studies within European demographics, this research scrutinized the association between breakfast habits and several neuropsychiatric conditions and physical health outcomes, including Alzheimer's disease (AD), Attention Deficit Hyperactivity Disorder (ADHD), Bipolar Disorder (BD), Major Depressive ...
New study finds mental health emergencies in kids were more severe
Credit: Pixabay/CC0 Public Domain. A new study has found that during the pandemic pediatric emergency departments (EDs) saw more children and adolescents who needed a psychiatric admission, as ...
Current research in child and adolescent bipolar disorder
The lifetime prevalence of a bipolar spectrum disorder in adults has been estimated to be approximately 4.5%, with subsyndromal bipolar disorders being more prevalent (2.4%) than Bipolar I Disorder (BP-I) or Bipolar II Disorder (BP-II). 6 Epidemiological studies have found bipolar spectrum disorders to be present in approximately 0.1% to 1% of ...
COMMENTS
"This is an important step towards the kind of research into disease mechanisms that, across the history of medicine, has underwritten successful therapeutics." Big study, big effect. Bipolar disorder is a severe, heritable mood disorder that affects approximately 1 percent of people and often begins in early adulthood.
The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression. Rochester, MN. The purpose of this research study is to find out if the medication known as ketamine can help the symptoms of depression. This drug is approved by the Food and ...
September 29, 2021 • Research Highlight. In the largest genome-wide association study of bipolar disorder to date, researchers found about twice as many genetic locations associated with bipolar disorder as reported in previous studies.
Bipolar disorder is a complex and heritable psychiatric condition that affects millions of people worldwide. This article reviews the current knowledge on the genetic factors that contribute to bipolar disorder, and discusses the challenges and opportunities for future research. The article also explores the implications of genetic findings for the diagnosis, treatment and prevention of ...
The aim of this study was to examine differences between patients with bipolar I a... Giulio Emilio Brancati, Abraham Nunes, Katie Scott, Claire O'Donovan, Pablo Cervantes, Paul Grof and Martin Alda. International Journal of Bipolar Disorders 2023 11 :25. Research Published on: 14 July 2023.
Call or text (650) 600-1609 or email [email protected]. Having Sleep Problems? Insomnia Related to Bipolar Disorder Study at VA Palo Alto Healthcare System. People with bipolar disorder (manic depression) often have trouble sleeping. This can lead to worsening problems with mood and functioning.
Bipolar disorder is a recurrent illness, but its longitudinal course is heterogeneous and difficult to predict.46 66 The few available long term studies of BD-I and BD-II have found a consistent average rate of recurrence of 0.40 mood episodes per year in historical studies67 and 0.44 mood episodes per year in more recent studies.68 The median ...
The aetiology of bipolar is not well understood and research into the disorder lags behind disorders such as psychosis. ... Epidemiology of bipolar disorder. Epidemiological studies have suggested a lifetime prevalence of around 1% for bipolar type I in the general population. 54,55 A large cross-sectional survey of 11 countries found the ...
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which ...
Human and animal studies reveal a neurobiological pathway that connects polygenic risks and behavioural changes that are shared between schizophrenia and bipolar mood disorder. Jake Rogers ...
Results: We synthesized evidence from 157 unique studies, 108 studies for 28 drugs, 49 studies for nondrug interventions. All drug study findings with at least low-strength evidence were based almost exclusively on adults with bipolar I disorder (BD-I).Asenapine, cariprazine, quetiapine, and olanzapine improved acute mania symptoms compared to placebo (low-strength evidence).
The Bipolar and Depression Research Program is a clinical research program focused on treatment of individuals with bipolar and major depressive disorders directed by Drs. Trisha Suppes and ... All studies are open to the general public as well as veterans and active duty military personnel. Our research focuses on Bipolar Disorder, including ...
To bridge the gap between research and clinical practice, patients' perspectives should be used in health care and research. This study aimed to understand the challenges people with bipolar disorder (BD) experience and examine what these challenges imply for health care and research needs. Two qualitative studies were used, one to formulate ...
Bipolar disorder (formerly called manic-depressive illness or manic depression) is a mental illness that causes unusual shifts in a person's mood, energy, activity levels, and concentration. These shifts can make it difficult to carry out day-to-day tasks. There are three types of bipolar disorder. All three types involve clear changes in ...
At her time with the clinic, Ms. Robbins has worked on multiple research studies on Bipolar and Depression. Currently Ms. Robbins is the lead study coordinator for a study on Posttraumatic Stress Disorder (PTSD); a Smoking cessation in individuals with Bipolar Disorder, and is a coordinator on a genomic trials of veterans with depression.
This research study is to evaluate if educational and motivational text messages might help patients take their medication for high blood pressure and bipolar disorder more regularly. Participants must have bipolar disorder and high blood pressure, be between the ages of 21 and 80, have a cell phone, take medication for high blood pressure, and ...
The link between bipolar disorder (BP) and immune dysfunction remains controversial. While epidemiological studies have long suggested an association, recent research has found only limited ...
Psychiatry researchers are embarking on a pilot study to see if a novel form of transcranial magnetic stimulation (TMS) can yield more rapid improvements for patients with treatment-resistant depression in the setting of a bipolar 1 disorder diagnosis. TMS is a noninvasive method of brain stimulation that uses an insulated coil placed over the ...
Bipolar disorder is marked by fluctuating mood states over months to years. Which biological mechanism can give rise to these long fluctuations is not well understood. In a recent study, researchers combined longitudinal hair cortisol, individual hair cortisol measurements over a year, and mood measurements with mathematical modeling to provide a potential link between
Current status of depression in bipolar disorder. Depression in bipolar disorder (BD) is the major residual psychiatric morbidity with available treatments, accounting for three-quarters of the 40-50% long-term time-ill. Unresolved morbidity, and especially depression, is associated with excess medical morbidity, including metabolic syndrome ...
A listing of 56 Bipolar Disorder clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas. There are currently 56 active clinical trials seeking participants for Bipolar Disorder research studies. The states with the highest number of trials for Autism participants are California, Florida ...
Enrolling nationally from around the country. National Institute of Mental Health (NIMH) researchers seek adults 18 to 70, who have a history of attempted suicide but are not currently suicidal, for a study of suicide and brain function. Participation includes up to seven days as an inpatient at the NIH Clinical Center in Bethesda, Maryland.
Although several studies have examined a diagnostic conversion from major depressive disorder (MDD) to bipolar disorder (BD), only a few studies specifically focused on adolescents and young adults who are at the peak ages of BD onset. Data from participants (N = 130,793) aged 10-29 years who were diagnosed with MDD were extracted from the Taiwan National Health Insurance Research Database ...
Functionality is a little better in bipolar II from the large Swedish studies, for example, though. ... How Patient-Centered Research Is Transforming Bipolar Disorder Care and Dispelling Stigma;
The Bipolar Disorders Clinic is a research clinic, and patients generally participate in one or more studies. Criteria for participating in research are the same as that for becoming a patient. Being part of a research clinic provides patients access to the latest treatments, some of which may not yet be generally available.
Abstract. Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown, and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the discovery of risk genes and their implications, with a focus on voltage-gated calcium channels as part of the disease process and as a drug target.
Interpersonal communication is central to the experience of illness for individuals and their relational partners (Hogan & Brashers, 2009). As such, many studies have explored the theoretical and p...
Utilizing data from genome-wide association studies within European demographics, this research scrutinized the association between breakfast habits and several neuropsychiatric conditions and physical health outcomes, including Alzheimer's disease (AD), Attention Deficit Hyperactivity Disorder (ADHD), Bipolar Disorder (BD), Major Depressive ...
Credit: Pixabay/CC0 Public Domain. A new study has found that during the pandemic pediatric emergency departments (EDs) saw more children and adolescents who needed a psychiatric admission, as ...
The lifetime prevalence of a bipolar spectrum disorder in adults has been estimated to be approximately 4.5%, with subsyndromal bipolar disorders being more prevalent (2.4%) than Bipolar I Disorder (BP-I) or Bipolar II Disorder (BP-II). 6 Epidemiological studies have found bipolar spectrum disorders to be present in approximately 0.1% to 1% of ...