biotechnology dissertation 2023

Research Topics & Ideas

Biotechnology and Genetic Engineering

If you’re just starting out exploring biotechnology-related topics for your dissertation, thesis or research project, you’ve come to the right place. In this post, we’ll help kickstart your research topic ideation process by providing a hearty list of research topics and ideas , including examples from recent studies.

PS – This is just the start…

We know it’s exciting to run through a list of research topics, but please keep in mind that this list is just a starting point . To develop a suitable research topic, you’ll need to identify a clear and convincing research gap , and a viable plan  to fill that gap.

If this sounds foreign to you, check out our free research topic webinar that explores how to find and refine a high-quality research topic, from scratch. Alternatively, if you’d like hands-on help, consider our 1-on-1 coaching service .

Biotechnology Research Topic Ideas

Below you’ll find a list of biotech and genetic engineering-related research topics ideas. These are intentionally broad and generic , so keep in mind that you will need to refine them a little. Nevertheless, they should inspire some ideas for your project.

• Developing CRISPR-Cas9 gene editing techniques for treating inherited blood disorders.
• The use of biotechnology in developing drought-resistant crop varieties.
• The role of genetic engineering in enhancing biofuel production efficiency.
• Investigating the potential of stem cell therapy in regenerative medicine for spinal cord injuries.
• Developing gene therapy approaches for the treatment of rare genetic diseases.
• The application of biotechnology in creating biodegradable plastics from plant materials.
• The use of gene editing to enhance nutritional content in staple crops.
• Investigating the potential of microbiome engineering in treating gastrointestinal diseases.
• The role of genetic engineering in vaccine development, with a focus on mRNA vaccines.
• Biotechnological approaches to combat antibiotic-resistant bacteria.
• Developing genetically engineered organisms for bioremediation of polluted environments.
• The use of gene editing to create hypoallergenic food products.
• Investigating the role of epigenetics in cancer development and therapy.
• The application of biotechnology in developing rapid diagnostic tools for infectious diseases.
• Genetic engineering for the production of synthetic spider silk for industrial use.
• Biotechnological strategies for improving animal health and productivity in agriculture.
• The use of gene editing in creating organ donor animals compatible with human transplantation.
• Developing algae-based bioreactors for carbon capture and biofuel production.
• The role of biotechnology in enhancing the shelf life and quality of fresh produce.
• Investigating the ethics and social implications of human gene editing technologies.
• The use of CRISPR technology in creating models for neurodegenerative diseases.
• Biotechnological approaches for the production of high-value pharmaceutical compounds.
• The application of genetic engineering in developing pest-resistant crops.
• Investigating the potential of gene therapy in treating autoimmune diseases.
• Developing biotechnological methods for producing environmentally friendly dyes.

Biotech & GE Research Topic Ideas (Continued)

• The use of genetic engineering in enhancing the efficiency of photosynthesis in plants.
• Biotechnological innovations in creating sustainable aquaculture practices.
• The role of biotechnology in developing non-invasive prenatal genetic testing methods.
• Genetic engineering for the development of novel enzymes for industrial applications.
• Investigating the potential of xenotransplantation in addressing organ donor shortages.
• The use of biotechnology in creating personalised cancer vaccines.
• Developing gene editing tools for combating invasive species in ecosystems.
• Biotechnological strategies for improving the nutritional quality of plant-based proteins.
• The application of genetic engineering in enhancing the production of renewable energy sources.
• Investigating the role of biotechnology in creating advanced wound care materials.
• The use of CRISPR for targeted gene activation in regenerative medicine.
• Biotechnological approaches to enhancing the sensory qualities of plant-based meat alternatives.
• Genetic engineering for improving the efficiency of water use in agriculture.
• The role of biotechnology in developing treatments for rare metabolic disorders.
• Investigating the use of gene therapy in age-related macular degeneration.
• The application of genetic engineering in developing allergen-free nuts.
• Biotechnological innovations in the production of sustainable and eco-friendly textiles.
• The use of gene editing in studying and treating sleep disorders.
• Developing biotechnological solutions for the management of plastic waste.
• The role of genetic engineering in enhancing the production of essential vitamins in crops.
• Biotechnological approaches to the treatment of chronic pain conditions.
• The use of gene therapy in treating muscular dystrophy.
• Investigating the potential of biotechnology in reversing environmental degradation.
• The application of genetic engineering in improving the shelf life of vaccines.
• Biotechnological strategies for enhancing the efficiency of mineral extraction in mining.

Recent Biotech & GE-Related Studies

While the ideas we’ve presented above are a decent starting point for finding a research topic in biotech, they are fairly generic and non-specific. So, it helps to look at actual studies in the biotech space to see how this all comes together in practice.

Below, we’ve included a selection of recent studies to help refine your thinking. These are actual studies,  so they can provide some useful insight as to what a research topic looks like in practice.

• Genetic modifications associated with sustainability aspects for sustainable developments (Sharma et al., 2022)
• Review On: Impact of Genetic Engineering in Biotic Stresses Resistance Crop Breeding (Abebe & Tafa, 2022)
• Biorisk assessment of genetic engineering — lessons learned from teaching interdisciplinary courses on responsible conduct in the life sciences (Himmel et al., 2022)
• Genetic Engineering Technologies for Improving Crop Yield and Quality (Ye et al., 2022)
• Legal Aspects of Genetically Modified Food Product Safety for Health in Indonesia (Khamdi, 2022)
• Innovative Teaching Practice and Exploration of Genetic Engineering Experiment (Jebur, 2022)
• Efficient Bacterial Genome Engineering throughout the Central Dogma Using the Dual-Selection Marker tetAOPT (Bayer et al., 2022)
• Gene engineering: its positive and negative effects (Makrushina & Klitsenko, 2022)
• Advances of genetic engineering in streptococci and enterococci (Kurushima & Tomita, 2022)
• Genetic Engineering of Immune Evasive Stem Cell-Derived Islets (Sackett et al., 2022)
• Establishment of High-Efficiency Screening System for Gene Deletion in Fusarium venenatum TB01 (Tong et al., 2022)
• Prospects of chloroplast metabolic engineering for developing nutrient-dense food crops (Tanwar et al., 2022)
• Genetic research: legal and ethical aspects (Rustambekov et al., 2023). Non-transgenic Gene Modulation via Spray Delivery of Nucleic Acid/Peptide Complexes into Plant Nuclei and Chloroplasts (Thagun et al., 2022)
• The role of genetic breeding in food security: A review (Sam et al., 2022). Biotechnology: use of available carbon sources on the planet to generate alternatives energy (Junior et al., 2022)
• Biotechnology and biodiversity for the sustainable development of our society (Jaime, 2023) Role Of Biotechnology in Agriculture (Shringarpure, 2022)
• Plants That Can be Used as Plant-Based Edible Vaccines; Current Situation and Recent Developments (İsmail, 2022)

As you can see, these research topics are a lot more focused than the generic topic ideas we presented earlier. So, in order for you to develop a high-quality research topic, you’ll need to get specific and laser-focused on a specific context with specific variables of interest.  In the video below, we explore some other important things you’ll need to consider when crafting your research topic.

Get 1-On-1 Help

If you’re still unsure about how to find a quality research topic, check out our Research Topic Kickstarter service, which is the perfect starting point for developing a unique, well-justified research topic.

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Digital Commons @ USF > College of Arts and Sciences > Molecular Biosciences > Theses and Dissertations

Molecular Biosciences Theses and Dissertations

Theses/dissertations from 2023 2023.

Exploring strain variation and bacteriophage predation in the gut microbiome of Ciona robusta , Celine Grace F. Atkinson

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression , Janine M. DeBlasi

Thermodynamic frustration of TAD2 and PRR contribute to autoinhibition of p53 , Emily Gregory

Utilization of Detonation Nanodiamonds: Nanocarrier for Gene Therapy in Non-Small Cell Lung Cancer , Allan E. Gutierrez

Role of HLA-DRB1 Fucosylation in Anti-Melanoma Immunity , Daniel K. Lester

Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML , Christopher T. Letson

Regulated Intramembrane Proteolysis by M82 Peptidases: The Role of PrsS in the Staphylococcus aureus Stress Response , Baylie M. Schott

Histone Deacetylase 8 is a Novel Therapeutic Target for Mantle Cell Lymphoma and Preserves Natural Killer Cell Cytotoxic Function , January M. Watters

Theses/Dissertations from 2022 2022

Regulation of the Heat Shock Response via Lysine Acetyltransferase CBP-1 and in Neurodegenerative Disease in Caenorhabditis elegans , Lindsey N. Barrett

Determining the Role of Dendritic Cells During Response to Treatment with Paclitaxel/Anti-TIM-3 , Alycia Gardner

Cell-free DNA Methylation Signatures in Cancer Detection and Classification , Jinyong Huang

The Role Of Eicosanoid Metabolism in Mammalian Wound Healing and Inflammation , Kenneth D. Maus

A Holistic Investigation of Acidosis in Breast Cancer , Bryce Ordway

Characterizing the Impact of Postharvest Temperature Stress on Polyphenol Profiles of Red and White-Fruited Strawberry Cultivars , Alyssa N. Smith

Theses/Dissertations from 2021 2021

Multifaceted Approach to Understanding Acinetobacter baumannii Biofilm Formation and Drug Resistance , Jessie L. Allen

Cellular And Molecular Alterations Associated with Ovarian and Renal Cancer Pathophysiology , Ravneet Kaur Chhabra

Ecology and diversity of boletes of the southeastern United States , Arian Farid

CircREV1 Expression in Triple-Negative Breast Cancer , Meagan P. Horton

Microbial Dark Matter: Culturing the Uncultured in Search of Novel Chemotaxonomy , Sarah J. Kennedy

The Multifaceted Role of CCAR-1 in the Alternative Splicing and Germline Regulation in Caenorhabditis elegans , Doreen Ikhuva Lugano

Unraveling the Role of Novel G5 Peptidase Family Proteins in Virulence and Cell Envelope Biogenesis of Staphylococcus aureus , Stephanie M. Marroquin

Cytoplasmic Polyadenylation Element Binding Protein 2 Alternative Splicing Regulates HIF1α During Chronic Hypoxia , Emily M. Mayo

Transcriptomic and Functional Investigation of Bacterial Biofilm Formation , Brooke R. Nemec

A Functional Characterization of the Omega (ω) subunit of RNA Polymerase in Staphylococcus aureus , Shrushti B. Patil

The Role Of Cpeb2 Alternative Splicing In TNBC Metastasis , Shaun C. Stevens

Screening Next-generation Fluorine-19 Probe and Preparation of Yeast-derived G Proteins for GPCR Conformation and Dynamics Study , Wenjie Zhao

Theses/Dissertations from 2020 2020

Understanding the Role of Cereblon in Hematopoiesis Through Structural and Functional Analyses , Afua Adutwumwa Akuffo

To Mid-cell and Beyond: Characterizing the Roles of GpsB and YpsA in Cell Division Regulation in Gram-positive Bacteria , Robert S. Brzozowski

Spatiotemporal Changes of Microbial Community Assemblages and Functions in the Subsurface , Madison C. Davis

New Mechanisms That Regulate DNA Double-Strand Break-Induced Gene Silencing and Genome Integrity , Dante Francis DeAscanis

Regulation of the Heat Shock Response and HSF-1 Nuclear Stress Bodies in C. elegans , Andrew Deonarine

New Mechanisms that Control FACT Histone Chaperone and Transcription-mediated Genome Stability , Angelo Vincenzo de Vivo Diaz

Targeting the ESKAPE Pathogens by Botanical and Microbial Approaches , Emily Dilandro

Succession in native groundwater microbial communities in response to effluent wastewater , Chelsea M. Dinon

Role of ceramide-1 phosphate in regulation of sphingolipid and eicosanoid metabolism in lung epithelial cells , Brittany A. Dudley

Allosteric Control of Proteins: New Methods and Mechanisms , Nalvi Duro

Microbial Community Structures in Three Bahamian Blue Holes , Meghan J. Gordon

A Novel Intramolecular Interaction in P53 , Fan He

The Impact of Myeloid-Mediated Co-Stimulation and Immunosuppression on the Anti-Tumor Efficacy of Adoptive T cell Therapy , Pasquale Patrick Innamarato

Investigating Mechanisms of Immune Suppression Secondary to an Inflammatory Microenvironment , Wendy Michelle Kandell

Posttranslational Modification and Protein Disorder Regulate Protein-Protein Interactions and DNA Binding Specificity of p53 , Robin Levy

Mechanistic and Translational Studies on Skeletal Malignancies , Jeremy McGuire

Novel Long Non-Coding RNA CDLINC Promotes NSCLC Progression , Christina J. Moss

Genome Maintenance Roles of Polycomb Transcriptional Repressors BMI1 and RNF2 , Anthony Richard Sanchez IV

The Ecology and Conservation of an Urban Karst Subterranean Estuary , Robert J. Scharping

Biological and Proteomic Characterization of Cornus officinalis on Human 1.1B4 Pancreatic β Cells: Exploring Use for T1D Interventional Application , Arielle E. Tawfik

Evaluation of Aging and Genetic Mutation Variants on Tauopathy , Amber M. Tetlow

Theses/Dissertations from 2019 2019

Investigating the Proteinaceous Regulome of the Acinetobacter baumannii , Leila G. Casella

Functional Characterization of the Ovarian Tumor Domain Deubiquitinating Enzyme 6B , Jasmin M. D'Andrea

Integrated Molecular Characterization of Lung Adenocarcinoma with Implications for Immunotherapy , Nicholas T. Gimbrone

The Role of Secreted Proteases in Regulating Disease Progression in Staphylococcus aureus , Brittney D. Gimza

Advanced Proteomic and Epigenetic Characterization of Ethanol-Induced Microglial Activation , Jennifer Guergues Guergues

Understanding immunometabolic and suppressive factors that impact cancer development , Rebecca Swearingen Hesterberg

Biochemical and Proteomic Approaches to Determine the Impact Level of Each Step of the Supply Chain on Tomato Fruit Quality , Robert T. Madden

Enhancing Immunotherapeutic Interventions for Treatment of Chronic Lymphocytic Leukemia , Kamira K. Maharaj

Characterization of the Autophagic-Iron Axis in the Pathophysiology of Endometriosis and Epithelial Ovarian Cancers , Stephanie Rockfield

Understanding the Influence of the Cancer Microenvironment on Metabolism and Metastasis , Shonagh Russell

Modeling of Interaction of Ions with Ether- and Ester-linked Phospholipids , Matthew W. Saunders

Novel Insights into the Multifaceted Roles of BLM in the Maintenance of Genome Stability , Vivek M. Shastri

Conserved glycine residues control transient helicity and disorder in the cold regulated protein, Cor15a , Oluwakemi Sowemimo

A Novel Cytokine Response Modulatory Function of MEK Inhibitors Mediates Therapeutic Efficacy , Mengyu Xie

Novel Strategies on Characterizing Biologically Specific Protein-protein Interaction Networks , Bi Zhao

Theses/Dissertations from 2018 2018

Characterization of the Transcriptional Elongation Factor ELL3 in B cells and Its Role in B-cell Lymphoma Proliferation and Survival , Lou-Ella M.m. Alexander

Identification of Regulatory miRNAs Associated with Ethanol-Induced Microglial Activation Using Integrated Proteomic and Transcriptomic Approaches , Brandi Jo Cook

Molecular Phylogenetics of Floridian Boletes , Arian Farid

MYC Distant Enhancers Underlie Ovarian Cancer Susceptibility at the 8q24.21 Locus , Anxhela Gjyshi Gustafson

Quantitative Proteomics to Support Translational Cancer Research , Melissa Hoffman

A Systems Chemical Biology Approach for Dissecting Differential Molecular Mechanisms of Action of Clinical Kinase Inhibitors in Lung Cancer , Natalia Junqueira Sumi

Investigating the Roles of Fucosylation and Calcium Signaling in Melanoma Invasion , Tyler S. Keeley

Synthesis, Oxidation, and Distribution of Polyphenols in Strawberry Fruit During Cold Storage , Katrina E. Kelly

Investigation of Alcohol-Induced Changes in Hepatic Histone Modifications Using Mass Spectrometry Based Proteomics , Crystina Leah Kriss

Off-Target Based Drug Repurposing Using Systems Pharmacology , Brent M. Kuenzi

Investigation of Anemarrhena asphodeloides and its Constituent Timosaponin-AIII as Novel, Naturally Derived Adjunctive Therapeutics for the Treatment of Advanced Pancreatic Cancer , Catherine B. MarElia

The Role of Phosphohistidine Phosphatase 1 in Ethanol-induced Liver Injury , Daniel Richard Martin

Theses/Dissertations from 2017 2017

Changing the Pathobiological Paradigm in Myelodysplastic Syndromes: The NLRP3 Inflammasome Drives the MDS Phenotype , Ashley Basiorka

Modeling of Dynamic Allostery in Proteins Enabled by Machine Learning , Mohsen Botlani-Esfahani

Uncovering Transcriptional Activators and Targets of HSF-1 in Caenorhabditis elegans , Jessica Brunquell

The Role of Sgs1 and Exo1 in the Maintenance of Genome Stability. , Lillian Campos-Doerfler

Mechanisms of IKBKE Activation in Cancer , Sridevi Challa

Discovering Antibacterial and Anti-Resistance Agents Targeting Multi-Drug Resistant ESKAPE Pathogens , Renee Fleeman

Functional Roles of Matrix Metalloproteinases in Bone Metastatic Prostate Cancer , Jeremy S. Frieling

Disorder Levels of c-Myb Transactivation Domain Regulate its Binding Affinity to the KIX Domain of CREB Binding Protein , Anusha Poosapati

Role of Heat Shock Transcription Factor 1 in Ovarian Cancer Epithelial-Mesenchymal Transition and Drug Sensitivity , Chase David Powell

Cell Division Regulation in Staphylococcus aureus , Catherine M. Spanoudis

A Novel Approach to the Discovery of Natural Products From Actinobacteria , Rahmy Tawfik

Non-classical regulators in Staphylococcus aureus , Andy Weiss

Theses/Dissertations from 2016 2016

In Vitro and In Vivo Antioxidant Capacity of Synthetic and Natural Polyphenolic Compounds Identified from Strawberry and Fruit Juices , Marvin Abountiolas

Quantitative Proteomic Investigation of Disease Models of Type 2 Diabetes , Mark Gabriel Athanason

CMG Helicase Assembly and Activation: Regulation by c-Myc through Chromatin Decondensation and Novel Therapeutic Avenues for Cancer Treatment , Victoria Bryant

Computational Modeling of Allosteric Stimulation of Nipah Virus Host Binding Protein , Priyanka Dutta

Cell Cycle Arrest by TGFß1 is Dependent on the Inhibition of CMG Helicase Assembly and Activation , Brook Samuel Nepon-Sixt

Gene Expression Profiling and the Role of HSF1 in Ovarian Cancer in 3D Spheroid Models , Trillitye Paullin

VDR-RIPK1 Interaction and its Implications in Cell Death and Cancer Intervention , Waise Quarni

Regulation of nAChRs and Stemness by Nicotine and E-cigarettes in NSCLC , Courtney Schaal

Targeting Histone Deacetylases in Melanoma and T-cells to Improve Cancer Immunotherapy , Andressa Sodre De Castro Laino

Nonreplicative DNA Helicases Involved in Maintaining Genome Stability , Salahuddin Syed

Theses/Dissertations from 2015 2015

Functional Analysis of the Ovarian Cancer Susceptibility Locus at 9p22.2 Reveals a Transcription Regulatory Network Mediated by BNC2 in Ovarian Cells , Melissa Buckley

Exploring the Pathogenic and Drug Resistance Mechanisms of Staphylococcus aureus , Whittney Burda

Regulation and Targeting of the FANCD2 Activation in DNA Repair , Valentina Celeste Caceres

Mass Spectrometry-Based Investigation of APP-Dependent Mechanisms in Neurodegeneration , Dale Chaput

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Home > SSE > BIOTECH > BIOTECH_ETD

Biotechnology Program Theses and Dissertations

Theses/dissertations from 2024 2024.

Investigating the Association Between Gut Bacteria and Childhood Neuropsychiatric Disorders , Maha Abdo

Cytotoxicity, Antibacterial and Anti-Inflammatory Properties of A Synthesized Curcumin Analog and One of Its Novel Derivatives , Marian Amir

Integrative Genomic Insights into Coral Resilience: Adaptive and Acclimatory Responses to Seasonal Environmental Shifts , Tasnim Ghanim

Can miRNA be the Missing Link Between Parkinson’s Disease and Pesticides? , fatma gobba

Antibacterial and Anticancer Activities of a Fosmid Clone from Atlantis II Red Sea Brine Pool. , Marina Nabil

Deciphering the Microbial Fingerprint of COVID-19: A Multi-Layered Exploration of the Oral and Gut Microbiome Dysbiosis , Iman Mostafa Sultan

Theses/Dissertations from 2023 2023

Preparation and Characterization of Salvia triloba Extract and Evaluation of Its Cytotoxic Effect on Bone Cancer Cell Line , Basma Hossam Abdelmonem

Computational Identification of Circulating MicroRNAs Associated with the Early Stage of Ovarian Cancer , Ahmed Abdelrahman El Hosseiny

Cytotoxic Activity of Salvia Officinalis Extract Mediated by the Inhibition of JAK2 in Breast Cancer , Salma Alawadi Dawood

Plastivore: Identification and Functional Characterization of Plastic Degrading Lipase and Carboxylesterase Enzyme Families from Galleria mellonella , Joseph Boctor

Terfezia Boudieri and Terfezia Claveryi Inhibit the LPS/IFN-γ-Mediated Inflammation in RAW 264.7 Macrophages Through an Nrf2-Independent Mechanism , Abdelhameed Dawood

Metaproteomics Profiling of Gut Microbiota in Pediatric Acute Lymphoblastic Leukemia Patients , Shahd Ezz El Din

Sperm DNA Integrity in Absolute Teratozoospermia Patients and its Impact on Assisted Reproductive Technology Outcome , Dina Faris

Association of Gut Microbiota Composition with Alzheimer’s-Like Disease in A Rat Model , Hana Heiba

A Review of COVID-19 Lockdown Across Different Countries During 2020: Characterization of Risk Factors and Severity of COVID-19 in Egyptian Patients , Hanya Mohamed

Targeting the Warburg and Q Effect: Novel Strategy to Disrupt Cancer Metabolism , Mahmoud Adel Mohamed

Molecular Diagnosis of Non X-linked Ectodermal Dysplasias Using Next Generation Sequencing , Eman AbdelAlim Rabie

Effects of Date Seed (Phoenix dactylifera) Extract in an Animal Model of Diabetes Mellitus , Sara Refaat

Neuroprotective Effects of Green Tea (Camellia Sinensis) and Broccoli (Brassica Oleracea) Extracts in an In Vitro Model of Multiple Sclerosis , Sara Taha Fathallah

Metabolomics Unveiled: Decoding Platelet Dynamics in Smokers, and Head-Neck Cancer Patients , Anthony Nasr Tanios

Theses/Dissertations from 2022 2022

A Predictive Model for Geographical Location Using Microbiome Composition and COVID-19 Based Analysis , Ahmed Adel Aboushanab

Characterization of Testis-Derived Mesenchymal Cells and the Hunt for Universal Stemness Markers , Myret Ghabriel

Knockdown of MDM2 in HepG2 Cell Line: A Step Towards Understanding the Relation Between miRNA590-3p and its Downstream Target Gene, MDM2, in Hepatocellular Carcinoma , Jihad Mahmoud

MiRNAs levels in a Streptozocin model of Alzheimer’s disease , Nada Moustafa

Selective GSK3β inhibition mediates an Nrf2-independent anti-inflammatory microglial response , Mohamed H. Yousef

Theses/Dissertations from 2021 2021

Optimization of In-Vitro Tissue Culture and Transformation System for Sweet Sorghum Cultivars Using Immature Inflorescence , Logayn Abushal

Identifying MicroRNAs Panel Associated With Hepatocellular Carcinoma in Serum of Chronic Hepatitis C Patients , Areeg Dabbish

Analysis of Single Cell RNA-seq Data Revealed Interferon Gamma Signaling Alteration in Severe COVID patients , Ahmed Elbaz

Herbal Extracts as Neuroprotective Agents in an In-vitro Model of Aluminum Neurotoxicity , Nada Ezzelarab

Anti-angiogenic effects of chemotherapeutic agents and their enhancement with OT-515 and S-NACH , Shimaa Adel Heikal

Autophagic Reprogramming of Bone Marrow-Derived Macrophages , Mayada Mahmoud Zaki Mohamed Mazher

Autophagic Reprogramming of Macrophages Polarization , Mayada Mahmoud Zaki Mohamed Mazher

Evaluation of the Anticancer Potential of Alchemilla vulgaris Extract Against Human Neuroblastoma Cells , Yomna Moqidem

Role of Ataxia Telangiectasia Mutated in the Repair of Magnetite Nanoparticles Induced Double Strand Breaks Associated with Heterochromatin , Mie Mohamed Mounir

Assessment of the Potential Anti-tumour Effect of Salvia triloba and the Combination of Salvia triloba and Paclitaxel on Ovarian Cancer: SKOV3 Cell Line , Naela Saleh

Insights Into Halophilic Microbial Adaptation: Analysis of Integrons and Associated Genomic Structures and Characterization of a Nitrilase in Hypersaline Environments , Sarah Sonbol

Mining Selected Metagenomes/metatranscriptomes for Biosynthetic Gene Clusters and Antimicrobial Resistance Genes , Ahmed Yamany

Theses/Dissertations from 2020 2020

Evaluation of the cytotoxic effect of Salvia triloba on Osteosarcoma (U2OS) cell line , Rowan Bahaa El-din Abd El-bary

The crosstalk between COBRA1 and Wnt/β-catenin signaling in cervical cancer , Omnia Mahmoud Abdelraheem

A patient-specific adaptation of the Living Human Heart Model in application to pulmonary hypertension , Yousof Abdel-Raouf

Analysis of single-cell RNA-Seq reveals dynamic changes during macrophage state transition in atherosclerosis mouse model , Ahmed Safwat Abouhashem

The anti-diabetic potential of the African Adansonia Digitata L. plant extract , Marwa Tawfik Badawy

In-depth analysis of culturable microalgae diversity in the river Nile at different locations , Amal Abouel-Fetouh Badr

Expression Levels of miR-590-3p in Hepatocellular Carcinoma and Osteosarcoma Cell Lines and its Downstream Target Genes , Mennatallah Mohamed Bassem Mahmoud Elfar

Fabrication and characterization of polycaprolactone-based nanofibrous scaffolds for neuronal tissue regeneration , Manar Ahmed Elnaggar

Profiling Genome-Wide DNA Methylation Patterns in Human Aortic and Mitral Valves , Sarah Halawa

Role of Ataxia Telangiectasia mutated in the repair of Magnetite Nanoparticles induced double strand breaks associated with Heterochromatin , Mie Mohamed Mounir

Circulating microRNAs in neuromuscular disorders , Nahla Mousa

Assessment of forage quality Among the sudangrasses, sweet and grain sorghum inbred lines at different cutting time points , Muziri Mugwanya

Novel DNA ligases from the Red Sea brine pools: Cloning, expression, in silico characterization and comparative thermostability , Iyanu Mumeen Oduwole

Role of microRNA-208a as a diagnostic and prognostic marker in patients with ST-elevation myocardial infarction , Abou bakr Mohamed Mohamed Hammad Salama

MiR-590-3p suppresses cellular migration and clonogenicity and epithelial to mesenchymal transition in the HepG2 cell line by targeting MDM2 and SETD7 , Alaa Youssef

Theses/Dissertations from 2019 2019

Modulation of stress response in Rice via genome editing of splicing factors , Dina Abou-Raiya

Fabrication of pomegranate peel extract/honey nanofibers loaded with bee venom as effective antibacterial wound dressings , Sara Abouzekry

Direct conversion of mouse fibroblasts into osteoblasts and investigating COBRA1 expression responce , Walid Almoafy Alasar

Identification, expression and biochemical characterization of AMP phosphorylases from extreme environments , Noha Attallah

Novel antimicrobial peptide with anticancer properties , Sheri Magdy Saleeb Bakheit

Predictions and Computational Analysis of Novel Chromosomal Type II Toxin Antitoxin Systems in the Human Oral Microbiome , Ashraf Abd-el-Raouf Bazan

Fabrication of layer-by-layer ECM/polysaccharides/electrospun composite nanofibrous scaffolds and hydrogels for in-vitro skin cell regeneration , Fatma Nabil El-Shishiny

Evaluating the bioactivity and biocompatibility of nylon coated ultra-high molecular weight polyethylene (UHMWPE) , Nancy Hassanein

Molecular and Functional dissection of IgaA, the negative regulator of the E.coli Rcs system. , Nahla A. Hussein

Growth factor-free and antimicrobial elastic nanocomposites for bone regeneration , Dina Mohsen Ibrahim

The effect of Ephedra foeminea on human bone osteosarcoma U2OS cell viability and migration , Eric Zadok Mpingirika

Genetic diversity comparison among invasive fish populations (Nemipterus randalli and Serranus cabrilla) from Mediterranean and Red Sea coastal waters using cytochrome c oxidase subunit I (COI) , Joel Ogwang

Turmeric/ Oregano extracts as wound healing agents in a diabetic animal model , Diana Guirguis Sami

Mining for specialized metabolism genes in Red Sea brine pool prokaryotic metagenomes for antibacterial and anticancer activities , Laila Ziko

Theses/Dissertations from 2018 2018

HeLa cell line, a model to study the role of cofactor of BRCA1 in cervical cancer , Noha Saad Abd Elhamied

The interplay of genetic variation and regulation of long noncoding RNAs in colorectal cancer , Amany Abdel-Motaleb

Evaluating the efficacy of liposomal delivery of nedaplatin in enhancing cytotoxicity, genotoxicity and DNA damage in lung, breast, and osteosarcoma cancer cell lines , Salma Abdelnaser

Therapeutic potential of curcumin in a spinal cord injury model: Local application versus dietary supplement , Sarah Kamel Farahat Abu hussein

Evaluation of cytotoxic potential of loratadine and the combination of loratadine and cisplatin on hepatocellular carcinoma cell lines , Nouran Adly

Mining the red sea metagenomics libraries for betaine pathways , Sherouk Allam

The effect of adding radiotherapy to the administrated chemotherapy on infants' gut microbiome , Nourhan Elsahly

Cytotoxic activity of the Red Sea anemone entacmaea quadricolor on liver cancer cells , Noha Moataz El Salakawy

Cofactor of BRCA1 promotes epithelial-mesenchymal transition and cell proliferation in intermediate stage hepatocellular carcinoma cell line , Mennatallah Ghouraba

Prevalence and determinants of self-medication with antibiotics in high and low-income areas within Cairo , Shaymaa Mohamed Hassan

Expression analysis of liver-specific circulating micrornas in hcv-induced hepatocellular carcinoma in Egyptian patients , Lobna Mohamed Mourad

Theses/Dissertations from 2017 2017

MicroRNAs as noninvasive biomarkers for the diagnosis and prognosis of liver fibrosis in HCV genotype 4 patients , Amanda Abdel-Al

Development of immuno- nanoparticles for targeting schistosoma parasites , Eman Rabie Abdul-Ghany

Virome of red sea brine pools and other hydrothermal vents , Sherry Kamal Berty Aziz

Impacts of exposure to low concentration of titanium dioxide nanoparticles on cell cycle control and DNA repair in normal, cancer and DNA repair deficient cells. , Nada EL Zahed

Transcriptional response to stressors in arabidopsis thaliana , Aya Abd Elsalam Galal

Analysis of the thermal stability of mercuric reductase from the hot brine environment of Atlantis II in the Red Sea by site-directed mutagenesis: Structural interpretation of thermolabile and enhanced thermostable mutants , Mohamad Maged Galal

Translational profiling of adipocytes within adipose depots and intermuscular adipose tissues , Sara Serag Hassan

Induced pluripotent stem cells derived from mouse germ cells , Nora Khan

Characterization of aggresome formation in choroid plexus carcinoma. , Marwa Mohamed Ali Nassar

Mannose binding lectin in the treatment of imiquimod induced psoriasis mouse model , Hagar Nofal

Molecular adaptation of mercuric reductase to hypersaline environments , Emanbellah Ramadan

Theses/Dissertations from 2016 2016

In silico screening, analysis, and modelling for a novel anticancer peptide , Youssef Abdou

Genome-wide transcriptomic analysis of alternative splicing modulation in Arabidopsis thaliana , Moustafa Ahmed Abohawya

Transcriptomic profiling of the extremophile eutrema salsugineum response to environmental stressors , Diana Abou El Hassan

Analysis of the D1S80 VNTR locus polymorphism in the Nubian population , Soha Rabie Ahmed

Antibiotic resistance in Red Sea brine pools , Ali Hassan Ali Elbehery

Calcified gelatin nanofibers for guided tissue regeneration using water-based benign solvent: An investigation for periodontal applications , Nihal Abdelnabi Elsayed

In silico identification and in Vitro assessment of a potential anticancer peptide sequence retrieved from the red sea metagenomics library , Mona Elradi Imam

Overexpression of cofactor of BRCA1 in HepG2 cells: A step towards understanding the role of COBRA1 in hepatocellular carcinoma , Razan Jamil Masad

The microbiome of The Egyptian Red Sea proper and Gulf of Aqaba , Ghada Alaa El-Din Mustafa

Regulatory networks in non-small cell lung cancer: Connecting differentially expressed genes, miRNAs, and incRNAs , Jasmine Omran

Identification of XPA and XPC gene mutations in patients with xeroderma pigmentosum , Eman AbdelAlim Sidky Rabie

Theses/Dissertations from 2015 2015

Isolation, propagation and characterization of mouse testis-derived mesenchymal stromal cells , Mai Abdul Rahman

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Molecular and Cellular Biology Masters Theses Collection

Theses from 2024 2024.

The Impact of a Non-ionic Adjuvant to the Persistence of Pesticides on Produce Surfaces , Daniel Barnes, Molecular & Cellular Biology

Investigating the Role of Got2 in Murine Organogenesis and Placenta Development , Olivia Macrorie, Molecular & Cellular Biology

Chromatin Accessibility Impacts Knockout of Mt-Bell4 Transcription Factor , Thomas Redden, Molecular & Cellular Biology

UNDERSTANDING THE FUNCTIONAL IMPACT OF DISEASE-ASSOCIATED PHOSPHORYLATION SITES ON THE NEURODEGENERATIVE PROTEIN TAU , Navya T. Sebastian, Molecular & Cellular Biology

Theses from 2023 2023

Elucidating the Priming Mechanism of ClpXP Protease by Single-Domain Response Regulator CpdR in Caulobacter crescentus , Kimberly E. Barker, Molecular & Cellular Biology

The Discovery of a Novel Bacteria from a Large Co-assembly of Metagenomes , Matthew Finkelberg, Molecular & Cellular Biology

Investigating Diterpene Biosynthesis in Medicago Truncatula , Sungwoo Hwang, Molecular & Cellular Biology

Combining Simulation and the MspA Nanopore to Study p53 Dynamics and Interactions , Samantha A. Schultz, Molecular & Cellular Biology

Caulobacter ClpXP Adaptor PopA’s Domain Interactions in the Adaptor Hierarchy of CtrA Degradation , Thomas P. Scudder, Molecular & Cellular Biology

Climate Change, Giant Viruses and Their Putative Hosts , Sarah K. Tucker, Molecular & Cellular Biology

Theses from 2022 2022

Changes in Gene Expression From Long-Term Warming Revealed Using Metatranscriptome Mapping to FAC-Sorted Bacteria , Christopher A. Colvin, Molecular & Cellular Biology

Determining CaMKII Variant Activities and Their Roles in Human Disease , Matthew J. Dunn, Molecular & Cellular Biology

Developmental Exposures to PFAS Mixtures Impair Elongation of the Exocrine Pancreas in Zebrafish (Danio rerio) , Emily M. Formato, Molecular & Cellular Biology

A Metatranscriptomic Analysis of the Long-Term Effects of Warming on the Harvard Forest Soil Microbiome , Brooke A. Linnehan, Molecular & Cellular Biology

Characterization of the Poly (ADP-Ribose) Polymerase Family in the Fusarium oxysporum Species Complex , Daniel Norment, Molecular & Cellular Biology

Theses from 2021 2021

Exploring Knockdown Phenotypes and Interactions between ATAD3 Proteins in Arabidopsis thaliana , Eli S. Gordon, Molecular & Cellular Biology

Development of a Site-Specific Labeling Assay to Study the Pseudomonas aeruginosa Type III Secretion Translocon in Native Membranes , Kyle A. Mahan, Molecular & Cellular Biology

Liposomal Nanoparticles Target TLR7/8-SHP2 to Repolarize Macrophages to Aid in Cancer Immunotherapy , Vaishali Malik, Molecular & Cellular Biology

Hsp70 Phosphorylation: A Case Study of Serine Residues 385 and 400 , Sashrika Saini, Molecular & Cellular Biology

Activation of Nrf2 at Critical Windows of Development Alters Protein S-Glutathionylation in the Zebrafish Embryo (Danio rerio) , Emily G. Severance, Molecular & Cellular Biology

Utilizing Fluorescence Microscopy to Characterize the Subcellular Distribution of the Novel Protein Acheron , Varun Sheel, Molecular & Cellular Biology

Theses from 2020 2020

The Association Between Sperm DNA Methylation and Sperm Mitochondrial DNA Copy Number , Emily Houle, Molecular & Cellular Biology

Gene Expression Regulation in the Mouse Liver by Mechanistic Target Of Rapamycin Complexes I and II , Anthony Poluyanoff, Molecular & Cellular Biology

Sperm Mitochondrial DNA Biomarkers as a Measure of Male Fecundity and Overall Sperm Quality , Allyson Rosati, Molecular & Cellular Biology

Exploration of the Association between Muscle Volume and Bone Geometry Reveals Surprising Relationship at the Genetic Level , Prakrit Subba, Molecular & Cellular Biology

Theses from 2019 2019

Studies on the Interaction and Organization of Bacterial Proteins on Membranes , Mariana Brena, Molecular & Cellular Biology

Investigating The Role Of LBH During Early Embryonic Development In Xenopus Laevis , Emma Weir, Molecular & Cellular Biology

Theses from 2018 2018

Exploring the Influence of PKC-theta Phosphorylation on Notch1 Activation and T Helper Cell Differentiation , Grace Trombley, Molecular & Cellular Biology

Theses from 2017 2017

Partial Craniofacial Cartilage Rescue in ace/fgf8 Mutants from Compensatory Signaling From the Ventricle of Danio Rerio , Douglas A. Calenda II, Molecular & Cellular Biology

THE FAR C-TERMINUS OF TPX2 CONTRIBUTES TO SPINDLE MORPHOGENESIS , Brett Estes, Molecular & Cellular Biology

Characterization of Calcium Homeostasis Parameters in TRPV3 and CaV3.2 Double Null Mice , Aujan Mehregan, Molecular & Cellular Biology

Microtransplantation of Rat Brain Neurolemma into Xenopus Laevis Oocytes to Study the Effect of Environmental Toxicants on Endogenous Voltage-Sensitive Ion Channels , Edwin Murenzi, Molecular & Cellular Biology

Regulation of Katanin Activity on Microtubules , Madison A. Tyler, Molecular & Cellular Biology

Theses from 2016 2016

The Role of MicroRNAs in Regulating the Translatability and Stability of Target Messenger RNAs During the Atrophy and Programmed Cell Death of the Intersegmental Muscles of the Tobacco Hawkmoth Manduca sexta. , Elizabeth Chan, Molecular & Cellular Biology

An in Vivo Study of Cortical Dynein Dynamics and its Contribution to Microtubule Sliding in the Midzone , Heather M. Jordan, Molecular & Cellular Biology

A Genetic Analysis of Cichlid Scale Morphology , Kenta C. Kawasaki, Molecular & Cellular Biology

Modulation of Notch in an Animal Model of Multiple Sclerosis , Manit Nikhil Munshi, Molecular & Cellular Biology

One-Carbon Metabolism Related B-Vitamins Alter The Expression Of MicroRNAS And Target Genes Within The Wnt Signaling Pathway In Mouse Colonic Epithelium , Riccardo Racicot, Molecular & Cellular Biology

Characterizing the Inhibition of Katanin Using Tubulin Carboxy-Terminal Tail Constructs , Corey E. Reed, Molecular & Cellular Biology

The Identification of Notch1 Functional Domains Responsible for its Physical Interaction with PKCθ , Wesley D. Rossiter, Molecular & Cellular Biology

Dynamics of Microtubule Networks with Antiparallel Crosslinkers , Kasimira T. Stanhope, Molecular & Cellular Biology

Modifications of Myofilament Structure and Function During Global Myocardial Ischemia , Mike K. Woodward, Molecular & Cellular Biology

Theses from 2015 2015

Regulation of Jak1 and Jak2 Synthesis through Non-Classical Progestin Receptors , Hillary Adams, Molecular & Cellular Biology

Antineoplastic Effects of Rhodiola Crenulata on B16-F10 Melanoma , Maxine Dudek, Molecular & Cellular Biology

RNAi Validation of Resistance Genes and Their Interactions in the Highly DDT-Resistant 91-R Strain of Drosophila Melanogaster , Kyle Gellatly, Molecular & Cellular Biology

Characterization of Protein-Protein Interactions for Therapeutic Drug Design Utilizing Mass Spectrometry , Alex J. Johnson, Molecular & Cellular Biology

Promoting Extracellular Matrix Crosslinking in Synthetic Hydrogels , Marcos M. Manganare, Molecular & Cellular Biology

Characterization of the Reconstituted and Native Pseudomonas aeruginosa Type III Secretion System Translocon , Kathryn R. Monopoli, Molecular & Cellular Biology

Thermocycle-regulated WALL REGULATOR INTERACTING bHLH Encodes a Protein That Interacts with Secondary-Cell-Wall-Associated Transcription Factors , Ian P. Whitney, Molecular & Cellular Biology

Theses from 2014 2014

Engineering Camelina sativa for Biofuel Production via increasing oil yield and tolerance to abiotic stresses , Kenny Ablordeppey, Molecular & Cellular Biology

Designing a Pore-Forming Toxin Cytolysin A (ClyA) Specific to Target Cancer Cells , Alzira Rocheteau Avelino, Molecular & Cellular Biology

The Role of the Novel Lupus Antigen, Acheron, in Moderating Life and Death Decisions , Ankur Sheel, Molecular & Cellular Biology

Expression and Purification of Human Lysosomal β-galactosidase from Pichia Pastoris , Sarah E. Tarullo, Molecular & Cellular Biology

Properties of Potential Substrates of a Cyanobacterial Small Heat Shock Protein , Yichen Zhang, Molecular & Cellular Biology

Theses from 2013 2013

Characterizing the Heavy Metal Chelator, Tpen, as a Ca2+ Tool in the Mammalian Oocyte , Robert A. Agreda Mccaughin, Molecular & Cellular Biology

Sustainable Biofuels Production Through Understanding Fundamental Bacterial Pathways Involved in Biomass Degradation and Sugar Utilization , James CM Hayes, Molecular & Cellular Biology

Stiffness and Modulus and Independent Controllers of Breast Cancer Metastasis , Dannielle Ryman, Molecular & Cellular Biology

Theses from 2012 2012

The Pyrethroid Deltamethrin, Which Causes Choreoathetosis with Salivation (CS-Syndrome), Enhances Calcium Ion Influx via Phosphorylated CaV2.2 expresssed in Xenopus laevis oocytes , Anna-maria Alves, Molecular & Cellular Biology

A Test of the Hypothesis That Environmental Chemicals Interfere With Thyroid Hormone Action in Human Placenta , Katherine Geromini, Molecular & Cellular Biology

Analyzing the Role of Reactive Oxygen Species in Male-Female Interactions in Arabidopsis thaliana. , Eric A. Johnson, Molecular & Cellular Biology

Rhythmic Growth And Vascular Development In Brachypodium Distachyon , Dominick A. Matos, Molecular & Cellular Biology

Polymer Prodrug Conjugation to Tumor Homing Mesenchymal Stem Cells , Nick Panzarino, Molecular & Cellular Biology

Investigation of Differential Vector Competence of Bartonella quintana in Human Head and Body Lice , Domenic j. Previte, Molecular & Cellular Biology

Downregulation of Cinnamyl Alcohol Dehydrogenase or Caffeic Acid O-Methyltransferase Leads to Improved Biological Conversion Efficiency in Brachypodium distachyon , Gina M. Trabucco, Molecular & Cellular Biology

Theses from 2011 2011

Evolutionary Relationship of the ampC Resistance Gene In E. cloacae , Shanika S. Collins, Molecular & Cellular Biology

Sex Difference in Calbindin Cell Number in the Mouse Preoptic Area: Effects of Neonatal Estradiol and Bax Gene Deletion , Richard F. Gilmore III, Molecular & Cellular Biology

In Vivo Investigations of Polymer Conjugates as Therapeutics , Elizabeth M. Henchey, Molecular & Cellular Biology

Examination of Sexually Dimorphic Cell Death in the Pubertal Mouse Brain , Amanda Holley, Molecular & Cellular Biology

Human Niemann-Pick Type C2 Disease Protein Expression, Purification and Crystallization , Yurie T. Kim, Molecular & Cellular Biology

Revealing the Localization of the Class I Formin Family in the Moss Physcomitrella patens Using Gene Targeting Strategies , Kelli Pattavina, Molecular & Cellular Biology

Connecting Motors and Membranes: A Quantitative Investigation of Dynein Pathway Components and in vitro Characterization of the Num1 Coiled Coil Domain , Bryan J. St. Germain, Molecular & Cellular Biology

Theses from 2010 2010

The Protective Effects A Full-term Pregnancy Plays Against Mammary Carcinoma , Matthew p. Carter, Molecular & Cellular Biology

Analysis Of An Actin Binding Guanine Exchange Factor, Gef8, And Actin Depolymerizing Factor In Arabidopsis Thaliana. , Aleksey Chudnovskiy, Molecular & Cellular Biology

The Role of Ykl-40, a Secreted Heparin-Binding Glycoprotein, in Tumor Angiogenesis, Metastasis, and Progression: a Potential Therapeutic Target , Michael Faibish, Molecular & Cellular Biology

In Vivo Visualization of Hedgehog Signaling in Zebrafish , Christopher J. Ferreira, Molecular & Cellular Biology

An In Vivo Study of the Mammalian Mitotic Kinesin Eg5 , Alyssa D. Gable, Molecular & Cellular Biology

Identification of Dynein Binding Sites in Budding Yeast Pac1/LIS1 , Christopher W. Meaden, Molecular & Cellular Biology

Functional Characterization of Arabidopsis Formin Homologues Afh1, Afh5, Afh6, Afh7 and Afh8 , Shahriar Niroomand, Molecular & Cellular Biology

Regulation of Crbp1 In Mammary Epithelial Cells , Stacy L. Pease, Molecular & Cellular Biology

In Vivo Labeling Of A Model β-Clam Protein With A Fluorescent Amino Acid , Mangayarkarasi Periasamy, Molecular & Cellular Biology

In Vivo Characterization of Interactions Among Dynein Complex Components at Microtubule Plus Ends , Karen M. Plevock, Molecular & Cellular Biology

Anti-Diabetic Potentials of Phenolic Enriched Chilean Potato and Select Herbs of Apiaceae and Lamiaceae Families , Fahad Saleem, Molecular & Cellular Biology

Interconversion of the Specificities of Human Lysosomal Enzymes , Ivan B. Tomasic, Molecular & Cellular Biology

Deletions of Fstl3 and/or Fst Isoforms 303 and 315 Results in Hepatic Steatosis , Nathan A. Ungerleider, Molecular & Cellular Biology

Theses from 2009 2009

A New Laser Pointer Driven Optical Microheater for Precise Local Heat Shock , Mike Placinta, Molecular & Cellular Biology

Theses from 2008 2008

Cysteine Dioxygenase: The Importance of Key Residues and Insight into the Mechanism of the Metal Center , Jonathan H. Leung, Molecular & Cellular Biology

Invertebrate Phenology and Prey Selection of Three Sympatric Species of Salmonids; Implications for Individual Fish Growth , Jeffrey V. Ojala, Wildlife & Fisheries Conservation

Paralemmin Splice Variants and mRNA and Protein Expression in Breast Cancer , Casey M. Turk, Molecular & Cellular Biology

Stability of the frog motor nerve terminal: roles of perisynaptic Schwann cells and muscle fibers , Ling Xin, Molecular & Cellular Biology

Theses from 2007 2007

Antioxidant Response Mechanism in Apples during Post-Harvest Storage and Implications for Human Health Benefits , Ishan Adyanthaya, Molecular & Cellular Biology

Progress Towards A Model Flavoenzyme System , Kevin M. Bardon, Molecular & Cellular Biology

The effect of Rhodiola crenulata on a highly metastatic murine mammary carcinoma , Jessica L. Doerner, Molecular & Cellular Biology

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200+ Biotechnology Research Topics: Let’s Shape the Future

In the dynamic landscape of scientific exploration, biotechnology stands at the forefront, revolutionizing the way we approach healthcare, agriculture, and environmental sustainability. This interdisciplinary field encompasses a vast array of research topics that hold the potential to reshape our world. 

In this blog post, we will delve into the realm of biotechnology research topics, understanding their significance and exploring the diverse avenues that researchers are actively investigating.

Overview of Biotechnology Research

Table of Contents

Biotechnology, at its core, involves the application of biological systems, organisms, or derivatives to develop technologies and products for the benefit of humanity. 

The scope of biotechnology research is broad, covering areas such as genetic engineering, biomedical engineering, environmental biotechnology, and industrial biotechnology. Its interdisciplinary nature makes it a melting pot of ideas and innovations, pushing the boundaries of what is possible.

How to Select The Best Biotechnology Research Topics?

• Identify Your Interests

Start by reflecting on your own interests within the broad field of biotechnology. What aspects of biotechnology excite you the most? Identifying your passion will make the research process more engaging.

• Stay Informed About Current Trends

Keep up with the latest developments and trends in biotechnology. Subscribe to scientific journals, attend conferences, and follow reputable websites to stay informed about cutting-edge research. This will help you identify gaps in knowledge or areas where advancements are needed.

• Consider Societal Impact

Evaluate the potential societal impact of your chosen research topic. How does it contribute to solving real-world problems? Biotechnology has applications in healthcare, agriculture, environmental conservation, and more. Choose a topic that aligns with the broader goal of improving quality of life or addressing global challenges.

• Assess Feasibility and Resources

Evaluate the feasibility of your research topic. Consider the availability of resources, including laboratory equipment, funding, and expertise. A well-defined and achievable research plan will increase the likelihood of successful outcomes.

• Explore Innovation Opportunities

Look for opportunities to contribute to innovation within the field. Consider topics that push the boundaries of current knowledge, introduce novel methodologies, or explore interdisciplinary approaches. Innovation often leads to groundbreaking discoveries.

• Consult with Mentors and Peers

Seek guidance from mentors, professors, or colleagues who have expertise in biotechnology. Discuss your research interests with them and gather insights. They can provide valuable advice on the feasibility and significance of your chosen topic.

• Balance Specificity and Breadth

Strike a balance between biotechnology research topics that are specific enough to address a particular aspect of biotechnology and broad enough to allow for meaningful research. A topic that is too narrow may limit your research scope, while one that is too broad may lack focus.

• Consider Ethical Implications

Be mindful of the ethical implications of your research. Biotechnology, especially areas like genetic engineering, can raise ethical concerns. Ensure that your chosen topic aligns with ethical standards and consider how your research may impact society.

• Evaluate Industry Relevance

Consider the relevance of your research topic to the biotechnology industry. Industry-relevant research has the potential for practical applications and may attract funding and collaboration opportunities.

• Stay Flexible and Open-Minded

Be open to refining or adjusting your research topic as you delve deeper into the literature and gather more information. Flexibility is key to adapting to new insights and developments in the field.

200+ Biotechnology Research Topics: Category-Wise

Genetic engineering.

• CRISPR-Cas9: Recent Advances and Applications
• Gene Editing for Therapeutic Purposes: Opportunities and Challenges
• Precision Medicine and Personalized Genomic Therapies
• Genome Sequencing Technologies: Current State and Future Prospects
• Synthetic Biology: Engineering New Life Forms
• Genetic Modification of Crops for Improved Yield and Resistance
• Ethical Considerations in Human Genetic Engineering
• Gene Therapy for Neurological Disorders
• Epigenetics: Understanding the Role of Gene Regulation
• CRISPR in Agriculture: Enhancing Crop Traits

Biomedical Engineering

• Tissue Engineering: Creating Organs in the Lab
• 3D Printing in Biomedical Applications
• Advances in Drug Delivery Systems
• Nanotechnology in Medicine: Theranostic Approaches
• Bioinformatics and Computational Biology in Biomedicine
• Wearable Biomedical Devices for Health Monitoring
• Stem Cell Research and Regenerative Medicine
• Precision Oncology: Tailoring Cancer Treatments
• Biomaterials for Biomedical Applications
• Biomechanics in Biomedical Engineering

Environmental Biotechnology

• Bioremediation of Polluted Environments
• Waste-to-Energy Technologies: Turning Trash into Power
• Sustainable Agriculture Practices Using Biotechnology
• Bioaugmentation in Wastewater Treatment
• Microbial Fuel Cells: Harnessing Microorganisms for Energy
• Biotechnology in Conservation Biology
• Phytoremediation: Plants as Environmental Cleanup Agents
• Aquaponics: Integration of Aquaculture and Hydroponics
• Biodiversity Monitoring Using DNA Barcoding
• Algal Biofuels: A Sustainable Energy Source

Industrial Biotechnology

• Enzyme Engineering for Industrial Applications
• Bioprocessing and Bio-manufacturing Innovations
• Industrial Applications of Microbial Biotechnology
• Bio-based Materials: Eco-friendly Alternatives
• Synthetic Biology for Industrial Processes
• Metabolic Engineering for Chemical Production
• Industrial Fermentation: Optimization and Scale-up
• Biocatalysis in Pharmaceutical Industry
• Advanced Bioprocess Monitoring and Control
• Green Chemistry: Sustainable Practices in Industry

Emerging Trends in Biotechnology

• CRISPR-Based Diagnostics: A New Era in Disease Detection
• Neurobiotechnology: Advancements in Brain-Computer Interfaces
• Advances in Nanotechnology for Healthcare
• Computational Biology: Modeling Biological Systems
• Organoids: Miniature Organs for Drug Testing
• Genome Editing in Non-Human Organisms
• Biotechnology and the Internet of Things (IoT)
• Exosome-based Therapeutics: Potential Applications
• Biohybrid Systems: Integrating Living and Artificial Components
• Metagenomics: Exploring Microbial Communities

Ethical and Social Implications

• Ethical Considerations in CRISPR-Based Gene Editing
• Privacy Concerns in Personal Genomic Data Sharing
• Biotechnology and Social Equity: Bridging the Gap
• Dual-Use Dilemmas in Biotechnological Research
• Informed Consent in Genetic Testing and Research
• Accessibility of Biotechnological Therapies: Global Perspectives
• Human Enhancement Technologies: Ethical Perspectives
• Biotechnology and Cultural Perspectives on Genetic Modification
• Social Impact Assessment of Biotechnological Interventions
• Intellectual Property Rights in Biotechnology

Computational Biology and Bioinformatics

• Machine Learning in Biomedical Data Analysis
• Network Biology: Understanding Biological Systems
• Structural Bioinformatics: Predicting Protein Structures
• Data Mining in Genomics and Proteomics
• Systems Biology Approaches in Biotechnology
• Comparative Genomics: Evolutionary Insights
• Bioinformatics Tools for Drug Discovery
• Cloud Computing in Biomedical Research
• Artificial Intelligence in Diagnostics and Treatment
• Computational Approaches to Vaccine Design

Health and Medicine

• Vaccines and Immunotherapy: Advancements in Disease Prevention
• CRISPR-Based Therapies for Genetic Disorders
• Infectious Disease Diagnostics Using Biotechnology
• Telemedicine and Biotechnology Integration
• Biotechnology in Rare Disease Research
• Gut Microbiome and Human Health
• Precision Nutrition: Personalized Diets Using Biotechnology
• Biotechnology Approaches to Combat Antibiotic Resistance
• Point-of-Care Diagnostics for Global Health
• Biotechnology in Aging Research and Longevity

Agricultural Biotechnology

• CRISPR and Gene Editing in Crop Improvement
• Precision Agriculture: Integrating Technology for Crop Management
• Biotechnology Solutions for Food Security
• RNA Interference in Pest Control
• Vertical Farming and Biotechnology
• Plant-Microbe Interactions for Sustainable Agriculture
• Biofortification: Enhancing Nutritional Content in Crops
• Smart Farming Technologies and Biotechnology
• Precision Livestock Farming Using Biotechnological Tools
• Drought-Tolerant Crops: Biotechnological Approaches

Biotechnology and Education

• Integrating Biotechnology into STEM Education
• Virtual Labs in Biotechnology Teaching
• Biotechnology Outreach Programs for Schools
• Online Courses in Biotechnology: Accessibility and Quality
• Hands-on Biotechnology Experiments for Students
• Bioethics Education in Biotechnology Programs
• Role of Internships in Biotechnology Education
• Collaborative Learning in Biotechnology Classrooms
• Biotechnology Education for Non-Science Majors
• Addressing Gender Disparities in Biotechnology Education

Funding and Policy

• Government Funding Initiatives for Biotechnology Research
• Private Sector Investment in Biotechnology Ventures
• Impact of Intellectual Property Policies on Biotechnology
• Ethical Guidelines for Biotechnological Research
• Public-Private Partnerships in Biotechnology
• Regulatory Frameworks for Gene Editing Technologies
• Biotechnology and Global Health Policy
• Biotechnology Diplomacy: International Collaboration
• Funding Challenges in Biotechnology Startups
• Role of Nonprofit Organizations in Biotechnological Research

Biotechnology and the Environment

• Biotechnology for Air Pollution Control
• Microbial Sensors for Environmental Monitoring
• Remote Sensing in Environmental Biotechnology
• Climate Change Mitigation Using Biotechnology
• Circular Economy and Biotechnological Innovations
• Marine Biotechnology for Ocean Conservation
• Bio-inspired Design for Environmental Solutions
• Ecological Restoration Using Biotechnological Approaches
• Impact of Biotechnology on Biodiversity
• Biotechnology and Sustainable Urban Development

Biosecurity and Biosafety

• Biosecurity Measures in Biotechnology Laboratories
• Dual-Use Research and Ethical Considerations
• Global Collaboration for Biosafety in Biotechnology
• Security Risks in Gene Editing Technologies
• Surveillance Technologies in Biotechnological Research
• Biosecurity Education for Biotechnology Professionals
• Risk Assessment in Biotechnology Research
• Bioethics in Biodefense Research
• Biotechnology and National Security
• Public Awareness and Biosecurity in Biotechnology

Industry Applications

• Biotechnology in the Pharmaceutical Industry
• Bioprocessing Innovations for Drug Production
• Industrial Enzymes and Their Applications
• Biotechnology in Food and Beverage Production
• Applications of Synthetic Biology in Industry
• Biotechnology in Textile Manufacturing
• Cosmetic and Personal Care Biotechnology
• Biotechnological Approaches in Renewable Energy
• Advanced Materials Production Using Biotechnology
• Biotechnology in the Automotive Industry

Miscellaneous Topics

• DNA Barcoding in Species Identification
• Bioart: The Intersection of Biology and Art
• Biotechnology in Forensic Science
• Using Biotechnology to Preserve Cultural Heritage
• Biohacking: DIY Biology and Citizen Science
• Microbiome Engineering for Human Health
• Environmental DNA (eDNA) for Biodiversity Monitoring
• Biotechnology and Astrobiology: Searching for Life Beyond Earth
• Biotechnology and Sports Science
• Biotechnology and the Future of Space Exploration

Challenges and Ethical Considerations in Biotechnology Research

As biotechnology continues to advance, it brings forth a set of challenges and ethical considerations. Biosecurity concerns, especially in the context of gene editing technologies, raise questions about the responsible use of powerful tools like CRISPR. 

Ethical implications of genetic manipulation, such as the creation of designer babies, demand careful consideration and international collaboration to establish guidelines and regulations. 

Moreover, the environmental and social impact of biotechnological interventions must be thoroughly assessed to ensure responsible and sustainable practices.

Funding and Resources for Biotechnology Research

The pursuit of biotechnology research topics requires substantial funding and resources. Government grants and funding agencies play a pivotal role in supporting research initiatives. 

Simultaneously, the private sector, including biotechnology companies and venture capitalists, invest in promising projects. Collaboration and partnerships between academia, industry, and nonprofit organizations further amplify the impact of biotechnological research.

Future Prospects of Biotechnology Research

As we look to the future, the integration of biotechnology with other scientific disciplines holds immense potential. Collaborations with fields like artificial intelligence, materials science, and robotics may lead to unprecedented breakthroughs. 

The development of innovative technologies and their application to global health and sustainability challenges will likely shape the future of biotechnology.

In conclusion, biotechnology research is a dynamic and transformative force with the potential to revolutionize multiple facets of our lives. The exploration of diverse biotechnology research topics, from genetic engineering to emerging trends like synthetic biology and nanobiotechnology, highlights the breadth of possibilities within this field. 

However, researchers must navigate challenges and ethical considerations to ensure that biotechnological advancements are used responsibly for the betterment of society. 

With continued funding, collaboration, and a commitment to ethical practices, the future of biotechnology research holds exciting promise, propelling us towards a more sustainable and technologically advanced world.

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Cancer variant modeling in vivo

Prime- and base-editor mouse models enable finely tuned, efficient functional studies of cancer-associated genetic changes.

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Recent patents relating to methods of characterizing metagenomic samples and analyzing and processing metagenomic data.

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Wireless multisite physiological sensor with clinical-grade accuracy

Bioengineered spider silk without critters

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The global patent landscape of artificial intelligence applications for cancer

A review of the emerging patent landscape can assist key actors in making informed strategic decisions about AI applications in oncology.

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From AI to the Y chromosome (and everything in between)

Nature Biotechnology editors pick their favorite research articles from 2023.

Nature Biotechnology ’s academic spinouts 2022

Nature Biotechnology ’s annual survey highlights academic start ups that are, among other things, correcting misfolded or disordered proteins, creating second-generation GPCR agonists, building a new gene delivery platform and mining cancer genomes for novel targets.

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Tracing the fate of AAV vectors in the body

A study of AAV gene therapy in monkeys proposes that integrated vectors may drive long-term transgene expression.

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DNA nanodevices map intracellular ions

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Top ten news stories in 2023

Our ranking is out, and it has a few surprises. In pole position — predictably — is Wegovy, the weight-slashing GLP-1 agonist, with AI-hallucinated proteins a close second. These are followed by drugging options for RNA. The dark horses are virus-free gene therapies and a sweet protein.

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β cells derived from stem cells improve blood glucose control in patients with diabetes.

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The go-ahead for Vertex’s gene editing therapy in sickle cell disease and β-thalassemia is a historic milestone, but this one-time treatment is costly.

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Biomolecular Engineering & Bioinformatics M.S. and Ph.D.

The Department of Biomolecular Engineering offers interdisciplinary M.S. and Ph.D. degrees in biomolecular engineering and bioinformatics and accepts students from a wide-variety of backgrounds. A typical cohort includes incoming students from molecular biology, genetics, computer science, engineering, and mathematics. The unifying theme of our research training program is using quantitative approaches to addressing fundamental questions in biology and biomedical science.

Program coursework is designed to provide the technical skills in programming and other technical skills required for independent and advanced scientific discovery. Incoming students undertake rigorous core coursework, conduct laboratory rotations (Ph.D. only), and are exposed to a rich environment of regular seminars and group meetings. Students interact closely with biomolecular engineering and bioinformatics faculty members while undertaking their dissertation research (Ph.D.) or capstone projects (M.S.), and have first-hand access to state-of-the-art computation tools and laboratory facilities throughout their training, including cluster computing and high-throughput sequencing facilities.

Please refer to the Division of Graduate Studies Admissions website for our current application due date .

Apply to MS Apply to PhD

NOTE: GRE no longer required for Biomolecular Engineering & Bioinformatics MS and PhD applications

The Ph.D. program prepares students to lead independent research programs in academic or industry settings.  The PhD program accepts students through the  BMEB track  of the umbrella  Program in Biomedical Sciences and Engineering  (PBSE).  The program duration is typically five to seven years.

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The M.S. program is designed to prepare students for careers in contemporary biomedical research settings in the biotechnology industry. The program duration is typically one to two years.

• Candidates pursuing M.Sc. / M.Pharm / M.Tech (during any semester) or B.Pharm / B.Tech / Integrated M.Sc. (from the third year onwards) in any branch of Life Sciences are eligible to apply for this program.
• The plicants should have first class throughout their Academic Career, i.e. 10 th , Intermediate or 12 th and Degree (till the previous semester).

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Ph.D. in Microbiology

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The Doctor of Philosophy (Ph.D.) is the highest degree offered by the Microbiology Graduate Program (MGP). The goal of our doctoral program is to provide students with the foundation necessary to pursue a career in a university, industry or research institute setting.

Students in our doctoral program are trained to recognize significant biological problems, design experimental approaches for solving these problems and communicate their results to the scientific community and the public.

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Review Our Admission Requirements and Apply Now! 

The requirements listed below are the minimum requirements to be met by all students in our Ph.D. program. A student’s advisory committee may recommend additional requirements as deemed appropriate, based on a student’s background and research plans.

Curriculum and Courses

The Microbiology Graduate Programs at NC State are interdisciplinary. Our Ph.D. students take many courses taught by MGP faculty, as well as elective courses offered in numerous disciplines and departments across campus, including Biochemistry , Biotechnology , Animal Science , Food Science and Genetics . Our Ph.D. curriculum allows for flexibility Doctoral students will have completed at least 72 credits by the end of their fourth year in the program.

All microbiology graduate students must maintain a minimum cumulative GPA of 3.0. The Graduate Student Support Plan (GSSP; tuition and health benefits) also requires continuous enrollment, meaning all graduate students must enroll for a minimum of nine credits in each Fall and Spring semester to qualify. After the first year, most of these are Research credits.

Required Course Credits for a Ph.D. in Microbiology

Required courses.

As listed above, students are required to register for the following:

MB 500s-700s – Microbiology Courses

Students are required to take 12 graduate-level, letter-graded microbiology (MB) credits. Courses are 3 credits each.

MGP students are able to take courses that focus on the various specialized disciplines of microbiology, including bacterial physiology, environmental microbiology, immunology, molecular genetics and virology. Prior experience can impact which courses a student can enroll in.

Prerequisites in biochemistry are required for many of these courses, so we recommend that all microbiology graduate students have the equivalent of introductory biochemistry ( BCH 553 ) at NC State early in the curriculum.

An example of courses that fit into two of many different microbiology “tracks” or concentrations:

Mb 870 – laboratory research rotations.

Doctoral students supported by a teaching or research assistantship are required to participate in a minimum of two research rotations , allowing them to experience the types of research performed in MGP faculty member’s laboratories and choose a research area of high interest to them. An additional rotation is possible, with approval from the Director of Graduate Programs (DGP) and the respective faculty.

Research rotations take place each year from July through the end of the Fall semester. Students earn 1 credit (MB 870) for both laboratory rotations, and their performance is formally evaluated by the principal investigator of the laboratory. Students must also provide a written or oral report about their rotation experience. Following their last research rotation, students may choose a laboratory for their dissertation research.

Although doctoral students supported by a stipend funded from a faculty grant or other source are not required to participate in the research rotations, they may choose to do so with approval from the principal investigators. We encourage all students to review MGP  faculty pages and meet with faculty before deciding upon a specific lab for their rotation.

MB 886 – Teaching Experience

A minimum teaching responsibility is part of the requirements for a Ph.D. degree in Microbiology from NC State. Students must serve as a laboratory teaching assistant for at least one semester in an NCSU on-campus course. Prior teaching experience in an M.S. program will be considered to fulfill this requirement. One credit of MB 886 is provided for each semester the student teaches.

The teaching requirement should be fulfilled at the earliest possible time in the graduate program. Example courses approved for fulfilling the teaching requirement are: MB 352, MB 412, MB 452 and BIO 181. Specific tools for enhancing teaching effectiveness are provided for teaching assistants, including workshops and constructive evaluation by the instructor and the students.

MB 801 – Seminar in Microbiology

The MGP requires all graduate students to attend Microbiology seminars throughout their degree program. All Ph.D. students must register for at least two semesters (two credits) of seminar.

MB 893/895 – Microbiology Research

MB 893 and MB 895 provide credit for research students perform in our Ph.D. program.  Students register for MB 893 prior to passing their Preliminary Exam , after which they may sign-up for a variable number of MB 895 credits each semester. A minimum of six credits is required for the Ph.D. degree. However, this is a research-intensive degree, so many credits will end up being for research (MB 895 Microbiology Research).

Other Professional Development

All our graduate students are required to attend either the Microbiology course in Professional Development and Responsible Conduct of Research, or a similar module offered in related programs (BIT, GN, etc.). One credit hour is required.

Elective Graduate Courses

Doctoral students can choose to take other courses offered by departments and programs throughout NC State (Biochemistry, Genetics, Statistics, etc.). Selection of elective courses is done by the student, in consultation with and approval by the advisory committee. Letter graded or satisfactory/unsatisfactory course formats can be used.

Below are examples of elective courses available. The graduate catalog  should be consulted for the current comprehensive listing.

• BAE 525 – Industrial Microbiology & Bioprocessing
• BCH 553 – Biochemistry of Gene Expression
• BCH 701 – Macromolecular Structure
• BCH 703 – Macromolecular Synthesis and Regulation
• BCH 705 – Molecular Biology of the Cell
• BIT 510 – Core Technologies in Biotechnology
• BIT 595X  – Advanced Modules in Biotechnology
• GN 513 – Advanced Genetics
• GN 701 – Molecular Genetics
• GN 735 – Functional Genomics
• GN 850  – Professionalism and Ethics
• MB(PP) 730  – Fungal Genetics and Physiology
• MB 610  – Special Topics in Microbiology
• MB 620  – Special Problems
• MB 801  – Seminar in Microbiology
• MB 705  – Biological Scanning Electron Microscopy
• MB(IMM) 783 – Advanced Immunology
• MB 790I  – Practical Digital Imaging

Advisory Committees

Doctoral students are required to select a dissertation advisor before the end of their second semester (until then, the Director of Graduate Programs (DGP) serves as a temporary advisor). By the end of their first year, each student must also have selected a graduate advisory committee with the help of their dissertation advisor. Advisory committee’s will consist of a student’s dissertation advisor, at least two additional faculty members from the MGP and one faculty member who holds a graduate faculty appointment in another program.

All required committee members must hold appointments within the Graduate School at NC State. Students may select scientists who are not members of the Graduate School faculty (e.g., adjunct faculty, industry scientists) for their committee, but it is in addition to the required members. Graduate advisory committees must meet no less than once a year.

Graduate Plan of Work (PoW)

A Graduate Plan of Work (PoW) will include all courses, a tentative dissertation title and an anticipated timetable for taking each course. Students and their dissertation advisors will informally outline the PoW as soon as possible. The plan will be submitted for approval to and/or amendment by the student’s advisory committee. Then the PoW will be formally submitted to the graduate school by the end of the student’s third semester at NC State.

Visit the Graduate School website for more information about the graduate PoW .

Annual Research Progress Reports

The MGP will facilitate scheduling an annual meeting of the student’s advisory committee, at which the student will make an oral presentation and submit a written report on their laboratory research. A Graduate Student Progress Evaluation Form will be completed by the advisory committee. A satisfactory evaluation will be necessary for the student to receive assistantship support and/or be able to register for the next semester.

Dissertation and Defense

All Ph.D. students must write a dissertation on their research and this must conform to the regulations laid down in the NCSU “Thesis and Dissertation Guide.” The content and structure of the dissertation must be approved by the advisory committee, and all degree candidates are expected to prepare their research results for publication prior to completing their program. Doctoral candidates who have completed their research and other degree requirements (72 credit hours) may enroll in MB 899 (Dissertation Preparation) while they are writing their dissertation. All Ph.D. candidates must also present a seminar hosted by the MGP prior to defending their dissertation. Subject to the satisfactory defense of the Ph.D. dissertation, the advisory committee will approve it for transmittal to the Graduate School.

Course Catalog

Explore our course offerings and microbiology course descriptions 

Review our admission requirements and apply now! 

Discover some of the helpful resources available to MGP students 

Fill out our interest form and we will be in touch! 

[100+] Biotechnology Research Topics With Free [Thesis Pdf] 2023

Are You Searching Research Topics For Biotechnology ,   Topics For Biotechnology Research Paper, Biotechnology Research Topics For Students, Research Topics Ideas For Biotechnology, Biotechnology Research Topics For PhD, Biotechnology PhD Topics. So You are in right place. 

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Note: All Research Work Idea on this website is inspired by Shodhganga: a reservoir of Indian Theses. We provide you mostly research work under Creative Commons Licence. Credit goes to https://shodhganga.inflibnet.ac.in/

If you find any copyright content on this website and you have any objection than plz immediately connect us on [email protected]. We Will remove that content as soon as.

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Biotechnology improves our lives and our planet. It’s used to develop technologies and products such as biofuel, medicine and vaccines. CSUBIOTECH is a committed network of faculty, deans and presidents representing the CSU’s 23 campuses. Together, their work champions biotechnology innovation and helps students embark on life science careers through experiential learning opportunities.

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Presently, the Department is headed by Dr. Anushree Gupta. The Department is known for its commitment to biomedical research and continuous efforts of the Faculty has established a name for the Department in the areas of Leprosy, TB, Malaria and Cancer. New fields of research initiated in the Department include Cardiogenomics, Bioinformatics, Osteoimmunology, Molecular Biology, Virology and Autoimmunity. The Departmental Faculty have published more than 500 research articles/chapters in journals/books of national and international repute and hold more than a dozen patents. For their research contributions, they have been recognized by various International and National Awards, Prizes and Fellowships from several Science and Medical Academies. The research projects in the Department are funded by various agencies of the Govt. of India, such as DBT, ICMR, DST, CSIR, UGC, intramural support as well as International funding agencies like CNRS, Bill and Melinda Gates Foundation,etc. with several Ph.D. students/Project fellows working on research topics in the afore mentioned areas. The Department regularly invites eminent scientists and academicians to deliver seminars on current topics of international and national importance to apprise the students and Faculty members of Institute on recent advances related to the field of Biotechnology.

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New incubator to fuel life science innovation in Stanford Research Park

A recently vacated building in Stanford Research Park will be the future home of a new life science incubator and lab suites. Located near campus, this incubator will serve as an anchor for a preeminent life science district.

September 17, 2019 - By Amy Adams

The 92,000 square foot building at 3160 Porter Dr will be developed into a life science incubator and small lab suites. Vantage Point Photography Inc.

To bolster the long-term vision of a thriving bioscience community near its campus, Stanford University is working to shape part of Stanford Research Park into a leading life science district focused on fast-growing sectors such as bioengineering, gene therapies, diagnostics, medical technology and devices, surgical robotics and digital health. As a key component of this effort, Stanford is collaborating with Alexandria Real Estate Equities, Inc. to convert an existing 92,000-square-foot facility at 3160 Porter Drive into a life science incubator — Alexandria LaunchLabs® at Stanford Research Park — and small lab suites.  

When the building was recently vacated, Stanford saw an opportunity to create a flexible and vibrant space that would enhance the connections between the existing life science ecosystem of medical facilities, researchers and companies in the surrounding area, while also encouraging progress toward an even more diverse life science community. The university held a competition for firms that specialize in this work and chose Alexandria, an experienced developer and operator of successful life science communities near academic campuses.

“Stanford has a legacy of translating life science research discoveries into cures, but the opportunities in this field are greater than ever before. We want to take advantage of this current momentum and further accelerate solutions,” said Stanford President Marc Tessier-Lavigne , PhD. “This new incubator will support entrepreneurs in the development of new therapies and cures for critical diseases and create a community for life sciences entrepreneurship and innovation. We were delighted to enlist Alexandria, which has a strong history of not only building lab space but stimulating discovery and collaboration through their unique approach to creating life science ecosystems.”

The university envisions the incubator as the anchor of an 85-acre life science district, within the existing Stanford Research Park, that will become a new center of gravity for life science innovation in the Bay Area — a community for scientists and entrepreneurs who desire to collaborate, discover and invent pioneering medicines, therapies, devices and technologies to help humankind.

Accelerating therapies

Positioned roughly a mile from campus and in close proximity to Stanford’s adult and children’s hospitals, the VA hospital, and Stanford University School of Medicine, as well as Jazz Pharmaceuticals, Varian Medical Systems, Kodiak Sciences, the Canary Foundation and other biotech firms, Alexandria LaunchLabs at Stanford Research Park will catalyze emerging life science research. It also aligns with the goals of the Innovative Medicines Accelerator — an initiative that arose out of Stanford’s long-range planning process, which aims to help basic and applied researchers from across the schools of Medicine, Engineering and Humanities & Sciences translate their research discoveries into new therapies and diagnostics.

“This space will be key to our shared vision of ensuring Stanford discoveries continue to benefit the world,” said Sanjiv Sam Gambhir , MD, PhD, Virginia and D.K. Ludwig Professor of Cancer Research and chair of the Department of Radiology. “Together with the Innovative Medicines Accelerator, the hope is the incubator can do even more to initiate commercialization of novel therapies for the greater good of humanity.”

Having an expanded life science-focused community close to campus will also complement existing efforts within the School of Medicine to translate basic science discoveries into new therapies.

“The breadth and depth of innovative research emerging from Stanford Medicine is astonishing,” said Lloyd Minor , MD, dean of the Stanford School of Medicine. “The incubator will provide our researchers with resources and access to experts to streamline and speed the translation of groundbreaking discoveries. Additionally, its close proximity to Stanford’s School of Medicine, two world-class hospitals, and the VA will help to realize the promise of bench-to-bedside research.”

As new technologies, devices, treatments and therapies move from ideas to labs to applications in the real world, it is important to have spaces that can adapt to support this development — and early-stage life science solutions have diverse needs. Such flexible spaces can be challenging to find in the Bay Area and companies often end up renting space that is longer-term than what they require. Spots close to the Stanford campus, and the venture capital groups nearby, are especially rare.

“Biotech entrepreneurs often need to commit to multiyear leases, large footprints and expensive lab build-outs when they aren’t even sure they have a viable product yet,” said Jennifer Cochran , PhD, Shriram chair of bioengineering at Stanford. “This flexibility and proximity to campus will greatly benefit Stanford faculty and other entrepreneurs, and provide them with a supportive community and shared resources to facilitate their new ventures.”

Bridging academia and industry

Since its origin in the 1950s, Stanford Research Park has drawn pioneering researchers and industry leaders, in part, due to the potential for collaboration with the university nearby. The 700-acre research park is home to about 150 diverse companies focused on scientific discovery, technological innovation and commercialization of groundbreaking research. It also includes existing biotechnology companies and School of Medicine lab space focused on precision medicine.

Under this new agreement, Stanford has sold a 51-year ground lease for 3160 Porter Drive to Alexandria. Building upon the success of Alexandria’s unique space offerings for life science companies near academic campuses, the company will bring its Alexandria LaunchLabs platform to Stanford Research Park to create an environment that stimulates discovery. Alexandria LaunchLabs at Stanford Research Park will provide flexible, move-in-ready lab and office space, as well as strategic programming and access to seed capital. The facility will also offer lab suites for maturing companies.

“As a University-affiliated research park, we recognize we have a unique mission — to bridge academia and industry in an effort to launch solutions that will have an enduring positive impact in our community and world,” said Tiffany Griego, managing director of asset management for Stanford Research Park. “Stanford Research Park and Palo Alto have always been at the forefront of new technological and scientific discoveries and inventions.  With a renewed focus on drawing life science entrepreneurs to Stanford Research Park, we will support them in their pursuits to deliver therapies and solutions to the public health challenges of the 21st century.”

Griego said Alexandria LaunchLabs at Stanford Research Park is expected to open in spring of 2021.

About Stanford Medicine

Stanford Medicine is an integrated academic health system comprising the Stanford School of Medicine and adult and pediatric health care delivery systems. Together, they harness the full potential of biomedicine through collaborative research, education and clinical care for patients. For more information, please visit med.stanford.edu .

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National Institute of Animal Biotechnology

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NIAB is aimed to harness novel and emerging biotechnologies and take up research in the cutting edge areas for improving animal health and productivity. The Institute’s focus of research will be on Animal Genetics and Genomics, Transgenic Technology, Reproductive Biotechnology, Infectious Diseases, Bioinformatics and Nutrition Enrichment. The institute aims at translational research leading to the development of novel vaccines, diagnostics and improved therapeutic molecules for farm animals. The Institute plans to promote bio entrepreneurship by providing support environment for commercial tenants involved in the development of farm animal based products

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Advanced Study/Thesis Research Form

Anyone wishing to register for Master's level Biology or Biotechnology Thesis Research or Advanced Study, needs to complete this form and send it to  [email protected] and copy their mentor, who agrees to oversee their research (before turning in the form).

Requester: Chrisine Stefano Email:  [email protected] Phone: 212-650-6800

Last Updated: 04/23/2024 10:44

(Your Own Biotechnology Corner)

PG dissertation at NCCS, Pune – Apply now

NATIONAL CENTRE FOR CELL SCIENCE, An Autonomous Institute of Department of Biotechnology, Ministry of Science & Technology, Govt. of India is inviting applications for the post-graduate dissertation program starting from January 2024. The detailed notification is as below:-

POST GRADUATE DISSERTATION January 2024 Session for 6 or 12 Months Last date for receipt of online applications: November 15, 2023

NCCS invites applications from eligible candidates for the post-graduate dissertation program, commencing in January 2024. Eligible applicants, who are bonafide PG students with a consistently strong academic record and a commitment to pursuing studies in modern biology such as Cell & Molecular Biology, Structural Biology, Bioinformatics, Systems Biology, Neuroscience, Immunology, Infection Biology, Cancer Biology and Microbial Ecology are encouraged to apply.

NCCS will admit dissertation students in four sessions annually, allowing applicants to apply year-round. For those looking to commence their dissertation after April 1, 2024, please apply during the next session. The application process for the April 2024 session will begin in December 2023.

ELIGIBILITY:

• Students who are currently pursuing their first year of M. Sc., M. Pharm, M. Tech programs, OR students in their fourth year of B. Tech, B. Pharm, B. Sc. or integrated M. Sc.
• Applicants with qualifications such as MBBS, MD, B. V. Sc, or M. V. Sc. who have a keen interest in translational clinical research.

Applicants who have already completed or expected to complete their post-graduation before the training session ends are ineligible to apply. However, this does not apply to MBBS, MD, B.V. Sc, or M. V. Sc degree holders. Please note that meeting the essential eligibility criteria does not guarantee shortlisting or subsequent selection for the PG dissertation at NCCS.

SCHEDULE: JAN 2024 SESSION Commencement of Online Application Submission October 26, 2023 Deadline for Online Application Submission November 15, 2023 Announcement of Selected Candidates November 30, 2023 Commencement of Dissertation January 01 to March 31, 2024

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NCCS Pune Post Graduate Dissertation January 2024 Session – Applications Open

NCCS Post Graduate Dissertation 2024 January Session – Apply Online

NCCS Post Graduate Dissertation 2024 January Session – Apply Online. Interested and eligible applicants can check out all of the details on the same below:

NATIONAL CENTRE FOR CELL SCIENCE राष्ट्रीय कोशिका शिज्ञान कें द्र

An Autonomous Institute of Department of Biotechnology, Ministry of Science & Technology, Govt. of India

NCCS Complex, Savitribai Phule Pune University Campus, Ganeshkhind, Pune 411 007

POST GRADUATE DISSERTATION January 2024 Session for 6 or 12 Months

Last date for receipt of online applications: November 15, 2023

NCCS invites applications from eligible candidates for the post-graduate dissertation program, commencing in January 2024. Eligible applicants, who are bonafide PG students with a consistently strong academic record and a commitment to pursuing studies in modern biology such as Cell & Molecular Biology, Structural Biology, Bioinformatics, Systems Biology, Neuroscience, Immunology, Infection Biology, Cancer Biology and Microbial Ecology are encouraged to apply.

NCCS will admit dissertation students in four sessions annually, allowing applicants to apply year-round. For those looking to commence their dissertation after April 1, 2024, please apply during the next session. The application process for the April 2024 session will begin in December 2023.

ELIGIBILITY:

• Students who are currently pursuing their first year of M. Sc., M. Pharm, M. Tech programs, OR students in their fourth year of B. Tech, B. Pharm, B. Sc. or integrated M. Sc.
• Applicants with qualifications such as MBBS, MD, B. V. Sc, or M. V. Sc. who have a keen interest in translational clinical research.

Applicants who have already completed or expected to complete their post-graduation before the training session ends are ineligible to apply . However, this does not apply to MBBS, MD, B.V. Sc, or M. V. Sc degree holders. Please note that meeting the essential eligibility criteria does not guarantee shortlisting or subsequent selection for the PG dissertation at NCCS.

• To submit your online application form, visit the ‘Project Positions’ section under the ‘Careers’ menu on the NCCS website. You need to have a Gmail account to fill in the online form.
• Please upload the following documents as a single PDF file. This two-page PDF should not exceed 1 MB in size. o The cumulative mark sheet of your Bachelor’s degree OR, for four-year programs, the cumulative mark sheet for the third year. o A certificate from the Head of the Department/ Principal of your College/ University, or Institute using the provided format in ‘Annexure A’ (Page 3). Please print out ‘Annexure A’ on official letterhead- without making any changes in the format, fill it out, add a photograph, have it duly signed, stamped, and scanned before you upload it. o Applications missing either of these attachments will not be considered for selection. It’s important to note that this requirement doesn’t apply to candidates with MBBS, MD, M. V. Sc., or B. V. Sc. qualifications. o Please bring the original HOD certificate and the B. Sc. marksheet at the time of joining.
• NCCS does not offer any stipend and does not impose any fees for the PG dissertation program.
• The PG dissertation program is a full-time commitment. On-campus hostel accommodation may be provided to a limited number of students on a chargeable, firstcome, first-served basis.
• NCCS does not accept applications for part-time dissertations from any students as the PG dissertation program is a full-time training program. Selected students are required to complete a minimum of 5 or 10 months of dissertation, and completion certificates will be issued only upon fulfillment of this requirement.
• Enrolled students are expected to rigorously adhere to all rules and regulations established by the NCCS throughout the duration of their dissertation. Regular attendance at given work place, scheduled lab activities, and any other academic events, is typically required.
• If you experience any technical difficulties during the online application process, please email us at [email protected] . All subsequent updates and information related to this process will be exclusively posted on https://www.nccs.res.in periodically.

SCHEDULE: JAN 2024 SESSION

APPLY ONLINE HERE

Click here for the notification and Download the annexure here

Editor’s Note : NCCS Post Graduate Dissertation 2024 January Session – Apply Online. Please ensure you are subscribed to the  Biotecnika Times Newsletter  and our  YouTube  channel to be notified of the latest industry news. Follow us on social media like  Twitter ,  Telegram ,  Facebook   and  Instagram .

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As Americans Spend More Out Of Pocket On Healthcare, Startups See Opportunity

Americans are spending ever-rising sums of their own money on healthcare.

So-called out-of-pocket expenses now top $470 billion annually, per the federal government’s latest accounting . Spending is expected to keep rising too, along with the spread of high-deductible health plans and care providers who don’t accept insurance.

While consumers aren’t exactly thrilled about this trend, startup founders and their backers see some very scalable opportunities. In the past couple of years, hundreds of millions of dollars have gone to companies working on things like health savings account platforms, care price comparison apps, and tools for employers offering high deductible plans.

Who’s getting funded? Using Crunchbase data , we curated a sample list of 19 companies innovating around the rise of out-of-pocket health spending. Collectively, they’ve raised more than a half-billion dollars to date.

Looking at the list above, we see that much of the funding activity skews early-stage. There’s likely potential for exponential growth ahead, however, given the vast sums at play coupled with the seemingly low bar for improving on the status quo.

As sector heavyweight Andreessen Horowitz put it in an explainer piece on its investment thesis: “Why are we so bullish on consumer health? The current state of affairs is dismal. Patients are unhappy; providers are burned out.”

The firm’s investment strategy rests on the notion that as consumers are footing more healthcare costs, they’re becoming more discerning about healthcare experiences and thus “likely to vote with their wallets.”

Key themes: Access, price transparency, alternative plans

It’s also worth noting that more consumers have wallets with which to vote. As of 2022, more than half of private-sector workers (53.6%) were enrolled in high deductible health plans, according to a recent study . Enrollees also commonly use health savings accounts or flexible spending accounts to cover day-to-day medical expenses.

Per Colin Tobias , a partner at SemperVirens Venture Capital , a lot of recent startup investment centers around making it easier to use HSAs and manage self-pay transactions. One he points to in this arena is San Francisco-based PayZen , which offers consumers payment plans for health expenses. Another is First Dollar , which develops tools to consolidate benefits in one digital wallet.

Others are working on tools to help healthcare consumers find the best value for their money. Among the more heavily funded startups taking this approach is Turquoise Health , which lets consumers compare prices for medical procedures from providers in their area. The San Diego company secured $30 million in Series B financing in January, bringing total funding to date to over $55 million.

Probably the most recent funding recipient on the price transparency front, meanwhile, is Milu Health . The Illinois startup picked up a $4.8 million seed round last month to build out technology that analyzes health records seeking ways to save on and improve care.

Employers and ICHRAs

The healthcare industry is famous for minting acronyms, which brings us to our next popular investment theme: ICHRAs, or Individual Coverage Health Reimbursement Arrangements.

This is acronym-ese for employers who, rather than offer their own health insurance plan, provide money to employees who can use it to pay for their own policies or cover out-of-pocket medical expenses. ICHRAs are increasingly popular with employers, and startups are looking to tap into some of that growth.

Several of these startups have raised funding pretty recently. Berkeley, California-based Venteur , which offers AI-enabled tools for finding the best use of ICHRA money, picked up $7.6 million in an August seed financing. Thatch , which offers tools for selecting suitable coverage and debit cards for health expenses, landed $6 million last year. StretchDollar , which markets to small businesses extending ICHRAs to employees, closed on a $1.6 million pre-seed round in September.

Getting to better

Overall, as much as most of us hate paying out of pocket for health expenses, especially when we already pay hefty sums for insurance, there are some encouraging takeaways from recent trendlines.

One is that employers are getting more tools to make contributions and help employees navigate coverage in a world of high deductibles and higher out-of-pocket spending. In addition to contributing to policy costs, employers can also fund FSAs to cover self-pay expenses.

Another is that, if AI-enabled tools perform well and providers make price transparency a priority, startups could help mitigate one of the biggest complaints about self-pay care, which is anxiety around price. Before opening our wallets, consumers would greatly appreciate the ability to know from the start what a consultation, test or procedure is going to cost.

Related Crunchbase Pro list:

• Funded Companies Tied To High-Deductible Insurance And Self-Pay Healthcare

Illustration: Dom Guzman

Stay up to date with recent funding rounds, acquisitions, and more with the Crunchbase Daily.

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Swiss biotech report 2024 shows sector performing well in 2023 by continuing to embrace international alliances, during 2023, switzerland’s biotech sector again demonstrated considerable agility particularly in commercialization and financing activities to continue to play a key role in driving global healthcare innovation. in addition to record revenues of chf 7.3 billion, the industry raised more than chf 2 billion – a remarkable 50% increase over 2022..

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• Record revenues of CHF 7.3 billion (USD 8.1 billion)
• Capital investments increase by more than 50% to CHF 2 billion – CHF 1.4 billion by public companies, CHF 0.6 billion by private companies
• Significant licensing and M&A activity in 2023 – VectivBio, T3, Vertex, Santhera
• R&D investments of publicly traded biotech companies have decreased in line with global markets, whereas privately financed companies were able to increase both R&D investments and liquidity reserves
• Record number of product approvals by Swissmedic, EMA and FDA – including world’s first CRISPR gene editing therapy
• Swiss Biotech Day increases international presence with full launch of Global Village, the partnering platform for international delegations

During 2023, Switzerland’s biotech sector again demonstrated considerable agility particularly in commercialization and financing activities to continue to play a key role in driving global healthcare innovation. In addition to record revenues of CHF 7.3 billion, the industry raised more than CHF 2 billion – a remarkable 50% increase over 2022. This comprised around CHF 1.4 billion collected by public companies, and the remaining CHF 0.6 billion by private companies. Although R&D investments dipped slightly to CHF 2.4 billion, they are still at very high levels. The latest edition of the Swiss Biotech Report launched today by the Swiss Biotech Association, in conjunction with EY and eight other partner organizations, provides an analysis of the 2023 biotech funding as well as other 2023 key ratios and statistics. The 2024 Swiss Biotech Report’s theme of ‘Reliable Partners Beyond Borders’ focuses on the positive impact of Swiss collaborations at all levels of the global life sciences ecosystem – from research & development to manufacturing and regulatory harmonization.

Michael Altorfer, CEO, Swiss Biotech Association, commented: «The World Intellectual Property Organization, WIPO, has placed Switzerland top of the Global Innovation Index for the past 13 consecutive years. The Swiss Biotech Report shows that Swiss biotech companies continue to harness this innovation power to develop effective new products and solutions that address global needs. Around 1.5 billion Swiss francs were dedicated to collaborations all over the world.»

Frederik Schmachtenberg, EY Partner and Global Life Sciences Lead for Financial Accounting Advisory Services, added «Swiss biotech companies attracted more than 2 billion Swiss francs, a more than 50% increase compared to 2022. While public biotech companies seemed to have been at least partially impacted by a dire global market sentiment, privately financed companies have raised a solid CHF 0.6 billion, which even allowed them to increase their overall liquidity reserves, despite record investments in R&D projects.»

Key Findings in the 2024 Swiss Biotech Report

Once again, the Swiss biotech industry generated record revenues of CHF 7.3 billion compared to CHF 6.8 billion in 2022. This was driven by significant collaboration and licensing deals, where Swiss biotech companies often successfully partner with large pharma companies, and product sales boosted by a record number of approvals from Swissmedic, EMA, FDA and other global regulatory authorities, including breakthrough advanced therapies from CRISPR Therapeutics, Santhera Pharmaceuticals, Idorsia, Relief Therapeutics and Basilea.

In a challenging global public market, the main fundraises were achieved by Oculis SA, with a SPAC transaction on NASDAQ and follow-on financing collecting USD 144 million and MoonLake Immunotherapeutics, with CHF 415 million through a follow-on transaction from 2022’s IPO. While the public market sentiment remained dire ever since the end of the Covid pandemic, the private funding environment held up well in 2023. Noema Pharma with CHF 103 million raised,  Alentis Therapeutics with CHF 94 million, Rejuveron with CHF 67 million, Nouscom with CHF 65 million, and NewBiologix with CHF 45 million led the way.

2023 also saw significant M&A activity at all levels from early stage to established companies demonstrating the maturity of the Swiss biotech sector. Particularly worth noting are Pierre Fabre Laboratories purchase of Vertical Bio, Ironwood Pharma’s takeover of VectivBio for USD 1 billion and Boehringer Ingelheim’s acquisition of T3 Pharma for an amount of up to CHF 450 million.

The number of FTEs working in Swiss R&D biotech companies remained with over 19,000 people almost unchanged in 2023 compared to 2022. Despite an overall slight decrease in R&D expenses, the private companies’ share continued to grow.

Finally, following the creation of an innovation office in 2022, Swissmedic again looked to foster international collaboration and harmonization by establishing ‘The Access Consortium’ with like-minded medium-sized regulatory authorities, including Australia's Therapeutic Goods Administration (TGA), Health Canada (HC), Singapore's Health Sciences Authority (HSA), and the UK’s Medicines and Healthcare Products Regulatory Agency (MHRA).

Expanding the Global Village and Swiss Biotech Success Stories Awards for outstanding achievements

The Swiss Biotech Report 2024 was launched at the Swiss Biotech Day which is attracting increasing numbers of international delegates. One contributing factor is the Global Village , a platform hosted by the Swiss Biotech Association in partnership Switzerland Global Enterprise to stimulate sustainable worldwide networking and international collaboration in biotech and life sciences. In only its second year, the Global Village has already grown by 70% and featured 17 international delegations.

To recognize outstanding achievements, the Swiss Biotech Association was also presenting the Swiss Biotech Success Stories Awards at this year’s Swiss Biotech Day to the winners Fondation Suisse de Recherche sur les Maladies Musculaires (FSRMM) and Dr. Hans-Peter Strebel.

FSRMM was founded in 1985 by Jacques and Monique Rognon together with two existing patient organizations to promote research on neuromuscular diseases. Since its inception, FSRMM has raised in excess of CHF 30 million and funded more than 200 research projects at Swiss universities and hospitals.

Dr. Hans-Peter Strebel founded Fumapharm AG with three other scientists in 1983. This was the start of more than 40 years of successful research leading to the development of Tecfidera, a disease modifying therapy for relapsing multiple sclerosis which has so far benefitted more than 600,000 patients worldwide.

Media Contact

Swiss Biotech Association Sabine Bamert Head of Communications [email protected] swissbiotech.org/media

The Swiss Biotech Report 2024

The Swiss Biotech Report sheds light on the most important trends, factors and sources of innovation, and summarizes topics and facts on the development of the Swiss biotech industry. This year’s theme is ‘Reliable Partners Beyond Borders’.

The Swiss Biotech Report Steering Committee

Michael Altorfer, Swiss Biotech Association Frederik Schmachtenberg, EY Florian Fisch, Swiss National Science Foundation Fabian Gerber, SIX Jan Lucht, scienceindustries Hans-Peter Meyer, Swiss Academy of Engineering Sciences Christian Moser Nikles, Swiss Federal Institute of Intellectual Property Jörg Schläpfer, Swissmedic Laura Suter-Dick, biotechnet Switzerland Sirpa Tsimal, Switzerland Global Enterprise

Swiss Biotech and the Swiss Biotech Association

Founded in 1998, the Swiss Biotech Association represents the interests of the Swiss biotech industry. To support its members in a competitive market, the association works to secure favorable framework conditions and facilitate access to talents, novel technologies and financial resources. To strengthen and promote the Swiss biotech industry, the Swiss Biotech Association collaborates with numerous partners and life science clusters globally under the brand Swiss Biotech™. For further information visit swissbiotech.org .

About the global EY organization

The global EY organization is a leader in assurance, tax, transaction and advisory services. We leverage our experience, knowledge and services to help build trust and confidence in the capital markets and in economies all over the world. We are ideally equipped for this task — with well-trained employees, strong teams, excellent services and outstanding client relations. Our global purpose is to drive progress and make a difference by building a better working world — for our people, for our clients and for our communities.

The global EY organization refers to all member firms of Ernst & Young Global Limited (EYG). Each EYG member firm is a separate legal entity and has no liability for another such entity’s acts or omissions. Ernst & Young Global Limited, a UK company limited by guarantee, does not provide services to clients. Information about how EY collects and uses personal data and a description of the rights individuals have under data protection legislation are available via ey.com/privacy. For more information about our organization, please visit ey.com.

EY’s organization is represented in Switzerland by Ernst & Young Ltd, Basel, with 10 offices across Switzerland, and in Liechtenstein by Ernst & Young AG, Vaduz. In this publication, “EY” and “we” refer to Ernst & Young Ltd, Basel, a member firm of Ernst & Young Global Limited.

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MIT Technology Review

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This creamy vegan cheese was made with AI

Climax Foods and other companies are using machine learning to create convincing replacements for conventional dairy cheese.

• Andrew Rosenblum archive page

As Climax Foods CEO Oliver Zahn serves up a plate of vegan brie, feta, and blue cheese in his offices in Emeryville, California, I’m keeping my expectations modest. Most vegan cheese falls into an edible uncanny valley full of discomforting not-quite-right versions of the real thing. But the brie I taste today is smooth, rich, and velvety—and delicious. I could easily believe it was made from cow’s milk, but it is made entirely from plants. And it couldn’t have come into existence, says Zahn, without the use of machine learning.

Climax Foods is one of several startups, also including Shiru of Alameda, California, and NotCo of Chile, that have used artificial intelligence to design plant-based foods. The companies train algorithms on datasets of ingredients with desirable traits like flavor, scent, or stretchability. Then they use AI to comb troves of data to develop new combinations of those ingredients that perform similarly.

“Traditional ingredient discovery can take years and tens of millions of dollars, and what results are ingredients only incrementally better than the previous generation,” says Shiru CEO Jasmin Hume, who wrote her PhD thesis on protein engineering. “ [Now] we can go from scratch, meaning what nature has to offer; pick out the proteins that will function best; and prototype and test them in about three months.”

Not everyone in the industry is bullish about AI-assisted ingredient discovery. Jonathan McIntyre, a food consultant who formerly headed R&D teams in both beverages and snacks at Pepsi, thinks the technology is “significantly” overhyped as a tool for his field. “AI is only as good as the data you feed it,” he says. And given how jealously food companies guard formulas and proprietary information, he adds, there won’t necessarily be sufficient data to yield productive results. McIntyre has a cautionary tale: during his stint at Pepsi, the company attempted to use IBM’s Watson to create a better soda. “It formulated the worst-tasting thing ever,” he says.

Climax Foods circumvented the data scarcity problem by creating its own training sets to essentially reverse-engineer why cheese tastes so good. “When we started, there was very little data on why an animal product tastes the way it does—animal cheddar, blue, brie, mozzarella—because it is what it is,” says Zahn, who previously headed data science for Google's massive ads business. “There [was] no commercial reason to understand it.”  

In the food science lab on the ground floor of the Climax offices, on the site of an old chocolate factory, Zahn shows off some of the instruments his team used to build its data trove. There’s a machine that uses ion chromatography to show the precise balance of different acids after bacterial strains break down lactose. A mass spectrometer acts like an “electronic nose” to reveal which volatile compounds generate our olfactory response to food. A device called a rheometer tracks how a cheese responds to physical deformation; part of our response to cheese is based on how it reacts to slicing or chewing. The cheese data creates target baselines of performance that an AI can try to reach with different combinations of plant ingredients.

Using educated guesswork about which plants might perform well as substitutes, Climax food scientists have created more than 5,000 cheese prototypes in the past four years. With the same lab instruments employed on animal cheese, the Climax team performs an analysis that includes roughly 50 different assays for texture and flavor, generating millions of data points in the process. The AI is trained on these prototypes, and the algorithm then suggests mixtures that might perform even better. The team tries them out and keeps iterating. “You vary all the input knobs, you measure the outputs, and then you try to squeeze the difference between the output and your animal target to be as small as possible,” Zahn says. Including small-scale “micro-prototypes,” he estimates, Climax has analyzed roughly 100,000 plant ingredient combinations.

Tasting and subtly adjusting the ingredient blends in so many prototypes by hand would take several thousand years, Zahn says. But starting from zero in early 2020, he and his AI-aided team were able to formulate their first cheese and bring it to market in April 2023 .  

The plant constituents of that product, a vegan blue cheese, are hardly exotic. The top four ingredients are pumpkin seeds, coconut oil, lima beans, and hemp protein powder. And yet Dominique Crenn , a Michelin-starred chef, described it as “soft, buttery, and surprisingly rich—beyond imagination for a vegan cheese.”  

Bel Group, the maker of Laughing Cow , has an agreement to license the company’s products, and a second large producer that Zahn cannot yet publicly name has also signed on. He is currently beating the venture capital bushes for a funding round and hopes to begin selling the brie and feta later this year. 

Unlike Watson’s ill-fated attempt to formulate a better Pepsi, the Climax algorithms can pull together ingredients in new ways that seem like alchemy. “There is an interaction of one component with another component that triggers a flavor or sensation that you didn’t expect,” Zahn says. “It’s not like just the sum of the two components—it’s something completely different.”  

One reason to develop alternatives to dairy-based cheese is its environmental cost: by weight, cheese has a higher carbon footprint than either chicken or pork , and humans eat roughly 22 million tons of it each year. For Zahn, the answer is not asking consumers to settle for a rubbery, bland substitute—but offering a plant-based version that tastes as good or better and could cost much less to make.

Artificial intelligence

Large language models can do jaw-dropping things. but nobody knows exactly why..

And that's a problem. Figuring it out is one of the biggest scientific puzzles of our time and a crucial step towards controlling more powerful future models.

• Will Douglas Heaven archive page

Google DeepMind’s new generative model makes Super Mario–like games from scratch

Genie learns how to control games by watching hours and hours of video. It could help train next-gen robots too.

What’s next for generative video

OpenAI's Sora has raised the bar for AI moviemaking. Here are four things to bear in mind as we wrap our heads around what's coming.

The AI Act is done. Here’s what will (and won’t) change

The hard work starts now.

• Melissa Heikkilä archive page

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GenScript Biotech Releases 2023 ESG Report: Deepening Green Development Practices, Constructing Sustainable Future Blueprint

PISCATAWAY, N.J. , April 24, 2024 /PRNewswire/ -- Recently, GenScript Biotech Corporation (HK.1548), a world leader in technologies and services for life science R&D and manufacture, released its 2023 Environmental, Social, and Governance (ESG) report. This report showcases the company's dedicated efforts in ESG governance, corporate social responsibility fulfillment, and environmental conservation practices. It underscores GenScript's unwavering commitment to advancing green initiatives and seamlessly integrating sustainable development strategies, reaffirming its strong belief in sustainability.

GenScript's ESG plan embodies its comprehensive and in-depth enhancement strategy, focusing on optimizing production processes, deepening customer R&D support, and advancing lean operations to enhance overall ESG performance. GenScript believes that ESG practices complement business growth, driving sustainable business expansion and positively impacting human society's sustainability. Through close collaboration with customers and continuous improvement of ESG standards, GenScript actively contributes to society.

In strengthening corporate ESG governance, GenScript demonstrates firm determination and systematic planning. The company establishes a risk management and ESG committee at the board level and deploys a cross-departmental ESG management team to continuously monitor and improve ESG practices. Additionally, GenScript maintains high ethical standards, providing anti-corruption training for all employees, strengthening institutional construction, and implementing rigorous annual audit plans to ensure strict compliance with business ethics and legal regulations, thus enhancing risk management and ESG governance.

In terms of fulfilling social responsibilities, GenScript adheres to sustainability as its core value, striving to provide safer and more reliable products and services to global customers. The company actively promotes the development of green and resilient supply chains with its supplier partners, integrating ESG indicators into supplier evaluations and cooperation mechanisms to drive transparency and performance improvement throughout the supply chain's lifecycle.

Moreover, GenScript prioritizes employee growth and well-being, fostering an inclusive and diverse corporate culture. Through comprehensive training systems, diversified career development channels, and efficient communication mechanisms, the company promotes symbiotic growth between employees and the organization. Furthermore, GenScript engages in philanthropic activities, such as organizing "Rare Disease Awareness Weeks", donating to earthquake-stricken areas, and hosting nationwide universities relay charity events, enriching the company's social responsibility endeavors with tangible actions.

The ESG report further illustrates GenScript's environmental practices, emphasizing resource management, waste management, and proactive green actions to combat climate change. By establishing a scientific and efficient environmental management system, optimizing resource utilization, and exploring clean energy transitions, GenScript reduces its environmental footprint. The company implements energy-saving measures such as continuous improvement of production and equipment processes and waste heat recovery, linking environmental performance to management evaluations from top to bottom.

This year, GenScript has further integrated renewable energy into its energy portfolio, purchasing green power and investing in photovoltaic power generation. In April 2024 , GenScript joined the Science-Based Targets initiative (SBTi), committing to scientific carbon goals and planning comprehensive carbon inventories and product carbon footprint identification to set scientific carbon targets. These efforts not only help reduce the company's environmental impact but also assist its customers in achieving carbon reduction goals, collectively fostering a favorable pattern of collaborative emission reduction throughout the industry chain.

Sherry Shao , GenScript's rotating CEO, said, "2023 was a critical year for GenScript's ESG practices. We took proactive actions to build a systematic framework for sustainable development and deeply integrated ESG concepts into the company's daily operations and long-term planning through the collaborative efforts of management, employees, and numerous stakeholders. Here, we sincerely thank all parties for their continuous support of GenScript's business development. In the future, we are willing to work hand in hand with all parties to tirelessly strive for the mission of 'Make People and Nature Healthier Through Biotechnology'."

In the pursuit of sustainable development and continuous enhancement of ESG standards, GenScript demonstrates a firm long-term commitment. In 2023, the company officially joined the United Nations Global Compact (UNGC) and integrated principles such as human rights, labor rights, environmental protection, and anti-corruption into its strategic planning, aiming to leverage the power of this international platform to deepen innovation and improvement in the ESG field. With significant improvements in environmental and sustainable procurement performance, GenScript was awarded the Bronze Medal by the international renowned provider of business sustainability ratings EcoVadis in March this year, ranking among the top 35% of over 130,000 assessed companies.

Moving forward, GenScript will continue to elevate its ESG standards, seize opportunities, and collaborate with stakeholders in a more open and transparent manner to collectively advance sustainable development goals. The "GenScript Biotech 2023 ESG Report" is available at company's official website:

https://www.genscript.com/gsfiles/esg/2023-ESG-Report.pdf

About GenScript

GenScript Biotech Corporation (HK.1548) is a world leader in technologies and services for life science R&D and manufacture. Built upon its solid DNA synthesis technology, the company comprises four major business units: a life-science services and products business unit, a biologics contract development and manufacturing organization (CDMO) business unit, an industrial synthetic products business unit, and an integrated global cell therapy company. GenScript accelerates scientific discovery and therapeutic breakthrough with its customers. Since its founding in New Jersey, USA in 2002, GenScript has expanded its operations to serve more than 200,000 customers across 100 countries with a dedicated team of 6,900 employees. As of December 31, 2023 , 87,700 peer-reviewed journal articles worldwide had cited GenScript 's services and products. Guided by its mission to make people and nature healthier through biotechnology, GenScript strives to become the most trustworthy biotech company in the world.

For more information, please visit GenScript Biotech's official website

https://www.genscript.com