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Little Girl Lost
A Case Study on Defective Cellular Organelles
By Tracie Y. Hudson
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This case study introduces students to the structure and function of cellular organelles and seeks to show their importance by discussing diseases and disorders that can result when an organelle does not function as it should. The storyline follows a family whose joy at bringing home a new baby is soon altered by their child's sudden illness, which is eventually diagnosed as Leigh Disease. This disease occurs when defective mitochondria fail to produce energy needed by the cell, particularly affecting cells with high-energy needs like those in the brain, muscle, and gastrointestinal tract. The narrative also discusses some of the ways in which Leigh disease is inherited, treatment options, and the typical prognosis. The case was designed for an introductory non-majors biology course, but could also be used in other science or health related courses. Instructors also have the option of running the case in a "flipped classroom" in which students watch three recommended videos outside of class as a way of preparing for working on the case in class.
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Date Posted
- Define the term organelle .
- List the key organelles found in animal cells.
- Describe the functions of animal cell organelles.
- Map other disorders and syndromes to the appropriate defective organelles.
- Describe Leigh Syndrome as well as other disorders and syndromes linked to defective cellular organelles.
- Compare and contrast cellular structure and function to that of a factory.
- Create analogies to aid in understanding and remembering the function of cellular organelles.
Organelles; cellular structure; inheritance; plant cells; animal cells; failure to thrive; Leigh Disease; mitochondria; mitochondrial disease; autosomal recessive mutation
Subject Headings
EDUCATIONAL LEVEL
High school, Undergraduate lower division, General public & informal education
TOPICAL AREAS
TYPE/METHODS
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Materials & Media
Supplemental materials.
- Through the Virtual Cell This video provides an overview of many cellular organelles and also discusses transcription and translation. Running time: 6:47 min. Produced by NDSU Virtual Cell Animations Project, 2009.
- Faces of Mitochondrial Disease—The Swinns Emily Swinn and her family discuss what life is like for Emily, who suffers from a mitochondrial disease. Running time: 2:58 min. Produced by the United Mitochondrial Disease Foundation. Uploaded to YouTube October 29, 2000.
- Cellular Respiration and the Mighty Mitochondria This video provides a general overview of mitochondria, ATP, and cellular respiration. Running time: 7:48 min. Produced by the Amoeba Sisters, 2014.
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Little Girl Lost: A Case Study on Defective Cellular Organelles
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Abstract. This case study introduces students to the structure and function of cellular organelles and seeks to show their importance by discussing diseases and disorders that can result when an organelle does not function as it should. The storyline follows a family whose joy at bringing home a new baby is soon altered by their child's sudden ...
Little Girl Lost: A Case Study Defective Cellular Organelles. After many years of trying to get pregnant again, Kenneth and Vicki Johnson were thrilled at the birth of their baby Nicole. T eir frst child had died mysteriously at 12 months of age, and it had taken fve years for Vicki to become pregnant again.
Little Girl Lost: A Case Study on Defective Cellular Organelles. NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE "Little Girl Lost" by Tracie Y. Hudson Page 2 Part II - The Diagnosis ... All living organisms are made of one or more cells. Cells contain organelles. Organelles are defi ned as a specialized subunit within a cell that has ...
Little Girl Lost: A Case Study on Defective Cellular Organelles "Little Girl Lost" by Tracie Y. Hudson Page Part II - The Diagnosis "Given the results of the metabolic screen, the multiple organ system involvement, and the telltale lesions in the brain, it appears that Nicole has Leigh Syndrome (LS)," reported the ER doctor.
Little Girl Lost: A Case Study on Defective Cellular Organelles. Flashcards. Learn. Test. Match. ... Nicole had problems sucking and turning her head, a low weight, little appetite, vomiting, and she was irritable and always crying. AT Hospital she had a seizure and decreased muscle tone.
organelle_defect_flip - Read online for free.
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AP bio extra credit - The Mystery of the Seven Deaths: A Case Study in Cellular Respiration; Chapter 7 Study Guide KEY; BIO10 Final Presentation Outline; Preview text. Strict restrictions apply to your use of this answer key. Only registered NCCSTS password account holders are permitted to view this material, and they are only allowed (1) to ...
Little Girl Lost A Case Study on Defective Cellular Organelles. Course. General Biology 101 (BI101) 18 Documents. Students shared 18 documents in this course. ... What do you think will happen to the cell and the oenergy? rganism over time if it can't produce The cell and eventually the organism will die.
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE Little Girl Lost: A Case Study on Defective Cellular Organelles by Tracie Y. Hudson Department of Biology Malcolm X College, Chicago, Illinois Part I - Bringing Home Baby After many years of trying to get pregnant again, Kenneth and Vicki Johnson were thrilled at the birth of their baby Nicole.
Little girl lost: study on defective cellular organelles case study. 38 terms. emsteadman. Preview. Little Girl Lost Case Study. 15 terms. ttifffanyyy. Preview. exam #1 ch. 3-6.
Little Girl Lost: A Case Study on Defective Cellular Organelles. Flashcards; Learn; Test; Match; ... Nicole had problems sucking and turning her head, a low weight, little appetite, vomiting, and she was irritable and always crying. AT Hospital she had a seizure and decreased muscle tone. what tests did the doctor order?
ANSWER KEY for "Little Girl Lost: A Case Study on Defective Cellular Organelles" by Tracie Y. Hudson Department of Biology Malcolm X College, ... Eventually this will lead to the death of the organism. 3. ... 9/14/2020 Answer Key for "Little Girl Lost" - Case Study Collection ...
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE by Tracie Y. Hudson Department of Biology Malcolm X College, Chicago, Illinois Little Girl Lost: A Case Study on Defective Cellular Organelles Part I - Bringing Home Baby After many years of trying to get pregnant again, Kenneth and Vicki Johnson were thrilled at the birth of their baby Nicole. . Teir frst child had died mysteriously at 12 ...
Little Girl Lost: A Case Study on Defective Cellular Organelles. NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE "Little Girl Lost" by Tracie Y. Hudson Page 2 Part II - The Diagnosis ... All living organisms are made of one or more cells. Cells contain organelles. Organelles are de! ned as a specialized subunit within a cell that has a ...
Little Girl Lost A Case Study on Defective Cellular Organelles. Part 1 1. What does the phrase "failure to thrive" mean? 2. What are some reasons why newborn babies "fail to thrive"? 3. What was the event that triggered Nicole's deterioration? 4. What symptoms caused her parents to take her to the doctor?
View Kami Export - Swetha Jakka - Little Girl Lost.pdf from APUSH 101 at Auburn University. NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE Little Girl Lost: A Case Study on Defective Cellular
1.2 Ultrastructure of Cells. 28 terms. SuryAm504. Preview. Exam 2 Chapter 5. 43 terms. phall1232. Preview. Study with Quizlet and memorize flashcards containing terms like What does the phrase failure to thrive mean?, Reasons some newborn babies fail to thrive, Leigh syndrome and more.
Study with Quizlet and memorize flashcards containing terms like Failure to Thrive, First baby died at 12 mos old, Leigh Syndrome and more. ... little girl lost case. 35 terms. tlopezpacheco01. Preview. chapter 29. 21 terms. katieeex20. Preview. PKU. 17 terms. Daliah_Gonzalez. ... In part caused by defective cell membranes. 3 years old. Age at ...
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE by Tracie Y. Hudson Department of Biology Malcolm X College, Chicago, Illinois Little Girl Lost: A Case Study on Defective Cellular Organelles Part I - Bringing Home Baby After many years of trying to get pregnant again, Kenneth and Vicki Johnson were thrilled at the birth of their baby Nicole. . Teir frst child had died mysteriously at 12 ...
Little Girl Lost: A Case Study on Defective Cellular Organelles Part I - Bringing Home Baby. After many years of trying to get pregnant again, Kenneth and Vicki Johnson were thrilled at the birth of their baby Nicole. Teir frst child had died mysteriously at 12 months of age, and it had taken fve years for Vicki to become pregnant again.
Chloroplast. site of photosynthesis in a plant (only found in plants). Vacuole. storage vesicleS (found in both plants and animals) large vacuole. fills with water to provide rigidity (only found in plants) Study with Quizlet and memorize flashcards containing terms like Nucleus, Nucleolus, Cytoplasm and more.
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE Little Girl Lost: A Case Study on Defective Cellular Organelles by Tracie Y. Hudson Department of Biology Malcolm X College, Chicago, Illinois Part I - Bringing Home Baby After many years of trying to get pregnant again, Kenneth and Vicki Johnson were thrilled at the birth of their baby Nicole. . Their first child had died mysteriously at 12 ...